Ppp4r3c (protein phosphatase 4 regulatory subunit 3C) - Rat Genome Database

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Gene: Ppp4r3c (protein phosphatase 4 regulatory subunit 3C) Rattus norvegicus
Analyze
Symbol: Ppp4r3c
Name: protein phosphatase 4 regulatory subunit 3C
RGD ID: 1559817
Description: Orthologous to human PPP4R3C (protein phosphatase 4 regulatory subunit 3C); INTERACTS WITH 17beta-estradiol; bisphenol A; lidocaine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302756; Ppp4r3cp; putative SMEK homolog 3; RGD1559817; similar to MGC79482 protein; SMEK homolog 3, suppressor of mek1 (Dictyostelium); SMEK homolog 3, suppressor of mek1 (Dictyostelium) pseudogene; SMEK homolog 3, suppressor of mek1 pseudogene; Smek3; Smek3p
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X57,585,557 - 57,694,044 (+)NCBIGRCr8
mRatBN7.2X53,630,250 - 53,722,658 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0X57,866,391 - 57,872,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X58,652,562 - 58,659,331 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X76,213,379 - 76,215,790 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX54,235,119 - 54,237,475 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Ppp4r3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X57,585,557 - 57,694,044 (+)NCBIGRCr8
mRatBN7.2X53,630,250 - 53,722,658 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0X57,866,391 - 57,872,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X58,652,562 - 58,659,331 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X76,213,379 - 76,215,790 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX54,235,119 - 54,237,475 (+)NCBICelera
Cytogenetic MapXq21NCBI
PPP4R3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X27,460,207 - 27,463,341 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX27,460,207 - 27,463,341 (-)EnsemblGRCh38hg38GRCh38
GRCh37X27,478,324 - 27,481,458 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X27,388,247 - 27,391,379 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX31,606,919 - 31,610,049 (-)NCBICelera
Cytogenetic MapXp21.3NCBI
HuRefX25,217,742 - 25,220,867 (-)NCBIHuRef
CHM1_1X27,509,142 - 27,512,272 (-)NCBICHM1_1
T2T-CHM13v2.0X27,050,535 - 27,053,669 (-)NCBIT2T-CHM13v2.0
Ppp4r3c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X88,973,703 - 88,976,458 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX88,973,704 - 88,976,458 (-)EnsemblGRCm39 Ensembl
GRCm38X89,930,097 - 89,932,852 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX89,930,098 - 89,932,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X87,175,436 - 87,178,191 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X86,182,817 - 86,185,571 (-)NCBIMGSCv36mm8
CeleraX57,573,136 - 57,575,900 (-)NCBICelera
Cytogenetic MapXC1NCBI
cM MapX39.95NCBI
PPP4R3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X29,254,061 - 29,260,078 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X29,257,441 - 29,263,458 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X20,054,934 - 20,058,418 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X27,411,140 - 27,414,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX27,411,142 - 27,414,318 (-)Ensemblpanpan1.1panPan2
LOC491791
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X22,666,395 - 22,670,128 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX27,624,163 - 27,626,986 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X22,680,135 - 22,682,958 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X22,722,580 - 22,725,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X22,736,440 - 22,739,263 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X22,805,720 - 22,808,543 (-)NCBIUU_Cfam_GSD_1.0
LOC100515114
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X23,301,323 - 23,303,743 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X25,019,135 - 25,022,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP4R3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X25,913,708 - 25,917,148 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605627,868,035 - 27,870,563 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ppp4r3c
271 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_001408850   ⟹   NP_001395779
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X57,585,577 - 57,694,044 (+)NCBI
mRatBN7.2X53,630,250 - 53,722,658 (+)NCBI
RefSeq Acc Id: NM_001408851   ⟹   NP_001395780
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X57,689,975 - 57,694,044 (+)NCBI
mRatBN7.2X53,718,589 - 53,722,658 (+)NCBI
RefSeq Acc Id: XM_063279945   ⟹   XP_063136015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X57,585,557 - 57,692,768 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395779 (Get FASTA)   NCBI Sequence Viewer  
  NP_001395780 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136015 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001395779   ⟸   NM_001408850
RefSeq Acc Id: NP_001395780   ⟸   NM_001408851
RefSeq Acc Id: XP_063136015   ⟸   XM_063279945
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559817 AgrOrtholog
BioCyc Gene G2FUF-2323 BioCyc
NCBI Gene 302756 ENTREZGENE
PhenoGen Ppp4r3c PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-18 Ppp4r3c  protein phosphatase 4 regulatory subunit 3C  Ppp4r3cp  protein phosphatase 4 regulatory subunit 3C  Symbol changed 629549 APPROVED
2016-10-12 Ppp4r3cp  protein phosphatase 4 regulatory subunit 3C  Smek3  SMEK homolog 3, suppressor of mek1 (Dictyostelium)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-23 Smek3  SMEK homolog 3, suppressor of mek1 (Dictyostelium)  Smek3p  SMEK homolog 3, suppressor of mek1 (Dictyostelium) pseudogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Smek3p  SMEK homolog 3, suppressor of mek1 (Dictyostelium) pseudogene  RGD1559817  similar to MGC79482 protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559817  similar to MGC79482 protein   RGD1559817_predicted  similar to MGC79482 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559817_predicted  similar to MGC79482 protein (predicted)  LOC302756  similar to MGC79482 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302756  similar to MGC79482 protein      Symbol and Name status set to provisional 70820 PROVISIONAL