Adam24 (ADAM metallopeptidase domain 24) - Rat Genome Database

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Gene: Adam24 (ADAM metallopeptidase domain 24) Rattus norvegicus
Analyze
Symbol: Adam24
Name: ADAM metallopeptidase domain 24
RGD ID: 1309066
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to act upstream of or within prevention of polyspermy. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM20 (ADAM metallopeptidase domain 20); INTERACTS WITH atrazine; bisphenol A; cyclophosphamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: a disintegrin and metallopeptidase domain 24; a disintegrin and metallopeptidase domain 24 (testase 1); a disintegrin and metalloprotease domain 24 (testase 1); a disintegrin and metalloproteinase domain 24; disintegrin and metalloproteinase domain-containing protein 24; LOC290774
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81658,281,748 - 58,287,735 (-)NCBIGRCr8
mRatBN7.21651,578,278 - 51,584,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,578,277 - 51,584,312 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01654,625,789 - 54,631,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,625,847 - 54,628,458 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01654,333,065 - 54,339,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,916,429 - 54,918,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11654,916,503 - 54,918,726 (-)NCBI
Celera1649,470,643 - 49,476,678 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19129510   PMID:19670298  


Genomics

Comparative Map Data
Adam24
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81658,281,748 - 58,287,735 (-)NCBIGRCr8
mRatBN7.21651,578,278 - 51,584,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1651,578,277 - 51,584,312 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01654,625,789 - 54,631,824 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1654,625,847 - 54,628,458 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01654,333,065 - 54,339,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,916,429 - 54,918,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11654,916,503 - 54,918,726 (-)NCBI
Celera1649,470,643 - 49,476,678 (-)NCBICelera
Cytogenetic Map16q12.1NCBI
ADAM29
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384174,918,358 - 174,978,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4174,829,668 - 174,978,180 (+)EnsemblGRCh38hg38GRCh38
GRCh374175,839,509 - 175,899,331 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364176,076,134 - 176,135,906 (+)NCBINCBI36Build 36hg18NCBI36
Build 344176,271,406 - 176,273,692NCBI
Celera4173,168,616 - 173,228,548 (+)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4171,588,769 - 171,648,620 (+)NCBIHuRef
CHM1_14175,815,949 - 175,875,773 (+)NCBICHM1_1
T2T-CHM13v2.04178,256,372 - 178,316,203 (+)NCBIT2T-CHM13v2.0
Adam24
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,128,118 - 41,135,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,128,118 - 41,135,238 (+)EnsemblGRCm39 Ensembl
GRCm38840,675,077 - 40,682,199 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl840,675,077 - 40,682,199 (+)EnsemblGRCm38mm10GRCm38
MGSCv37841,760,448 - 41,767,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,173,911 - 42,181,016 (+)NCBIMGSCv36mm8
Celera843,321,556 - 43,328,596 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Adam29
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540332,233,949 - 32,236,375 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540332,233,940 - 32,257,782 (-)NCBIChiLan1.0ChiLan1.0
ADAM29
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23172,666,680 - 172,727,706 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14173,046,705 - 173,107,718 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04167,133,174 - 167,194,160 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14179,368,671 - 179,428,753 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4179,426,082 - 179,428,753 (+)Ensemblpanpan1.1panPan2
ADAM29
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12525,372,342 - 25,442,760 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,024,913 - 26,095,792 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02525,536,308 - 25,607,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2525,604,567 - 25,607,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12525,470,229 - 25,540,838 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02525,373,125 - 25,443,529 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02525,524,740 - 25,595,635 (+)NCBIUU_Cfam_GSD_1.0
ADAM29
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11415,302,879 - 15,307,649 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,491,921 - 16,530,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM29
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17121,006,675 - 121,053,292 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037101,073,375 - 101,127,006 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adam29
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247696,491,682 - 6,509,400 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adam24
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:17
Count of miRNA genes:17
Interacting mature miRNAs:17
Transcripts:ENSRNOT00000042587
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 1 1
Below cutoff 2 2 2 2 2 2 2 1 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042587   ⟹   ENSRNOP00000040040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1651,578,277 - 51,584,312 (-)Ensembl
Rnor_6.0 Ensembl1654,625,847 - 54,628,458 (-)Ensembl
RefSeq Acc Id: NM_001408681   ⟹   NP_001395610
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81658,281,748 - 58,287,735 (-)NCBI
mRatBN7.21651,578,278 - 51,584,265 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395610 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040040
  ENSRNOP00000040040.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000040040   ⟸   ENSRNOT00000042587
RefSeq Acc Id: NP_001395610   ⟸   NM_001408681
- Peptide Label: precursor
- UniProtKB: F1LW54 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LW54-F1-model_v2 AlphaFold F1LW54 1-740 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309066 AgrOrtholog
BioCyc Gene G2FUF-11246 BioCyc
Ensembl Genes ENSRNOG00000038671 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042587 ENTREZGENE
  ENSRNOT00000042587.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report rno:290774 UniProtKB/TrEMBL
NCBI Gene 290774 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  PTHR11905:SF118 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam24 PhenoGen
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038671 RatGTEx
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt F1LW54 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-18 Adam24  ADAM metallopeptidase domain 24  Adam24  a disintegrin and metallopeptidase domain 24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2020-08-13 Adam24  a disintegrin and metallopeptidase domain 24  Adam24  ADAM metallopeptidase domain 24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-28 Adam24  ADAM metallopeptidase domain 24  Adam24  a disintegrin and metalloproteinase domain 24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-17 Adam24  a disintegrin and metalloproteinase domain 24  Adam24  a disintegrin and metallopeptidase domain 24 (testase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Adam24  a disintegrin and metallopeptidase domain 24 (testase 1)  Adam24  a disintegrin and metallopeptidase domain 24  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Adam24  a disintegrin and metallopeptidase domain 24  Adam24_predicted  a disintegrin and metalloprotease domain 24 (testase 1) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Adam24_predicted  a disintegrin and metalloprotease domain 24 (testase 1) (predicted)      Symbol and Name status set to approved 70820 APPROVED