Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Sephs1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SEPHS1 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SEPHS1 mRNA | CTD | PMID:21215274 and PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sephs1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SEPHS1 mRNA | CTD | PMID:21570461 | 2,4,6-tribromophenol | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of SEPHS1 mRNA | CTD | PMID:21346803 | 4,4'-diaminodiphenylmethane | decreases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of SEPHS1 mRNA | CTD | PMID:30723492 | 5-aza-2'-deoxycytidine | affects expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Decitabine affects the expression of SEPHS1 mRNA | CTD | PMID:23300844 | 5-fluorouracil | affects response to substance | ISO | SEPHS1 (Homo sapiens) | 6480464 | SEPHS1 protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | aconitine | increases expression | EXP | | 6480464 | Aconitine results in increased expression of SEPHS1 protein | CTD | PMID:33236894 | all-trans-retinoic acid | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SEPHS1 mRNA | CTD | PMID:23724009 | all-trans-retinoic acid | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SEPHS1 mRNA | CTD | PMID:33167477 | antirheumatic drug | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SEPHS1 mRNA | CTD | PMID:24449571 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SEPHS1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SEPHS1 protein | CTD | PMID:31675489 and PMID:37567409 | bisphenol A | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SEPHS1 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | Sephs1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SEPHS1 mRNA | CTD | PMID:33221593 | cadmium dichloride | affects expression | EXP | | 6480464 | Cadmium Chloride affects the expression of SEPHS1 mRNA | CTD | PMID:22110744 | choline | multiple interactions | ISO | Sephs1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SEPHS1 gene | CTD | PMID:20938992 | cisplatin | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [Piroxicam co-treated with Cisplatin] results in increased expression of SEPHS1 mRNA | CTD | PMID:21858171 | cisplatin | affects expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Cisplatin affects the expression of SEPHS1 mRNA | CTD | PMID:23300844 | cobalt dichloride | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of SEPHS1 mRNA | CTD | PMID:19320972 and PMID:19376846 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of SEPHS1 mRNA | CTD | PMID:24386269 | copper atom | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SEPHS1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of SEPHS1 mRNA | CTD | PMID:20971185 | coumarin | increases phosphorylation | ISO | SEPHS1 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of SEPHS1 protein | CTD | PMID:35688186 | coumestrol | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of SEPHS1 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SEPHS1 mRNA | CTD | PMID:19167446 | decabromodiphenyl ether | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of SEPHS1 protein | CTD | PMID:31675489 | dibutyl phthalate | decreases expression | ISO | Sephs1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of SEPHS1 mRNA | CTD | PMID:17361019 and PMID:21266533 | disodium selenite | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of SEPHS1 mRNA | CTD | PMID:18175754 | disodium selenite | multiple interactions | ISO | Sephs1 (Mus musculus) | 6480464 | SEPHS1 protein affects the reaction [Sodium Selenite results in increased expression of GPX1 protein] | CTD | PMID:21669866 | doxorubicin | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of SEPHS1 mRNA | CTD | PMID:29803840 | Enterolactone | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of SEPHS1 mRNA | CTD | PMID:19167446 | entinostat | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | entinostat results in decreased expression of SEPHS1 mRNA | CTD | PMID:27188386 | epoxiconazole | decreases expression | ISO | Sephs1 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of SEPHS1 mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of SEPHS1 mRNA | CTD | PMID:23649840 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of SEPHS1 mRNA | CTD | PMID:24136188 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of SEPHS1 mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Sephs1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SEPHS1 gene | CTD | PMID:20938992 | folic acid | decreases expression | ISO | Sephs1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SEPHS1 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SEPHS1 mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of SEPHS1 gene | CTD | PMID:31601247 | genistein | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | ESR1 promotes the reaction [Genistein results in decreased expression of SEPHS1 protein] and ESR2 promotes the reaction [Genistein results in increased expression of SEPHS1 protein] | CTD | PMID:20884965 | genistein | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Genistein results in increased expression of SEPHS1 protein | CTD | PMID:20884965 | genistein | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Genistein results in decreased expression of SEPHS1 protein | CTD | PMID:20884965 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SEPHS1 mRNA | CTD | PMID:33387578 | ivermectin | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SEPHS1 protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Sephs1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SEPHS1 gene | CTD | PMID:20938992 | lead(0) | affects expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Lead affects the expression of SEPHS1 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of SEPHS1 mRNA | CTD | PMID:24136188 | lovastatin | increases expression | ISO | Sephs1 (Mus musculus) | 6480464 | Lovastatin results in increased expression of SEPHS1 mRNA | CTD | PMID:20493250 | methyl methanesulfonate | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of SEPHS1 mRNA | CTD | PMID:23649840 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SEPHS1 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of SEPHS1 mRNA | CTD | PMID:35430440 | paracetamol | affects expression | ISO | Sephs1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SEPHS1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of SEPHS1 mRNA | CTD | PMID:33387578 | phenethyl isothiocyanate | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | phenethyl isothiocyanate results in decreased expression of SEPHS1 mRNA | CTD | PMID:26678675 | phenobarbital | affects expression | ISO | Sephs1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SEPHS1 mRNA | CTD | PMID:23091169 | piroxicam | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [Piroxicam co-treated with Cisplatin] results in increased expression of SEPHS1 mRNA | CTD | PMID:21858171 | rotenone | increases expression | EXP | | 6480464 | Rotenone results in increased expression of SEPHS1 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | SEPHS1 (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of SEPHS1 protein | CTD | PMID:37664457 | sodium arsenite | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SEPHS1 mRNA | CTD | PMID:34032870 | tert-butyl hydroperoxide | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of SEPHS1 mRNA | CTD | PMID:15336504 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of SEPHS1 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SEPHS1 mRNA | CTD | PMID:25729387 | trichostatin A | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SEPHS1 mRNA | CTD | PMID:28542535 | triptonide | decreases expression | ISO | Sephs1 (Mus musculus) | 6480464 | triptonide results in decreased expression of SEPHS1 mRNA | CTD | PMID:33045310 | valdecoxib | increases expression | EXP | | 6480464 | valdecoxib results in increased expression of SEPHS1 mRNA | CTD | PMID:24136188 | valproic acid | affects expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SEPHS1 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SEPHS1 mRNA | CTD | PMID:19101580 more ... | vitamin E | increases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | Vitamin E results in increased expression of SEPHS1 mRNA | CTD | PMID:19244175 | vorinostat | decreases expression | ISO | SEPHS1 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of SEPHS1 mRNA | CTD | PMID:22083351 | warfarin | increases expression | ISO | Sephs1 (Mus musculus) | 6480464 | Warfarin results in increased expression of SEPHS1 mRNA | CTD | PMID:20493250 | |