Nub1 (negative regulator of ubiquitin-like proteins 1)

Gene: Nub1 (negative regulator of ubiquitin-like proteins 1) Rattus norvegicus

Analyze

Symbol:

Nub1

Name:

negative regulator of ubiquitin-like proteins 1

RGD ID:

1359489

Description:

Predicted to be involved in several processes, including positive regulation of proteasomal ubiquitin-dependent protein catabolic process; response to tumor necrosis factor; and response to type II interferon. Predicted to act upstream of or within proteasomal protein catabolic process. Predicted to be located in Lewy body; cytosol; and nuclear lumen. Orthologous to human NUB1 (negative regulator of ubiquitin like proteins 1); PARTICIPATES IN neddylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

BS4; NEDD8 ultimate buster 1; NEDD8 ultimate buster-1; NY-REN-18 antigen; NYREN18

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,335,376 - 11,366,263 (-)	NCBI		GRCr8
mRatBN7.2	4	10,442,917 - 10,473,689 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,442,917 - 10,473,694 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	15,589,502 - 15,619,758 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,409,700 - 11,439,956 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	9,761,499 - 9,791,741 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	6,950,870 - 6,981,400 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	6,951,478 - 6,978,073 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	6,964,480 - 6,994,708 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	5,820,488 - 5,850,809 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	5,820,488 - 5,850,809 (-)	NCBI
Celera	4	6,058,478 - 6,088,841 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

lethal congenital glycogen storage disease of heart (ISO)

long QT syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,10-phenanthroline (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (EXP)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

bortezomib (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diethylstilbestrol (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

ketoconazole (ISO)

methimazole (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (ISO)

phenobarbital (EXP)

sodium arsenite (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

thimerosal (ISO)

trichostatin A (ISO)

tungsten (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

proteasomal protein catabolic process (ISO)

protein ubiquitination (ISO)

regulation of ubiquitin-dependent protein catabolic process (IBA)

response to tumor necrosis factor (ISO)

response to type II interferon (ISO)

ubiquitin-dependent protein catabolic process (ISO)

Cellular Component

cytosol (IEA,ISO)

Lewy body (ISO)

nucleolus (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

neddylation pathway (ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression.	Kito K, etal., J Biol Chem 2001 Jun 8;276(23):20603-9. Epub 2001 Mar 19.
3.	Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins.	Parry G and Estelle M, Semin Cell Dev Biol. 2004 Apr;15(2):221-9.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:16707496	PMID:22965877

Genomics

Comparative Map Data

Nub1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	11,335,376 - 11,366,263 (-)	NCBI		GRCr8
mRatBN7.2	4	10,442,917 - 10,473,689 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	10,442,917 - 10,473,694 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	15,589,502 - 15,619,758 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	11,409,700 - 11,439,956 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	9,761,499 - 9,791,741 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	6,950,870 - 6,981,400 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	6,951,478 - 6,978,073 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	6,964,480 - 6,994,708 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	5,820,488 - 5,850,809 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	5,820,488 - 5,850,809 (-)	NCBI
Celera	4	6,058,478 - 6,088,841 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

NUB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	151,341,812 - 151,378,449 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	151,341,772 - 151,378,449 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	151,038,898 - 151,075,535 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	150,669,791 - 150,706,468 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	145,596,247 - 145,632,781 (+)	NCBI		Celera
Cytogenetic Map	7	q36.1	NCBI
HuRef	7	144,850,514 - 144,887,070 (+)	NCBI		HuRef
CHM1_1	7	151,047,250 - 151,083,821 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	152,514,799 - 152,551,295 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	150,368,354 - 150,404,911 (+)	NCBI

Nub1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	24,890,813 - 24,915,376 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	24,890,530 - 24,915,376 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	24,685,815 - 24,710,378 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	24,685,532 - 24,710,378 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	24,191,633 - 24,216,373 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	24,196,041 - 24,220,443 (+)	NCBI		MGSCv36	mm8
Celera	5	21,642,444 - 21,667,264 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	11.93	NCBI

Nub1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955491	5,709,791 - 5,739,079 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955491	5,709,791 - 5,737,620 (+)	NCBI	ChiLan1.0	ChiLan1.0

