Rffl (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Rffl (ring finger and FYVE-like domain containing E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Rffl
Name: ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RGD ID: 727916
Description: Predicted to enable enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; protein K48-linked ubiquitination; and regulation of fibroblast migration. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in endosome membrane. Predicted to be active in cytoplasm and plasma membrane. Biomarker of hypertension. Orthologous to human RFFL (ring finger and FYVE like domain containing E3 ubiquitin protein ligase); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase rififylin; fring; FYVE-RING finger protein Sakura; LOC282844; MGC94279; ring finger and FYVE like domain containing protein; ring finger and FYVE-like domain containing 1; RING finger and FYVE-like domain-containing protein 1; RING finger protein SAKURA; RING-type E3 ubiquitin transferase rififylin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp301
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,238,273 - 68,301,225 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,238,273 - 68,321,902 (-)EnsemblGRCr8
mRatBN7.21067,740,711 - 67,803,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,740,712 - 67,824,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,360,780 - 72,423,716 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,866,156 - 71,929,095 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,327,967 - 67,393,247 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,157,621 - 70,220,618 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,157,621 - 70,220,582 (-)Ensemblrn6Rnor6.0
Rnor_5.01069,788,330 - 69,851,298 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,025,035 - 71,047,280 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1066,686,813 - 66,709,204 (-)NCBICelera
RGSC_v3.11071,038,657 - 71,060,903 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
hypertension  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
FR900359  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptoethanol  (ISO)
metformin  (EXP)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosomorpholine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
quercetin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. A palmitoylated RING finger ubiquitin ligase and its homologue in the brain membranes. Araki K, etal., J Neurochem 2003 Aug;86(3):749-62.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Augmented rififylin is a risk factor linked to aberrant cardiomyocyte function, short-QT interval and hypertension. Gopalakrishnan K, etal., Hypertension. 2011 Apr;57(4):764-71. doi: 10.1161/HYPERTENSIONAHA.110.165803. Epub 2011 Feb 28.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15069192   PMID:15229288   PMID:15489334   PMID:17121812   PMID:18382127   PMID:18450452   PMID:19946888   PMID:22609986   PMID:28827789  


Genomics

Comparative Map Data
Rffl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,238,273 - 68,301,225 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1068,238,273 - 68,321,902 (-)EnsemblGRCr8
mRatBN7.21067,740,711 - 67,803,669 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,740,712 - 67,824,434 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1072,360,780 - 72,423,716 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,866,156 - 71,929,095 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,327,967 - 67,393,247 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,157,621 - 70,220,618 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,157,621 - 70,220,582 (-)Ensemblrn6Rnor6.0
Rnor_5.01069,788,330 - 69,851,298 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41071,025,035 - 71,047,280 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1066,686,813 - 66,709,204 (-)NCBICelera
RGSC_v3.11071,038,657 - 71,060,903 (-)NCBI
Cytogenetic Map10q26NCBI
RFFL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,005,990 - 35,089,226 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,005,990 - 35,089,899 (-)Ensemblhg38GRCh38
GRCh371733,333,009 - 33,416,245 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,360,244 - 30,440,407 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1730,246,327 - 30,326,489 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,522,054 - 29,601,016 (-)NCBIHuRef
CHM1_11733,400,524 - 33,480,727 (-)NCBICHM1_1
T2T-CHM13v2.01735,953,906 - 36,037,140 (-)NCBIT2T-CHM13v2.0
Rffl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,694,645 - 82,762,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,693,275 - 82,762,036 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381182,803,819 - 82,871,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,802,449 - 82,871,210 (-)Ensemblmm10GRCm38
MGSCv371182,617,321 - 82,684,712 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361182,620,017 - 82,686,939 (-)NCBIMGSCv36mm8
Celera1192,423,191 - 92,490,746 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.25NCBI
Rffl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554819,718,369 - 9,765,132 (-)Ensembl
ChiLan1.0NW_0049554819,718,369 - 9,788,048 (-)NCBIChiLan1.0ChiLan1.0
RFFL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21929,376,768 - 29,456,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11731,312,229 - 31,337,987 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,696,808 - 21,779,878 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,014,167 - 22,069,553 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,035,643 - 22,069,546 (+)EnsemblpanPan2panpan1.1
RFFL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1938,271,419 - 38,346,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl938,222,051 - 38,365,621 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha937,495,000 - 37,573,581 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0939,083,074 - 39,162,504 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl939,054,329 - 39,156,002 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,866,520 - 37,945,113 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,151,818 - 38,231,027 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,239,649 - 38,318,516 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rffl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560237,282,719 - 37,325,679 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936538139,723 - 203,600 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936538139,690 - 203,600 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFFL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,515,393 - 28,593,289 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1628,518,231 - 28,533,070 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660751,388,544 - 1,472,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rffl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248752,897,832 - 2,964,866 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248752,896,888 - 2,964,838 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rffl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1987,646,166 - 87,710,475 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rffl
220 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:829
Count of miRNA genes:257
Interacting mature miRNAs:321
Transcripts:ENSRNOT00000010015, ENSRNOT00000041389
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D10Got87  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,765,546 - 67,765,709 (+)MAPPERmRatBN7.2
Rnor_6.01070,182,462 - 70,182,622NCBIRnor6.0
Rnor_5.01069,813,167 - 69,813,327UniSTSRnor5.0
Rnor_5.01070,947,551 - 70,947,711UniSTSRnor5.0
RGSC_v3.41071,048,033 - 71,048,194RGDRGSC3.4
RGSC_v3.41071,048,034 - 71,048,194UniSTSRGSC3.4
Celera1066,709,958 - 66,710,118UniSTS
RGSC_v3.11071,061,656 - 71,061,817RGD
RH 2.0 Map10689.8RGD
Cytogenetic Map10q26UniSTS
D10Chm171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,750,049 - 67,750,281 (+)MAPPERmRatBN7.2
Rnor_6.01070,166,960 - 70,167,191NCBIRnor6.0
Rnor_5.01069,797,667 - 69,797,898UniSTSRnor5.0
RGSC_v3.41071,032,534 - 71,032,765UniSTSRGSC3.4
Celera1066,694,510 - 66,694,687UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001004068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001399574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY157969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010015   ⟹   ENSRNOP00000010015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,238,273 - 68,321,902 (-)Ensembl
mRatBN7.2 Ensembl1067,740,981 - 67,824,434 (-)Ensembl
Rnor_6.0 Ensembl1070,159,607 - 70,172,739 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000038376   ⟹   ENSRNOP00000036257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,810,289 - 67,824,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041389   ⟹   ENSRNOP00000045245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,238,273 - 68,301,225 (-)Ensembl
mRatBN7.2 Ensembl1067,740,884 - 67,779,898 (-)Ensembl
Rnor_6.0 Ensembl1070,157,621 - 70,220,558 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076089   ⟹   ENSRNOP00000068502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1070,159,740 - 70,202,398 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076398   ⟹   ENSRNOP00000068077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,239,457 - 68,301,225 (-)Ensembl
mRatBN7.2 Ensembl1067,740,981 - 67,803,751 (-)Ensembl
Rnor_6.0 Ensembl1070,157,626 - 70,220,560 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076509   ⟹   ENSRNOP00000093509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,252,730 - 68,321,902 (-)Ensembl
mRatBN7.2 Ensembl1067,805,799 - 67,824,434 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076596   ⟹   ENSRNOP00000068131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,238,273 - 68,277,758 (-)Ensembl
mRatBN7.2 Ensembl1067,740,712 - 67,779,935 (-)Ensembl
Rnor_6.0 Ensembl1070,157,624 - 70,220,582 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076598   ⟹   ENSRNOP00000067950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,238,273 - 68,262,352 (-)Ensembl
mRatBN7.2 Ensembl1067,742,487 - 67,764,793 (-)Ensembl
Rnor_6.0 Ensembl1070,159,397 - 70,181,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117637   ⟹   ENSRNOP00000082234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,810,289 - 67,824,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119950   ⟹   ENSRNOP00000096856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,810,289 - 67,824,354 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170731   ⟹   ENSRNOP00000108638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1068,238,273 - 68,262,247 (-)Ensembl
RefSeq Acc Id: NM_001004068   ⟹   NP_001004068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,238,273 - 68,262,352 (-)NCBI
mRatBN7.21067,740,711 - 67,764,790 (-)NCBI
Rnor_6.01070,159,397 - 70,181,708 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
RGSC_v3.41071,025,035 - 71,047,280 (-)RGD
Celera1066,686,813 - 66,709,204 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399574   ⟹   NP_001386503
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,238,273 - 68,301,225 (-)NCBI
mRatBN7.21067,740,711 - 67,803,669 (-)NCBI
RefSeq Acc Id: XM_006246969   ⟹   XP_006247031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,277,700 (-)NCBI
mRatBN7.21067,740,711 - 67,780,135 (-)NCBI
Rnor_6.01070,157,621 - 70,197,081 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246970   ⟹   XP_006247032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,277,694 (-)NCBI
mRatBN7.21067,740,711 - 67,780,129 (-)NCBI
Rnor_6.01070,157,621 - 70,197,081 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246974   ⟹   XP_006247036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,301,198 (-)NCBI
mRatBN7.21067,740,711 - 67,803,637 (-)NCBI
Rnor_6.01070,157,621 - 70,220,618 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246977   ⟹   XP_006247039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,284,785 (-)NCBI
mRatBN7.21067,740,711 - 67,780,770 (-)NCBI
Rnor_6.01070,157,621 - 70,198,173 (-)NCBI
Rnor_5.01069,788,330 - 69,851,298 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085321   ⟹   XP_038941249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,277,697 (-)NCBI
mRatBN7.21067,740,711 - 67,780,131 (-)NCBI
RefSeq Acc Id: XM_039085323   ⟹   XP_038941251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,277,307 (-)NCBI
mRatBN7.21067,740,711 - 67,779,748 (-)NCBI
RefSeq Acc Id: XM_063268498   ⟹   XP_063124568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,277,700 (-)NCBI
RefSeq Acc Id: XM_063268499   ⟹   XP_063124569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,277,692 (-)NCBI
RefSeq Acc Id: XM_063268500   ⟹   XP_063124570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,286,852 (-)NCBI
RefSeq Acc Id: XM_063268501   ⟹   XP_063124571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,240,049 - 68,301,198 (-)NCBI
RefSeq Acc Id: NP_001004068   ⟸   NM_001004068
- Peptide Label: isoform 2
- UniProtKB: A0A8L2QM30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247036   ⟸   XM_006246974
- Peptide Label: isoform X5
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247039   ⟸   XM_006246977
- Peptide Label: isoform X5
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247032   ⟸   XM_006246970
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QZU3 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247031   ⟸   XM_006246969
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QM30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010015   ⟸   ENSRNOT00000010015
Ensembl Acc Id: ENSRNOP00000045245   ⟸   ENSRNOT00000041389
Ensembl Acc Id: ENSRNOP00000068077   ⟸   ENSRNOT00000076398
Ensembl Acc Id: ENSRNOP00000068502   ⟸   ENSRNOT00000076089
Ensembl Acc Id: ENSRNOP00000067950   ⟸   ENSRNOT00000076598
Ensembl Acc Id: ENSRNOP00000068131   ⟸   ENSRNOT00000076596
RefSeq Acc Id: XP_038941249   ⟸   XM_039085321
- Peptide Label: isoform X5
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941251   ⟸   XM_039085323
- Peptide Label: isoform X5
- UniProtKB: A0A096MJC6 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000036257   ⟸   ENSRNOT00000038376
Ensembl Acc Id: ENSRNOP00000082234   ⟸   ENSRNOT00000117637
Ensembl Acc Id: ENSRNOP00000096856   ⟸   ENSRNOT00000119950
Ensembl Acc Id: ENSRNOP00000093509   ⟸   ENSRNOT00000076509
RefSeq Acc Id: NP_001386503   ⟸   NM_001399574
- Peptide Label: isoform 1
- UniProtKB: Q8CIN9 (UniProtKB/Swiss-Prot),   Q6AY29 (UniProtKB/Swiss-Prot),   A6HHE4 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124571   ⟸   XM_063268501
- Peptide Label: isoform X7
- UniProtKB: A6HHE7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124570   ⟸   XM_063268500
- Peptide Label: isoform X6
- UniProtKB: Q8CIN9 (UniProtKB/Swiss-Prot),   Q6AY29 (UniProtKB/Swiss-Prot),   A6HHE4 (UniProtKB/TrEMBL),   A0A8L2QM30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124568   ⟸   XM_063268498
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QM30 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124569   ⟸   XM_063268499
- Peptide Label: isoform X4
- UniProtKB: A0A8L2QM30 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108638   ⟸   ENSRNOT00000170731
Protein Domains
E3 ubiquitin-protein ligase CARP1/2 FYVE/PHD zinc   RING-type   RNF34/RFFL HeH   RNF34/RFFL SAP   SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CIN9-F1-model_v2 AlphaFold Q8CIN9 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697516
Promoter ID:EPDNEW_R8040
Type:initiation region
Name:Rffl_2
Description:ring finger and FYVE-like domain containing E3 ubiquitin proteinligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8041  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,181,705 - 70,181,765EPDNEW
RGD ID:13697522
Promoter ID:EPDNEW_R8041
Type:initiation region
Name:Rffl_1
Description:ring finger and FYVE-like domain containing E3 ubiquitin proteinligase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8040  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,220,578 - 70,220,638EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727916 AgrOrtholog
BioCyc Gene G2FUF-23918 BioCyc
Ensembl Genes ENSRNOG00000007596 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000041389 ENTREZGENE
  ENSRNOT00000076596 ENTREZGENE
  ENSRNOT00000076598 ENTREZGENE
  ENSRNOT00000076598.3 UniProtKB/Swiss-Prot
  ENSRNOT00000170731 ENTREZGENE
Gene3D-CATH 1.10.720.140 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7131890 IMAGE-MGC_LOAD
InterPro CARP1_2_FYVE UniProtKB/Swiss-Prot
  CARP2_FYVE UniProtKB/Swiss-Prot
  RING-FYVE_E3_ubiquitin-ligase UniProtKB/Swiss-Prot
  RNF34L-like_HeH UniProtKB/Swiss-Prot
  SAP_dom_sf UniProtKB/Swiss-Prot
  Znf_FYVE_PHD UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
KEGG Report rno:282844 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94279 IMAGE-MGC_LOAD
NCBI Gene 282844 ENTREZGENE
PANTHER CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN UniProtKB/Swiss-Prot
Pfam FYVE_CARP1-2 UniProtKB/Swiss-Prot
  RNF34L-like_3rd UniProtKB/Swiss-Prot
  SAP_RNF34_RFFL UniProtKB/Swiss-Prot
  zf-C3HC4_3 UniProtKB/Swiss-Prot
PhenoGen Rffl PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007596 RatGTEx
SMART RING UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF57903 UniProtKB/Swiss-Prot
  SSF68906 UniProtKB/Swiss-Prot
UniProt A0A096MJC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QM30 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QZU3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LUN0_RAT UniProtKB/TrEMBL
  A6HHE4 ENTREZGENE, UniProtKB/TrEMBL
  A6HHE6_RAT UniProtKB/TrEMBL
  A6HHE7 ENTREZGENE, UniProtKB/TrEMBL
  Q6AY29 ENTREZGENE
  Q8CIN9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6AY29 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Rffl  ring finger and FYVE-like domain containing E3 ubiquitin protein ligase  Rffl  ring finger and FYVE-like domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Rffl  ring finger and FYVE-like domain containing 1  Rffl  ring finger and FYVE like domain containing protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Rffl  ring finger and FYVE like domain containing protein    fring  Name updated 1299863 APPROVED
2005-07-08 Rffl  fring  LOC282844    Symbol updated 1299863 APPROVED