Sdhd (succinate dehydrogenase complex subunit D) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Sdhd (succinate dehydrogenase complex subunit D) Rattus norvegicus
Analyze
Symbol: Sdhd
Name: succinate dehydrogenase complex subunit D
RGD ID: 735231
Description: Predicted to enable several functions, including heme binding activity; succinate dehydrogenase (quinone) activity; and ubiquinone binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to act upstream of or within cellular response to hypoxia and regulation of catecholamine secretion. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHD (succinate dehydrogenase complex subunit D); PARTICIPATES IN altered citric acid cycle pathway; citric acid cycle pathway; electron transport chain pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CII-4; cybS; malate dehydrogenase [quinone] cytochrome b small subunit; MGC72971; QPs3; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; succinate-ubiquinone reductase membrane anchor subunit
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,841,090 - 59,850,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,841,090 - 59,850,641 (-)EnsemblGRCr8
mRatBN7.2850,944,702 - 50,954,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,944,704 - 50,954,238 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,450,402 - 56,459,946 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,729,300 - 54,738,844 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,593,576 - 52,603,120 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,028,125 - 55,037,604 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,028,125 - 55,037,604 (-)Ensemblrn6Rnor6.0
Rnor_5.0853,625,447 - 53,634,926 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4853,955,067 - 53,964,547 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,493,184 - 50,502,624 (-)NCBICelera
RGSC_v3.1853,974,120 - 53,983,601 (-)NCBI
Cytogenetic Map8q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chlorobiphenyl  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clotrimazole  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
indometacin  (EXP,ISO)
isoniazide  (ISO)
L-ethionine  (EXP)
Mesaconitine  (EXP)
methimazole  (EXP)
N-nitrosodiethylamine  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP)
rac-1,2-dichloropropane  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. SDH mutations in cancer. Bardella C, etal., Biochim Biophys Acta. 2011 Nov;1807(11):1432-43. doi: 10.1016/j.bbabio.2011.07.003. Epub 2011 Jul 13.
2. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Baysal BE, etal., Science 2000 Feb 4;287(5454):848-51.
3. Succinate dehydrogenase deficiency in human. Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Regulation of the hypoxia-dependent plasminogen activator inhibitor 1 expression by MAP kinases. Kietzmann T, etal., Thromb Haemost. 2003 Apr;89(4):666-73.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Circadian gene expression of clock genes and plasminogen activator inhibitor-1 in heart and aorta of spontaneously hypertensive and Wistar-Kyoto rats. Naito Y, etal., J Hypertens. 2003 Jun;21(6):1107-15.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia. Piruat JI, etal., Mol Cell Biol. 2004 Dec;24(24):10933-40.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A and Fernandez-Vizarra E, Essays Biochem. 2018 Jul 20;62(3):255-270. doi: 10.1042/EBC20170098. Print 2018 Jul 20.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:9533030   PMID:14651853   PMID:15489334   PMID:15989954   PMID:16120479   PMID:17480203   PMID:18614015   PMID:19808025   PMID:26225774   PMID:31774353  


Genomics

Comparative Map Data
Sdhd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8859,841,090 - 59,850,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl859,841,090 - 59,850,641 (-)EnsemblGRCr8
mRatBN7.2850,944,702 - 50,954,298 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl850,944,704 - 50,954,238 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx856,450,402 - 56,459,946 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0854,729,300 - 54,738,844 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0852,593,576 - 52,603,120 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0855,028,125 - 55,037,604 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,028,125 - 55,037,604 (-)Ensemblrn6Rnor6.0
Rnor_5.0853,625,447 - 53,634,926 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4853,955,067 - 53,964,547 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera850,493,184 - 50,502,624 (-)NCBICelera
RGSC_v3.1853,974,120 - 53,983,601 (-)NCBI
Cytogenetic Map8q23NCBI
SDHD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811112,086,873 - 112,095,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11112,086,824 - 112,120,016 (+)Ensemblhg38GRCh38
GRCh3711111,957,597 - 111,966,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,462,832 - 111,471,727 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411111,462,831 - 111,471,727NCBI
Celera11109,110,763 - 109,119,710 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,881,580 - 107,890,557 (+)NCBIHuRef
CHM1_111111,840,726 - 111,849,704 (+)NCBICHM1_1
T2T-CHM13v2.011112,097,127 - 112,106,049 (+)NCBIT2T-CHM13v2.0
Sdhd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,507,640 - 50,515,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,507,657 - 50,515,112 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38950,596,340 - 50,603,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,596,357 - 50,603,812 (-)Ensemblmm10GRCm38
MGSCv37950,404,445 - 50,411,954 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36950,348,576 - 50,356,047 (-)NCBIMGSCv36mm8
Celera947,891,569 - 47,899,078 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Sdhd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,768,501 - 13,778,932 (+)Ensembl
ChiLan1.0NW_00495541213,768,501 - 13,778,944 (+)NCBIChiLan1.0ChiLan1.0
SDHD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,030,295 - 21,041,125 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha520,952,816 - 20,963,688 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0521,053,488 - 21,064,559 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl521,053,492 - 21,064,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1521,115,095 - 21,126,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,015,331 - 21,026,183 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,063,761 - 21,074,834 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sdhd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494794,336,365 - 94,348,330 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,357,336 - 2,369,192 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,357,336 - 2,369,204 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,790,595 - 39,803,950 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1939,790,654 - 39,803,602 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,632,268 - 44,645,249 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SDHD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,443,666 - 103,452,681 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604322,530,988 - 22,540,558 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247847,241,836 - 7,251,916 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247847,241,770 - 7,252,016 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sdhd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1845,067,220 - 45,076,645 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sdhd
52 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:81
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000059169
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat

Markers in Region
RH127747  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2729,973,870 - 29,974,056 (+)MAPPERmRatBN7.2
mRatBN7.2850,955,427 - 50,955,614 (+)MAPPERmRatBN7.2
Rnor_6.0855,038,828 - 55,039,014NCBIRnor6.0
Rnor_6.0736,429,551 - 36,429,736NCBIRnor6.0
Rnor_5.0853,636,150 - 53,636,336UniSTSRnor5.0
Rnor_5.0736,491,796 - 36,491,981UniSTSRnor5.0
RGSC_v3.4732,538,544 - 32,538,729UniSTSRGSC3.4
RGSC_v3.4853,965,771 - 53,965,957UniSTSRGSC3.4
Celera850,503,848 - 50,504,034UniSTS
Celera727,047,463 - 27,047,648UniSTS
Cytogenetic Map8q23UniSTS
RH127901  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,944,915 - 50,945,109 (+)MAPPERmRatBN7.2
Rnor_6.0855,028,317 - 55,028,510NCBIRnor6.0
Rnor_5.0853,625,639 - 53,625,832UniSTSRnor5.0
RGSC_v3.4853,955,259 - 53,955,452UniSTSRGSC3.4
Celera850,493,376 - 50,493,569UniSTS
RH 3.4 Map8543.1UniSTS
Cytogenetic Map8q23UniSTS
AI535349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22184,127,219 - 184,127,379 (+)MAPPERmRatBN7.2
Rnor_6.02198,717,301 - 198,717,460NCBIRnor6.0
Rnor_5.02218,204,235 - 218,204,394UniSTSRnor5.0
RGSC_v3.42191,391,086 - 191,391,245UniSTSRGSC3.4
Celera2176,652,443 - 176,652,602UniSTS
RH 3.4 Map3735.19UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map8q23UniSTS
RH134598  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2850,955,700 - 50,955,881 (+)MAPPERmRatBN7.2
Rnor_6.0855,039,101 - 55,039,281NCBIRnor6.0
Rnor_5.0853,636,423 - 53,636,603UniSTSRnor5.0
RGSC_v3.4853,966,044 - 53,966,224UniSTSRGSC3.4
Celera850,504,121 - 50,504,301UniSTS
Cytogenetic Map8q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_198788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000059169   ⟹   ENSRNOP00000055942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl859,841,090 - 59,850,641 (-)Ensembl
mRatBN7.2 Ensembl850,944,719 - 50,954,238 (-)Ensembl
Rnor_6.0 Ensembl855,028,125 - 55,037,604 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095581   ⟹   ENSRNOP00000081393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl850,944,704 - 50,952,224 (-)Ensembl
RefSeq Acc Id: NM_198788   ⟹   NP_942083
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8859,841,090 - 59,850,641 (-)NCBI
mRatBN7.2850,944,702 - 50,954,254 (-)NCBI
Rnor_6.0855,028,125 - 55,037,604 (-)NCBI
Rnor_5.0853,625,447 - 53,634,926 (-)NCBI
RGSC_v3.4853,955,067 - 53,964,547 (-)RGD
Celera850,493,184 - 50,502,624 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_942083 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH59160 (Get FASTA)   NCBI Sequence Viewer  
  EDL95463 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055942
  ENSRNOP00000055942.2
GenBank Protein Q6PCT8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_942083   ⟸   NM_198788
- UniProtKB: Q6PCT8 (UniProtKB/Swiss-Prot),   A6J4E0 (UniProtKB/TrEMBL),   A0A8I5ZSF4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055942   ⟸   ENSRNOT00000059169
Ensembl Acc Id: ENSRNOP00000081393   ⟸   ENSRNOT00000095581

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6PCT8-F1-model_v2 AlphaFold Q6PCT8 1-159 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695947
Promoter ID:EPDNEW_R6471
Type:initiation region
Name:Sdhd_1
Description:succinate dehydrogenase complex subunit D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,037,623 - 55,037,683EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735231 AgrOrtholog
BioCyc Gene G2FUF-30560 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
  PWY-7279 [aerobic respiration II (cytochrome c) (yeast)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
  PWY-7279 BioCyc
Ensembl Genes ENSRNOG00000022980 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059169 ENTREZGENE
  ENSRNOT00000059169.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1300.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6887444 IMAGE-MGC_LOAD
InterPro CybS UniProtKB/Swiss-Prot
  SQR/QFR_C/D UniProtKB/Swiss-Prot
KEGG Report rno:363061 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72971 IMAGE-MGC_LOAD
NCBI Gene 363061 ENTREZGENE
PANTHER PTHR13337 UniProtKB/Swiss-Prot
  SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam CybS UniProtKB/Swiss-Prot
PhenoGen Sdhd PhenoGen
RatGTEx ENSRNOG00000022980 RatGTEx
Superfamily-SCOP SSF81343 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSF4 ENTREZGENE
  A6J4E0 ENTREZGENE, UniProtKB/TrEMBL
  DHSD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Sdhd  succinate dehydrogenase complex subunit D  Sdhd  succinate dehydrogenase complex, subunit D, integral membrane protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Sdhd  succinate dehydrogenase complex, subunit D, integral membrane protein      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is detected in hereditary paraganglioma (PGL), which is characterized by development of benign, vascularized tumors in the head and neck 1302858