Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Gramd4 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of GRAMD4 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Gramd4 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of GRAMD4 mRNA | CTD | PMID:25975270 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Gramd4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GRAMD4 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2-methylcholine | affects expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of GRAMD4 mRNA | CTD | PMID:21179406 | 4,4'-sulfonyldiphenol | decreases methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | bisphenol S results in decreased methylation of GRAMD4 gene | CTD | PMID:31601247 | 5-fluorouracil | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of GRAMD4 mRNA | CTD | PMID:21127500 | 5-fluorouracil | multiple interactions | ISO | GRAMD4 (Homo sapiens) | 6480464 | TP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA] | CTD | PMID:21127500 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of GRAMD4 mRNA | CTD | PMID:24780913 | Aflatoxin B2 alpha | increases methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of GRAMD4 intron | CTD | PMID:30157460 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of GRAMD4 mRNA | CTD | PMID:30779732 | arsane | affects methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of GRAMD4 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | Arsenic affects the methylation of GRAMD4 gene | CTD | PMID:25304211 | atrazine | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of GRAMD4 mRNA | CTD | PMID:22378314 | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of GRAMD4 gene | CTD | PMID:35440735 | atrazine | increases expression | EXP | | 6480464 | Atrazine results in increased expression of GRAMD4 mRNA | CTD | PMID:36841081 | benzo[a]pyrene | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of GRAMD4 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of GRAMD4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Gramd4 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of GRAMD4 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bisphenol A | increases expression | ISO | Gramd4 (Mus musculus) | 6480464 | bisphenol A results in increased expression of GRAMD4 mRNA | CTD | PMID:23798566 and PMID:32156529 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GRAMD4 mRNA | CTD | PMID:32145629 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of GRAMD4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of GRAMD4 mRNA | CTD | PMID:25047013 and PMID:29275510 | bisphenol A | decreases expression | ISO | Gramd4 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of GRAMD4 mRNA | CTD | PMID:26063408 | butanal | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of GRAMD4 mRNA | CTD | PMID:26079696 | calcitriol | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of GRAMD4 mRNA | CTD | PMID:16002434 | carbon nanotube | decreases expression | ISO | Gramd4 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of GRAMD4 mRNA | CTD | PMID:25554681 | chlorpyrifos | decreases expression | ISO | Gramd4 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of GRAMD4 mRNA | CTD | PMID:32715474 | chlorpyrifos | increases expression | ISO | Gramd4 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of GRAMD4 mRNA | CTD | PMID:37019170 | cisplatin | multiple interactions | ISO | GRAMD4 (Homo sapiens) | 6480464 | Cisplatin promotes the reaction [[TP73 protein binds to GRAMD4 promoter] which results in increased expression of GRAMD4 mRNA] more ... | CTD | PMID:21127500 and PMID:27392435 | cisplatin | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of GRAMD4 mRNA | CTD | PMID:27392435 | cisplatin | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of GRAMD4 mRNA | CTD | PMID:27594783 | disodium selenite | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of GRAMD4 mRNA | CTD | PMID:18175754 | doxorubicin | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of GRAMD4 mRNA | CTD | PMID:29803840 | fluoranthene | increases expression | ISO | Gramd4 (Mus musculus) | 6480464 | fluoranthene results in increased expression of GRAMD4 mRNA | CTD | PMID:28329830 | fluoranthene | multiple interactions | ISO | Gramd4 (Mus musculus) | 6480464 | [1-methylanthracene co-treated with fluoranthene] results in increased expression of GRAMD4 mRNA | CTD | PMID:28329830 | folic acid | decreases expression | ISO | Gramd4 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of GRAMD4 mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of GRAMD4 protein | CTD | PMID:37730182 | fulvestrant | decreases methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | Fulvestrant results in decreased methylation of GRAMD4 gene | CTD | PMID:31601247 | inulin | multiple interactions | ISO | Gramd4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of GRAMD4 mRNA | CTD | PMID:36331819 | lipopolysaccharide | multiple interactions | ISO | GRAMD4 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of GRAMD4 mRNA | CTD | PMID:35811015 | malathion | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Malathion results in decreased expression of GRAMD4 mRNA | CTD | PMID:32069766 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of GRAMD4 mRNA | CTD | PMID:33387578 | perfluorohexanesulfonic acid | decreases expression | ISO | Gramd4 (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in decreased expression of GRAMD4 mRNA | CTD | PMID:37995155 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Gramd4 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of GRAMD4 mRNA | CTD | PMID:36331819 | pirinixic acid | increases expression | ISO | Gramd4 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of GRAMD4 mRNA | CTD | PMID:23811191 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | GRAMD4 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of GRAMD4 mRNA | CTD | PMID:35811015 | silicon dioxide | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of GRAMD4 mRNA | CTD | PMID:25895662 | sodium arsenite | decreases methylation | ISO | Gramd4 (Mus musculus) | 6480464 | sodium arsenite results in decreased methylation of GRAMD4 gene | CTD | PMID:32068019 | sodium arsenite | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of GRAMD4 mRNA | CTD | PMID:34032870 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of GRAMD4 mRNA | CTD | PMID:34492290 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of GRAMD4 mRNA | CTD | PMID:33387578 | trichostatin A | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of GRAMD4 mRNA | CTD | PMID:24935251 | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of GRAMD4 mRNA | CTD | PMID:30589522 | tunicamycin | decreases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Tunicamycin results in decreased expression of GRAMD4 mRNA | CTD | PMID:22378314 | valproic acid | increases methylation | ISO | GRAMD4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of GRAMD4 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | Gramd4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of GRAMD4 mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of GRAMD4 mRNA | CTD | PMID:24935251 | valproic acid | affects expression | ISO | GRAMD4 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of GRAMD4 mRNA | CTD | PMID:25979313 | |