Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:25575267 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of PIK3IP1 mRNA | CTD | PMID:17351261 | 17beta-estradiol | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of PIK3IP1 mRNA | CTD | PMID:25575267 | 17beta-estradiol | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PIK3IP1 mRNA | CTD | PMID:31614463 | 17beta-estradiol | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of PIK3IP1 mRNA | CTD | PMID:30165855 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PIK3IP1 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PIK3IP1 mRNA | CTD | PMID:34747641 | 3,3',4,4',5-pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 3 more ... | CTD | PMID:23196670 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of PIK3IP1 mRNA | CTD | PMID:25172293 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PIK3IP1 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PIK3IP1 mRNA | CTD | PMID:20188158 | 4-hydroxyphenyl retinamide | increases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Fenretinide results in increased expression of PIK3IP1 mRNA | CTD | PMID:28973697 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PIK3IP1 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30047161 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of PIK3IP1 mRNA | CTD | PMID:28959563 | Aflatoxin B2 alpha | increases methylation | ISO | PIK3IP1 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PIK3IP1 promoter | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PIK3IP1 mRNA | CTD | PMID:16249480 and PMID:33167477 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30047161 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30779732 | aristolochic acid A | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of PIK3IP1 mRNA | CTD | PMID:33212167 | arsane | increases methylation | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of PIK3IP1 gene | CTD | PMID:24525453 | arsenic atom | increases methylation | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of PIK3IP1 gene | CTD | PMID:24525453 | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of PIK3IP1 mRNA | CTD | PMID:36841081 | avobenzone | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | avobenzone results in increased expression of PIK3IP1 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PIK3IP1 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | increases methylation | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PIK3IP1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PIK3IP1 exon | CTD | PMID:27901495 | bisphenol A | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PIK3IP1 mRNA | CTD | PMID:25575267 | bisphenol A | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PIK3IP1 mRNA | CTD | PMID:29275510 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PIK3IP1 mRNA | CTD | PMID:25181051 more ... | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PIK3IP1 mRNA | CTD | PMID:19167457 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of PIK3IP1 mRNA | CTD | PMID:33453195 | calcitriol | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of PIK3IP1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of PIK3IP1 mRNA | CTD | PMID:21592394 | carbon nanotube | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | choline | multiple interactions | ISO | Pik3ip1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PIK3IP1 gene | CTD | PMID:20938992 | copper atom | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA | CTD | PMID:24690739 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of PIK3IP1 mRNA | CTD | PMID:30556269 | copper(0) | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA | CTD | PMID:24690739 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of PIK3IP1 mRNA | CTD | PMID:30556269 | cyclosporin A | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PIK3IP1 mRNA | CTD | PMID:20106945 and PMID:27989131 | dexamethasone | increases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Dexamethasone results in increased expression of PIK3IP1 mRNA | CTD | PMID:22733784 | dibutyl phthalate | increases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of PIK3IP1 mRNA | CTD | PMID:21266533 | diethyl malate | affects expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | diethyl malate affects the expression of PIK3IP1 mRNA | CTD | PMID:24814887 | diethylstilbestrol | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Diethylstilbestrol results in decreased expression of PIK3IP1 mRNA | CTD | PMID:19371625 | diethylstilbestrol | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Diethylstilbestrol results in decreased expression of PIK3IP1 mRNA | CTD | PMID:25575267 | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of PIK3IP1 mRNA | CTD | PMID:33729688 | disulfiram | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Disulfiram binds to Copper] which results in increased expression of PIK3IP1 mRNA | CTD | PMID:24690739 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PIK3IP1 mRNA | CTD | PMID:21551480 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of PIK3IP1 mRNA | CTD | PMID:29391264 | estriol | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Estriol results in decreased expression of PIK3IP1 mRNA | CTD | PMID:25575267 | folic acid | multiple interactions | ISO | Pik3ip1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PIK3IP1 gene | CTD | PMID:20938992 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of PIK3IP1 gene | CTD | PMID:22079235 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of PIK3IP1 mRNA | CTD | PMID:27387713 | hydroquinone | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | hydroquinone results in decreased expression of PIK3IP1 mRNA | CTD | PMID:31256213 | idelalisib | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | idelalisib results in increased expression of PIK3IP1 mRNA | CTD | PMID:23676220 | ketamine | increases expression | EXP | | 6480464 | Ketamine results in increased expression of PIK3IP1 mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | ISO | Pik3ip1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PIK3IP1 gene | CTD | PMID:20938992 | methamphetamine | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | Methamphetamine results in decreased expression of PIK3IP1 mRNA | CTD | PMID:36914120 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30047161 | motexafin gadolinium | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | motexafin gadolinium results in increased expression of PIK3IP1 mRNA | CTD | PMID:16357179 | motexafin gadolinium | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA | CTD | PMID:16357179 | nevirapine | increases expression | EXP | | 6480464 | Nevirapine results in increased expression of PIK3IP1 mRNA | CTD | PMID:23947594 | nickel dichloride | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | nickel chloride results in increased expression of PIK3IP1 mRNA | CTD | PMID:21455298 | niclosamide | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of PIK3IP1 mRNA | CTD | PMID:36318118 | ozone | multiple interactions | ISO | Pik3ip1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PIK3IP1 mRNA | CTD | PMID:27106289 | paracetamol | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PIK3IP1 mRNA | CTD | PMID:26690555 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PIK3IP1 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PIK3IP1 mRNA | CTD | PMID:29067470 | perfluorohexanesulfonic acid | increases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of PIK3IP1 mRNA | CTD | PMID:37995155 | perfluorononanoic acid | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of PIK3IP1 mRNA | CTD | PMID:32588087 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of PIK3IP1 mRNA | CTD | PMID:35163327 | pirinixic acid | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIK3IP1 mRNA | CTD | PMID:19710929 | potassium chromate | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PIK3IP1 mRNA | CTD | PMID:22714537 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30047161 | silicon dioxide | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PIK3IP1 mRNA | CTD | PMID:25895662 | sotorasib | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIK3IP1 mRNA | CTD | PMID:36139627 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30047161 | sunitinib | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PIK3IP1 mRNA | CTD | PMID:31533062 | testosterone | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of PIK3IP1 mRNA | CTD | PMID:21592394 | testosterone | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Testosterone results in increased expression of PIK3IP1 mRNA | CTD | PMID:21592394 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PIK3IP1 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PIK3IP1 mRNA | CTD | PMID:23409001 | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30012374 | trametinib | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in increased expression of PIK3IP1 mRNA | CTD | PMID:36139627 | triadimefon | decreases expression | EXP | | 6480464 | triadimefon results in decreased expression of PIK3IP1 mRNA | CTD | PMID:30047161 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of PIK3IP1 mRNA | CTD | PMID:33387578 | triclosan | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Triclosan results in increased expression of PIK3IP1 mRNA | CTD | PMID:30510588 | triptonide | affects expression | ISO | Pik3ip1 (Mus musculus) | 6480464 | triptonide affects the expression of PIK3IP1 mRNA | CTD | PMID:33045310 | urethane | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Urethane results in increased expression of PIK3IP1 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PIK3IP1 mRNA | CTD | PMID:29154799 | valproic acid | affects expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PIK3IP1 mRNA | CTD | PMID:25979313 | zinc acetate | multiple interactions | ISO | PIK3IP1 (Homo sapiens) | 6480464 | [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA | CTD | PMID:16357179 | zinc acetate | increases expression | ISO | PIK3IP1 (Homo sapiens) | 6480464 | Zinc Acetate results in increased expression of PIK3IP1 mRNA | CTD | PMID:16357179 | |