NUB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	187,762,530 - 187,799,621 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	39,772,796 - 39,809,887 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	142,927,730 - 142,964,475 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	155,079,171 - 155,115,913 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	155,079,243 - 155,114,676 (+)	Ensembl	panpan1.1		panPan2

NUB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	15,355,237 - 15,382,284 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	15,352,476 - 15,381,095 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	15,962,876 - 15,989,492 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	17,077,383 - 17,104,127 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	17,075,097 - 17,104,127 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	15,449,341 - 15,475,957 (+)	NCBI		UMICH_Zoey_3.1

Nub1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	6,146,984 - 6,177,063 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	6,726,357 - 6,755,318 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	6,726,363 - 6,756,445 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NUB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	5,899,568 - 5,928,884 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	5,899,566 - 5,928,981 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	6,247,107 - 6,274,794 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NUB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	119,525,757 - 119,559,412 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	119,525,932 - 119,560,886 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	15,496,939 - 15,530,260 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nub1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	5,315,381 - 5,345,801 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	5,314,203 - 5,345,301 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Nub1
217 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	76
Count of miRNA genes:	65
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000045311
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61351	Bp33	Blood pressure QTL 33		0.0018	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	1	27716890	Rat
61408	Scl23	Serum cholesterol level QTL 23		0.0005	blood HDL phospholipid amount (VT:0010504)	serum high density lipoprotein phospholipid level (CMO:0001567)	4	1	27716890	Rat
724557	Plsm1	Polydactyly-luxate syndrome (PLS) morphotypes QTL 1		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	4	1	27716890	Rat
1641905	Colcr1	Colorectal carcinoma resistance QTL 1	4.3	0.0003	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	4	1	29494328	Rat
61333	Gluco16	Glucose level QTL 16	4.3	0.00001	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	1	30372989	Rat
9589097	Slep11	Serum leptin concentration QTL 11	5.09	0.001	blood leptin amount (VT:0005667)	plasma leptin level (CMO:0000781)	4	1	31934116	Rat
8552903	Pigfal2	Plasma insulin-like growth factor 1 level QTL 2	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	1	31934116	Rat
9589046	Scfw2	Subcutaneous fat weight QTL 2	5.54	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	4	1	31934116	Rat
9590100	Sffal4	Serum free fatty acids level QTL 4	7.36	0.05	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	4	1	31934116	Rat
738021	Hcar13	Hepatocarcinoma resistance QTL 13	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	4	1	32584199	Rat
1357341	Gluco5	Glucose level QTL 5	6.4		adipocyte free fatty acid secretion trait (VT:0010465)	absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)	4	1	33250345	Rat
1357343	Gluco4	Glucose level QTL 4		0.00002	adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	4	1	33250345	Rat
61415	Eae11	Experimental allergic encephalomyelitis QTL 11	2.9		nervous system integrity trait (VT:0010566)	post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)	4	1	39505420	Rat
634323	Hc2	Hypercalciuria QTL 2	2.15		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	4	210796	45210796	Rat
619616	Bp79	Blood pressure QTL 79		0.0292	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	5214602	78882945	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2302371	Stl22	Serum triglyceride level QTL 22	5.15		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	57114705	Rat
1358203	Stl19	Serum triglyceride level QTL 19	2.8	0.002	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5218294	65958103	Rat
1358201	Gluco12	Glucose level QTL12	1.6		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake (CMO:0000870)	4	5218392	29593287	Rat
631642	Stl2	Serum triglyceride level QTL 2	3.3		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	4	5219178	56647776	Rat
631209	Bw2	Body weight QTL2	4.2		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	4	9940885	44463908	Rat
1300141	Bp178	Blood pressure QTL 178			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	10024901	39524530	Rat
6478724	Anxrr35	Anxiety related response QTL 35		0.00449	defecation behavior trait (VT:0010462)	defecation measurement (CMO:0000997)	4	10084089	55084089	Rat
6478766	Anxrr47	Anxiety related response QTL 47		0.09637	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	10084089	55084089	Rat
6478769	Anxrr48	Anxiety related response QTL 48		0.02514	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	10084089	55084089	Rat
8694374	Bw155	Body weight QTL 155	3.39	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	4	10084089	55084089	Rat
9590304	Scort17	Serum corticosterone level QTL 17	4.96	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	10084089	55084089	Rat
8552906	Pigfal3	Plasma insulin-like growth factor 1 level QTL 3			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	4	10084089	55084089	Rat

