Zfhx3 (zinc finger homeobox 3) - Rat Genome Database

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Gene: Zfhx3 (zinc finger homeobox 3) Rattus norvegicus
Analyze
Symbol: Zfhx3
Name: zinc finger homeobox 3
RGD ID: 1560268
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme binding activity. Involved in regulation of neuron differentiation. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); prostate cancer; and spinocerebellar ataxia type 4. Orthologous to human ZFHX3 (zinc finger homeobox 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atbf1; LOC108353193; LOC307829; RGD1560268; similar to AT motif-binding factor; uncharacterized LOC108353193; zinc finger homeobox protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,789,146 - 53,795,664 (+)NCBIGRCr8
mRatBN7.21936,257,196 - 36,886,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1936,630,254 - 36,881,771 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01942,753,983 - 42,925,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,758,127 - 42,920,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01953,580,987 - 53,764,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41938,547,428 - 38,783,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1936,050,820 - 36,295,322 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
dicrotophos  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fonofos  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methoxychlor  (EXP)
nitrofen  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
poly(vinylpyrrolidone)  (EXP)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
terbufos  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. ZFHX3 Promotes the Proliferation and Tumor Growth of ER-Positive Breast Cancer Cells Likely by Enhancing Stem-Like Features and MYC and TBX3 Transcription. Dong G, etal., Cancers (Basel). 2020 Nov 18;12(11). pii: cancers12113415. doi: 10.3390/cancers12113415.
2. The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells. Fu C, etal., J Biol Chem. 2020 May 15;295(20):7060-7074. doi: 10.1074/jbc.RA119.012131. Epub 2020 Apr 10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. ATBF1-A protein, but not ATBF1-B, is preferentially expressed in developing rat brain. Ishii Y, etal., J Comp Neurol. 2003 Oct 6;465(1):57-71.
5. [A preliminary functional study of AT motif binding factor 1 in colorectal cancer]. Ji SF and Zhong L, Nan Fang Yi Ke Da Xue Xue Bao. 2016 Jun 20;36(7):957-63.
6. Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation. Jung CG, etal., Development. 2005 Dec;132(23):5137-45. Epub 2005 Oct 26.
7. Expression and subcellular localization of AT motif binding factor 1 in colon tumours. Kataoka H, etal., Mol Med Rep. 2017 Sep;16(3):3095-3102. doi: 10.3892/mmr.2017.7016. Epub 2017 Jul 15.
8. Expression of homeobox genes in cervical cancer. Li H, etal., Gynecol Oncol. 2002 Feb;84(2):216-21.
9. Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients. Minamiya Y, etal., Cancer Biomark. 2012;11(4):139-46. doi: 10.3233/CBM-2012-00272.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Blood serum alpha fetoprotein enhancer binding protein, a tumor suppressor, decreases in chronic HBV hepatitis patients as hepatocellular cancer appears. Riggins JN, etal., Dis Markers. 2010;28(3):125-35. doi: 10.3233/DMA-2010-0692.
16. Genomic profiles and tumor immune microenvironment of primary lung carcinoma and brain oligo-metastasis. Song Z, etal., Cell Death Dis. 2021 Jan 21;12(1):106. doi: 10.1038/s41419-021-03410-7.
17. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Sun X, etal., Nat Genet. 2005 Apr;37(4):407-12. Epub 2005 Mar 6.
18. Germline ATBF1 mutations and prostate cancer risk. Xu J, etal., Prostate. 2006 Jul 1;66(10):1082-5.
19. Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression. Zhan X and Zhao A, J Clin Lab Anal. 2021 Mar;35(3):e23686. doi: 10.1002/jcla.23686. Epub 2020 Dec 24.
20. ZFHX3 mutation as a protective biomarker for immune checkpoint blockade in non-small cell lung cancer. Zhang J, etal., Cancer Immunol Immunother. 2021 Jan;70(1):137-151. doi: 10.1007/s00262-020-02668-8. Epub 2020 Jul 11.
21. ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer. Zhang Z, etal., Clin Cancer Res. 2005 Jan 1;11(1):193-8.
Additional References at PubMed
PMID:7507206   PMID:10318867   PMID:11312261   PMID:11314020   PMID:14651853   PMID:14715251   PMID:20599712   PMID:20876357   PMID:24651376   PMID:26232227  


Genomics

Comparative Map Data
Zfhx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,789,146 - 53,795,664 (+)NCBIGRCr8
mRatBN7.21936,257,196 - 36,886,104 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1936,630,254 - 36,881,771 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01942,753,983 - 42,925,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1942,758,127 - 42,920,344 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01953,580,987 - 53,764,787 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41938,547,428 - 38,783,613 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1936,050,820 - 36,295,322 (+)NCBICelera
Cytogenetic Map19q12NCBI
ZFHX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381672,782,885 - 73,891,930 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1672,782,885 - 73,891,871 (-)EnsemblGRCh38hg38GRCh38
GRCh371672,816,784 - 73,925,829 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361671,374,285 - 71,639,775 (-)NCBINCBI36Build 36hg18NCBI36
Build 341671,378,455 - 71,639,775NCBI
Celera1657,132,611 - 57,398,274 (-)NCBICelera
Cytogenetic Map16q22.2-q22.3NCBI
HuRef1658,584,915 - 58,866,797 (-)NCBIHuRef
CHM1_11674,229,746 - 74,505,362 (-)NCBICHM1_1
T2T-CHM13v2.01678,600,697 - 79,709,756 (-)NCBIT2T-CHM13v2.0
Zfhx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398109,005,975 - 109,688,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,669,276 - 109,688,262 (+)EnsemblGRCm39 Ensembl
GRCm388108,279,311 - 108,961,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,942,644 - 108,961,630 (+)EnsemblGRCm38mm10GRCm38
MGSCv378111,238,544 - 111,485,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368111,603,773 - 111,846,367 (+)NCBIMGSCv36mm8
Celera8112,939,113 - 113,186,662 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map856.02NCBI
Zfhx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554845,474,769 - 5,789,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554845,470,203 - 5,746,325 (-)NCBIChiLan1.0ChiLan1.0
ZFHX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21881,085,000 - 81,357,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11687,015,073 - 87,287,908 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01651,936,471 - 52,209,695 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11672,631,428 - 72,895,974 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1672,635,666 - 72,808,360 (-)Ensemblpanpan1.1panPan2
ZFHX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1578,450,963 - 78,635,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl578,455,005 - 78,610,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha578,441,233 - 78,600,526 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0578,880,298 - 79,039,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl578,884,635 - 79,127,274 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1578,710,322 - 78,869,472 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0578,398,650 - 78,557,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0579,031,731 - 79,190,942 (-)NCBIUU_Cfam_GSD_1.0
Zfhx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934938,353,405 - 39,283,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647521,080,302 - 21,231,544 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647521,005,242 - 21,235,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFHX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl615,698,199 - 15,863,270 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1615,693,987 - 15,941,301 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2615,056,290 - 15,160,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFHX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1555,912,325 - 56,174,010 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl555,907,983 - 56,085,112 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604718,623,958 - 18,901,761 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfhx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474615,098,960 - 15,254,127 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474615,094,890 - 15,330,653 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfhx3
2560 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:8
Count of miRNA genes:3
Interacting mature miRNAs:4
Transcripts:ENSRNOT00000019408, ENSRNOT00000068594
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat

Markers in Region
D19Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,739,682 - 36,739,793 (-)MAPPERmRatBN7.2
Rnor_6.01942,899,998 - 42,900,108NCBIRnor6.0
Rnor_5.01953,727,002 - 53,727,112UniSTSRnor5.0
RGSC_v3.41938,640,782 - 38,640,892UniSTSRGSC3.4
RGSC_v3.11938,645,662 - 38,645,773RGD
Celera1936,151,959 - 36,152,068UniSTS
Cytogenetic Map19q12UniSTS
BF388462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,801,182 - 36,801,405 (-)MAPPERmRatBN7.2
Rnor_6.01942,838,668 - 42,838,890NCBIRnor6.0
Rnor_5.01953,665,672 - 53,665,894UniSTSRnor5.0
RGSC_v3.41938,702,945 - 38,703,167UniSTSRGSC3.4
Celera1936,212,742 - 36,212,964UniSTS
RH 3.4 Map19394.53UniSTS
Cytogenetic Map19q12UniSTS
RH143619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,692,878 - 36,693,134 (-)MAPPERmRatBN7.2
Rnor_6.01942,946,376 - 42,946,631NCBIRnor6.0
Rnor_5.01953,773,417 - 53,773,672UniSTSRnor5.0
RGSC_v3.41938,521,138 - 38,521,393UniSTSRGSC3.4
Celera1936,105,329 - 36,105,584UniSTS
RH 3.4 Map19394.26UniSTS
Cytogenetic Map19q12UniSTS
BF404326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,797,129 - 36,797,347 (-)MAPPERmRatBN7.2
Rnor_6.01942,842,726 - 42,842,943NCBIRnor6.0
Rnor_5.01953,669,730 - 53,669,947UniSTSRnor5.0
RGSC_v3.41938,698,892 - 38,699,109UniSTSRGSC3.4
Celera1936,208,689 - 36,208,906UniSTS
Cytogenetic Map19q12UniSTS
BE121290  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,773,724 - 36,773,902 (-)MAPPERmRatBN7.2
Rnor_6.01942,865,892 - 42,866,069NCBIRnor6.0
Rnor_5.01953,692,896 - 53,693,073UniSTSRnor5.0
Celera1936,185,996 - 36,186,173UniSTS
Cytogenetic Map19q12UniSTS
AU047879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,761,999 - 36,762,193 (-)MAPPERmRatBN7.2
Rnor_6.01942,877,600 - 42,877,793NCBIRnor6.0
Rnor_5.01953,704,604 - 53,704,797UniSTSRnor5.0
RGSC_v3.41938,663,097 - 38,663,290UniSTSRGSC3.4
Celera1936,174,267 - 36,174,460UniSTS
Cytogenetic Map19q12UniSTS
BF409224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,730,772 - 36,730,908 (-)MAPPERmRatBN7.2
Rnor_6.01942,908,879 - 42,909,014NCBIRnor6.0
Rnor_5.01953,735,883 - 53,736,018UniSTSRnor5.0
RGSC_v3.41938,631,876 - 38,632,011UniSTSRGSC3.4
Celera1936,143,215 - 36,143,350UniSTS
Cytogenetic Map19q12UniSTS
MARC_17823-17824:1024943874:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,870,742 - 36,871,233 (-)MAPPERmRatBN7.2
Rnor_6.01942,768,853 - 42,769,343NCBIRnor6.0
Rnor_5.01953,595,857 - 53,596,347UniSTSRnor5.0
RGSC_v3.41938,772,492 - 38,772,982UniSTSRGSC3.4
Celera1936,282,373 - 36,282,863UniSTS
Cytogenetic Map19q12UniSTS
ATBF1_4388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21936,880,989 - 36,881,912 (-)MAPPERmRatBN7.2
Rnor_6.01942,758,174 - 42,759,096NCBIRnor6.0
Rnor_5.01953,585,178 - 53,586,100UniSTSRnor5.0
RGSC_v3.41938,782,739 - 38,783,661UniSTSRGSC3.4
Celera1936,292,643 - 36,293,565UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 2 2 37 10 1
Low 3 42 48 39 19 39 8 11 37 35 31 10 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019408   ⟹   ENSRNOP00000019408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1936,630,254 - 36,881,771 (+)Ensembl
Rnor_6.0 Ensembl1942,758,127 - 42,920,344 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068594   ⟹   ENSRNOP00000061590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1942,758,127 - 42,920,344 (-)Ensembl
RefSeq Acc Id: NM_001427481   ⟹   NP_001414410
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,551,488 - 53,795,664 (+)NCBI
RefSeq Acc Id: XM_039098311   ⟹   XP_038954239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,540,689 - 53,795,664 (+)NCBI
mRatBN7.21936,631,098 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098312   ⟹   XP_038954240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,528,405 - 53,795,664 (+)NCBI
mRatBN7.21936,621,387 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098313   ⟹   XP_038954241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,165,754 - 53,795,664 (+)NCBI
mRatBN7.21936,257,196 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098314   ⟹   XP_038954242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,450,898 - 53,795,664 (+)NCBI
mRatBN7.21936,541,274 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098316   ⟹   XP_038954244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,611,270 - 53,795,664 (+)NCBI
mRatBN7.21936,701,618 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098317   ⟹   XP_038954245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,551,225 - 53,795,664 (+)NCBI
mRatBN7.21936,631,958 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098318   ⟹   XP_038954246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,540,687 - 53,795,664 (+)NCBI
mRatBN7.21936,631,101 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_039098319   ⟹   XP_038954247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,528,407 - 53,795,664 (+)NCBI
mRatBN7.21936,621,388 - 36,886,104 (+)NCBI
RefSeq Acc Id: XM_063278047   ⟹   XP_063134117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81952,789,146 - 53,795,664 (+)NCBI
RefSeq Acc Id: XM_063278048   ⟹   XP_063134118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81953,475,331 - 53,795,664 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000061590   ⟸   ENSRNOT00000068594
RefSeq Acc Id: ENSRNOP00000019408   ⟸   ENSRNOT00000019408
RefSeq Acc Id: XP_038954241   ⟸   XM_039098313
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954242   ⟸   XM_039098314
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954240   ⟸   XM_039098312
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954247   ⟸   XM_039098319
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954239   ⟸   XM_039098311
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954246   ⟸   XM_039098318
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954245   ⟸   XM_039098317
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954244   ⟸   XM_039098316
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134117   ⟸   XM_063278047
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134118   ⟸   XM_063278048
- Peptide Label: isoform X1
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414410   ⟸   NM_001427481
- UniProtKB: F1M4Q6 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type   Homeobox

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560268 AgrOrtholog
BioCyc Gene G2FUF-5744 BioCyc
Ensembl Genes ENSRNOG00000014452 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019408.7 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_U1 UniProtKB/TrEMBL
NCBI Gene 307829 ENTREZGENE
PANTHER ZINC FINGER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  ZINC FINGER HOMEOBOX PROTEIN 3 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfhx3 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014452 RatGTEx
SMART HOX UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
  ZnF_U1 UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt F1M4Q6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Zfhx3  zinc finger homeobox 3  LOC108353193  uncharacterized LOC108353193  Data merged from RGD:11396217 737654 PROVISIONAL
2016-08-02 LOC108353193  uncharacterized LOC108353193      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Zfhx3  zinc finger homeobox 3   Zfhx3_predicted  zinc finger homeobox 3 (predicted)  'predicted' is removed 2292626 APPROVED
2007-09-21 Zfhx3_predicted  zinc finger homeobox 3 (predicted)  RGD1560268_predicted  similar to AT motif-binding factor (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560268_predicted  similar to AT motif-binding factor (predicted)  LOC307829  similar to AT motif-binding factor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC307829  similar to AT motif-binding factor      Symbol and Name status set to provisional 70820 PROVISIONAL