Mtif2 (mitochondrial translational initiation factor 2)

Gene: Mtif2 (mitochondrial translational initiation factor 2) Rattus norvegicus

Analyze

Symbol:

Mtif2

Name:

mitochondrial translational initiation factor 2

RGD ID:

1303046

Description:

Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human MTIF2 (mitochondrial translational initiation factor 2); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC94962; translation initiation factor IF-2, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	107,465,719 - 107,486,663 (+)	NCBI		GRCr8
mRatBN7.2	14	103,265,808 - 103,285,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	103,270,039 - 103,285,728 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	107,606,266 - 107,625,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	108,839,576 - 108,858,733 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	105,312,009 - 105,331,162 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	113,946,084 - 113,965,574 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	113,945,843 - 113,965,745 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	113,612,463 - 113,631,953 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	110,538,911 - 110,559,208 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	110,565,257 - 110,585,554 (+)	NCBI
Celera	14	102,143,108 - 102,162,277 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

aconitine (EXP)

acrolein (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chloramphenicol (ISO)

chlorpyrifos (ISO)

clarithromycin (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

dicrotophos (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

hydrogen peroxide (ISO)

josamycin (ISO)

methimazole (EXP)

nicotine (ISO)

ozone (EXP,ISO)

paracetamol (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (EXP)

quercetin (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial translational initiation (IBA,ISS)

ribosome disassembly (ISS)

translation (TAS)

translational initiation (TAS)

Cellular Component

cytoplasm (IBA)

mitochondrion (IBA,ISO)

nucleoplasm (IEA,ISO)

Molecular Function

GTP binding (TAS)

GTPase activity (IEA)

ribosomal small subunit binding (ISS)

translation factor activity, RNA binding (ISS)

translation initiation factor activity (IBA,TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene.	Overman RG Jr, etal., Biochim Biophys Acta 2003 Aug 25;1628(3):195-205.
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14651853	PMID:18614015	PMID:22658674

Genomics

Comparative Map Data

Mtif2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	107,465,719 - 107,486,663 (+)	NCBI		GRCr8
mRatBN7.2	14	103,265,808 - 103,285,733 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	103,270,039 - 103,285,728 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	107,606,266 - 107,625,241 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	108,839,576 - 108,858,733 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	105,312,009 - 105,331,162 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	113,946,084 - 113,965,574 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	113,945,843 - 113,965,745 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	113,612,463 - 113,631,953 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	110,538,911 - 110,559,208 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	110,565,257 - 110,585,554 (+)	NCBI
Celera	14	102,143,108 - 102,162,277 (+)	NCBI		Celera
Cytogenetic Map	14	q22	NCBI

MTIF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	55,236,595 - 55,269,248 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	55,236,595 - 55,269,347 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	55,463,731 - 55,496,384 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	55,317,260 - 55,349,888 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	55,375,408 - 55,408,035	NCBI
Celera	2	55,304,281 - 55,336,881 (-)	NCBI		Celera
Cytogenetic Map	2	p16.1	NCBI
HuRef	2	55,198,510 - 55,231,124 (-)	NCBI		HuRef
CHM1_1	2	55,393,812 - 55,426,430 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	55,233,823 - 55,266,465 (-)	NCBI		T2T-CHM13v2.0

Mtif2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	29,475,352 - 29,495,452 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	29,476,408 - 29,495,279 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	29,525,352 - 29,545,452 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	29,526,408 - 29,545,279 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	29,426,457 - 29,445,255 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	29,426,465 - 29,445,279 (+)	NCBI		MGSCv36	mm8
Celera	11	31,887,773 - 31,906,537 (+)	NCBI		Celera
Cytogenetic Map	11	A3.3	NCBI
cM Map	11	16.77	NCBI

Mtif2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	27,795,831 - 27,823,106 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	27,796,213 - 27,823,106 (+)	NCBI	ChiLan1.0	ChiLan1.0

MTIF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	71,055,251 - 71,090,572 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	71,059,185 - 71,093,514 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	55,393,726 - 55,427,469 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	56,533,501 - 56,566,725 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

MTIF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	56,136,231 - 56,157,940 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	56,136,229 - 56,155,118 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	56,092,957 - 56,114,566 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	57,140,282 - 57,161,892 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	57,140,315 - 57,161,836 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	56,841,449 - 56,863,061 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	57,120,686 - 57,142,296 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	57,411,167 - 57,432,794 (-)	NCBI		UU_Cfam_GSD_1.0

Mtif2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	26,912,737 - 26,937,695 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	1,630,128 - 1,658,575 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	1,632,996 - 1,658,529 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTIF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	85,947,635 - 85,989,111 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	85,947,617 - 85,989,455 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	90,731,516 - 90,773,925 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MTIF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	51,631,399 - 51,662,977 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	51,635,661 - 51,667,143 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	60,056,770 - 60,088,462 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mtif2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624833	6,285,515 - 6,309,350 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mtif2
99 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	23
Count of miRNA genes:	22
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000005834
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	70053989	104886043	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	70053989	104886043	Rat

Markers in Region

RH131424

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	14	113,632,011 - 113,632,228	NCBI	Rnor5.0
RGSC_v3.4	14	110,559,267 - 110,559,483	UniSTS	RGSC3.4
Celera	14	102,162,336 - 102,162,552	UniSTS
Cytogenetic Map	14	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	42	32	17	19	17	7	9	74	34	38	11	7
Low		1	25	24		24	1	2		1	3		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004254	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092122	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092124	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039092127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063273288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079421	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005834 ⟹ ENSRNOP00000005834

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	103,270,247 - 103,285,724 (+)	Ensembl
Rnor_6.0 Ensembl	14	113,945,843 - 113,965,745 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094337 ⟹ ENSRNOP00000078141

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	103,270,039 - 103,285,728 (+)	Ensembl

RefSeq Acc Id:

NM_001004254 ⟹ NP_001004254

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,466,933 - 107,486,663 (+)	NCBI
mRatBN7.2	14	103,266,002 - 103,285,733 (+)	NCBI
Rnor_6.0	14	113,946,084 - 113,965,574 (+)	NCBI
Rnor_5.0	14	113,612,463 - 113,631,953 (+)	NCBI
RGSC_v3.4	14	110,538,911 - 110,559,208 (+)	RGD
Celera	14	102,143,108 - 102,162,277 (+)	RGD

Sequence:

show sequence

CGCCTGGGAACTGAGAGAAACATGAACCAGAAGCTACTGAAGTTGGAAAAGTTGCTACGATTTC
ACACTATTTGTAGGCAATTGCACAGCCTGAGTCAAAGAAGATTGTTAGCATGGTGGAAGCATGG
GTCTGCACCGGCTTCCCCAGTGTGGGCAGATTGGCTGTGTGCCCGGCCTTGGCCGACAGACGTG
CTTACTGGTTCAGCTTTGCATCAGCACAGACTTCTTGTTACAAAGAAGGAAAAACGACCACCGA
GATCTCAGTTGTCTCCAATAAAAACTAAAAAAGAGGTAGAAGTATGGGTTGGAATGACTGTTGA
AGAACTAGCCAGAGCAATGGCAAAAGACACAGATTGTGTATATGAAGCTTTATTGAACACCGCC
ATTGACATAGACTCACTAGAAGCAAACTCACATTTAGACGAAGTCTGGATCAAAGAAGTTATAA
AGAAGGCAGGAATGAAGCTGAAATGGAGCAAATTAAAACTGGAGAGAATAAGAGAAAATAAGGA
TGCTGTGAGAAGGCCTGGGGCAGATCCAGCTTTACTAAAGCCAAGGTCCCCAGTTGTTACTATA
ATGGGTCATGTTGATCATGGGAAAACGACCTTACTTGACAAACTTCGGGAAACTCAAGTGGCAG
CGATGGAAGTTGGAGGCATTACTCAACATATTGGTGCTTTTCTTGTCTCTCTGCCTTCTGGAGA
AAAGATAACCTTTCTTGATACTCCGGGACATGCTGCTTTCTCAGCAATGAGAGCTAGAGGAGCT
CAGGTCACTGACATTGTTGTGTTGGTTGTAGCTGCAGATGATGGGGTAATGAAACAAACTGTGG
AATCCATTCAGCACGCCAAGGATGCAGGAGTTCCTATTATCCTTGCAATAAATAAATGTGACAA
GACAGATGCTGATCCTGAAAAGGTGAAAAAAGAGCTCCTGGCTTATGATGTGGTGTGTGAAGAG
TATGGTGGTGATGTTCAAGCAGTGCACGTCTCTGCACTAACAGGAAAGAACCTGATGGCTTTGG
CAGAAGCAACAATTGCTCTCGCAGAAATGTTGGAACTGAAAGCAGATCCCACAGGCCCAGTGGA
AGGAACAGTAATAGAGTCTTTCACAGACAAAGGAAGAGGTCCTGTTACAACAGCTATAATTCAA
AGAGGAACTCTGAAAAAAGGCTCAATTCTAGTTGCTGGGAAGAGTTGGGCAAAAGTTCGACTAA
TGTTTGATGAAAATGGAAAAACAGTTAATGAGGCCTATCCTAGCATGCCAGTGGGAATCATAGG
CTGGAGAGACCTCCCTTCTGCAGGAGATGAAATTCTTGAAGTACAGTCTGAGCCAAGGGCCCGT
GAAGTTGTTGACTGGAGGAAGTCTGAGCAAAAAGAAGAAAAGGGCAAAGATGACCTGAAAATAA
TGGAAGAAAAGCGAAAGGAACACCAAGAAGCACATCGGAAAGCCCGTGAGAAGTATGGCAGCCT
GCACTGGAAGCAGAGATCATATATAAAGTACCTTGAAAGAAAAGAACAGAGACCCTTAAAGCCC
AAAGAAAAGGTAGAAAGGGACTCAAATGTACTTCCTATAATTATTAAAGGTGACGTTGATGGGT
CTGTGGAGGCCATCTTGAACCTTCTGGATACCTATGATGCTTCCCATGAATGTGAACTAGAATT
AGTGCATTTTGGATTGGGTGACATCAGTGAAAATGATGTTACCTTTGCTGAGACATTTGATGGT
GTTATTTATGGCTTTAATGTGGATGCAGGCAGTGCTATCCAGCAGTCAGCTGCACAAAAGGGAG
TCAAGATTAAACTTCACAAAATCATCTACCATCTTATTGAAGATTTGCAGGAGGAACTAAGCAA
CAGATTGCCCTACAAGGTGGAGGAGTACCCAATAGGTGAGGCTTCTATACTAGCTACCTTCACT
ATAACAGAAGGGAAGAAAAAAGTTCCTGTTGCTGGCTGCAGAGTTCAAAAGGGACAGCTAGAAA
GACAGAAGAAGTTTAAATTAATCCGCAACGGCCAAGTTATTTGGAAGGGCTCATTAACTTCGCT
GAAACACCATAAAGATGACGTTTTAGTTATAAAAACTGGTGTGGACTGTGGTCTTAGTTTAGAT
GAAGAAAACGTAGAATTTAAAGTGGGCGATCAAGTTATCTGTTATGAAGAAAATAAAGTACCAA
CTAAGACTTCCTGGGATCCAGGATTTTAAATGTGCATTAAAAATGGTAAAAATGTAAAAAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039092118 ⟹ XP_038948046

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,466,953 - 107,486,663 (+)	NCBI
mRatBN7.2	14	103,265,812 - 103,285,733 (+)	NCBI

RefSeq Acc Id:

XM_039092121 ⟹ XP_038948049

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,466,953 - 107,486,663 (+)	NCBI
mRatBN7.2	14	103,265,812 - 103,285,733 (+)	NCBI

RefSeq Acc Id:

XM_039092122 ⟹ XP_038948050

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,465,719 - 107,486,663 (+)	NCBI
mRatBN7.2	14	103,265,812 - 103,285,733 (+)	NCBI

RefSeq Acc Id:

XM_039092124 ⟹ XP_038948052

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,466,953 - 107,486,663 (+)	NCBI
mRatBN7.2	14	103,270,298 - 103,285,733 (+)	NCBI

RefSeq Acc Id:

XM_039092126 ⟹ XP_038948054

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,466,953 - 107,482,980 (+)	NCBI
mRatBN7.2	14	103,265,808 - 103,282,005 (+)	NCBI

RefSeq Acc Id:

XM_039092127 ⟹ XP_038948055

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,479,210 - 107,486,663 (+)	NCBI
mRatBN7.2	14	103,278,292 - 103,285,733 (+)	NCBI

RefSeq Acc Id:

XM_063273288 ⟹ XP_063129358

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	107,466,953 - 107,486,663 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004254	(Get FASTA)	NCBI Sequence Viewer
	XP_038948046	(Get FASTA)	NCBI Sequence Viewer
	XP_038948049	(Get FASTA)	NCBI Sequence Viewer
	XP_038948050	(Get FASTA)	NCBI Sequence Viewer
	XP_038948052	(Get FASTA)	NCBI Sequence Viewer
	XP_038948054	(Get FASTA)	NCBI Sequence Viewer
	XP_038948055	(Get FASTA)	NCBI Sequence Viewer
	XP_063129358	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79421	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005834
	ENSRNOP00000005834.6
	ENSRNOP00000078141.1

RefSeq Acc Id:

NP_001004254 ⟸ NM_001004254

- UniProtKB:

Q68FQ5 (UniProtKB/TrEMBL), F7FDM3 (UniProtKB/TrEMBL), A0A8I5Y2H0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNQKLLKLEKLLRFHTICRQLHSLSQRRLLAWWKHGSAPASPVWADWLCARPWPTDVLTGSALH
QHRLLVTKKEKRPPRSQLSPIKTKKEVEVWVGMTVEELARAMAKDTDCVYEALLNTAIDIDSLE
ANSHLDEVWIKEVIKKAGMKLKWSKLKLERIRENKDAVRRPGADPALLKPRSPVVTIMGHVDHG
KTTLLDKLRETQVAAMEVGGITQHIGAFLVSLPSGEKITFLDTPGHAAFSAMRARGAQVTDIVV
LVVAADDGVMKQTVESIQHAKDAGVPIILAINKCDKTDADPEKVKKELLAYDVVCEEYGGDVQA
VHVSALTGKNLMALAEATIALAEMLELKADPTGPVEGTVIESFTDKGRGPVTTAIIQRGTLKKG
SILVAGKSWAKVRLMFDENGKTVNEAYPSMPVGIIGWRDLPSAGDEILEVQSEPRAREVVDWRK
SEQKEEKGKDDLKIMEEKRKEHQEAHRKAREKYGSLHWKQRSYIKYLERKEQRPLKPKEKVERD
SNVLPIIIKGDVDGSVEAILNLLDTYDASHECELELVHFGLGDISENDVTFAETFDGVIYGFNV
DAGSAIQQSAAQKGVKIKLHKIIYHLIEDLQEELSNRLPYKVEEYPIGEASILATFTITEGKKK
VPVAGCRVQKGQLERQKKFKLIRNGQVIWKGSLTSLKHHKDDVLVIKTGVDCGLSLDEENVEFK
VGDQVICYEENKVPTKTSWDPGF

hide sequence

RefSeq Acc Id:

ENSRNOP00000005834 ⟸ ENSRNOT00000005834

RefSeq Acc Id:	XP_038948054 ⟸ XM_039092126
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038948046 ⟸ XM_039092118
- Peptide Label:	isoform X1
- UniProtKB:	F7FDM3 (UniProtKB/TrEMBL), Q68FQ5 (UniProtKB/TrEMBL), A0A8I5Y2H0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038948049 ⟸ XM_039092121
- Peptide Label:	isoform X1
- UniProtKB:	F7FDM3 (UniProtKB/TrEMBL), Q68FQ5 (UniProtKB/TrEMBL), A0A8I5Y2H0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038948050 ⟸ XM_039092122
- Peptide Label:	isoform X1
- UniProtKB:	F7FDM3 (UniProtKB/TrEMBL), Q68FQ5 (UniProtKB/TrEMBL), A0A8I5Y2H0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038948052 ⟸ XM_039092124
- Peptide Label:	isoform X1
- UniProtKB:	F7FDM3 (UniProtKB/TrEMBL), Q68FQ5 (UniProtKB/TrEMBL), A0A8I5Y2H0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038948055 ⟸ XM_039092127
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSRNOP00000078141 ⟸ ENSRNOT00000094337

RefSeq Acc Id:	XP_063129358 ⟸ XM_063273288
- Peptide Label:	isoform X1
- UniProtKB:	F7FDM3 (UniProtKB/TrEMBL), Q68FQ5 (UniProtKB/TrEMBL)

Protein Domains

tr-type G

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699534

Promoter ID:

EPDNEW_R10058

Type:

multiple initiation site

Name:

Mtif2_1

Description:

mitochondrial translational initiation factor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	113,946,055 - 113,946,115	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303046	AgrOrtholog
BioCyc Gene	G2FUF-14650	BioCyc
Ensembl Genes	ENSRNOG00000004161	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005834.7	UniProtKB/TrEMBL
	ENSRNOT00000094337.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10050	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	Translation factors	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113831	IMAGE-MGC_LOAD
InterPro	IF2_II	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	ProtSyn_GTP_bd	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	TF_IF2_bacterial-like	UniProtKB/TrEMBL
	TIF_IF2	UniProtKB/TrEMBL
	TIF_IF2_dom3	UniProtKB/TrEMBL
	TIF_IF2_dom3_sf	UniProtKB/TrEMBL
	Transl_elong_init/rib_B-barrel	UniProtKB/TrEMBL
KEGG Report	rno:305606	UniProtKB/TrEMBL
MGC_CLONE	MGC:94962	IMAGE-MGC_LOAD
NCBI Gene	305606	ENTREZGENE
PANTHER	PTHR43381	UniProtKB/TrEMBL
	TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	GTP_EFTU	UniProtKB/TrEMBL
	IF-2	UniProtKB/TrEMBL
PhenoGen	Mtif2	PhenoGen
PROSITE	G_TR_2	UniProtKB/TrEMBL
	IF2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004161	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
	TIF_IF2_dom3	UniProtKB/TrEMBL
	Translat_factor	UniProtKB/TrEMBL
UniProt	A0A8I5Y2H0	ENTREZGENE, UniProtKB/TrEMBL
	F7FDM3	ENTREZGENE
	Q68FQ5	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F7FDM3	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Mtif2	mitochondrial translational initiation factor 2			Symbol and Name status set to approved	1299863	APPROVED
2005-02-14	Mtif2	mitochondrial translational initiation factor 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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