Sumf1 (sulfatase modifying factor 1)

Gene: Sumf1 (sulfatase modifying factor 1) Rattus norvegicus

Analyze

Symbol:

Sumf1

Name:

sulfatase modifying factor 1

RGD ID:

1309939

Description:

Predicted to enable identical protein binding activity. Predicted to be involved in post-translational protein modification. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

formylglycine-generating enzyme; LOC362409; sulfatase-modifying factor 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SUMF1 (sulfatase modifying factor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sumf1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sumf1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SUMF1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SUMF1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sumf1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SUMF1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SUMF1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sumf1 (sulfatase modifying factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SUMF1 (sulfatase modifying factor 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Alliance orthologs ³
Homo sapiens (human):	SUMF1 (sulfatase modifying factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sumf1 (sulfatase modifying factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sumf1 (sulfatase modifying factor 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG7049	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sumf1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	142,634,766 - 142,716,726 (-)	NCBI		GRCr8
mRatBN7.2	4	141,078,735 - 141,160,711 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	141,078,741 - 141,160,708 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	146,495,350 - 146,582,629 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	142,276,073 - 142,363,346 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	140,920,035 - 141,007,308 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	140,139,017 - 140,220,482 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	140,139,003 - 140,220,487 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	204,606,895 - 204,688,362 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	143,596,618 - 143,678,517 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	143,841,457 - 143,923,349 (-)	NCBI
Celera	4	129,731,612 - 129,812,899 (-)	NCBI		Celera
Cytogenetic Map	4	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

mucosulfatidosis (ISS)

sphingolipidosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

Aroclor 1254 (ISO)

bisphenol A (EXP)

bisphenol F (EXP)

chlorpyrifos (ISO)

choline (ISO)

dibutyl phthalate (ISO)

epoxiconazole (ISO)

finasteride (EXP)

folic acid (ISO)

folpet (ISO)

ketamine (EXP)

L-methionine (ISO)

leflunomide (EXP)

levofloxacin (EXP)

methimazole (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (EXP)

triptonide (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

post-translational protein modification (IEA)

Cellular Component

endoplasmic reticulum (IBA,ISO)

endoplasmic reticulum lumen (IEA)

Molecular Function

cupric ion binding (IEA)

formylglycine-generating oxidase activity (IEA)

identical protein binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme.	Dierks T, etal., Cell. 2003 May 16;113(4):435-44.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:15962010	PMID:18266766	PMID:21224894	PMID:25931126

Genomics

Comparative Map Data

Sumf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	142,634,766 - 142,716,726 (-)	NCBI		GRCr8
mRatBN7.2	4	141,078,735 - 141,160,711 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	141,078,741 - 141,160,708 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	146,495,350 - 146,582,629 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	142,276,073 - 142,363,346 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	140,920,035 - 141,007,308 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	140,139,017 - 140,220,482 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	140,139,003 - 140,220,487 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	204,606,895 - 204,688,362 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	143,596,618 - 143,678,517 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	143,841,457 - 143,923,349 (-)	NCBI
Celera	4	129,731,612 - 129,812,899 (-)	NCBI		Celera
Cytogenetic Map	4	q41	NCBI

SUMF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	3,700,814 - 3,800,875 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	3,700,814 - 4,467,273 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	3,742,498 - 3,842,559 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	4,377,830 - 4,483,954 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	4,377,829 - 4,483,954	NCBI
Celera	3	4,340,773 - 4,447,046 (-)	NCBI		Celera
Cytogenetic Map	3	p26.2	NCBI
HuRef	3	4,336,301 - 4,442,706 (-)	NCBI		HuRef
CHM1_1	3	3,733,077 - 3,819,079 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	3,696,988 - 3,797,158 (-)	NCBI		T2T-CHM13v2.0

Sumf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	108,083,989 - 108,162,552 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	108,083,989 - 108,162,543 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	108,107,021 - 108,185,591 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	108,107,028 - 108,185,582 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	108,057,022 - 108,135,576 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	108,072,805 - 108,151,333 (-)	NCBI		MGSCv36	mm8
Celera	6	109,910,767 - 109,990,697 (-)	NCBI		Celera
Cytogenetic Map	6	E1	NCBI
cM Map	6	49.71	NCBI

