Fundc2 (FUN14 domain containing 2) - Rat Genome Database

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Gene: Fundc2 (FUN14 domain containing 2) Rattus norvegicus
Analyze
Symbol: Fundc2
Name: FUN14 domain containing 2
RGD ID: 1560916
Description: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in intracellular triglyceride homeostasis and regulation of platelet activation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC2 (FUN14 domain containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FUN14 domain-containing protein 2; LOC361288; RGD1560916; similar to FUN14 domain containing 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818142,829 - 155,123 (-)NCBIGRCr8
mRatBN7.218128,473 - 138,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18132,248 - 138,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18143,997 - 149,596 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018931,838 - 937,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018145,906 - 151,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018401,878 - 407,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18402,295 - 407,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018447,139 - 453,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418112,408 - 118,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera18125,282 - 130,946 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20833797   PMID:21630459  


Genomics

Comparative Map Data
Fundc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818142,829 - 155,123 (-)NCBIGRCr8
mRatBN7.218128,473 - 138,232 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18132,248 - 138,345 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18143,997 - 149,596 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018931,838 - 937,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018145,906 - 151,505 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018401,878 - 407,954 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18402,295 - 407,954 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018447,139 - 453,204 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.418112,408 - 118,067 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera18125,282 - 130,946 (-)NCBICelera
Cytogenetic Map18p13NCBI
FUNDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,026,844 - 155,060,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,025,980 - 155,060,304 (+)EnsemblGRCh38hg38GRCh38
GRCh37X154,255,119 - 154,288,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,908,258 - 153,938,385 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X153,818,825 - 153,847,085NCBI
CeleraX154,413,800 - 154,443,906 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,800,036 - 142,830,182 (+)NCBIHuRef
CHM1_1X154,166,689 - 154,196,808 (+)NCBICHM1_1
T2T-CHM13v2.0X153,263,246 - 153,296,709 (+)NCBIT2T-CHM13v2.0
Fundc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,426,005 - 74,440,764 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,426,005 - 74,440,065 (+)EnsemblGRCm39 Ensembl
GRCm38X75,382,399 - 75,397,158 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,382,399 - 75,396,459 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X72,627,738 - 72,642,497 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X71,635,142 - 71,648,836 (+)NCBIMGSCv36mm8
CeleraX66,783,170 - 66,799,149 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.22NCBI
Fundc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594625,701 - 656,400 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955594627,839 - 656,241 (-)NCBIChiLan1.0ChiLan1.0
FUNDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,004,611 - 155,032,998 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,008,219 - 155,037,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,505,703 - 144,534,871 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,345,251 - 154,373,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,345,251 - 154,374,743 (+)Ensemblpanpan1.1panPan2
FUNDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,046,451 - 123,064,580 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,045,954 - 123,064,580 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,039,832 - 108,057,960 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,174,003 - 126,192,133 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X121,921,891 - 121,940,021 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,444,308 - 124,462,462 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,165,031 - 124,183,161 (+)NCBIUU_Cfam_GSD_1.0
Fundc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,945,691 - 119,960,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927304,197 - 318,271 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927304,162 - 318,271 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FUNDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,354,021 - 125,372,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,354,032 - 125,366,029 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,117,012 - 143,129,015 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FUNDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,315,315 - 129,342,395 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,315,465 - 129,342,193 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,293,273 - 67,320,970 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fundc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624963226,564 - 251,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624963223,145 - 250,841 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fundc2
101 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:383
Count of miRNA genes:187
Interacting mature miRNAs:216
Transcripts:ENSRNOT00000033618
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat

Markers in Region
RH140880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218132,454 - 132,643 (-)MAPPERmRatBN7.2
Rnor_6.018407,555 - 407,743NCBIRnor6.0
Rnor_5.018452,805 - 452,993UniSTSRnor5.0
RGSC_v3.418112,619 - 112,807UniSTSRGSC3.4
Celera18125,493 - 125,681UniSTS
RH 3.4 Map1835.5UniSTS
Cytogenetic Map18p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 29 20 19 20 8 11 74 34 34 11 8
Low 1 28 21 21 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033618   ⟹   ENSRNOP00000036105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18132,248 - 138,345 (-)Ensembl
Rnor_6.0 Ensembl18402,295 - 407,954 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098932   ⟹   ENSRNOP00000084945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18133,140 - 136,276 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108744   ⟹   ENSRNOP00000091610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18132,263 - 136,557 (-)Ensembl
RefSeq Acc Id: NM_001135757   ⟹   NP_001129229
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818146,600 - 152,259 (-)NCBI
mRatBN7.218132,244 - 137,903 (-)NCBI
Rnor_6.018402,295 - 407,954 (+)NCBI
Rnor_5.018447,139 - 453,204 (+)NCBI
RGSC_v3.418112,408 - 118,067 (-)RGD
Celera18125,282 - 130,946 (-)RGD
Sequence:
RefSeq Acc Id: XM_017600984   ⟹   XP_017456473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818146,602 - 152,598 (-)NCBI
mRatBN7.218132,693 - 137,764 (-)NCBI
Rnor_6.018401,886 - 407,503 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096944   ⟹   XP_038952872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818142,829 - 152,119 (-)NCBI
mRatBN7.218128,473 - 137,763 (-)NCBI
RefSeq Acc Id: XM_039096945   ⟹   XP_038952873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818142,829 - 155,123 (-)NCBI
mRatBN7.218128,473 - 138,232 (-)NCBI
RefSeq Acc Id: XM_039096946   ⟹   XP_038952874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818142,829 - 152,119 (-)NCBI
mRatBN7.218128,473 - 137,763 (-)NCBI
RefSeq Acc Id: XM_039096948   ⟹   XP_038952876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818142,829 - 152,605 (-)NCBI
mRatBN7.218128,473 - 138,218 (-)NCBI
RefSeq Acc Id: XM_039096949   ⟹   XP_038952877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818146,794 - 152,119 (-)NCBI
mRatBN7.218132,246 - 137,764 (-)NCBI
RefSeq Acc Id: XM_063277458   ⟹   XP_063133528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818146,602 - 152,569 (-)NCBI
RefSeq Acc Id: XM_063277459   ⟹   XP_063133529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818146,602 - 152,119 (-)NCBI
RefSeq Acc Id: XM_063277460   ⟹   XP_063133530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818148,121 - 152,583 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001129229   ⟸   NM_001135757
- UniProtKB: A0A8I6AFI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456473   ⟸   XM_017600984
- Peptide Label: isoform X4
- UniProtKB: D3ZAQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000036105   ⟸   ENSRNOT00000033618
RefSeq Acc Id: XP_038952873   ⟸   XM_039096945
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952876   ⟸   XM_039096948
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038952874   ⟸   XM_039096946
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038952872   ⟸   XM_039096944
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952877   ⟸   XM_039096949
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000084945   ⟸   ENSRNOT00000098932
RefSeq Acc Id: ENSRNOP00000091610   ⟸   ENSRNOT00000108744
RefSeq Acc Id: XP_063133528   ⟸   XM_063277458
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063133529   ⟸   XM_063277459
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063133530   ⟸   XM_063277460
- Peptide Label: isoform X9

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAQ0-F1-model_v2 AlphaFold D3ZAQ0 1-151 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700624
Promoter ID:EPDNEW_R11148
Type:initiation region
Name:Fundc2_1
Description:FUN14 domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.018402,349 - 402,409EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560916 AgrOrtholog
BioCyc Gene G2FUF-8441 BioCyc
Ensembl Genes ENSRNOG00000024066 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033618.4 UniProtKB/TrEMBL
  ENSRNOT00000098932.1 UniProtKB/TrEMBL
  ENSRNOT00000108744 ENTREZGENE
  ENSRNOT00000108744.1 UniProtKB/TrEMBL
InterPro FUN14 UniProtKB/TrEMBL
NCBI Gene 361288 ENTREZGENE
PANTHER FUN14 DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  PTHR21346 UniProtKB/TrEMBL
Pfam FUN14 UniProtKB/TrEMBL
PhenoGen Fundc2 PhenoGen
RatGTEx ENSRNOG00000024066 RatGTEx
UniProt A0A8I6A167_RAT UniProtKB/TrEMBL
  A0A8I6AFI8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAQ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-01 Fundc2  FUN14 domain containing 2  RGD1560916  similar to FUN14 domain containing 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560916  similar to FUN14 domain containing 2   RGD1560916_predicted  similar to FUN14 domain containing 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560916_predicted  similar to FUN14 domain containing 2 (predicted)  LOC361288  similar to FUN14 domain containing 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361288  similar to FUN14 domain containing 2      Symbol and Name status set to provisional 70820 PROVISIONAL