Markers in Region

D4Rat144

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,495,201 - 10,495,445 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	7,023,217 - 7,023,460	NCBI	Rnor6.0
Rnor_5.0	4	7,035,728 - 7,035,971	UniSTS	Rnor5.0
RGSC_v3.4	4	5,874,672 - 5,874,916	RGD	RGSC3.4
RGSC_v3.4	4	5,874,673 - 5,874,916	UniSTS	RGSC3.4
RGSC_v3.1	4	5,874,588 - 5,874,945	RGD
Celera	4	6,111,278 - 6,111,521	UniSTS
SHRSP x BN Map	4	0.0	UniSTS
SHRSP x BN Map	4	0.0	RGD
Cytogenetic Map	4	q11	UniSTS

D4Got11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,447,700 - 10,447,806 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	6,955,148 - 6,955,253	NCBI	Rnor6.0
Rnor_5.0	4	6,968,758 - 6,968,863	UniSTS	Rnor5.0
RGSC_v3.4	4	5,824,766 - 5,824,871	UniSTS	RGSC3.4
RGSC_v3.4	4	5,825,097 - 5,825,203	RGD	RGSC3.4
RGSC_v3.4	4	5,824,765 - 5,824,871	RGD	RGSC3.4
RGSC_v3.4	4	5,825,098 - 5,825,203	UniSTS	RGSC3.4
RGSC_v3.1	4	5,825,098 - 5,825,203	RGD
RH 3.4 Map	4	14.0	UniSTS
RH 3.4 Map	4	14.0	RGD
RH 2.0 Map	4	63.2	RGD
Cytogenetic Map	4	q11	UniSTS

RH128463

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,443,019 - 10,443,209 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	6,950,467 - 6,950,656	NCBI	Rnor6.0
Rnor_5.0	4	6,964,077 - 6,964,266	UniSTS	Rnor5.0
RGSC_v3.4	4	5,820,085 - 5,820,274	UniSTS	RGSC3.4
Celera	4	6,058,075 - 6,058,264	UniSTS
Cytogenetic Map	4	q11	UniSTS

RH128761

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,443,580 - 10,443,766 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	6,951,028 - 6,951,213	NCBI	Rnor6.0
Rnor_5.0	4	6,964,638 - 6,964,823	UniSTS	Rnor5.0
RGSC_v3.4	4	5,820,646 - 5,820,831	UniSTS	RGSC3.4
Celera	4	6,058,636 - 6,058,821	UniSTS
Cytogenetic Map	4	q11	UniSTS

RH138616

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,448,936 - 10,449,117 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	6,956,381 - 6,956,561	NCBI	Rnor6.0
Rnor_5.0	4	6,969,991 - 6,970,171	UniSTS	Rnor5.0
RGSC_v3.4	4	5,826,331 - 5,826,511	UniSTS	RGSC3.4
Celera	4	6,064,102 - 6,064,282	UniSTS
Cytogenetic Map	4	q11	UniSTS

RH139609

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	10,443,184 - 10,443,376 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	6,950,632 - 6,950,823	NCBI	Rnor6.0
Rnor_5.0	4	6,964,242 - 6,964,433	UniSTS	Rnor5.0
RGSC_v3.4	4	5,820,250 - 5,820,441	UniSTS	RGSC3.4
Celera	4	6,058,240 - 6,058,431	UniSTS
Cytogenetic Map	4	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063285691	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083586	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000045311 ⟹ ENSRNOP00000048314

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	10,444,031 - 10,473,694 (-)	Ensembl
Rnor_6.0 Ensembl	4	6,951,478 - 6,978,073 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098051 ⟹ ENSRNOP00000086699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	10,442,917 - 10,471,056 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108045 ⟹ ENSRNOP00000078815

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	10,442,919 - 10,470,461 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115102 ⟹ ENSRNOP00000076727

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	10,442,917 - 10,472,315 (-)	Ensembl

RefSeq Acc Id:

NM_001013925 ⟹ NP_001013947

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,335,882 - 11,366,146 (-)	NCBI
mRatBN7.2	4	10,443,423 - 10,473,689 (-)	NCBI
Rnor_6.0	4	6,950,870 - 6,981,400 (-)	NCBI
Rnor_5.0	4	6,964,480 - 6,994,708 (-)	NCBI
RGSC_v3.4	4	5,820,488 - 5,850,809 (-)	RGD
Celera	4	6,058,478 - 6,088,841 (-)	RGD

Sequence:

show sequence

CACCCGGAATGAAAACAAACGGCGGCCTCTGCCGCATCCGGGCATTTGGCTGGTCTCGGCTGGC
TCGGTGGTGGCGCAGTTTTACTTTCAAGGATGGCGCAGAAGAAATATCTTCAAGCAAAACTGAC
CCAGTTTCTAAGGGAAGACAGAATTCAACTTTGGAAACCTCCATATACTGAAGAAAATAAAGAA
GTTGGTTTGGCCTTAAAGGACCTTGCTAAGAGGTACTCCGAGCGGCTAGAGTGCTGTGAAAATG
AAGTGGAAAACATAATAGAGGAAATCCGATGCAAAGCGATTGAGCGCGGCACTGGGAATGAGCA
CTACCGCACAACTGGGATTGCTACGATTGAGGTGTTCCTGCCTCCGAGGCTCCGGAAAGATAAG
AAAAGCTTGTTGGAGACCCGCTTGCATGTCACTGGTAGAGACCTGAGGAGTAAAATAGCTGAAA
CCTTTGGATTTCAAGAAAATTACATCAAGATCGTAATAAATAAGAAACAGCTTCAACTAGGGAA
AAGCCTTGAAGAGCAAGGAGTCACTCACAATGTGAAGGCCATGGTGTTGGAGCTGAAACAGTCT
GAAGAGGATGTGAGGAGAAACCTGCAGCTGGAGGAGGAGGAACAGAACGAGGCTGAGCAGAAGG
AGAAACGCATTCAGAGGACCAAAAGGGGACTGGAGATCCTGGCCGAGAGAGCTGAGATGGTGGT
AGACCCGGAAACGATGCCTTACTTAGACATTGCGAACCAGACTGGCAGGTCAATCAGAATTCCC
CCTTCAGAAAGAAAAGCCCTAATGTTAGCCATGGGGTACCATGAGAAGGGCAGGGCTTTCCTGA
AAAGAAAAGAGTATGGGATAGCCTTGCCATGCCTTCTGGACGCCGACAGATACTTCTGTGAGTG
CAAAGAGCTGCTGGACACTGTGGACAACTATGCAGTCCTCCAGCTGGACATCGTGTGGTGCTAC
TTCCGCCTGGAACAGCTGGAGTGCCTTGATGATGCAGAGAAAAAGCTGAACTTGGCCCAGACGT
GCTTTACAAACTGTTACGGGGAGAATCACCAGAGACTGGTCAACATAAAAGGGAACTGTGGGAA
AGAGAAGGTGTTGTTTTTAAGACTCTACTTGCTTCAGGGAATCCGAAACTATCACAGTGGAAAT
GGAGAGGAGGCTCGGGAATATCTCAACAAGGCACGTCAGCTCTTTAAAGAGCTGTACATCGACC
CATCGAAAGTTCACAACTTGTTACAGTTGGGGTTCACTGCCCAGGAAGCACGGCTGGGCCTGCG
GGCCTGTGATGGGAACGTGGACCACGCAGCCACTCACATTTCCAACCGCAGAGAGGAACTGGCC
CAGATACGGAAGGAAGAGAAGGAGAAGAGGAAACGCCGTCTGGAAAGTGTCAACACTTTGAGAG
GAATGGGCTACTCCACACAAGCTGCCAAACAAGCCCTTCACCAGGCCAGAGGCAACCTGGACGA
TGCCCTGAAGATTCTCCTCAGCAACCCCCACATGTGGTGGTTACAGGATTCAGACTCTGAGAAC
AACAGCCGGCAAGCAAGCCCTTCCCAAGAAAGCATCGACCAGCTGGTGTACATGGGCTTCGACA
CAGTGGTGGCCGAAGCTGCGCTGAGGGTGTTTGCAGGCAATGTCCAGCTGGCAGCTCAGACCCT
GGCACACCATGGAGGAAGCCTCCCTCCTGACCTACAGTTCTCAGGAGAGGACTCCTCCTCCACC
CCATCCACATCCCCGTCTGACTCCGCAGGGACCTCTAGTGCCTCCACGGATGAGGACATGGAGA
CAGAGGCCGTGAACGAAATCCTGGAGGACATTCCGGAGCACGAGGAAGACTACCTGGACTCCAC
ACTGGAGGACGAAGAAGTCATCATCGCTGAGTACCTGTCCTACGTGGACAGGACCAGTTCTGCC
ACAAAGGACAACTGAGCGGAGGGACAGAAGGGCTACGCTTCTGCTATAAATTCTGGCGTTGTGA
ATGGTTGAATGCTTTGCGTTCCTCTTGCTTTTCAACGATTTTGCTCTAAGTAGGCTTCCTCCTC
AGGTCCAGGGACCCAGCGCAGCAGAGACTTGTCAGTCAGAGGACAGTCTAGGAGAAGGAATTCT
CCAGCCCAGCTCTGCTGCCCCCTCCTCTTCTAGGTCTGCACCCCTGACGGCCACTCTGCTGGCT
TTCCATCCAGTCCCGGAGGGCCTGGGACTAACTCTGTCTCCTGTCTTCTCCTCAGCTAGTCCTC
CTGTGCACTCTTCCCACTGTCCGCTGCTGAAACTGCTCTCCTCTGCTGTGCGAGCTTCCCTCGG
CCCTCGCTGCTCTGCCTCACCCCTTGAGTCTCCAAGTGCTGTCGAGCACAGCAGCAAGGTACCA
GCCGTCACTATGCAGATGGTGCAGATACCTTAATCTAGAAATGTCAGTGTTTTGTGCTCTCAGA
TCAGTAAAATCTGTACTTAAAATTCAAGGTTGCAAAATCAGAGTTTATATGGATTCTAAATTCC
TCATACAAAATGAAAAATCTTTTATTAAATGGAAGTTTTAAATGCTAAAAAAAAAAAAAAAAAA
AAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039107214 ⟹ XP_038963142

