Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | increases expression | ISO | Foxk1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of FOXK1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Estradiol binds to ESR2 protein] which results in increased expression of FOXK1 mRNA | CTD | PMID:20404318 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Foxk1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of FOXK1 mRNA | CTD | PMID:24058054 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of FOXK1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FOXK1 mRNA | CTD | PMID:26290441 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Foxk1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of FOXK1 mRNA | CTD | PMID:21570461 and PMID:24680724 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of FOXK1 mRNA | CTD | PMID:18648102 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Decitabine co-treated with trichostatin A] results in decreased expression of FOXK1 mRNA | CTD | PMID:17891453 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of FOXK1 mRNA | CTD | PMID:31881176 | acrolein | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of FOXK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of FOXK1 mRNA | CTD | PMID:32699268 | all-trans-retinoic acid | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of FOXK1 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of FOXK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of FOXK1 mRNA | CTD | PMID:32699268 | amosite asbestos | decreases methylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Asbestos and Amosite results in decreased methylation of FOXK1 promoter | CTD | PMID:29626692 | arsane | affects methylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of FOXK1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of FOXK1 gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to FOXK1 mRNA] | CTD | PMID:32406909 | avobenzone | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | avobenzone results in increased expression of FOXK1 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of FOXK1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | affects methylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of FOXK1 3' UTR | CTD | PMID:27901495 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of FOXK1 mRNA | CTD | PMID:25181051 | bisphenol A | increases methylation | ISO | Foxk1 (Mus musculus) | 6480464 | bisphenol A results in increased methylation of FOXK1 promoter | CTD | PMID:27312807 | bisphenol A | affects methylation | ISO | Foxk1 (Mus musculus) | 6480464 | bisphenol A affects the methylation of FOXK1 promoter | CTD | PMID:27334623 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of FOXK1 mRNA | CTD | PMID:30816183 | buta-1,3-diene | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of FOXK1 mRNA | CTD | PMID:29038090 | butanal | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of FOXK1 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FOXK1 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FOXK1 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of FOXK1 protein | CTD | PMID:35688186 | calcitriol | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of FOXK1 mRNA | CTD | PMID:16002434 | carbon nanotube | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | cisplatin | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of FOXK1 mRNA | CTD | PMID:27594783 | clobetasol | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | Clobetasol results in decreased expression of FOXK1 mRNA | CTD | PMID:27462272 | clofibrate | multiple interactions | ISO | Foxk1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of FOXK1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FOXK1 mRNA] | CTD | PMID:17585979 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of FOXK1 mRNA | CTD | PMID:24386269 | coumarin | increases phosphorylation | ISO | FOXK1 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of FOXK1 protein | CTD | PMID:35688186 | crocidolite asbestos | decreases methylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased methylation of FOXK1 promoter | CTD | PMID:29626692 | cyclosporin A | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of FOXK1 mRNA | CTD | PMID:25562108 | dicrotophos | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of FOXK1 mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of FOXK1 protein | CTD | PMID:23301498 | epoxiconazole | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of FOXK1 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | Foxk1 (Mus musculus) | 6480464 | Ethanol affects the splicing of FOXK1 mRNA | CTD | PMID:30319688 | folic acid | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of FOXK1 mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | FOXK1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of FOXK1 protein | CTD | PMID:37730182 | lead(0) | affects expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Lead affects the expression of FOXK1 mRNA | CTD | PMID:28903495 | maneb | multiple interactions | ISO | Foxk1 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of FOXK1 mRNA | CTD | PMID:36117858 | mercury atom | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Mercury results in increased expression of FOXK1 mRNA | CTD | PMID:19937285 | mercury(0) | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Mercury results in increased expression of FOXK1 mRNA | CTD | PMID:19937285 | methylmercury chloride | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of FOXK1 mRNA | CTD | PMID:28001369 | ozone | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of FOXK1 mRNA more ... | CTD | PMID:32699268 | ozone | multiple interactions | ISO | Foxk1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of FOXK1 mRNA | CTD | PMID:34911549 | paracetamol | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of FOXK1 mRNA | CTD | PMID:21420995 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of FOXK1 mRNA | CTD | PMID:33387578 | paracetamol | multiple interactions | ISO | Foxk1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of FOXK1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of FOXK1 mRNA] | CTD | PMID:17585979 | paracetamol | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of FOXK1 mRNA | CTD | PMID:22230336 | paraquat | multiple interactions | ISO | Foxk1 (Mus musculus) | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of FOXK1 mRNA | CTD | PMID:36117858 | SB 431542 | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sunitinib | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of FOXK1 mRNA | CTD | PMID:31533062 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of FOXK1 mRNA | CTD | PMID:34492290 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of FOXK1 mRNA | CTD | PMID:33387578 | trichostatin A | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [Decitabine co-treated with trichostatin A] results in decreased expression of FOXK1 mRNA more ... | CTD | PMID:17891453 and PMID:27188386 | trichostatin A | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of FOXK1 mRNA | CTD | PMID:24935251 and PMID:26272509 | triptonide | increases expression | ISO | Foxk1 (Mus musculus) | 6480464 | triptonide results in increased expression of FOXK1 mRNA | CTD | PMID:33045310 | troglitazone | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | troglitazone results in decreased expression of FOXK1 mRNA | CTD | PMID:28973697 | tungsten | decreases expression | ISO | Foxk1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of FOXK1 mRNA | CTD | PMID:30912803 | valproic acid | increases methylation | ISO | FOXK1 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of FOXK1 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | Foxk1 (Mus musculus) | 6480464 | Valproic Acid affects the expression of FOXK1 mRNA | CTD | PMID:17292431 | valproic acid | affects expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of FOXK1 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of FOXK1 mRNA | CTD | PMID:23179753 and PMID:26272509 | valproic acid | multiple interactions | ISO | FOXK1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FOXK1 mRNA | CTD | PMID:27188386 | xylitol | increases expression | ISO | FOXK1 (Homo sapiens) | 6480464 | Xylitol results in increased expression of FOXK1 mRNA | CTD | PMID:32275922 | |