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Gene: Get1 (guided entry of tail-anchored proteins factor 1) Rattus norvegicus

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Symbol:

Get1

Name:

guided entry of tail-anchored proteins factor 1

RGD ID:

735104

Description:

Predicted to enable protein-membrane adaptor activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

tail-anchored protein insertion receptor WRB; tryptophan rich basic protein; tryptophan-rich basic protein; tryptophan-rich protein; Wrb

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	48,915,298 - 48,929,235 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	48,915,289 - 48,929,416 (+)	Ensembl				GRCr8
mRatBN7.2	11	35,438,555 - 35,460,156 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	35,445,815 - 35,459,973 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	44,103,011 - 44,116,953 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	36,774,391 - 36,788,333 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	35,920,216 - 35,934,148 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	36,497,513 - 36,511,445 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	36,497,509 - 36,511,535 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	40,028,142 - 40,042,074 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	36,453,285 - 36,467,217 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	33,012,406 - 33,026,338 (-)	NCBI		Celera
RGSC_v3.1	11	36,510,873 - 36,524,805 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dieldrin (ISO)

doxorubicin (ISO)

fenthion (ISO)

folic acid (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

lycopene (ISO)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodimethylamine (EXP)

nitrogen dioxide (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (ISO)

quercetin (ISO)

rotenone (ISO)

sodium arsenate (ISO)

Soman (EXP)

temozolomide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

establishment of protein localization to membrane (IEA)

otic vesicle development (ISO)

post-translational protein targeting to endoplasmic reticulum membrane (ISO)

protein insertion into ER membrane (ISO)

protein stabilization (ISO,ISS)

sensory perception of sound (ISO)

synapse organization (ISO)

tail-anchored membrane protein insertion into ER membrane (IBA,IDA,IEA,ISO)

Cellular Component

endoplasmic reticulum membrane (IEA)

GET complex (IBA,IPI,ISO)

Molecular Function

protein binding (ISO)

protein-membrane adaptor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6.	Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells.	Yamamoto Y and Sakisaka T, Mol Cell. 2012 Nov 9;48(3):387-97. doi: 10.1016/j.molcel.2012.08.028. Epub 2012 Oct 4.

Additional References at PubMed

PMID:15489334	PMID:27458190

Genomics

Comparative Map Data

Get1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	48,915,298 - 48,929,235 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	11	48,915,289 - 48,929,416 (+)	Ensembl				GRCr8
mRatBN7.2	11	35,438,555 - 35,460,156 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	35,445,815 - 35,459,973 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	11	44,103,011 - 44,116,953 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	36,774,391 - 36,788,333 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	35,920,216 - 35,934,148 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	36,497,513 - 36,511,445 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	36,497,509 - 36,511,535 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	11	40,028,142 - 40,042,074 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	11	36,453,285 - 36,467,217 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	11	33,012,406 - 33,026,338 (-)	NCBI		Celera
RGSC_v3.1	11	36,510,873 - 36,524,805 (+)	NCBI
Cytogenetic Map	11	q11	NCBI

GET1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	39,380,326 - 39,428,528 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	39,377,698 - 39,428,528 (+)	Ensembl			hg38	GRCh38
GRCh37	21	40,752,252 - 40,800,454 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	39,674,140 - 39,691,496 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	39,674,139 - 39,691,486	NCBI
Celera	21	25,949,901 - 25,967,508 (+)	NCBI		Celera
Cytogenetic Map	21	q22.2	NCBI
HuRef	21	26,220,985 - 26,238,560 (+)	NCBI		HuRef
CHM1_1	21	40,313,371 - 40,330,979 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	37,764,912 - 37,813,128 (+)	NCBI		T2T-CHM13v2.0

Get1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	95,946,600 - 95,959,052 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	95,946,607 - 95,959,052 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	16	96,145,400 - 96,157,852 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	96,145,407 - 96,157,852 (+)	Ensembl			mm10	GRCm38
MGSCv37	16	96,367,026 - 96,379,459 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	16	96,250,329 - 96,262,762 (+)	NCBI		MGSCv36	mm8
Celera	16	97,220,073 - 97,232,510 (+)	NCBI		Celera
Cytogenetic Map	16	C4	NCBI
cM Map	16	56.84	NCBI

Get1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	38,160,218 - 38,168,808 (+)	Ensembl
ChiLan1.0	NW_004955407	38,160,951 - 38,168,808 (+)	NCBI	ChiLan1.0	ChiLan1.0

GET1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	35,478,596 - 35,496,578 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	30,334,471 - 30,352,451 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	25,734,722 - 25,752,196 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	39,072,103 - 39,088,937 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	39,072,103 - 39,088,928 (+)	Ensembl			panPan2	panpan1.1