Sumf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	8,981,211 - 9,049,948 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	8,982,059 - 9,050,936 (+)	NCBI	ChiLan1.0	ChiLan1.0

SUMF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	3,784,278 - 4,480,847 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	3,888,323 - 4,486,797 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	4,314,790 - 4,422,503 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	4,415,726 - 4,523,850 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	4,415,726 - 4,523,850 (-)	Ensembl	panpan1.1		panPan2

SUMF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	13,093,427 - 13,190,621 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	13,092,901 - 13,299,314 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	13,066,961 - 13,163,715 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	13,137,091 - 13,228,066 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	13,137,096 - 13,229,598 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	12,841,772 - 12,932,488 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	13,182,237 - 13,272,688 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	13,169,249 - 13,260,076 (+)	NCBI		UU_Cfam_GSD_1.0

Sumf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	10,836,722 - 10,910,566 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936577	3,791,862 - 3,866,125 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936577	3,792,108 - 3,865,967 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SUMF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	60,946,021 - 61,037,295 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	60,946,718 - 61,037,298 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	67,255,357 - 67,345,941 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SUMF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	40,443,134 - 40,547,480 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	40,444,131 - 40,547,448 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	126,121,865 - 126,226,535 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sumf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624773	14,746,094 - 14,828,914 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624773	14,746,089 - 14,828,928 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sumf1
595 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	154
Count of miRNA genes:	120
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000009008
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82798864	152731274	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	85253748	148090731	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	85253748	150276390	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	85379421	167139601	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	93308457	167139447	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	103194656	148194656	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	105789505	150789505	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	106649412	151649412	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	106805662	151805662	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	109827074	154827074	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	109827074	154827074	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	109866907	167139601	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	114627026	159627026	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	116179486	151161268	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	118856416	163856416	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	119428175	157578333	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	119463257	147278687	Rat
70201	Gcr1	Gastric cancer resistance QTL 1	2.7		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	4	120260281	147278687	Rat
2293840	Kiddil9	Kidney dilation QTL 9	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	4	120926564	148090731	Rat
634347	Hcar8	Hepatocarcinoma resistance QTL 8	5.8		liver integrity trait (VT:0010547)	liver tumorous lesion area to total liver area ratio (CMO:0001075)	4	123143783	168143783	Rat
631683	Bp116	Blood pressure QTL 116		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	124303370	169303370	Rat
6478778	Anxrr51	Anxiety related response QTL 51		0.25384	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	124778595	169778595	Rat
7411558	Bw133	Body weight QTL 133	13.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	4	125590636	170590636	Rat
61451	Ciaa4	CIA Autoantibody QTL 4	3.1		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	4	126395976	167139601	Rat
737978	Pia23	Pristane induced arthritis QTL 23	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
631511	Pia7	Pristane induced arthritis QTL 7	4.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	131730738	167139601	Rat
1549827	Scl46	Serum cholesterol level QTL 46	3.5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	132396220	177396220	Rat
724558	Plsm2	Polydactyly-luxate syndrome (PLS) morphotypes QTL 2		0.0003	hindlimb integrity trait (VT:0010563)	hind foot phalanges count (CMO:0001949)	4	132422778	177422778	Rat
61422	Cia13	Collagen induced arthritis QTL 13	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	132642577	167139601	Rat
2303623	Vencon2	Ventilatory control QTL 2	3.8		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	4	135204660	180204660	Rat
1578674	Bmd12	Bone mineral density QTL 12	3.8		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	4	135699135	180699135	Rat
2293659	Bmd35	Bone mineral density QTL 35	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	4	137755016	181392681	Rat
61362	Oia2	Oil induced arthritis QTL 2		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
1298524	Oia8	Oil induced arthritis QTL 8			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	138503169	173369699	Rat
1331738	Bp209	Blood pressure QTL 209	2.979		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	138503169	179293946	Rat

Markers in Region

RH128047

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	141,096,667 - 141,096,848 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	144,323,037 - 144,323,218 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	151,354,867 - 151,355,047	NCBI	Rnor6.0
Rnor_6.0	4	140,156,713 - 140,156,893	NCBI	Rnor6.0
Rnor_5.0	4	204,624,591 - 204,624,771	UniSTS	Rnor5.0
Rnor_5.0	3	157,720,078 - 157,720,258	UniSTS	Rnor5.0
RGSC_v3.4	4	143,614,485 - 143,614,665	UniSTS	RGSC3.4
Celera	4	129,748,880 - 129,749,060	UniSTS
Celera	3	143,047,279 - 143,047,459	UniSTS
RH 3.4 Map	4	875.22	UniSTS
Cytogenetic Map	4	q41	UniSTS

RH130572

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	141,078,766 - 141,078,986 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	140,139,042 - 140,139,261	NCBI	Rnor6.0
Rnor_5.0	4	204,606,920 - 204,607,139	UniSTS	Rnor5.0
RGSC_v3.4	4	143,596,643 - 143,596,862	UniSTS	RGSC3.4
Celera	4	129,731,637 - 129,731,856	UniSTS
RH 3.4 Map	4	881.0	UniSTS
Cytogenetic Map	4	q41	UniSTS

RH139257

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	141,079,097 - 141,079,340 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	140,139,373 - 140,139,615	NCBI	Rnor6.0
Rnor_5.0	4	204,607,251 - 204,607,493	UniSTS	Rnor5.0
RGSC_v3.4	4	143,596,974 - 143,597,216	UniSTS	RGSC3.4
Celera	4	129,731,968 - 129,732,210	UniSTS
Cytogenetic Map	4	q41	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	30	46	35	14	35			57	35	35	11
Low		13	11	6	5	6	8	11	17		6		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039107827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000009008 ⟹ ENSRNOP00000009008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	141,078,741 - 141,160,708 (-)	Ensembl
Rnor_6.0 Ensembl	4	140,139,003 - 140,220,487 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098361 ⟹ ENSRNOP00000089270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	141,078,741 - 141,160,708 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000106772 ⟹ ENSRNOP00000081326

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	141,078,741 - 141,160,708 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000115716 ⟹ ENSRNOP00000079041

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	141,080,092 - 141,160,708 (-)	Ensembl

RefSeq Acc Id:

NM_001108639 ⟹ NP_001102109

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	142,634,767 - 142,716,712 (-)	NCBI
mRatBN7.2	4	141,078,742 - 141,160,694 (-)	NCBI
Rnor_6.0	4	140,139,017 - 140,220,482 (-)	NCBI
Rnor_5.0	4	204,606,895 - 204,688,362 (-)	NCBI
RGSC_v3.4	4	143,596,618 - 143,678,517 (-)	RGD
Celera	4	129,731,612 - 129,812,899 (-)	RGD

Sequence:

show sequence

GAGAACAACATGGCTGCGCCCGCGGGAGAGCCTGCTCCCCGCTGCTGTACAGGGCTGGCTCAGG
TCTTCTTGCTGCTGGTGCTGGCGTGCGGGGCAGCGGGGAGCGATGAGGCCGAGGCCGGGGAAGG
TGCGGTGTCCCTCGCTGGTTCCTGCGGCTGCGGAACGCCCCAGAGGGCTGGGGCCCATGGCAGC
TCGGCGGCCGCGCAGCGCTACTCCCGGGAGGCGAATGCCCAGGGCCTGACCTCGGGCCCACGAT
CGCTCGCTCTCACTAAGATGGTCCCCATCCCTGCTGGAGTATTTACAATGGGCACTGATGATCC
TCAGATCAAGCAGGATGGAGAAGCCCCTGCCAGGAGAGTCACTGTCGATGCCTTTTACATGGAT
GCCTATGAAGTCAGCAACGCTGATTTTGAGAAGTTCGTGAACTCAACTGGCTATTTAACAGAGG
CTGAGAAGTTTGGAGACTCTTTTGTCTTTGAAGGCATGCTGAGTGAGCCAGTCAAGGCGCAAAT
TCACCAGGCAGTTGCAGCTGCTCCATGGTGGTTACCTGTCAAGGGCGCTGATTGGAGACACCCA
GAGGGCCCAGACTCCACTATTCTGCACAGGTCAAATCATCCAGTCCTCCATGTCTCCTGGAATG
ACGCCGTTGCCTACTGCGCATGGGCGGGGAAGAGGCTGCCCACGGAGGCAGAGTGGGAGTACAG
CTGCAGAGGAGGCCTGCAGAACAGGCTTTTCCCCTGGGGCAACAAACTGCAGCCCAAAGGACAG
CATTATGCCAACATTTGGCAGGGCGAGTTTCCTGTGACCAACACTGGCGAGGATGGCTTCCAAG
GAACTGCCCCCGTTGATGCCTTTCCTCCCAATGGCTATGGCTTATACAACATAGTGGGGAACGC
ATGGGAGTGGACCTCAGACTGGTGGACCGTTCACCATTCTGCTGAGGAAACGCTCAACCCAAAA
GGCCCCACTTCTGGGAAAGACCGAGTGAAGAAGGGTGGATCCTACATGTGCCATAAGTCCTATT
GCTACAGGTATCGCTGTGCAGCTCGAAGCCAGAACACACCAGATAGCTCTGCATCCAACCTGGG
ATTCCGTTGTGCAGCAGATCACCTGCCCACTGCAAACTGACAGAGGAGCTTTTCCAAATCCAAG
AAGTTGCTCACTTGCAGCTGGCCTCCCGCTGGACATCTGAACAGATCTTATGTAAAGTATTCCC
ACACCTGAGGAGAGTTACATGTCCACCCCGTGGCCAAAGGAACTGTGTCGTGTGACCAAATTGC
TGACGTCTGTCAGTGCTTGTGCTTTATCGTGTGGTGCATCGTTGGGGATCATCACCGTGTTTTA
CTTTGAGAGCCTTTTGAAGAGGAGAGAGCTGAGAACCATGAAGTCCTAGCCAGACTCTGCCACA
GGGTCAAACCCTGGGGTTCAGCACCTTGTCTGCCTGGGCCTCTATCCCCTCATGGAATGAGGGA
TGGACTGGACGACATGAGGCGCTCTCCACCTTACAGATTCTATTCGCACTAGTGGAGTGTATTG
TGATTGCATAGTAAGAATTTATGACAGATTATTTTTAGCTATTTTTTTGCCATGTGTGAATCTT
GAGTAATGCTAATCATATAAGGTGAGAGTTCTCTTACGTGTTATTTTCAGAAGAGGGTGGGGTT
TGAGTCTTTTATATTCATACTGCACTTTGTTCTTTCAAGGAAATCAGTGTCTTTTACATTGTTG
TGACAAATCTCATTGGGACAGTGAGGGGACACTCAAATTCCGAGTTCTGAGCACACAGGAATGC
CTGTGGAGTGACTCTACTGTCCTTTTTCTTTTGACATTAAGTGCCTTTGGCTCAGAGGGACAGT
TTGAAGCCTTGTTTCCCATTTGCCCCACAAGCCTTCAAAGAATGTGAAATGTGTACTAATTAGG
GAAACCCTTAAATTCTAGGTACAAGGGTTTGATGTTGTGTATTGTAATGCTAAATCTGTATATG
AAGGTTTAGGCCTGTGAGTGAATTCTTACATTTACAAGCTTTTGTTGTGCAAACCTTGTTCCTT
AATTTAGAACTATTGGTTAAAAAAAAGAAAATTGTCTACAGCCAATTATTGGAGGGATTAGTAG
GTAGGTTTGAGTTACCTGGGGGTAGAGAGAGAGAGGAGAGAGAGGAGAGCAAGAGGAAGAAGGA
AAGCGCTGGAGGAGCTGCCATGAGGGAAATGGACATGTGGCCAGGAGAAACATCAGTATCTGGG
CACAGTACTGCAGAGGTAGCCAGGCCAGCAGTTAGAAAAGTAGATTAGGGATTAACCCCCAGTA
ATGGTCAAAGCCACGCAAAATAACCATAGTCTGAGTCTCATTTATTTGTAAGCCTTGAATAGAC
TACGTTCAGGGTATCTAGTATATTATACCAGAGAGATGAGAAATTGTGTTCATTTTGTGATATC
AGATGCTTTGAATCATGCACTATGTCAAATAAACTAATACCTCTCA

hide sequence

RefSeq Acc Id:

XM_039107827 ⟹ XP_038963755

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	142,634,766 - 142,716,726 (-)	NCBI
mRatBN7.2	4	141,078,735 - 141,160,711 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102109	(Get FASTA)	NCBI Sequence Viewer
	XP_038963755	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL91477	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009008
	ENSRNOP00000009008.4
	ENSRNOP00000079041
	ENSRNOP00000079041.1
	ENSRNOP00000081326.1
	ENSRNOP00000089270.1

RefSeq Acc Id:	NP_001102109 ⟸ NM_001108639
- Peptide Label:	precursor
- UniProtKB:	D4A7I8 (UniProtKB/TrEMBL), A6IBK9 (UniProtKB/TrEMBL), A0A8I5ZM54 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAPAGEPAPRCCTGLAQVFLLLVLACGAAGSDEAEAGEGAVSLAGSCGCGTPQRAGAHGSSAA AQRYSREANAQGLTSGPRSLALTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVTVDAFYMDAYE VSNADFEKFVNSTGYLTEAEKFGDSFVFEGMLSEPVKAQIHQAVAAAPWWLPVKGADWRHPEGP DSTILHRSNHPVLHVSWNDAVAYCAWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYA NIWQGEFPVTNTGEDGFQGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETLNPKGPT SGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTAN hide sequence

RefSeq Acc Id:

ENSRNOP00000009008 ⟸ ENSRNOT00000009008

RefSeq Acc Id:	XP_038963755 ⟸ XM_039107827
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZM54 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000079041 ⟸ ENSRNOT00000115716

RefSeq Acc Id:

ENSRNOP00000089270 ⟸ ENSRNOT00000098361

RefSeq Acc Id:

ENSRNOP00000081326 ⟸ ENSRNOT00000106772

Protein Domains

Sulfatase-modifying factor enzyme

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A7I8-F1-model_v2	AlphaFold	D4A7I8	1-372	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693282

Promoter ID:

EPDNEW_R3806

Type:

multiple initiation site

Name:

Sumf1_1

Description:

sulfatase modifying factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	140,220,491 - 140,220,551	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309939	AgrOrtholog
BioCyc Gene	G2FUF-43455	BioCyc
Ensembl Genes	ENSRNOG00000006813	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009008	ENTREZGENE
	ENSRNOT00000009008.6	UniProtKB/TrEMBL
	ENSRNOT00000098361.1	UniProtKB/TrEMBL
	ENSRNOT00000106772.1	UniProtKB/TrEMBL
	ENSRNOT00000115716.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.1580.10	UniProtKB/TrEMBL
InterPro	C-type_lectin_fold	UniProtKB/TrEMBL
	Sulphatase-mod_factor	UniProtKB/TrEMBL
	SUMF_sf	UniProtKB/TrEMBL
KEGG Report	rno:362409	UniProtKB/TrEMBL
NCBI Gene	362409	ENTREZGENE
PANTHER	FORMYLGLYCINE-GENERATING ENZYME	UniProtKB/TrEMBL
	SULFATASE MODIFYING FACTOR 1, 2	UniProtKB/TrEMBL
Pfam	DUF323	UniProtKB/TrEMBL
PhenoGen	Sumf1	PhenoGen
RatGTEx	ENSRNOG00000006813	RatGTEx
Superfamily-SCOP	C-type_lectin_fold	UniProtKB/TrEMBL
UniProt	A0A8I5ZM54	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZRR9_RAT	UniProtKB/TrEMBL
	A0A8I6ABB3_RAT	UniProtKB/TrEMBL
	A6IBK9	ENTREZGENE, UniProtKB/TrEMBL
	D4A7I8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Sumf1	sulfatase modifying factor 1	Sumf1_predicted	sulfatase modifying factor 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Sumf1_predicted	sulfatase modifying factor 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI