Arrdc3 (arrestin domain containing 3)

Gene: Arrdc3 (arrestin domain containing 3) Rattus norvegicus

Analyze

Symbol:

Arrdc3

Name:

arrestin domain containing 3

RGD ID:

1359478

Description:

Predicted to enable beta-3 adrenergic receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; positive regulation of hippo signaling; and protein transport. Predicted to act upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC3 (arrestin domain containing 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

arrestin domain-containing protein 3; liver regeneration-related protein LRRG00048; LRRGT00048

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ARRDC3 (arrestin domain containing 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Arrdc3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Arrdc3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ARRDC3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ARRDC3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Arrdc3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ARRDC3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ARRDC3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Arrdc3 (arrestin domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ARRDC3 (arrestin domain containing 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Arrdc3 (arrestin domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	arrdc3a (arrestin domain containing 3a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10086	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1105	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18746	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18747	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18748	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RIM8	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	arrd-5	Alliance	DIOPT (Ensembl Compara\|OMA\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18745	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ROG3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	arrd-8	Alliance	DIOPT (Ensembl Compara\|OMA\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ROD1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	arrd-7	Alliance	DIOPT (Ensembl Compara\|OMA\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG2641	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector)
Caenorhabditis elegans (roundworm):	arrd-24	Alliance	DIOPT (Ensembl Compara\|OMA\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ALY2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	ECM21	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	CSR2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	ALY1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	LDB19	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	arrdc3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	12,873,202 - 12,885,716 (+)	NCBI		GRCr8
mRatBN7.2	2	11,137,464 - 11,149,978 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	11,137,460 - 11,149,978 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	18,258,314 - 18,268,034 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	16,357,917 - 16,367,640 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	10,989,854 - 10,999,566 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	8,732,907 - 8,745,445 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	8,732,932 - 8,743,069 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	8,617,733 - 8,630,270 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	7,507,150 - 7,516,860 (+)	NCBI		Celera
Cytogenetic Map	2	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

familial adenomatous polyposis 1 (ISO)

Hereditary Neoplastic Syndromes (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

2-methylcholine (ISO)

3,3',5-triiodo-L-thyronine (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

Alisol A (EXP)

Alisol B (EXP)

Alisol C 23-acetate (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

amosite asbestos (ISO)

amphetamine (EXP)

ampicillin (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium sulfate (ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

chromium atom (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

dioxygen (ISO)

diuron (EXP,ISO)

doxorubicin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (EXP,ISO)

ethyl methanesulfonate (ISO)

fentin chloride (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glycidol (EXP)

glyphosate (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

inulin (ISO)

iron atom (ISO)

iron(0) (ISO)

isoprenaline (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

metformin (EXP)

methimazole (EXP)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

ochratoxin A (ISO)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

pravastatin (EXP,ISO)

prednisolone (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

resorcinol (ISO)

rotenone (EXP)

sodium arsenate (ISO)

sulfadimethoxine (EXP)

sulindac (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vanadyl sulfate (ISO)

vinclozolin (EXP)

zaragozic acid A (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fat pad development (IEA,ISO)

heat generation (IEA,ISO)

negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway (IEA,ISO)

negative regulation of cold-induced thermogenesis (IEA,ISO,ISS)

negative regulation of heat generation (IEA,ISO)

negative regulation of locomotion involved in locomotory behavior (IEA,ISO)

positive regulation of hippo signaling (IEA,ISO)

protein transport (IBA)

skin development (IEA,ISO)

temperature homeostasis (ISO)

Cellular Component

cytoplasm (IBA)

early endosome (IEA)

endosome (IBA,ISO)

lysosome (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

beta-3 adrenergic receptor binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	null	JRS Domain-based curation
3.	The arrestin domain-containing 3 protein regulates body mass and energy expenditure.	Patwari P, etal., Cell Metab. 2011 Nov 2;14(5):671-83. doi: 10.1016/j.cmet.2011.08.011. Epub 2011 Oct 6.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23236378	PMID:36154540

Genomics

Comparative Map Data

Arrdc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	12,873,202 - 12,885,716 (+)	NCBI		GRCr8
mRatBN7.2	2	11,137,464 - 11,149,978 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	11,137,460 - 11,149,978 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	18,258,314 - 18,268,034 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	16,357,917 - 16,367,640 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	10,989,854 - 10,999,566 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	8,732,907 - 8,745,445 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	8,732,932 - 8,743,069 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	8,617,733 - 8,630,270 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	7,507,150 - 7,516,860 (+)	NCBI		Celera
Cytogenetic Map	2	q11	NCBI

ARRDC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	91,368,631 - 91,383,317 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	91,368,631 - 91,383,317 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	90,664,448 - 90,679,134 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	90,700,297 - 90,714,877 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	90,700,297 - 90,714,877	NCBI
Celera	5	86,566,595 - 86,581,203 (-)	NCBI		Celera
Cytogenetic Map	5	q14.3	NCBI
HuRef	5	85,876,398 - 85,891,271 (-)	NCBI		HuRef
CHM1_1	5	90,097,255 - 90,111,863 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	91,852,479 - 91,867,169 (-)	NCBI		T2T-CHM13v2.0

Arrdc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	81,031,508 - 81,044,161 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	81,031,503 - 81,044,161 (+)	Ensembl		GRCm39 Ensembl
GRCm38	13	80,883,384 - 80,896,042 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	80,883,384 - 80,896,042 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	81,022,683 - 81,035,303 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	81,347,107 - 81,359,733 (+)	NCBI		MGSCv36	mm8
Celera	13	83,148,553 - 83,161,173 (+)	NCBI		Celera
Cytogenetic Map	13	C2	NCBI
cM Map	13	41.95	NCBI

Arrdc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955418	20,538,983 - 20,548,862 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955418	20,538,858 - 20,550,876 (+)	NCBI	ChiLan1.0	ChiLan1.0

ARRDC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	24,016,183 - 24,030,776 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	22,169,817 - 22,184,396 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	23,991,325 - 24,005,913 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	24,126,407 - 24,140,858 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	24,126,427 - 24,140,858 (+)	Ensembl	panpan1.1		panPan2

ARRDC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	17,691,631 - 17,705,507 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	17,691,961 - 17,703,308 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	19,060,400 - 19,074,268 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	17,596,484 - 17,610,370 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	17,596,591 - 17,610,370 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	17,567,848 - 17,581,735 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	17,537,838 - 17,551,679 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	17,822,875 - 17,836,765 (+)	NCBI		UU_Cfam_GSD_1.0

Arrdc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	173,248,294 - 173,261,323 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	9,364,347 - 9,377,501 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	9,364,291 - 9,377,504 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARRDC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	98,430,465 - 98,444,647 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	98,430,451 - 98,444,835 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	101,569,570 - 101,583,907 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARRDC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	85,286,243 - 85,301,208 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	85,286,173 - 85,301,202 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	34,348,931 - 34,363,917 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arrdc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624743	10,333,693 - 10,346,272 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624743	10,334,114 - 10,346,030 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Arrdc3
33 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	17
Count of miRNA genes:	14
Interacting mature miRNAs:	16
Transcripts:	ENSRNOT00000072849
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631682	Bp115	Blood pressure QTL 115	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	1	37410502	Rat
738010	Lnnr3	Liver neoplastic nodule remodeling QTL 3	2.94		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	2	1	41244106	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
731166	Mamtr2	Mammary tumor resistance QTL 2		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	12654247	Rat
61368	Mcs1	Mammary carcinoma susceptibility QTL 1	4.4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	23319447	Rat
1600379	Mcs18	Mammary carcinoma susceptibility QTL 18	2.6		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	7887772	42804738	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	9023519	54023519	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	42	57	41	19	41	8	9	74	35	41	11	8
Low	1	1						2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_178214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY383703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000072849 ⟹ ENSRNOP00000067658

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	11,137,460 - 11,146,306 (+)	Ensembl
Rnor_6.0 Ensembl	2	8,732,932 - 8,743,069 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106948 ⟹ ENSRNOP00000078331

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	11,137,464 - 11,149,978 (+)	Ensembl

RefSeq Acc Id:

NM_001007797 ⟹ NP_001007798

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	12,873,202 - 12,885,716 (+)	NCBI
mRatBN7.2	2	11,137,464 - 11,149,978 (+)	NCBI
Rnor_6.0	2	8,733,167 - 8,742,871 (+)	NCBI
Rnor_5.0	2	8,617,733 - 8,630,270 (+)	NCBI
Celera	2	7,507,150 - 7,516,860 (+)	RGD

Sequence:

show sequence

ATGGTGCTGGGAAAGGTAAAGAGTTTGACAATAAGCTTTGACTGTCTTAATGACAGTAATGTCC
CCGTGTATTCTAGCGGGGACACTGTCTCAGGAAGGGTAAATTTAGAAGTTACTGGGGAAATCAG
AGTAAAATCTCTTAAAATTCATGCAAGAGGACATGCGAAAGTACGCTGGACTGAATCAAGAAAC
GCCGGCTCCAATACTGCCTATACACAGAATTACACTGAAGAAGTAGAATATTTCAACCATAAAG
ACATCTTAATTGGGCACGAAAGAGATGATGATAATTGTGAAGAAGGCTTCAGCACTATTCATTC
AGGACGGCATGAATATGCATTTAGCTTCGAGCTTCCACAGACACCACTTGCTACCTCATTTGAA
GGCCGACATGGCAGTGTGCGCTATTGGGTGAAGGCCGAATTGCATAGGCCTTGGCTTCTACCAG
TAAAATTAAAGAAGGAATTTACAGTCTTTGAGCACATAGATATCAACACTCCTTCATTACTGTC
ACCCCAAGCAGGCACAAAAGAAAAGACACTCTGTTGCTGGTTCTGCACCTCAGGCCCAATATCC
TTAAGTGCCAAAATTGAGAGGAAGGGCTACACCCCAGGTGAATCAATACAGATATTTGCTGAGA
TTGAGAACTGCTCTTCCCGAATGGTAGTGCCAAAGGCAGCCATTTACCAAACGCAGGCCTTCTA
CGCCAAAGGGAAAATGAAGGAAGTAAAACAGCTGGTGGCAAACTTACGTGGGGAATCCTTATCA
TCTGGGAAGACGGAGACGTGGGACGGCAAGCTGCTCAAGATCCCACCAGTTTCACCCTCCATCC
TCGACTGTAGTATAATCCGTGTGGAGTATTCGCTAATGGTATACGTGGATATTCCCGGGGCCAT
GGATTTGCTTCTCAGTTTGCCACTAGTCATTGGGACCATCCCTCTACATCCATTTGGGAGCAGA
ACCTCAAGTGTGAGCAGTCAGTGTAGCATGAATATGAACTGGCTCGGTCTATCCCTTCCTGAAA
GACCTGAAGCACCACCCAGTTATGCAGAGGTTGTAACGGAGGAACAGAGACGGAATAATCTTGC
ACCAGTGAGTGCTTGTGATGATTTTGAGAGAGCTCTTCAAGGACCACTGTTCGCATATATCCAG
GAGTTCCGGTTCCTGCCTCCACCTCTCTATTCAGAGATTGATCCAAATCCTGATCAGTCATCCG
AGGACAGACCATCATGCCCCTCTCGCTGA

hide sequence

RefSeq Acc Id:

NR_178214

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	12,873,202 - 12,885,716 (+)	NCBI
mRatBN7.2	2	11,137,464 - 11,149,978 (+)	NCBI

RefSeq Acc Id:

XM_017590815 ⟹ XP_017446304

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	12,875,919 - 12,885,716 (+)	NCBI
mRatBN7.2	2	11,140,246 - 11,149,978 (+)	NCBI
Rnor_6.0	2	8,735,217 - 8,745,445 (+)	NCBI

Sequence:

show sequence

GGAACCGGCGTGCGCCGGTAAAGGTCTCTCCCGGCCAGCCGCCTCCGCCCCTCGGCGCGCCCCT
CTCCGGGTGTCCCAGGCCCCTCGCCCACTGCAGCCGCCGCAGGTTTCATTGCCCTGGGCTCAAG
CTCGGTTAAAAATCCCACCAAAGGCTGATCGAGGTGCGGGCGCCAGGGTACCCCCGGGGCTGGT
ACCTGTGTGACCCGAGGGGACATGACACAGGACAGATAGGGGAGACATCACCGGCACCAACTGG
GCCTCGCCCATTGTTCCCCGGGGCCTCCGCCTCCGCGCCGCCGCCCCAGTTCCCCCTCGCTGTA
ACAGCGAAGGTGTCAGGGTGGCCTGAGCCAGATTGAACCGGTCACCGGCTGGGGCGTGGAAAGC
GGAAGCTCGGCTTGCTGTGGCTCCGCCTCCGGCCCAGCATTCTAGGCTGCTCGGGCGCGAGCGC
CGCGCGACGTATGCCGTATGTATAGCGGGGCGCGCGGAGCGCGGCCGCGCGCGGGCGGGCCGGC
TGGGATCTGCTCAGCGCCGGTTTAGGCCGGTCCTCTCCTGCTCTAGTCTAGTTCTTGATTGACA
GCCAGGCACTTGTTTACCACGGCGCGGCGGCCGCAGCACTCCTCAATGAGACTGCTGAGCTGGC
ACAAAAGGGAGCCGAGGAAGAAAGGGAGAGAGGCGAAGTTTGGGCGCCTTGGAGGGAGCGAATT
GACGGGCCATGGCTCCCCCGGCCGGTCCTCAGGGCTGACGCTGTACAGGGGCTCCCCAGGAGGC
TCTGGAAGCAATGCGCAGATATGATGATGATAATTGTGAAGAAGGCTTCAGCACTATTCATTCA
GGACGGCATGAATATGCATTTAGCTTCGAGCTTCCACAGACACCACTTGCTACCTCATTTGAAG
GCCGACATGGCAGTGTGCGCTATTGGGTGAAGGCCGAATTGCATAGGCCTTGGCTTCTACCAGT
AAAATTAAAGAAGGAATTTACAGTCTTTGAGCACATAGATATCAACACTCCTTCATTACTGTCA
CCCCAAGCAGGCACAAAAGAAAAGACACTCTGTTGCTGGTTCTGCACCTCAGGCCCAATATCCT
TAAGTGCCAAAATTGAGAGGAAGGGCTACACCCCAGGTGAATCAATACAGATATTTGCTGAGAT
TGAGAACTGCTCTTCCCGAATGGTAGTGCCAAAGGCAGCCATTTACCAAACGCAGGCCTTCTAC
GCCAAAGGGAAAATGAAGGAAGTAAAACAGCTGGTGGCAAACTTACGTGGGGAATCCTTATCAT
CTGGGAAGACGGAGACGTGGGACGGCAAGCTGCTCAAGATCCCACCAGTTTCACCCTCCATCCT
CGACTGTAGTATAATCCGTGTGGAGTATTCGCTAATGGTATACGTGGATATTCCCGGGGCCATG
GATTTGCTTCTCAGTTTGCCACTAGTCATTGGGACCATCCCTCTACATCCATTTGGGAGCAGAA
CCTCAAGTGTGAGCAGTCAGTGTAGCATGAATATGAACTGGCTCGGTCTATCCCTTCCTGAAAG
ACCTGAAGCACCACCCAGTTATGCAGAGGTTGTAACGGAGGAACAGAGACGGAATAATCTTGCA
CCAGTGAGTGCTTGTGATGATTTTGAGAGAGCTCTTCAAGGACCACTGTTCGCATATATCCAGG
AGTTCCGGTTCCTGCCTCCACCTCTCTATTCAGAGATTGATCCAAATCCTGATCAGTCATCCGA
GGACAGACCATCATGCCCCTCTCGCTGAAGGAACACTTGATTGAATCAAGTTGATGTGGGTTCC
GAACTGTATCTCTTCCGGCTGAGGACAGAGAAGTATCTTGGAGACACGTTTTCAGAGGAAGTGG
AATTGCTTTTGCCCAGACAAATGGCAAACACGTGAAACAACCAGTGATCATGCTTTAGAATCCT
ACAGCATCATTCTGGGCTGCTCCAACACGCTTGAAGATCTGAGCTTTCCTTAAAACTAAGGGCA
GTCTTCTTAGCCTGTGATCATGTGTCAAGACACCGTTGCAAAGAAGGATATTGTCCTTCCTATT
TGAAAATTTGCACATGCTCAATGCTTACATTGTGCAGTTCAATGTCACTACAGCTTTTTTCCAT
TTATGCCAGACTCTTGATACTCTTAAAAACTATGTGGTCAGCACAACATGGAACAAAAGAAAGC
TTTGAAAAACTTTGACATTAAAAAACAAAAACGCACTGACAGGTTTGTTTTTTGTTTTTGTTTT
TGTTTTTTAAGTTAATGTAGCCTGGACTCTACCTGCGTATGCACATGCTCAGAATTGTCCTACT
AGGCTGACCATGTATCACCTCTTCAGCTTGGATCCTATTGTGGATTTATTTACAAACATCAAAT
GCCTTCAAGCCAATCCTTTTGCTGTATGTTTTGCAGCCTACTGTAGTAGATAAGCAACAGATAC
GAGGAGAAAAGAGACGGGAGGAGGAGGCCGCCGAGAGACTTTGTAGGGCTGTTGTGTGGGTTCT
ATGAGAGTGTTGCCTTTCTATTGACAGCAGAGCAGCATTGTGTTACTGACTGCCTACCATCACT
CAATCTCAGGTGAATGCATCACTTGCCAAACTGTCGGAATGCCGTCTGTTTCGTTGCACTGTTA
CGTTCTTGTTCTTGTTCTTGTCGTTCTTGTTATTTGGTTGGCTTTTTGGAGAGGGAACTTCGGA
AATGGGACATACACAAAACTGATAACCCACCCACATTCCCCTTTTTATTATTAAATATAAGAAG
AAACAAAGCTCAGAGTGGAGAAAGACAGTAGGGCAAGCACCAGCGGAGAGTCAAGGGCTGTTGC
TCTGAGGAAGTATTTTTATTATTTTAAGAATGAGTGGGAACTGTCCAGTCACTAGGGAAGGGAG
GGGAAAGTGCATTTATTTTTATACAGAGTTACTTAATTACCTCCAAAACACATATGTTGGAAAT
CATTTTTGCTGATGCAAAGTACTTCAATAAGCCAGAATATGTACATCAAGGTAATGATGGGAGA
CGCTCCATTTTTACATTGCTCACGTTTGAGAGAACGAAATCCCAAATTTGTTTCCACAGTGAAC
ACACTTTATAAGTAGAAATACCAGAATGTTTTCTGGGATAAACAGCTTTAGTTTGTACATGTAT
AGAATATTGTTTTTCAACAATTTTTTTCTATCATCTAAAAGAGGAATTGATAGGTCTCTAGCTT
TGAGTATATGTAGATCAACACATCAATAAATTATTTTTAAAGATAACTTATGGCTATATTGTAA
CCATATACTAACATTCATGAAACAACTAAAACCCCATCTTCTCAAAGTACAAAGTAGCGTGATT
TTTTTTTTTAGAGTTCACTTGTGTTTCTAGCAGCACCAGCATCTCTGATGTTGCAACATATGTG
TGAGATGGGTGTTACATCTGTCCACCTTGCCATCTGACCCACAGCTCGAGTGACTGAGAATTAT
AGTAACTCTGGCCTGGTGCTTGACCTGGTTAAATACTGTCTTAAAGCTTCATACAAAATAGGCT
TTTCCATAAGTGGCCTTTAAGAAAACATGGAAGATAATTCATGTTTGAAATAATGCCGACAGGG
TGAAGAAAGCCCATTGTAAAAATGGATCACGTTTTAAGTGATTCAGTTAAAGGGTTATGTGCTC
CCATAGCAAACAATACTAGATAATAAGGAGTTGGGGGTGAATTATTTTTTTAATTGTTAAATCA
TTTTGTGAATGTCCCCCCTCAGAAGAAGCTGATGGGATATTTGGCATAAAGGGCATTTGGTGGA
TTTGTTTTTGTTGGGAGGGATTGTGTAAAAACACCTGACTCTGTGTTATGTCTGACTAGGGAAC
AATTGTTGGTGTGCATGGCCTCGGGGCGCTCACTACCATGTTCTACAAAATACTTTATTAAGCA
AGAATGACCAATATTCTGATAATTGGCATTGGTGACAAAATTATTTTAAGAGTTGGTGAAGTAA
AGTTTTATTTTTCCCATTAAGTATTTCTTTACTCTTTTGAGGCATTACACTATTCTAAATATTG
GTCAATTCCTGACATAACATCTGAGGGTCACAGTTGCGCTCTAGTATTCAAGCTATCTTGAATT
CCTAATTTTTCATTTAGGAAAAGTAAAATCCAAAATGTTTGCGAAACAAAGTGCAATATTAAAT
GTTTGCTTTATAGATTATATTCTATGGCTGTTGTAATCTTTTATTTGGTGCTGAATATGTCCTT
GTAGGCTCTGTTTTAAGAAAACCATGTGGGAAATGATTTGACTTTTCCTATTGCTCTTCCTTGT
GGAAAATAAAAGTGTTTTTTTTTTTTTCTTTTTTTTGTAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007798	(Get FASTA)	NCBI Sequence Viewer
	XP_017446304	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAQ96261	(Get FASTA)	NCBI Sequence Viewer
	EDM09939	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067658.2
	ENSRNOP00000078331
	ENSRNOP00000078331.1
	ENSRNOP00055032302
	ENSRNOP00060003067
	ENSRNOP00065005619
GenBank Protein	Q6TXF1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001007798 ⟸ NM_001007797

- UniProtKB:

Q6TXF1 (UniProtKB/Swiss-Prot), A6I4I1 (UniProtKB/TrEMBL), A0A8L2QZ95 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRN
AGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNCEEGFSTIHSGRHEYAFSFELPQTPLATSFE
GRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPIS
LSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLS
SGKTETWDGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLLLSLPLVIGTIPLHPFGSR
TSSVSSQCSMNMNWLGLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQ
EFRFLPPPLYSEIDPNPDQSSEDRPSCPSR

hide sequence

RefSeq Acc Id:

XP_017446304 ⟸ XM_017590815

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRRYDDDNCEEGFSTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLK
KEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENC
SSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWDGKLLKIPPVSPSILDCS
IIRVEYSLMVYVDIPGAMDLLLSLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLGLSLPERPEA
PPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSSEDRP
SCPSR

hide sequence

RefSeq Acc Id:

ENSRNOP00000067658 ⟸ ENSRNOT00000072849

RefSeq Acc Id:

ENSRNOP00000078331 ⟸ ENSRNOT00000106948

Protein Domains

Arrestin C-terminal-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6TXF1-F1-model_v2	AlphaFold	Q6TXF1	1-414	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691043

Promoter ID:

EPDNEW_R1568

Type:

multiple initiation site

Name:

Arrdc3_1

Description:

arrestin domain containing 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	8,732,931 - 8,732,991	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359478	AgrOrtholog
BioCyc Gene	G2FUF-55032	BioCyc
Ensembl Genes	ENSRNOG00000045649	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055023151	UniProtKB/Swiss-Prot
	ENSRNOG00060002727	UniProtKB/Swiss-Prot
	ENSRNOG00065005415	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000072849.3	UniProtKB/TrEMBL
	ENSRNOT00000106948	ENTREZGENE
	ENSRNOT00000106948.1	UniProtKB/Swiss-Prot
	ENSRNOT00055039788	UniProtKB/Swiss-Prot
	ENSRNOT00060004361	UniProtKB/Swiss-Prot
	ENSRNOT00065008034	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.640	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Arrestin-like_C	UniProtKB/TrEMBL
	Arrestin-like_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Arrestin_C	UniProtKB/Swiss-Prot
	Arrestin_C-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_E-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:309945	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	309945	ENTREZGENE
PANTHER	ARRESTIN DOMAIN CONTAINING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ARRESTIN DOMAIN-CONTAINING PROTEIN 3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Arrestin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Arrestin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Arrdc3	PhenoGen
RatGTEx	ENSRNOG00000045649	RatGTEx
	ENSRNOG00055023151	RatGTEx
	ENSRNOG00060002727	RatGTEx
	ENSRNOG00065005415	RatGTEx
SMART	Arrestin_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF81296	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2QZ95	ENTREZGENE, UniProtKB/TrEMBL
	A6I4I1	ENTREZGENE, UniProtKB/TrEMBL
	ARRD3_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-29	Arrdc3	arrestin domain containing 3			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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