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,335,376 - 11,366,263 (-)	NCBI
mRatBN7.2	4	10,442,917 - 10,473,681 (-)	NCBI

RefSeq Acc Id:

XM_039107215 ⟹ XP_038963143

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,335,376 - 11,355,597 (-)	NCBI
mRatBN7.2	4	10,442,917 - 10,463,139 (-)	NCBI

RefSeq Acc Id:

XM_063285691 ⟹ XP_063141761

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	11,335,376 - 11,366,065 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001013947	(Get FASTA)	NCBI Sequence Viewer
	XP_038963142	(Get FASTA)	NCBI Sequence Viewer
	XP_038963143	(Get FASTA)	NCBI Sequence Viewer
	XP_063141761	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83586	(Get FASTA)	NCBI Sequence Viewer
	EDL99337	(Get FASTA)	NCBI Sequence Viewer
	EDL99338	(Get FASTA)	NCBI Sequence Viewer
	EDL99339	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048314
	ENSRNOP00000048314.4
	ENSRNOP00000076727.1
	ENSRNOP00000078815.1
	ENSRNOP00000086699
	ENSRNOP00000086699.1

RefSeq Acc Id:

NP_001013947 ⟸ NM_001013925

- UniProtKB:

Q5XIT4 (UniProtKB/TrEMBL), A0A8I6A4A9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQKKYLQAKLTQFLREDRIQLWKPPYTEENKEVGLALKDLAKRYSERLECCENEVENIIEEIR
CKAIERGTGNEHYRTTGIATIEVFLPPRLRKDKKSLLETRLHVTGRDLRSKIAETFGFQENYIK
IVINKKQLQLGKSLEEQGVTHNVKAMVLELKQSEEDVRRNLQLEEEEQNEAEQKEKRIQRTKRG
LEILAERAEMVVDPETMPYLDIANQTGRSIRIPPSERKALMLAMGYHEKGRAFLKRKEYGIALP
CLLDADRYFCECKELLDTVDNYAVLQLDIVWCYFRLEQLECLDDAEKKLNLAQTCFTNCYGENH
QRLVNIKGNCGKEKVLFLRLYLLQGIRNYHSGNGEEAREYLNKARQLFKELYIDPSKVHNLLQL
GFTAQEARLGLRACDGNVDHAATHISNRREELAQIRKEEKEKRKRRLESVNTLRGMGYSTQAAK
QALHQARGNLDDALKILLSNPHMWWLQDSDSENNSRQASPSQESIDQLVYMGFDTVVAEAALRV
FAGNVQLAAQTLAHHGGSLPPDLQFSGEDSSSTPSTSPSDSAGTSSASTDEDMETEAVNEILED
IPEHEEDYLDSTLEDEEVIIAEYLSYVDRTSSATKDN

hide sequence

RefSeq Acc Id:

ENSRNOP00000048314 ⟸ ENSRNOT00000045311

RefSeq Acc Id:	XP_038963142 ⟸ XM_039107214
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6A4A9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038963143 ⟸ XM_039107215
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000078815 ⟸ ENSRNOT00000108045

RefSeq Acc Id:

ENSRNOP00000086699 ⟸ ENSRNOT00000098051

RefSeq Acc Id:

ENSRNOP00000076727 ⟸ ENSRNOT00000115102

RefSeq Acc Id:	XP_063141761 ⟸ XM_063285691
- Peptide Label:	isoform X2

Protein Domains

NEDD8 ultimate buster 1 ubiquitin-like UBA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F7ES73-F1-model_v2	AlphaFold	F7ES73	1-612	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359489	AgrOrtholog
BioCyc Gene	G2FUF-46056	BioCyc
Ensembl Genes	ENSRNOG00000009282	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000045311	ENTREZGENE
	ENSRNOT00000045311.5	UniProtKB/TrEMBL
	ENSRNOT00000098051.1	UniProtKB/TrEMBL
	ENSRNOT00000108045.1	UniProtKB/TrEMBL
	ENSRNOT00000115102.1	UniProtKB/TrEMBL
Gene3D-CATH	DNA helicase RuvA subunit, C-terminal domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7131376	IMAGE-MGC_LOAD
InterPro	NUB1	UniProtKB/TrEMBL
	NUB1_ubiquitin-like_dom	UniProtKB/TrEMBL
	TPR-like_helical_dom	UniProtKB/TrEMBL
	UBA-like	UniProtKB/TrEMBL
	UBA/transl_elong_EF1B_N_euk	UniProtKB/TrEMBL
	Ubiquitin-rel_dom	UniProtKB/TrEMBL
KEGG Report	rno:296731	UniProtKB/TrEMBL
MGC_CLONE	MGC:94244	IMAGE-MGC_LOAD
NCBI Gene	296731	ENTREZGENE
PANTHER	NEDD8 ULTIMATE BUSTER 1	UniProtKB/TrEMBL
	PTHR12948	UniProtKB/TrEMBL
Pfam	UBA	UniProtKB/TrEMBL
	Ubiquitin_5	UniProtKB/TrEMBL
PhenoGen	Nub1	PhenoGen
PROSITE	UBA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009282	RatGTEx
SMART	UBA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48452	UniProtKB/TrEMBL
	SSF54236	UniProtKB/TrEMBL
	UBA_like	UniProtKB/TrEMBL
UniProt	A0A8I5Y4X4_RAT	UniProtKB/TrEMBL
	A0A8I5ZLQ1_RAT	UniProtKB/TrEMBL
	A0A8I6A4A9	ENTREZGENE, UniProtKB/TrEMBL
	A6K528_RAT	UniProtKB/TrEMBL
	A6K529_RAT	UniProtKB/TrEMBL
	A6K530_RAT	UniProtKB/TrEMBL
	F7ES73_RAT	UniProtKB/TrEMBL
	Q5XIT4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Nub1	negative regulator of ubiquitin-like proteins 1	Nub1	NEDD8 ultimate buster-1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	Nub1	NEDD8 ultimate buster-1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations