Spopl (speckle type BTB/POZ protein like) - Rat Genome Database

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Gene: Spopl (speckle type BTB/POZ protein like) Rattus norvegicus
Analyze
Symbol: Spopl
Name: speckle type BTB/POZ protein like
RGD ID: 1305847
Description: Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human SPOPL (speckle type BTB/POZ protein like); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC296532; RGD1305847; similar to speckle-type POZ protein; speckle-type POZ protein-like; speckle-type POZ protein-like A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8326,478,535 - 26,552,344 (-)NCBIGRCr8
mRatBN7.236,074,681 - 6,148,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,078,310 - 6,108,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx39,178,010 - 9,238,205 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0317,764,209 - 17,824,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0315,954,015 - 16,014,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03397,834 - 471,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3401,429 - 471,634 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03396,611 - 456,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.431,518,951 - 1,579,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.131,518,250 - 1,549,357 (-)NCBI
Celera3917,060 - 977,065 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:22632832  


Genomics

Comparative Map Data
Spopl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8326,478,535 - 26,552,344 (-)NCBIGRCr8
mRatBN7.236,074,681 - 6,148,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl36,078,310 - 6,108,794 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx39,178,010 - 9,238,205 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0317,764,209 - 17,824,402 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0315,954,015 - 16,014,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03397,834 - 471,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3401,429 - 471,634 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03396,611 - 456,801 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.431,518,951 - 1,579,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.131,518,250 - 1,549,357 (-)NCBI
Celera3917,060 - 977,065 (-)NCBICelera
Cytogenetic Map3p13NCBI
SPOPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382138,501,770 - 138,573,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2138,501,770 - 138,573,547 (+)EnsemblGRCh38hg38GRCh38
GRCh372139,259,340 - 139,331,117 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362138,975,841 - 139,047,271 (+)NCBINCBI36Build 36hg18NCBI36
Celera2132,970,983 - 133,042,402 (+)NCBICelera
Cytogenetic Map2q22.1NCBI
HuRef2131,250,702 - 131,322,126 (+)NCBIHuRef
CHM1_12139,263,966 - 139,335,423 (+)NCBICHM1_1
T2T-CHM13v2.02138,947,462 - 139,019,229 (+)NCBIT2T-CHM13v2.0
Spopl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39223,382,942 - 23,462,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl223,396,232 - 23,462,118 (-)EnsemblGRCm39 Ensembl
GRCm38223,507,466 - 23,572,132 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl223,506,220 - 23,572,106 (-)EnsemblGRCm38mm10GRCm38
MGSCv37223,365,574 - 23,427,624 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36223,332,063 - 23,394,063 (-)NCBIMGSCv36mm8
Celera223,242,836 - 23,304,878 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.48NCBI
Spopl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554405,568,073 - 5,612,677 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554405,594,970 - 5,612,677 (+)NCBIChiLan1.0ChiLan1.0
SPOPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21336,351,382 - 36,422,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B36,366,348 - 36,437,740 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B21,280,143 - 21,351,547 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B142,577,019 - 142,648,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B142,577,019 - 142,648,257 (+)Ensemblpanpan1.1panPan2
SPOPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11941,167,511 - 41,240,741 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1941,215,826 - 41,236,735 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1941,421,068 - 41,494,005 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01942,603,649 - 42,676,830 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1942,608,284 - 42,674,020 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11941,272,145 - 41,338,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01941,415,046 - 41,488,065 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01942,646,187 - 42,713,252 (+)NCBIUU_Cfam_GSD_1.0
Spopl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303103,952,007 - 104,013,819 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646937,603,803 - 37,661,436 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646937,608,044 - 37,661,337 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPOPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1513,134,225 - 13,207,731 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11513,134,221 - 13,207,737 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21515,277,896 - 15,351,897 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPOPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11023,868,104 - 23,934,157 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040175,444,328 - 175,510,428 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spopl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473238,277,686 - 38,293,970 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473238,214,876 - 38,297,363 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spopl
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:95
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000033653
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 32 32 16 17 16 8 9 74 35 37 11 8
Low 2 11 25 25 2 25 2 4
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000033653   ⟹   ENSRNOP00000035106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl36,078,310 - 6,108,794 (-)Ensembl
Rnor_6.0 Ensembl3401,462 - 431,933 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081816   ⟹   ENSRNOP00000075640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl36,078,310 - 6,108,794 (-)Ensembl
Rnor_6.0 Ensembl3401,429 - 471,634 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095228   ⟹   ENSRNOP00000077719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl36,078,476 - 6,108,794 (-)Ensembl
RefSeq Acc Id: NM_001134447   ⟹   NP_001127919
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,482,162 - 26,542,352 (-)NCBI
mRatBN7.236,078,309 - 6,138,513 (-)NCBI
Rnor_6.03401,461 - 461,651 (-)NCBI
Rnor_5.03396,611 - 456,801 (-)NCBI
RGSC_v3.431,518,951 - 1,579,141 (-)RGD
Celera3917,060 - 977,065 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591625   ⟹   XP_017447114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,478,535 - 26,552,344 (-)NCBI
mRatBN7.236,074,681 - 6,148,506 (-)NCBI
Rnor_6.03397,834 - 471,648 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591626   ⟹   XP_017447115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,478,535 - 26,519,039 (-)NCBI
mRatBN7.236,074,681 - 6,114,932 (-)NCBI
Rnor_6.03397,834 - 432,774 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591627   ⟹   XP_017447116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,478,535 - 26,552,343 (-)NCBI
mRatBN7.236,074,681 - 6,148,506 (-)NCBI
Rnor_6.03397,834 - 471,647 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104707   ⟹   XP_038960635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,478,535 - 26,542,823 (-)NCBI
mRatBN7.236,074,681 - 6,138,971 (-)NCBI
RefSeq Acc Id: XM_063283453   ⟹   XP_063139523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,478,535 - 26,552,344 (-)NCBI
RefSeq Acc Id: XR_005501835
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8326,482,390 - 26,552,344 (-)NCBI
mRatBN7.236,078,530 - 6,148,508 (-)NCBI
RefSeq Acc Id: NP_001127919   ⟸   NM_001134447
- UniProtKB: B2RZC7 (UniProtKB/TrEMBL),   F7FKB4 (UniProtKB/TrEMBL),   A0A8I5Y679 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447114   ⟸   XM_017591625
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB38 (UniProtKB/TrEMBL),   A0A8I5Y679 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447116   ⟸   XM_017591627
- Peptide Label: isoform X2
- UniProtKB: B2RZC7 (UniProtKB/TrEMBL),   F7FKB4 (UniProtKB/TrEMBL),   A0A8I5Y679 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447115   ⟸   XM_017591626
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB38 (UniProtKB/TrEMBL),   A0A8I5Y679 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035106   ⟸   ENSRNOT00000033653
RefSeq Acc Id: ENSRNOP00000075640   ⟸   ENSRNOT00000081816
RefSeq Acc Id: XP_038960635   ⟸   XM_039104707
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB38 (UniProtKB/TrEMBL),   A0A8I5Y679 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077719   ⟸   ENSRNOT00000095228
RefSeq Acc Id: XP_063139523   ⟸   XM_063283453
- Peptide Label: isoform X1
- UniProtKB: A0A0G2KB38 (UniProtKB/TrEMBL)
Protein Domains
BTB   MATH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KB38-F1-model_v2 AlphaFold A0A0G2KB38 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691854
Promoter ID:EPDNEW_R2370
Type:initiation region
Name:Spopl_1
Description:speckle type BTB/POZ protein like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03471,615 - 471,675EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305847 AgrOrtholog
BioCyc Gene G2FUF-50533 BioCyc
Ensembl Genes ENSRNOG00000005070 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033653 ENTREZGENE
  ENSRNOT00000033653.5 UniProtKB/TrEMBL
  ENSRNOT00000081816.2 UniProtKB/TrEMBL
  ENSRNOT00000095228.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.3030 UniProtKB/TrEMBL
  6.20.250.50 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133920 IMAGE-MGC_LOAD
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
  TRAF-like UniProtKB/TrEMBL
KEGG Report rno:296532 UniProtKB/TrEMBL
MGC_CLONE MGC:189563 IMAGE-MGC_LOAD
NCBI Gene 296532 ENTREZGENE
PANTHER SPECKLE-TYPE POZ PROTEIN UniProtKB/TrEMBL
  SPECKLE-TYPE POZ PROTEIN-LIKE UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
PhenoGen Spopl PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005070 RatGTEx
SMART BTB UniProtKB/TrEMBL
  MATH UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  TRAF domain-like UniProtKB/TrEMBL
UniProt A0A0G2KB38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y679 ENTREZGENE, UniProtKB/TrEMBL
  B2RZC7 ENTREZGENE, UniProtKB/TrEMBL
  F7FKB4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Spopl  speckle type BTB/POZ protein like  Spopl  speckle-type POZ protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Spopl  speckle-type POZ protein-like  RGD1305847_predicted  similar to speckle-type POZ protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305847_predicted  similar to speckle-type POZ protein (predicted)  LOC296532_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296532_predicted  similar to speckle-type POZ protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL