Mettl6 (methyltransferase 6, tRNA N3-cytidine) - Rat Genome Database

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Gene: Mettl6 (methyltransferase 6, tRNA N3-cytidine) Rattus norvegicus
Analyze
Symbol: Mettl6
Name: methyltransferase 6, tRNA N3-cytidine (Ensembl:methyltransferase 6, methylcytidine)
RGD ID: 1359565
Description: Predicted to enable enzyme binding activity and tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human METTL6 (methyltransferase 6, tRNA N3-cytidine); PARTICIPATES IN selenoamino acid metabolic pathway; histidine metabolic pathway; tyrosine metabolic pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: methyltransferase 6, methylcytidine; methyltransferase like 6; methyltransferase-like protein 6; MGC94452; similar to RIKEN cDNA 1600013P15; tRNA N(3)-methylcytidine methyltransferase METTL6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,667,971 - 6,705,385 (-)NCBIGRCr8
mRatBN7.2166,683,820 - 6,699,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,583,465 - 6,698,975 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,696,843 - 6,711,455 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,841,737 - 7,856,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,704,309 - 6,719,120 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,559,964 - 7,588,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,573,750 - 7,588,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,508,042 - 7,523,705 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,924,470 - 6,939,562 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,924,468 - 6,939,560 (-)NCBI
Celera168,491,500 - 8,506,251 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleus  (ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:21873635   PMID:28655767   PMID:35591810  


Genomics

Comparative Map Data
Mettl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,667,971 - 6,705,385 (-)NCBIGRCr8
mRatBN7.2166,683,820 - 6,699,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,583,465 - 6,698,975 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,696,843 - 6,711,455 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,841,737 - 7,856,349 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,704,309 - 6,719,120 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,559,964 - 7,588,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,573,750 - 7,588,841 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,508,042 - 7,523,705 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,924,470 - 6,939,562 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,924,468 - 6,939,560 (-)NCBI
Celera168,491,500 - 8,506,251 (+)NCBICelera
Cytogenetic Map16p16NCBI
METTL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38315,381,275 - 15,427,643 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl315,381,275 - 15,440,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37315,451,267 - 15,469,051 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36315,426,381 - 15,444,046 (-)NCBINCBI36Build 36hg18NCBI36
Celera315,389,607 - 15,407,274 (-)NCBICelera
Cytogenetic Map3p25.1NCBI
HuRef315,386,707 - 15,404,381 (-)NCBIHuRef
CHM1_1315,402,252 - 15,419,927 (-)NCBICHM1_1
T2T-CHM13v2.0315,383,684 - 15,430,055 (-)NCBIT2T-CHM13v2.0
Mettl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391431,180,775 - 31,217,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1431,195,535 - 31,216,997 (-)EnsemblGRCm39 Ensembl
GRCm381431,463,715 - 31,495,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,473,578 - 31,495,040 (-)EnsemblGRCm38mm10GRCm38
MGSCv371432,291,984 - 32,308,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,307,807 - 30,323,986 (-)NCBIMGSCv36mm8
Celera1427,737,717 - 27,753,955 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.12NCBI
Mettl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554301,909,404 - 1,933,239 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554301,910,557 - 1,933,249 (-)NCBIChiLan1.0ChiLan1.0
METTL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2215,366,067 - 15,412,690 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1315,370,831 - 15,417,454 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0315,306,890 - 15,353,505 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1315,643,545 - 15,690,253 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl315,643,545 - 15,690,238 (-)Ensemblpanpan1.1panPan2
SH3BP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12327,202,880 - 27,217,753 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2327,202,875 - 27,334,010 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2327,177,237 - 27,192,107 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02327,715,048 - 27,729,938 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2327,715,728 - 27,847,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12327,404,497 - 27,419,376 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02327,466,265 - 27,481,138 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02327,715,048 - 27,729,929 (+)NCBIUU_Cfam_GSD_1.0
Mettl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118169,824,965 - 169,846,260 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364732,963,466 - 2,985,634 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364732,963,591 - 2,984,827 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl132,638,389 - 2,654,836 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1132,638,972 - 2,654,845 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2132,565,960 - 2,581,817 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METTL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11560,219,348 - 60,261,030 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1560,245,126 - 60,259,957 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604133,249,012 - 33,293,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248225,254,938 - 5,282,742 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248225,253,659 - 5,349,292 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl6
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:548
Count of miRNA genes:288
Interacting mature miRNAs:365
Transcripts:ENSRNOT00000026413
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
RH134000  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2166,683,934 - 6,684,116 (+)MAPPERmRatBN7.2
Rnor_6.0167,573,831 - 7,574,012NCBIRnor6.0
Rnor_5.0167,508,538 - 7,508,719UniSTSRnor5.0
RGSC_v3.4166,924,552 - 6,924,733UniSTSRGSC3.4
Celera168,505,988 - 8,506,169UniSTS
RH 3.4 Map1649.9UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 36 20 19 20 1 1 74 30 41 11 1
Low 15 21 21 21 7 10 5 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063275137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005494556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010058283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000084645   ⟹   ENSRNOP00000074466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl167,573,750 - 7,588,841 (-)Ensembl
RefSeq Acc Id: NM_001007623   ⟹   NP_001007624
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,259 - 6,705,351 (-)NCBI
mRatBN7.2166,683,853 - 6,698,946 (-)NCBI
Rnor_6.0167,573,749 - 7,588,841 (-)NCBI
Rnor_5.0167,508,042 - 7,523,705 (-)NCBI
RGSC_v3.4166,924,470 - 6,939,562 (-)RGD
Celera168,491,500 - 8,506,251 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252582   ⟹   XP_006252644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,226 - 6,705,385 (-)NCBI
mRatBN7.2166,683,820 - 6,699,013 (-)NCBI
Rnor_6.0167,573,716 - 7,588,824 (-)NCBI
Rnor_5.0167,508,042 - 7,523,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252583   ⟹   XP_006252645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,226 - 6,705,384 (-)NCBI
mRatBN7.2166,683,820 - 6,699,013 (-)NCBI
Rnor_6.0167,573,716 - 7,588,823 (-)NCBI
Rnor_5.0167,508,042 - 7,523,705 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770988   ⟹   XP_008769210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,896 - 6,705,385 (-)NCBI
mRatBN7.2166,684,509 - 6,699,013 (-)NCBI
Rnor_6.0167,574,448 - 7,588,824 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094268   ⟹   XP_038950196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,226 - 6,705,384 (-)NCBI
mRatBN7.2166,683,820 - 6,699,013 (-)NCBI
RefSeq Acc Id: XM_039094269   ⟹   XP_038950197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,226 - 6,705,385 (-)NCBI
mRatBN7.2166,683,820 - 6,699,013 (-)NCBI
RefSeq Acc Id: XM_063275136   ⟹   XP_063131206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,667,971 - 6,705,385 (-)NCBI
RefSeq Acc Id: XM_063275137   ⟹   XP_063131207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,690,226 - 6,705,384 (-)NCBI
RefSeq Acc Id: XR_005494553
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,694,260 - 6,705,385 (-)NCBI
mRatBN7.2166,687,833 - 6,699,013 (-)NCBI
RefSeq Acc Id: XR_005494554
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,694,260 - 6,705,385 (-)NCBI
mRatBN7.2166,687,833 - 6,699,013 (-)NCBI
RefSeq Acc Id: XR_005494555
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,694,260 - 6,705,385 (-)NCBI
mRatBN7.2166,687,836 - 6,699,013 (-)NCBI
RefSeq Acc Id: XR_005494556
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,695,529 - 6,705,385 (-)NCBI
mRatBN7.2166,689,134 - 6,699,013 (-)NCBI
RefSeq Acc Id: XR_010058283
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8166,694,260 - 6,705,384 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001007624   ⟸   NM_001007623
- UniProtKB: Q6AXU8 (UniProtKB/Swiss-Prot),   A6KFY8 (UniProtKB/TrEMBL),   A0A8I6GE72 (UniProtKB/TrEMBL),   A6KFY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252644   ⟸   XM_006252582
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006252645   ⟸   XM_006252583
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008769210   ⟸   XM_008770988
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000074466   ⟸   ENSRNOT00000084645
RefSeq Acc Id: XP_038950197   ⟸   XM_039094269
- Peptide Label: isoform X5
- UniProtKB: A6KFZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950196   ⟸   XM_039094268
- Peptide Label: isoform X2
- UniProtKB: Q6AXU8 (UniProtKB/Swiss-Prot),   A6KFY8 (UniProtKB/TrEMBL),   A0A8I6GE72 (UniProtKB/TrEMBL),   A6KFY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131206   ⟸   XM_063275136
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063131207   ⟸   XM_063275137
- Peptide Label: isoform X5
- UniProtKB: A6KFZ0 (UniProtKB/TrEMBL)
Protein Domains
Methyltransferase type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXU8-F1-model_v2 AlphaFold Q6AXU8 1-287 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699934
Promoter ID:EPDNEW_R10457
Type:multiple initiation site
Name:Mettl6_1
Description:methyltransferase like 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0167,588,862 - 7,588,922EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359565 AgrOrtholog
BioCyc Gene G2FUF-12146 BioCyc
Ensembl Genes ENSRNOG00000052391 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000057372 Ensembl
  ENSRNOG00055022766 UniProtKB/Swiss-Prot
  ENSRNOG00060012551 UniProtKB/Swiss-Prot
  ENSRNOG00065013903 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084645 ENTREZGENE
  ENSRNOT00000084645.2 UniProtKB/Swiss-Prot
  ENSRNOT00000098759.1 UniProtKB/TrEMBL
  ENSRNOT00000103715.1 UniProtKB/TrEMBL
  ENSRNOT00000104042.1 UniProtKB/TrEMBL
  ENSRNOT00000110815.1 UniProtKB/TrEMBL
  ENSRNOT00055039098 UniProtKB/Swiss-Prot
  ENSRNOT00060021262 UniProtKB/Swiss-Prot
  ENSRNOT00065022927 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134747 IMAGE-MGC_LOAD
InterPro Methyltransf_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3BP5 UniProtKB/TrEMBL
KEGG Report rno:290564 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94452 IMAGE-MGC_LOAD
NCBI Gene 290564 ENTREZGENE
PANTHER PTHR19423 UniProtKB/TrEMBL
  PTHR22809 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 DOMAIN-BINDING PROTEIN 5 UniProtKB/TrEMBL
  TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Methyltransf_12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Methyltransf_23 UniProtKB/TrEMBL
  SH3BP5 UniProtKB/TrEMBL
PhenoGen Mettl6 PhenoGen
PIRSF Mettl2_prd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052391 RatGTEx
  ENSRNOG00000057372 RatGTEx
  ENSRNOG00055022766 RatGTEx
  ENSRNOG00060012551 RatGTEx
  ENSRNOG00065013903 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZL43_RAT UniProtKB/TrEMBL
  A0A8I5ZS33_RAT UniProtKB/TrEMBL
  A0A8I6GE72 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GH93_RAT UniProtKB/TrEMBL
  A6KFY8 ENTREZGENE, UniProtKB/TrEMBL
  A6KFY9 ENTREZGENE, UniProtKB/TrEMBL
  A6KFZ0 ENTREZGENE, UniProtKB/TrEMBL
  A6KFZ1_RAT UniProtKB/TrEMBL
  METL6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-09 Mettl6  methyltransferase 6, tRNA N3-cytidine  Mettl6  methyltransferase 6, methylcytidine  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-06-17 Mettl6  methyltransferase 6, methylcytidine  Mettl6  methyltransferase like 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mettl6  methyltransferase like 6  MGC94452  similar to RIKEN cDNA 1600013P15  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC94452  similar to RIKEN cDNA 1600013P15      Symbol and Name status set to provisional 70820 PROVISIONAL