Actl9 (actin-like 9) - Rat Genome Database

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Gene: Actl9 (actin-like 9) Rattus norvegicus
Analyze
Symbol: Actl9
Name: actin-like 9
RGD ID: 1306886
Description: Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in several processes, including acrosome assembly; axonogenesis; and fertilization. Predicted to be located in acrosomal vesicle; perinuclear theca; and sperm head. Predicted to be part of NuA4 histone acetyltransferase complex. Predicted to be active in several cellular components, including actin filament; axon; and synapse. Human ortholog(s) of this gene implicated in spermatogenic failure 53. Orthologous to human ACTL9 (actin like 9); INTERACTS WITH bisphenol A; cadmium dichloride; benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin-like 9A; actin-like 9A ; actin-like protein 9; Actl9a; LOC314659; RGD1306886; similar to actin-like 7-alpha-like protein
RGD Orthologs
Human
Mouse
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8714,936,690 - 14,938,067 (+)NCBIGRCr8
mRatBN7.2714,234,504 - 14,235,881 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,234,504 - 14,235,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,237,799 - 17,239,176 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,108,924 - 19,110,301 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0716,989,328 - 16,990,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,310,624 - 18,312,001 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,310,624 - 18,312,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,488,144 - 18,489,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4715,944,094 - 15,945,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1715,944,166 - 15,945,467 (+)NCBI
Celera713,134,241 - 13,135,618 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Actl9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8714,936,690 - 14,938,067 (+)NCBIGRCr8
mRatBN7.2714,234,504 - 14,235,881 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,234,504 - 14,235,881 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,237,799 - 17,239,176 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,108,924 - 19,110,301 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0716,989,328 - 16,990,705 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,310,624 - 18,312,001 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,310,624 - 18,312,001 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,488,144 - 18,489,521 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4715,944,094 - 15,945,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1715,944,166 - 15,945,467 (+)NCBI
Celera713,134,241 - 13,135,618 (+)NCBICelera
Cytogenetic Map7q11NCBI
ACTL9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,697,400 - 8,698,795 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,697,400 - 8,698,795 (-)EnsemblGRCh38hg38GRCh38
GRCh37198,807,750 - 8,809,145 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,668,753 - 8,670,172 (-)NCBINCBI36Build 36hg18NCBI36
Celera198,627,110 - 8,628,531 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,423,908 - 8,425,329 (-)NCBIHuRef
CHM1_1198,807,253 - 8,808,674 (-)NCBICHM1_1
T2T-CHM13v2.0198,692,998 - 8,694,393 (-)NCBIT2T-CHM13v2.0
Actl9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,651,873 - 33,653,242 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,651,870 - 33,653,242 (+)EnsemblGRCm39 Ensembl
GRCm381733,432,899 - 33,434,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,432,896 - 33,434,268 (+)EnsemblGRCm38mm10GRCm38
MGSCv371733,569,844 - 33,571,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,035,344 - 33,036,713 (+)NCBIMGSCv36mm8
Celera1736,194,369 - 36,195,738 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
ACTL9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,658,247 - 70,659,497 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,658,141 - 70,659,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,026,249 - 71,027,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTL9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,045,858 - 8,047,510 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl68,045,910 - 8,047,160 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607412,181,584 - 12,183,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actl9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,379,751 - 1,380,965 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248281,379,709 - 1,381,237 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Actl9
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000075258
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 2 2 1 1 2
Below cutoff 1 1 10 4 8 4 2 3 2 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000075258   ⟹   ENSRNOP00000067593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl714,234,504 - 14,235,881 (+)Ensembl
Rnor_6.0 Ensembl718,310,624 - 18,312,001 (+)Ensembl
RefSeq Acc Id: NM_001108077   ⟹   NP_001101547
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8714,936,690 - 14,938,067 (+)NCBI
mRatBN7.2714,234,504 - 14,235,881 (+)NCBI
Rnor_6.0718,310,624 - 18,312,001 (+)NCBI
Rnor_5.0718,488,144 - 18,489,521 (+)NCBI
RGSC_v3.4715,944,094 - 15,945,471 (+)RGD
Celera713,134,241 - 13,135,618 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101547 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67767 (Get FASTA)   NCBI Sequence Viewer  
  EDL86637 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067593
  ENSRNOP00000067593.1
Reference Protein Sequences
RefSeq Acc Id: NP_001101547   ⟸   NM_001108077
- UniProtKB: B3DMA6 (UniProtKB/TrEMBL),   M0RD96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067593   ⟸   ENSRNOT00000075258

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B3DMA6-F1-model_v2 AlphaFold B3DMA6 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695078
Promoter ID:EPDNEW_R5603
Type:multiple initiation site
Name:Actl9_1
Description:actin-like 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,310,628 - 18,310,688EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306886 AgrOrtholog
BioCyc Gene G2FUF-34725 BioCyc
Ensembl Genes ENSRNOG00000049571 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075258 ENTREZGENE
  ENSRNOT00000075258.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456143 IMAGE-MGC_LOAD
InterPro Actin-like UniProtKB/TrEMBL
  ATPase_NBD UniProtKB/TrEMBL
KEGG Report rno:314659 UniProtKB/TrEMBL
MGC_CLONE MGC:187540 IMAGE-MGC_LOAD
NCBI Gene 314659 ENTREZGENE
PANTHER Actin_like UniProtKB/TrEMBL
  PTHR11937:SF194 UniProtKB/TrEMBL
Pfam Actin UniProtKB/TrEMBL
PhenoGen Actl9 PhenoGen
PRINTS ACTIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049571 RatGTEx
SMART ACTIN UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt B3DMA6 ENTREZGENE, UniProtKB/TrEMBL
  M0RD96 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Actl9  actin-like 9  RGD1306886  similar to actin-like 7-alpha-like protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1306886  similar to actin-like 7-alpha-like protein   RGD1306886_predicted  similar to actin-like 7-alpha-like protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1306886_predicted  similar to actin-like 7-alpha-like protein (predicted)  LOC314659_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314659_predicted  similar to actin-like 7-alpha-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL