Kpna1 (karyopherin subunit alpha 1) - Rat Genome Database

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Gene: Kpna1 (karyopherin subunit alpha 1) Rattus norvegicus
Analyze
Symbol: Kpna1
Name: karyopherin subunit alpha 1
RGD ID: 735064
Description: Enables nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus. Located in dendrite and nucleus. Orthologous to human KPNA1 (karyopherin subunit alpha 1); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; influenza A pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: importin alpha 5; importin alpha-5; importin subunit alpha-1; importin subunit alpha-5; karyopherin (importin) alpha 1; karyopherin alpha 1; karyopherin alpha 1 (importin alpha 5); karyopherin subunit alpha-1; karyopherin/importin alpha-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Kpna1-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,221,165 - 78,279,778 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,222,884 - 78,267,067 (-)EnsemblGRCr8
mRatBN7.21164,715,844 - 64,774,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,717,563 - 64,774,623 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1173,546,142 - 73,586,119 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,208,404 - 66,248,383 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,239,652 - 65,279,629 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,652,573 - 67,717,180 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,652,577 - 67,703,025 (-)Ensemblrn6Rnor6.0
Rnor_5.01170,738,335 - 70,805,985 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41166,555,859 - 66,595,898 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1164,186,787 - 64,226,798 (-)NCBICelera
RGSC_v3.11166,610,214 - 66,653,556 (-)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
Cuprizon  (EXP)
cyproterone acetate  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
erianin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furan  (ISO)
gentamycin  (EXP)
hypochlorous acid  (ISO)
inulin  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. Dieterich DC, etal., PLoS Biol. 2008 Feb;6(2):e34. doi: 10.1371/journal.pbio.0060034.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Molecular cloning and characterization of rat karyopherin alpha 1 gene: structure and expression. Wang B, etal., Gene 2004 Apr 28;331:149-57.
Additional References at PubMed
PMID:15603742   PMID:16574786   PMID:16906019   PMID:17728463   PMID:23106098   PMID:27434733   PMID:30053369  


Genomics

Comparative Map Data
Kpna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,221,165 - 78,279,778 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,222,884 - 78,267,067 (-)EnsemblGRCr8
mRatBN7.21164,715,844 - 64,774,647 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,717,563 - 64,774,623 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1173,546,142 - 73,586,119 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,208,404 - 66,248,383 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,239,652 - 65,279,629 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,652,573 - 67,717,180 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,652,577 - 67,703,025 (-)Ensemblrn6Rnor6.0
Rnor_5.01170,738,335 - 70,805,985 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41166,555,859 - 66,595,898 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1164,186,787 - 64,226,798 (-)NCBICelera
RGSC_v3.11166,610,214 - 66,653,556 (-)NCBI
Cytogenetic Map11q22NCBI
KPNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,421,902 - 122,514,939 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,421,902 - 122,514,947 (-)Ensemblhg38GRCh38
GRCh373122,140,749 - 122,233,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,623,438 - 123,716,474 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343123,627,216 - 123,716,335NCBI
Celera3120,550,374 - 120,643,600 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3119,513,915 - 119,606,857 (-)NCBIHuRef
CHM1_13122,104,233 - 122,197,287 (-)NCBICHM1_1
T2T-CHM13v2.03125,141,131 - 125,234,261 (-)NCBIT2T-CHM13v2.0
Kpna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,803,693 - 35,859,479 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,799,120 - 35,857,501 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381635,983,288 - 36,037,136 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,978,750 - 36,037,131 (+)Ensemblmm10GRCm38
MGSCv371635,983,449 - 36,036,248 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361635,903,110 - 35,955,909 (+)NCBIMGSCv36mm8
Celera1636,463,542 - 36,516,772 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
Kpna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,705,412 - 21,764,913 (-)Ensembl
ChiLan1.0NW_00495542721,705,407 - 21,764,913 (-)NCBIChiLan1.0ChiLan1.0
KPNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,370,934 - 120,459,639 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,374,860 - 120,464,419 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,513,919 - 119,604,737 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,418,157 - 126,510,325 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,421,700 - 126,510,325 (-)EnsemblpanPan2panpan1.1
KPNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,561,335 - 25,631,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,566,419 - 25,631,718 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3325,585,686 - 25,656,082 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03325,796,537 - 25,867,021 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,782,759 - 25,867,039 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,593,501 - 25,663,791 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,636,870 - 25,707,309 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,194,435 - 26,265,045 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kpna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,720,609 - 128,786,630 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,737,488 - 8,801,428 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,735,159 - 8,801,385 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KPNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13138,018,407 - 138,103,838 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113138,045,083 - 138,100,830 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,681,201 - 147,711,773 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KPNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,346,008 - 58,437,737 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,346,009 - 58,439,143 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041107,903,389 - 108,002,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kpna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624912772,420 - 822,580 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kpna1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1420,755,582 - 21,012,701 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kpna1
614 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:365
Count of miRNA genes:207
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000035611
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat

Markers in Region
Kpna1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,720,817 - 64,720,938 (+)MAPPERmRatBN7.2
Rnor_6.01167,655,832 - 67,655,952NCBIRnor6.0
Rnor_5.01170,743,309 - 70,743,429UniSTSRnor5.0
RGSC_v3.41166,555,881 - 66,556,001UniSTSRGSC3.4
Celera1164,186,809 - 64,186,929UniSTS
Cytogenetic Map11q22UniSTS
BE113307  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,723,612 - 64,723,787 (+)MAPPERmRatBN7.2
Rnor_6.01167,658,590 - 67,658,764NCBIRnor6.0
Rnor_5.01170,746,095 - 70,746,269UniSTSRnor5.0
RGSC_v3.41166,558,677 - 66,558,851UniSTSRGSC3.4
Celera1164,189,583 - 64,189,757UniSTS
RH 3.4 Map11468.5UniSTS
Cytogenetic Map11q22UniSTS
AA800028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21164,718,971 - 64,719,183 (+)MAPPERmRatBN7.2
Rnor_6.01167,653,986 - 67,654,197NCBIRnor6.0
Rnor_5.01170,741,463 - 70,741,674UniSTSRnor5.0
RGSC_v3.41166,554,035 - 66,554,246UniSTSRGSC3.4
Celera1164,184,963 - 64,185,174UniSTS
RH 3.4 Map11468.01UniSTS
Cytogenetic Map11q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000078285   ⟹   ENSRNOP00000071569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,222,884 - 78,266,417 (-)Ensembl
mRatBN7.2 Ensembl1164,717,563 - 64,761,104 (-)Ensembl
Rnor_6.0 Ensembl1167,652,577 - 67,703,025 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084540   ⟹   ENSRNOP00000070449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,717,640 - 64,774,623 (-)Ensembl
Rnor_6.0 Ensembl1167,655,836 - 67,702,955 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097087   ⟹   ENSRNOP00000089735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1164,717,581 - 64,774,623 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117532   ⟹   ENSRNOP00000094957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,222,884 - 78,267,067 (-)Ensembl
mRatBN7.2 Ensembl1164,717,563 - 64,761,754 (-)Ensembl
RefSeq Acc Id: NM_198726   ⟹   NP_942021
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,226,117 - 78,266,131 (-)NCBI
mRatBN7.21164,720,796 - 64,760,818 (-)NCBI
Rnor_6.01167,655,810 - 67,702,956 (-)NCBI
Rnor_5.01170,738,335 - 70,805,985 (-)NCBI
RGSC_v3.41166,555,859 - 66,595,898 (-)RGD
Celera1164,186,787 - 64,226,798 (-)RGD
Sequence:
RefSeq Acc Id: XM_017597922   ⟹   XP_017453411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,221,165 - 78,279,391 (-)NCBI
mRatBN7.21164,715,844 - 64,774,087 (-)NCBI
Rnor_6.01167,652,573 - 67,717,180 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088121   ⟹   XP_038944049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,221,165 - 78,279,778 (-)NCBI
mRatBN7.21164,715,844 - 64,774,647 (-)NCBI
RefSeq Acc Id: XM_039088122   ⟹   XP_038944050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,221,165 - 78,249,645 (-)NCBI
mRatBN7.21164,715,844 - 64,744,327 (-)NCBI
RefSeq Acc Id: NP_942021   ⟸   NM_198726
- UniProtKB: P83953 (UniProtKB/Swiss-Prot),   Q56R20 (UniProtKB/TrEMBL),   A0A0G2JXY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453411   ⟸   XM_017597922
- Peptide Label: isoform X1
- UniProtKB: P83953 (UniProtKB/Swiss-Prot),   Q56R20 (UniProtKB/TrEMBL),   A0A0G2JXY5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070449   ⟸   ENSRNOT00000084540
Ensembl Acc Id: ENSRNOP00000071569   ⟸   ENSRNOT00000078285
RefSeq Acc Id: XP_038944049   ⟸   XM_039088121
- Peptide Label: isoform X1
- UniProtKB: P83953 (UniProtKB/Swiss-Prot),   Q56R20 (UniProtKB/TrEMBL),   A0A0G2JXY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944050   ⟸   XM_039088122
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000094957   ⟸   ENSRNOT00000117532
Ensembl Acc Id: ENSRNOP00000089735   ⟸   ENSRNOT00000097087
Protein Domains
IBB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83953-F1-model_v2 AlphaFold P83953 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735064 AgrOrtholog
BioCyc Gene G2FUF-21209 BioCyc
Ensembl Genes ENSRNOG00000051711 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000078285 ENTREZGENE
Gene3D-CATH 1.20.5.690 UniProtKB/Swiss-Prot
  1.25.10.10 UniProtKB/Swiss-Prot
InterPro ARM-like UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  Arm_3 UniProtKB/Swiss-Prot
  Armadillo UniProtKB/Swiss-Prot
  Importin-a-like_IBB-bd_dom UniProtKB/Swiss-Prot
  Importin-a_IBB_sf UniProtKB/Swiss-Prot
  Importing_su_alpha UniProtKB/Swiss-Prot
NCBI Gene 288064 ENTREZGENE
PANTHER IMPORTIN ALPHA UniProtKB/Swiss-Prot
Pfam Arm UniProtKB/Swiss-Prot
  Arm_3 UniProtKB/Swiss-Prot
  IBB UniProtKB/Swiss-Prot
PhenoGen Kpna1 PhenoGen
PIRSF Importin_alpha UniProtKB/Swiss-Prot
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot
  IBB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051711 RatGTEx
SMART ARM UniProtKB/Swiss-Prot
Superfamily-SCOP ARM-type_fold UniProtKB/Swiss-Prot
UniProt A0A0G2JXY5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K0T0_RAT UniProtKB/TrEMBL
  A0A8I6AKK8_RAT UniProtKB/TrEMBL
  IMA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q56R20 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kpna1  karyopherin subunit alpha 1  Kpna1  karyopherin alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Kpna1  karyopherin alpha 1  Kpna1  karyopherin (importin) alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Kpna1  karyopherin (importin) alpha 1    karyopherin alpha 1 (importin alpha 5)  Name updated 1299863 APPROVED
2005-07-08 Kpna1  karyopherin alpha 1 (importin alpha 5)      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression was found to be higher in heart, kidney, placenta, pancreas, and spleen and relatively lower in brain, liver, and skeletal muscle (by semi-quantitative RT-PCR) 1302832
gene_homology cDNA is 99% homolgous to mouse Kpna1 and 98% homologous to human KPNA1 1302832
gene_regulation 6-OHDA treatment resulted in up to 2-fold increases in Kpna1 mRNA levels 2 weeks post-treatment with levels less but still higher than controls at 5 weeks post-treatment (p<0.05) 1302832