GET1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	34,282,650 - 34,299,916 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	33,396,185 - 33,433,643 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	33,630,745 - 33,667,483 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	33,650,809 - 33,674,732 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	33,502,811 - 33,539,864 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	33,508,008 - 33,544,636 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	33,998,996 - 34,035,703 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

GET1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	202,962,664 - 202,979,902 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	202,962,652 - 202,978,390 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	213,126,901 - 213,142,261 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Get1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	24,627,526 - 24,635,159 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	24,625,206 - 24,635,129 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Get1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	48,515,274 - 48,529,654 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Get1
55 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	886
Count of miRNA genes:	322
Interacting mature miRNAs:	438
Transcripts:	ENSRNOT00000002222
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	22524746	82951192	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	46443168	91443168	Rat
1598841	Memor7	Memory QTL 7			exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	11	33306008	78306008	Rat
1598811	Bp291	Blood pressure QTL 291	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	33306008	78306008	Rat
634339	Niddm50	Non-insulin dependent diabetes mellitus QTL 50	3.32		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	10806125	55806125	Rat
634341	Bw121	Body weight QTL 121	3.56		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	11	35323199	55805892	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	32943067	89836615	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	29958996	57754989	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	31915469	76915469	Rat
2290451	Scl58	Serum cholesterol level QTL 58	3.48		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	11	26318031	55806125	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	36428416	81428416	Rat
1600394	Edcs1	Endometrial carcinoma susceptibility QTL1	2.9	0.04	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	11	12823152	57823152	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	34618760	79618760	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	20193549	96351019	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	36749459	81749459	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	36749459	81749459	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	36749459	81749459	Rat
631510	Spl2	Serum phospholipid level QTL 2	4.1		blood phospholipid amount (VT:0006084)	serum phospholipid level (CMO:0001171)	11	27556685	72556685	Rat

Markers in Region

BI275060

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	35,459,417 - 35,459,567 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	36,511,114 - 36,511,263	NCBI	Rnor6.0
Rnor_5.0	11	40,041,743 - 40,041,892	UniSTS	Rnor5.0
RGSC_v3.4	11	36,466,886 - 36,467,035	UniSTS	RGSC3.4
Celera	11	33,012,588 - 33,012,737	UniSTS
RH 3.4 Map	11	265.0	UniSTS
Cytogenetic Map	11	q11	UniSTS

BI276795

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	35,459,461 - 35,459,618 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	36,511,158 - 36,511,314	NCBI	Rnor6.0
Rnor_5.0	11	40,041,787 - 40,041,943	UniSTS	Rnor5.0
RGSC_v3.4	11	36,466,930 - 36,467,086	UniSTS	RGSC3.4
Celera	11	33,012,537 - 33,012,693	UniSTS
RH 3.4 Map	11	262.7	UniSTS
Cytogenetic Map	11	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_199373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC112406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC142178	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000002222 ⟹ ENSRNOP00000002222

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	48,915,289 - 48,929,416 (+)	Ensembl
mRatBN7.2 Ensembl	11	35,445,838 - 35,459,973 (+)	Ensembl
Rnor_6.0 Ensembl	11	36,497,509 - 36,511,535 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095254 ⟹ ENSRNOP00000078941

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	48,915,289 - 48,927,418 (+)	Ensembl
mRatBN7.2 Ensembl	11	35,445,815 - 35,457,937 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000098902 ⟹ ENSRNOP00000079459

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	48,915,367 - 48,929,416 (+)	Ensembl
mRatBN7.2 Ensembl	11	35,445,884 - 35,459,733 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112143 ⟹ ENSRNOP00000089517

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	11	48,915,289 - 48,929,416 (+)	Ensembl
mRatBN7.2 Ensembl	11	35,445,838 - 35,459,973 (+)	Ensembl

RefSeq Acc Id:

NM_199373 ⟹ NP_955405

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	48,915,298 - 48,929,230 (+)	NCBI
mRatBN7.2	11	35,445,815 - 35,459,749 (+)	NCBI
Rnor_6.0	11	36,497,513 - 36,511,445 (+)	NCBI
Rnor_5.0	11	40,028,142 - 40,042,074 (+)	NCBI
RGSC_v3.4	11	36,453,285 - 36,467,217 (+)	RGD
Celera	11	33,012,406 - 33,026,338 (-)	RGD

Sequence:

show sequence

GGCGTAGGCGAGCGCGGAGGCGCGGTCTCCATGGCGCTGCTGTAGCGGTGCAGGTGCCTGGGAT
CCAGAATGAGCGCGTCCGAGACAGATCGCTGGGCGTGGTTGCTGGTGCTGTGCTTCGTGTTCGG
GTGCAACGTGCTGCGCATCCTTCTGCCGACCTTGTCCTCGTTTATTTCCAGGGTGCTGCAGAAG
GATGCAGAGCAGGAGTCACAGATGAGAGCAGAGATCCAGAGCATGAAGCAGGAGCTGTCCACCG
TCAACATGATGGATGAGTTTGCCAGATACGCCAGGCTGGAGAGAAAAATCAACAAAATGACAGA
CAAACTCAAAACTCACGTGAAGGCACGGACAGCTCAGTTGGCCAAGATCAAGTGGTTTATAAGT
GTTGCTTTCTACGTACTACAAGCAGCGTTGATGATCTCACTCATCTGGAAGTATTACTCTGTCC
CTGTGGCTGTGGTGCCCAGCAAGTGGATCACCCCACTAGACCGGCTGGTGGCCTTTCCTACTCG
AGTAGCAGGTGGAATCGGAGTCACCTGCTGGATTTTAGTCTGCAACAAAGTCGTGGCTATCATT
CTCCACCCTTTCAGCTGAGGGGAGGCCAGCCACAGCCTTTACCCGAGAATTCTGTTAGGTGAAG
AGCGGATTGCGCACAAGGCCACAGATTGTTGTTTTTTGTGTTCTGGAGTACGATTGCTTTTGTG
TGTCACCTGGGATTCTTGTTGAAGTCAGGATTTCCTATACTCGCCATTGAGCCAGAAAGACCAG
TTACGTACGGCATTCCCGCACTGTCTGACGTCTGACGTAACTCTGGATCCTTACCGACTGGGAA
CCACCACGTGGCATCTGCTGGTGCTTGTTCCGCAGTGAAAGTCACACTTGTAACAGCTCCGATA
GTGCCGTTTCTAACTTTAGAAAAACCCACACTTTTGTACCACTACTAAACCTCCTTTTTATCTC
ACAGTTGCCGAGAGTGACACATACTAGTGGATGTCACTCTGCTGTACCCTGTTGAAATGCCACA
CTTCAGTGTGTGAAAAGTATCGACGTTTGTCTAAGCTTGTTAATTTTTCATAGTTGCTCCTACA
TGTGTTCACGAGCCTACGTATATTTTATTTAAAGCATTTCAATGAAGTCTGTCTTTAAAGCATT
GGGCGTTTGTGCTGTGCAGAGTGGAATAGGGTTAAGCAAGGTGCGGTCTGATCCAGTTCATCTG
AGACTCCAGACTCATGAAGAATTCTGCCAAGTCTGGTTGTTTTTGTTTTGCTTTTTTGAGACAA
GGTCTCTCAGTGTAGCTGTGGCTGTCCTGAAATCCTCTGTGTAGACCAGGCTTGTCTCAAACCC
TCAGAGATCCACCTGCCTCTGTCTCCGAGATGGCCGGATTACAGGTGTGTGCTGCACCAGGTGG
TTTTGAAGCACTTTTGCTACTTACAGTGTTTGCCAGTGCTAGCGTGACTGTTCCAGTAGCCATA
CTGCAGGAGTCGTCTGGGCTGCAAGCTGTGGGATTGCCTCTAGGGAAGCATAGCATAGAAAATC
CACCTGCCAGCACTGCATGTCTGCACAGCTCTGGCTGCCCTGGAATTACAATGTAGACCAGGAT
GACCTGGAATTTACAGAAGCCCTCTTGCCTCTGCCTCAGAGCTGCCGGGATTAAAGGCATGCAC
TGGGTTTCGAAGGATCGTATTTATATTCCTGCGTTTCCTAATCTAAGACCTCCTAAGTAGCTCT
TTGTTACTTTGACTGTACTGTGAATGCATGTACTGTGAAGTGCATGGCCCTTGGGTTGGTTGTA
GGCTGAGTGCCACCAGAGCAGTCCACTGATTTAAACTCACCAGATGCTGCAGATAGATCCACGT
GGTACCAAGGTTACTTGGCTGTACTTGTAATGGGCACGAATGGGATACAGCAGTAGGCACAGCT
AGCAATGCCAGGAGAACCTGCCCACTAGCTCCAGCATGCTCACCCCAAGGAAGCACTTGGTCTA
CACAAGATTAGTTCAGGACCTGAGGAGGTTGGCTGCAGCATCTGGGTTCCCTCCAGGGACCCAG
CCCTTGGTGTGGGGAGGGTGTGTGGTAGTGAACTGCAGTCTGAGGTGGTGCTTTTTGCCCATGT
CATTTAGGTAGCCAGGGTCAGTATCTGGCTTTCACCACTGAAAGGGTGCCCAGACCAGATGCCT
CTCACAGAACTCATCATTTCAGCCGATCTGAAGGAACAAGCGACTGTTAGTGTTCCTGTGTGTG
TATAACATGGATGTCAGCACTTCCACATGCGTAATGTGTGTTATGTTCCCATGTATGCAGTGTA
TGTAACACCAAGTAGGGGACATCAGTGTGTTTTACCCCCAAATTGTATTTGTTTAAAAATGGGT
AATAAACATTGAGTTAAAAAGGGACTAGGTCAACATCAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088204 ⟹ XP_038944132

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	48,915,451 - 48,929,235 (+)	NCBI
mRatBN7.2	11	35,445,847 - 35,460,156 (+)	NCBI

RefSeq Acc Id:

XM_039088205 ⟹ XP_038944133

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	48,915,426 - 48,929,235 (+)	NCBI
mRatBN7.2	11	35,445,837 - 35,460,156 (+)	NCBI

RefSeq Acc Id:

XM_039088208 ⟹ XP_038944136

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	48,919,931 - 48,929,235 (+)	NCBI
mRatBN7.2	11	35,449,901 - 35,460,156 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_955405	(Get FASTA)	NCBI Sequence Viewer
	XP_038944132	(Get FASTA)	NCBI Sequence Viewer
	XP_038944133	(Get FASTA)	NCBI Sequence Viewer
	XP_038944136	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62049	(Get FASTA)	NCBI Sequence Viewer
	EDL76661	(Get FASTA)	NCBI Sequence Viewer
	EDL76662	(Get FASTA)	NCBI Sequence Viewer
	EDL76663	(Get FASTA)	NCBI Sequence Viewer
	EDL76664	(Get FASTA)	NCBI Sequence Viewer
	EDL76665	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002222
	ENSRNOP00000002222.3
GenBank Protein	Q6P6S5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_955405 ⟸ NM_199373
- UniProtKB:	Q6P6S5 (UniProtKB/Swiss-Prot), A6KPR9 (UniProtKB/TrEMBL), A6KPS0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSASETDRWAWLLVLCFVFGCNVLRILLPTLSSFISRVLQKDAEQESQMRAEIQSMKQELSTVN MMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWFISVAFYVLQAALMISLIWKYYSVPV AVVPSKWITPLDRLVAFPTRVAGGIGVTCWILVCNKVVAIILHPFS hide sequence

Ensembl Acc Id:

ENSRNOP00000002222 ⟸ ENSRNOT00000002222

RefSeq Acc Id:	XP_038944133 ⟸ XM_039088205
- Peptide Label:	isoform X1
- UniProtKB:	A6KPS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944132 ⟸ XM_039088204
- Peptide Label:	isoform X1
- UniProtKB:	A6KPS1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944136 ⟸ XM_039088208
- Peptide Label:	isoform X1
- UniProtKB:	A6KPS1 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000079459 ⟸ ENSRNOT00000098902

Ensembl Acc Id:

ENSRNOP00000089517 ⟸ ENSRNOT00000112143

Ensembl Acc Id:

ENSRNOP00000078941 ⟸ ENSRNOT00000095254

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P6S5-F1-model_v2	AlphaFold	Q6P6S5	1-174	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698088

Promoter ID:

EPDNEW_R8612

Type:

initiation region

Name:

Wrb_1

Description:

tryptophan rich basic protein

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	36,497,505 - 36,497,565	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:735104	AgrOrtholog
BioCyc Gene	G2FUF-21712	BioCyc
Ensembl Genes	ENSRNOG00000001629	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002222	ENTREZGENE
	ENSRNOT00000002222.6	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.287.660	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5598163	IMAGE-MGC_LOAD
InterPro	Helix_hairpin_bin_sf	UniProtKB/Swiss-Prot
	WRB/Get1	UniProtKB/Swiss-Prot
KEGG Report	rno:288233	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72575	IMAGE-MGC_LOAD
NCBI Gene	288233	ENTREZGENE
PANTHER	GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1	UniProtKB/Swiss-Prot
	TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB	UniProtKB/Swiss-Prot
Pfam	CHD5	UniProtKB/Swiss-Prot
PhenoGen	Get1	PhenoGen
RatGTEx	ENSRNOG00000001629	RatGTEx
UniProt	A0A8I5ZLZ4_RAT	UniProtKB/TrEMBL
	A0A8I5ZMV3_RAT	UniProtKB/TrEMBL
	A0A8I6AAH3_RAT	UniProtKB/TrEMBL
	A6KPR9	ENTREZGENE, UniProtKB/TrEMBL
	A6KPS0	ENTREZGENE, UniProtKB/TrEMBL
	A6KPS1	ENTREZGENE, UniProtKB/TrEMBL
	Q6P6S5	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-05	Get1	guided entry of tail-anchored proteins factor 1	Wrb	tryptophan rich basic protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Wrb	tryptophan rich basic protein			Symbol and Name status set to approved	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD