Gsdme (gasdermin E) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gsdme (gasdermin E) Rattus norvegicus
Analyze
Symbol: Gsdme
Name: gasdermin E
RGD ID: 727871
Description: Predicted to enable cardiolipin binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and wide pore channel activity. Predicted to be involved in several processes, including cellular response to virus; granzyme-mediated programmed cell death signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within inner ear auditory receptor cell differentiation and pyroptotic cell death. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 5 and sensorineural hearing loss. Orthologous to human GSDME (gasdermin E); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; aristolochic acid A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: deafness, autosomal dominant 5; deafness, autosomal dominant 5 (human); deafness, autosomal dominant 5 homolog; deafness, autosomal dominant 5 homolog (human); Dfna5; DFNA5, deafness associated tumor suppressor; Dfna5h; gasdermin-E; non-syndromic hearing impairment protein 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,590,344 - 80,651,943 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl480,588,614 - 80,641,525 (-)EnsemblGRCr8
mRatBN7.2479,258,799 - 79,321,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,257,804 - 79,320,806 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,481,566 - 84,538,385 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,257,093 - 80,313,918 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,697,400 - 78,754,225 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,934,075 - 79,999,678 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,934,887 - 79,989,572 (-)Ensemblrn6Rnor6.0
Rnor_5.04144,606,016 - 144,670,696 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,431,841 - 78,492,217 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera474,170,353 - 74,229,548 (-)NCBICelera
RGSC_v3.1478,707,973 - 78,721,124 (-)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,6-dimethoxyphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
afatinib  (ISO)
aflatoxin B1  (ISO)
ajmalicine  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calpeptin  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dihydroartemisinin  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
glutathione  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methylformamide  (ISO)
N-nitrosodimethylamine  (ISO)
naled  (ISO)
Nitidine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
membrane  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A yeast model for the study of human DFNA5, a gene mutated in nonsyndromic hearing impairment. Gregan J, etal., Biochim Biophys Acta 2003 Jul 14;1638(2):179-86.
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma. Peng LS, etal., Front Oncol. 2022 Nov 25;12:1043862. doi: 10.3389/fonc.2022.1043862. eCollection 2022.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Nonsyndromic hearing impairment is associated with a mutation in DFNA5. Van Laer L, etal., Nat Genet. 1998 Oct;20(2):194-7.
Additional References at PubMed
PMID:16023581   PMID:18223688   PMID:21522185   PMID:26236191   PMID:28045099   PMID:28459430   PMID:37531918   PMID:37955688  


Genomics

Comparative Map Data
Gsdme
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,590,344 - 80,651,943 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl480,588,614 - 80,641,525 (-)EnsemblGRCr8
mRatBN7.2479,258,799 - 79,321,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,257,804 - 79,320,806 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,481,566 - 84,538,385 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,257,093 - 80,313,918 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,697,400 - 78,754,225 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,934,075 - 79,999,678 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,934,887 - 79,989,572 (-)Ensemblrn6Rnor6.0
Rnor_5.04144,606,016 - 144,670,696 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,431,841 - 78,492,217 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera474,170,353 - 74,229,548 (-)NCBICelera
RGSC_v3.1478,707,973 - 78,721,124 (-)NCBI
Cytogenetic Map4q24NCBI
GSDME
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,698,355 - 24,795,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,698,355 - 24,757,940 (-)Ensemblhg38GRCh38
GRCh37724,737,974 - 24,797,558 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,704,499 - 24,764,164 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34724,511,214 - 24,570,603NCBI
Celera724,726,449 - 24,786,103 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,622,538 - 24,682,209 (-)NCBIHuRef
CHM1_1724,739,537 - 24,799,201 (-)NCBICHM1_1
T2T-CHM13v2.0724,836,367 - 24,933,504 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,789,534 - 24,849,193 (-)NCBI
Gsdme
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39650,167,013 - 50,240,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl650,165,868 - 50,240,842 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38650,207,401 - 50,263,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl650,188,888 - 50,263,862 (-)Ensemblmm10GRCm38
MGSCv37650,157,402 - 50,211,768 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36650,136,989 - 50,191,355 (-)NCBIMGSCv36mm8
Celera650,724,199 - 50,778,504 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.13NCBI
Gsdme
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,701,893 - 26,769,989 (-)Ensembl
ChiLan1.0NW_00495541026,700,977 - 26,761,683 (-)NCBIChiLan1.0ChiLan1.0
GSDME
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,555,469 - 29,615,294 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,880,196 - 77,940,638 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0725,373,485 - 25,433,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,977,838 - 25,039,525 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,977,838 - 25,039,525 (-)EnsemblpanPan2panpan1.1
GSDME
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11438,210,975 - 38,286,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1438,211,540 - 38,292,280 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1437,761,175 - 37,836,931 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01438,147,520 - 38,223,342 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1438,147,531 - 38,220,379 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11438,261,120 - 38,336,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,953,705 - 38,029,068 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01438,295,918 - 38,371,682 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gsdme
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,443,029 - 82,508,175 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364781,655,983 - 1,705,252 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364781,655,487 - 1,720,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSDME
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,526,797 - 47,583,731 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11847,524,637 - 47,583,748 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,434,841 - 52,489,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSDME
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12133,611,068 - 33,671,497 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2133,612,013 - 33,672,461 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604270,981,267 - 71,041,514 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsdme
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247395,798,771 - 5,871,088 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247395,790,372 - 5,879,979 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gsdme
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1690,843,298 - 90,900,356 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gsdme
515 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:496
Count of miRNA genes:254
Interacting mature miRNAs:316
Transcripts:ENSRNOT00000013264
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)48021363484338055Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 87 86 55 91 55 6 351 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013264   ⟹   ENSRNOP00000013264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,592,322 - 80,641,525 (-)Ensembl
mRatBN7.2 Ensembl479,261,512 - 79,310,717 (-)Ensembl
Rnor_6.0 Ensembl479,934,887 - 79,989,572 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086453   ⟹   ENSRNOP00000073987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,588,614 - 80,641,525 (-)Ensembl
mRatBN7.2 Ensembl479,257,804 - 79,320,806 (-)Ensembl
Rnor_6.0 Ensembl479,944,750 - 79,989,572 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107780   ⟹   ENSRNOP00000081162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,592,322 - 80,641,525 (-)Ensembl
mRatBN7.2 Ensembl479,261,512 - 79,310,717 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134517   ⟹   ENSRNOP00000108602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,592,322 - 80,641,525 (-)Ensembl
RefSeq Acc Id: NM_001191749   ⟹   NP_001178678
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,592,322 - 80,651,611 (-)NCBI
mRatBN7.2479,261,512 - 79,320,804 (-)NCBI
Rnor_6.0479,934,075 - 79,999,678 (-)NCBI
Rnor_5.04144,606,016 - 144,670,696 (-)NCBI
Celera474,170,353 - 74,229,548 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107726   ⟹   XP_038963654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,590,344 - 80,651,940 (-)NCBI
mRatBN7.2479,258,799 - 79,321,127 (-)NCBI
RefSeq Acc Id: XM_039107727   ⟹   XP_038963655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,590,344 - 80,651,940 (-)NCBI
mRatBN7.2479,258,799 - 79,321,127 (-)NCBI
RefSeq Acc Id: XM_039107728   ⟹   XP_038963656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,590,344 - 80,651,942 (-)NCBI
mRatBN7.2479,262,389 - 79,321,129 (-)NCBI
RefSeq Acc Id: XM_039107729   ⟹   XP_038963657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,590,344 - 80,651,942 (-)NCBI
mRatBN7.2479,258,799 - 79,321,129 (-)NCBI
RefSeq Acc Id: XM_039107730   ⟹   XP_038963658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,590,344 - 80,651,940 (-)NCBI
mRatBN7.2479,262,389 - 79,321,126 (-)NCBI
RefSeq Acc Id: XM_039107731   ⟹   XP_038963659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,590,344 - 80,651,941 (-)NCBI
mRatBN7.2479,258,799 - 79,321,127 (-)NCBI
RefSeq Acc Id: XM_039107732   ⟹   XP_038963660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,607,437 - 80,651,940 (-)NCBI
mRatBN7.2479,279,857 - 79,321,126 (-)NCBI
RefSeq Acc Id: XM_063286213   ⟹   XP_063142283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,599,076 - 80,651,943 (-)NCBI
RefSeq Acc Id: XR_005503244
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,593,276 - 80,651,941 (-)NCBI
mRatBN7.2479,262,467 - 79,321,127 (-)NCBI
RefSeq Acc Id: NP_001178678   ⟸   NM_001191749
- UniProtKB: A0A8I5ZRE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073987   ⟸   ENSRNOT00000086453
Ensembl Acc Id: ENSRNOP00000013264   ⟸   ENSRNOT00000013264
RefSeq Acc Id: XP_038963657   ⟸   XM_039107729
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038963659   ⟸   XM_039107731
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038963655   ⟸   XM_039107727
- Peptide Label: isoform X1
- UniProtKB: F1MAG0 (UniProtKB/TrEMBL),   A6K0M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963654   ⟸   XM_039107726
- Peptide Label: isoform X1
- UniProtKB: F1MAG0 (UniProtKB/TrEMBL),   A6K0M0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963656   ⟸   XM_039107728
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K6Y3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963658   ⟸   XM_039107730
- Peptide Label: isoform X5
- UniProtKB: A0A0G2K6Y3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963660   ⟸   XM_039107732
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000081162   ⟸   ENSRNOT00000107780
RefSeq Acc Id: XP_063142283   ⟸   XM_063286213
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K6Y3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000108602   ⟸   ENSRNOT00000134517
Protein Domains
Gasdermin pore forming   Gasdermin PUB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAG0-F1-model_v2 AlphaFold F1MAG0 1-513 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727871 AgrOrtholog
BioCyc Gene G2FUF-44898 BioCyc
Ensembl Genes ENSRNOG00000009970 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013264 ENTREZGENE
  ENSRNOT00000013264.9 UniProtKB/TrEMBL
  ENSRNOT00000086453 ENTREZGENE
  ENSRNOT00000086453.3 UniProtKB/TrEMBL
  ENSRNOT00000107780 ENTREZGENE
  ENSRNOT00000107780.2 UniProtKB/TrEMBL
  ENSRNOT00000134517 ENTREZGENE
  ENSRNOT00000134517.1 UniProtKB/TrEMBL
InterPro Gasdermin_pore UniProtKB/TrEMBL
  Gasdermin_PUB UniProtKB/TrEMBL
  GSDME UniProtKB/TrEMBL
KEGG Report rno:353316 UniProtKB/TrEMBL
NCBI Gene 353316 ENTREZGENE
PANTHER GASDERMIN-E UniProtKB/TrEMBL
  PTHR15207 UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/TrEMBL
  Gasdermin_C UniProtKB/TrEMBL
PhenoGen Gsdme PhenoGen
RatGTEx ENSRNOG00000009970 RatGTEx
UniProt A0A0G2K6Y3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZRE3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LD07_RAT UniProtKB/TrEMBL
  A6K0M0 ENTREZGENE, UniProtKB/TrEMBL
  F1MAG0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-28 Gsdme  gasdermin E  Dfna5  DFNA5, deafness associated tumor suppressor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-02 Dfna5  DFNA5, deafness associated tumor suppressor  Dfna5  deafness, autosomal dominant 5 (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-11-06 Dfna5  deafness, autosomal dominant 5 (human)  Dfna5h  deafness, autosomal dominant 5 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Dfna5h  deafness, autosomal dominant 5 homolog (human)      Symbol and Name status set to approved 1299863 APPROVED