GSDME (gasdermin E) - Rat Genome Database

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Pathways
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Gene: GSDME (gasdermin E) Sus scrofa
Analyze
Symbol: GSDME
Name: gasdermin E
RGD ID: 14014348
Description: ENCODES a protein that exhibits cardiolipin binding (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); wide pore channel activity (inferred); INVOLVED IN granzyme-mediated programmed cell death signaling pathway (ortholog); inner ear auditory receptor cell differentiation (ortholog); ASSOCIATED WITH autosomal dominant nonsyndromic deafness 5 (ortholog); genetic disease (ortholog); Hearing Loss (ortholog); FOUND IN membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DFNA5; DFNA5, deafness associated tumor suppressor; non-syndromic hearing impairment protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,526,797 - 47,583,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11847,524,637 - 47,583,748 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,434,841 - 52,489,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
GSDME
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,526,797 - 47,583,731 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11847,524,637 - 47,583,748 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,434,841 - 52,489,985 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSDME
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,698,355 - 24,795,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,698,355 - 24,757,940 (-)EnsemblGRCh38hg38GRCh38
GRCh37724,737,974 - 24,797,558 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,704,499 - 24,764,164 (-)NCBINCBI36Build 36hg18NCBI36
Build 34724,511,214 - 24,570,603NCBI
Celera724,726,449 - 24,786,103 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,622,538 - 24,682,209 (-)NCBIHuRef
CHM1_1724,739,537 - 24,799,201 (-)NCBICHM1_1
T2T-CHM13v2.0724,836,367 - 24,933,504 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,789,534 - 24,849,193 (-)NCBI
Gsdme
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39650,167,013 - 50,240,837 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl650,165,868 - 50,240,842 (-)EnsemblGRCm39 Ensembl
GRCm38650,207,401 - 50,263,857 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl650,188,888 - 50,263,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv37650,157,402 - 50,211,768 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36650,136,989 - 50,191,355 (-)NCBIMGSCv36mm8
Celera650,724,199 - 50,778,504 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.13NCBI
Gsdme
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,590,344 - 80,651,943 (-)NCBIGRCr8
mRatBN7.2479,258,799 - 79,321,129 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl479,257,804 - 79,320,806 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx484,481,566 - 84,538,385 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0480,257,093 - 80,313,918 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,697,400 - 78,754,225 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,934,075 - 79,999,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,934,887 - 79,989,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04144,606,016 - 144,670,696 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4478,431,841 - 78,492,217 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1478,707,973 - 78,721,124 (-)NCBI
Celera474,170,353 - 74,229,548 (-)NCBICelera
Cytogenetic Map4q24NCBI
Gsdme
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,701,893 - 26,769,989 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541026,700,977 - 26,761,683 (-)NCBIChiLan1.0ChiLan1.0
GSDME
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,555,469 - 29,615,294 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,880,196 - 77,940,638 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0725,373,485 - 25,433,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,977,838 - 25,039,525 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,977,838 - 25,039,525 (-)Ensemblpanpan1.1panPan2
GSDME
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11438,210,975 - 38,286,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1438,211,540 - 38,292,280 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1437,761,175 - 37,836,931 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01438,147,520 - 38,223,342 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1438,147,531 - 38,220,379 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11438,261,120 - 38,336,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,953,705 - 38,029,068 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01438,295,918 - 38,371,682 (-)NCBIUU_Cfam_GSD_1.0
Gsdme
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,443,029 - 82,508,175 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364781,655,487 - 1,720,996 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSDME
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12133,611,068 - 33,671,497 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2133,612,013 - 33,672,461 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604270,981,267 - 71,041,514 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsdme
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247395,798,771 - 5,871,088 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247395,790,372 - 5,879,979 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GSDME
3346 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 6 3 3 3 2 23 2 3
Below cutoff 4 1 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000061973   ⟹   ENSSSCP00000041192
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1847,526,797 - 47,583,731 (+)Ensembl
RefSeq Acc Id: XM_003134855   ⟹   XP_003134903
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,526,302 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673318   ⟹   XP_005673375
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,526,304 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005673319   ⟹   XP_005673376
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,526,304 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013985788   ⟹   XP_013841242
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,526,280 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078674   ⟹   XP_020934333
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,526,304 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078675   ⟹   XP_020934334
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,524,637 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021078676   ⟹   XP_020934335
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,524,637 - 47,583,748 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002340265
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11847,526,304 - 47,577,112 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020934334   ⟸   XM_021078675
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934335   ⟸   XM_021078676
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013841242   ⟸   XM_013985788
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003134903   ⟸   XM_003134855
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020934333   ⟸   XM_021078674
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005673376   ⟸   XM_005673319
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005673375   ⟸   XM_005673318
- UniProtKB: F1ST94 (UniProtKB/TrEMBL),   A0A8D0KCL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000041192   ⟸   ENSSSCT00000061973
Protein Domains
Gasdermin pore forming   Gasdermin PUB


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000016716 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005037969 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061973 ENTREZGENE
  ENSSSCT00000061973.3 UniProtKB/TrEMBL
  ENSSSCT00005060921.1 UniProtKB/TrEMBL
  ENSSSCT00005060948.1 UniProtKB/TrEMBL
InterPro Gasdermin_pore UniProtKB/TrEMBL
  Gasdermin_PUB UniProtKB/TrEMBL
  GSDME UniProtKB/TrEMBL
NCBI Gene GSDME ENTREZGENE
PANTHER GASDERMIN-E UniProtKB/TrEMBL
  PTHR15207 UniProtKB/TrEMBL
Pfam Gasdermin UniProtKB/TrEMBL
  Gasdermin_C UniProtKB/TrEMBL
UniProt A0A8D0KCL3 ENTREZGENE, UniProtKB/TrEMBL
  F1ST94 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88719 ENTREZGENE