Mfsd14b (major facilitator superfamily domain containing 14B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Mfsd14b (major facilitator superfamily domain containing 14B) Rattus norvegicus
Analyze
Symbol: Mfsd14b
Name: major facilitator superfamily domain containing 14B
RGD ID: 1308377
Description: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD14B (major facilitator superfamily domain containing 14B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hiatl1; hippocampus abundant transcript-like 1; hippocampus abundant transcript-like protein 1; LOC306687; major facilitator superfamily domain-containing 14B; RGD1308377; similar to RIKEN cDNA 5730414C17
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81783,686 - 136,623 (+)NCBIGRCr8
mRatBN7.21777,895 - 130,837 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,840 - 130,839 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17104,776 - 157,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,647,347 - 1,700,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017102,195 - 155,292 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,607,777 - 2,660,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,607,777 - 2,660,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0174,842,401 - 4,894,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,549,459 - 5,602,364 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1175,549,428 - 5,602,364 (+)NCBI
Celera172,378,210 - 2,431,231 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21873635  


Genomics

Comparative Map Data
Mfsd14b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81783,686 - 136,623 (+)NCBIGRCr8
mRatBN7.21777,895 - 130,837 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1777,840 - 130,839 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17104,776 - 157,872 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0171,647,347 - 1,700,444 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017102,195 - 155,292 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,607,777 - 2,660,902 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,607,777 - 2,660,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0174,842,401 - 4,894,762 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4175,549,459 - 5,602,364 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1175,549,428 - 5,602,364 (+)NCBI
Celera172,378,210 - 2,431,231 (-)NCBICelera
Cytogenetic Map17p14NCBI
MFSD14B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,374,417 - 94,461,042 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,374,569 - 94,461,042 (+)EnsemblGRCh38hg38GRCh38
GRCh37997,136,851 - 97,223,324 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,176,654 - 96,263,023 (+)NCBINCBI36Build 36hg18NCBI36
Celera967,632,673 - 67,664,431 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef966,801,145 - 66,831,792 (+)NCBIHuRef
CHM1_1997,283,355 - 97,369,639 (+)NCBICHM1_1
T2T-CHM13v2.09106,544,066 - 106,630,677 (+)NCBIT2T-CHM13v2.0
Mfsd14b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391365,212,843 - 65,260,813 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1365,212,477 - 65,260,789 (-)EnsemblGRCm39 Ensembl
GRCm381365,065,030 - 65,112,999 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1365,064,663 - 65,112,975 (-)EnsemblGRCm38mm10GRCm38
MGSCv371365,166,338 - 65,214,290 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361365,079,823 - 65,127,735 (-)NCBIMGSCv36mm8
Celera1366,698,682 - 66,747,027 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1334.21NCBI
Mfsd14b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542223,999,269 - 24,035,045 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542224,000,123 - 24,061,998 (-)NCBIChiLan1.0ChiLan1.0
MFSD14B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21144,995,208 - 45,082,018 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1944,997,588 - 45,084,398 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0965,531,739 - 65,554,432 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1993,661,986 - 93,684,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl993,661,986 - 93,684,591 (+)Ensemblpanpan1.1panPan2
MFSD14B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1199,201,206 - 99,271,351 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl199,203,170 - 99,271,067 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha199,593,805 - 99,669,684 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0199,816,991 - 99,887,821 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl199,818,718 - 99,887,797 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1199,429,826 - 99,503,063 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0199,165,219 - 99,240,335 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0199,922,297 - 99,997,394 (-)NCBIUU_Cfam_GSD_1.0
Mfsd14b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049447,538,494 - 7,588,823 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364871,785,419 - 1,803,633 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364871,710,576 - 1,804,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MFSD14B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1038,834,125 - 38,889,457 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11038,835,365 - 38,889,403 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MFSD14B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112104,699,920 - 104,777,035 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12104,700,138 - 104,777,228 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603893,020,140 - 93,100,007 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mfsd14b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624819252,407 - 339,380 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mfsd14b
121 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:384
Count of miRNA genes:215
Interacting mature miRNAs:248
Transcripts:ENSRNOT00000067979
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat

Markers in Region
D17Rat1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217111,663 - 111,831 (-)MAPPERmRatBN7.2
Rnor_6.0172,626,512 - 2,626,679NCBIRnor6.0
Rnor_5.0174,861,136 - 4,861,303UniSTSRnor5.0
RGSC_v3.4175,583,326 - 5,583,494RGDRGSC3.4
RGSC_v3.4175,583,327 - 5,583,494UniSTSRGSC3.4
RGSC_v3.1175,583,327 - 5,583,494RGD
Celera172,397,215 - 2,397,382UniSTS
RH 3.4 Map1716.0UniSTS
RH 3.4 Map1716.0RGD
SHRSP x BN Map173.67UniSTS
SHRSP x BN Map173.67RGD
Cytogenetic Map17p14UniSTS
AU045608  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0172,837,767 - 2,838,032NCBIRnor6.0
RGSC_v3.4175,602,026 - 5,602,285UniSTSRGSC3.4
Celera172,378,289 - 2,378,548UniSTS
Cytogenetic Map17p14UniSTS
RH143226  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0174,843,068 - 4,843,332UniSTSRnor5.0
RGSC_v3.4175,601,168 - 5,601,432UniSTSRGSC3.4
Celera172,379,142 - 2,379,406UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS
AI175472  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217130,400 - 130,650 (+)MAPPERmRatBN7.2
Rnor_6.0172,840,270 - 2,840,517NCBIRnor6.0
Rnor_5.0174,842,401 - 4,842,572NCBIRnor5.0
RGSC_v3.4175,601,928 - 5,602,176UniSTSRGSC3.4
Celera172,378,398 - 2,378,646UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 32 57 41 19 41 2 2 74 35 35 11 2
Low 11 6 9 6 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067979   ⟹   ENSRNOP00000060101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1777,840 - 130,839 (+)Ensembl
Rnor_6.0 Ensembl172,607,777 - 2,660,902 (-)Ensembl
RefSeq Acc Id: NM_001107334   ⟹   NP_001100804
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81783,686 - 136,623 (+)NCBI
mRatBN7.21777,895 - 130,837 (+)NCBI
Rnor_6.0172,607,777 - 2,660,902 (-)NCBI
Rnor_5.0174,842,401 - 4,894,762 (-)NCBI
RGSC_v3.4175,549,459 - 5,602,364 (+)RGD
Celera172,378,210 - 2,431,231 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100804 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66784 (Get FASTA)   NCBI Sequence Viewer  
  B2RYH9 (Get FASTA)   NCBI Sequence Viewer  
  EDL84449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060101
  ENSRNOP00000060101.2
  ENSRNOP00055032765
  ENSRNOP00060029442
  ENSRNOP00065031669
Reference Protein Sequences
RefSeq Acc Id: NP_001100804   ⟸   NM_001107334
- UniProtKB: B2RYH9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060101   ⟸   ENSRNOT00000067979

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYH9-F1-model_v2 AlphaFold B2RYH9 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700267
Promoter ID:EPDNEW_R10791
Type:initiation region
Name:Mfsd14b_1
Description:major facilitator superfamily domain containing 14B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0172,660,852 - 2,660,912EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308377 AgrOrtholog
BioCyc Gene G2FUF-10561 BioCyc
Ensembl Genes ENSRNOG00000018227 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055023458 UniProtKB/Swiss-Prot
  ENSRNOG00060020649 UniProtKB/Swiss-Prot
  ENSRNOG00065022845 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000067979 ENTREZGENE
  ENSRNOT00000067979.4 UniProtKB/Swiss-Prot
  ENSRNOT00055040326 UniProtKB/Swiss-Prot
  ENSRNOT00060035781 UniProtKB/Swiss-Prot
  ENSRNOT00065039013 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7935371 IMAGE-MGC_LOAD
InterPro MFS UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
  Tet-R_TetA/multi-R_MdtG UniProtKB/Swiss-Prot
KEGG Report rno:306687 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188565 IMAGE-MGC_LOAD
NCBI Gene 306687 ENTREZGENE
PANTHER HIPPOCAMPUS ABUNDANT TRANSCRIPT-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
  MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10 UniProtKB/Swiss-Prot
Pfam MFS_1 UniProtKB/Swiss-Prot
PhenoGen Mfsd14b PhenoGen
PRINTS TCRTETA UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018227 RatGTEx
  ENSRNOG00055023458 RatGTEx
  ENSRNOG00060020649 RatGTEx
  ENSRNOG00065022845 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt B2RYH9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Mfsd14b  major facilitator superfamily domain containing 14B  Hiatl1  hippocampus abundant transcript-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Hiatl1  hippocampus abundant transcript-like 1  RGD1308377_predicted  similar to RIKEN cDNA 5730414C17 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308377_predicted  similar to RIKEN cDNA 5730414C17 (predicted)  LOC306687_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306687_predicted  similar to RIKEN cDNA 5730414C17 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL