Terc (telomerase RNA component) - Rat Genome Database

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Gene: Terc (telomerase RNA component) Rattus norvegicus
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Symbol: Terc
Name: telomerase RNA component
RGD ID: 727802
Description: Predicted to enable telomerase activity. Predicted to be involved in telomere maintenance via telomerase. Predicted to be part of telomerase catalytic core complex. Human ortholog(s) of this gene implicated in autosomal dominant dyskeratosis congenita 1; cervix uteri carcinoma in situ; melanoma; and prostate cancer. Orthologous to human TERC (telomerase RNA component); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; aflatoxin B1.
Type: ncrna (Ensembl: misc_RNA)
RefSeq Status: VALIDATED
Previously known as: telomerase RNA; Tr
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,744,148 - 114,744,535 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.22112,815,654 - 112,816,041 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2119,466,989 - 119,467,376 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,579,552 - 117,579,939 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02112,290,386 - 112,290,773 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02116,432,723 - 116,433,110 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,432,691 - 116,433,110 (+)Ensemblrn6Rnor6.0
Rnor_5.02136,126,300 - 136,126,687 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42117,234,446 - 117,234,833 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2107,993,694 - 107,994,082 (+)NCBICelera
RGSC_v3.12117,179,407 - 117,179,795 (+)NCBI
Cytogenetic Map2q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Expression of telomerase subunits in gastric cancer. Chen F, etal., J Huazhong Univ Sci Technolog Med Sci. 2005;25(6):741-3. doi: 10.1007/BF02896189.
2. Secondary structure of vertebrate telomerase RNA. Chen JL, etal., Cell 2000 Mar 3;100(5):503-14.
3. Telomerase RNA as a detection marker in the serum of breast cancer patients. Chen XQ, etal., Clin Cancer Res. 2000 Oct;6(10):3823-6.
4. High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor. Dome JS, etal., J Clin Oncol. 2005 Dec 20;23(36):9138-45. Epub 2005 Sep 19.
5. Gene amplifications associated with the development of hormone-resistant prostate cancer. Edwards J, etal., Clin Cancer Res. 2003 Nov 1;9(14):5271-81.
6. Detection of telomerase in urine by 3 methods: evaluation of diagnostic accuracy for bladder cancer. Eissa S, etal., J Urol. 2007 Sep;178(3 Pt 1):1068-72. Epub 2007 Jul 20.
7. Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer. Heselmeyer-Haddad K, etal., Am J Pathol. 2005 Apr;166(4):1229-38.
8. Genomic integration of oncogenic HPV and gain of the human telomerase gene TERC at 3q26 are strongly associated events in the progression of uterine cervical dysplasia to invasive cancer. Hopman AH, etal., J Pathol. 2006 Dec;210(4):412-9.
9. The effect on melanoma risk of genes previously associated with telomere length. Iles MM, etal., J Natl Cancer Inst. 2014 Sep 17;106(10). pii: dju267. doi: 10.1093/jnci/dju267. Print 2014 Oct.
10. Telomere length, telomerase activity and telomerase RNA expression during mouse mammary tumor progression. Kiyozuka Y, etal., Int J Mol Med. 1998 Oct;2(4):437-44.
11. Detection of human telomerase RNA in the tumour-surrounding mucosa of bladder carcinomas as a marker for premalignant transformation. Leuenroth S, etal., BJU Int. 2005 Sep;96(4):553-7.
12. Telomerase regulation of myofibroblast differentiation. Liu T, etal., Am J Respir Cell Mol Biol. 2006 May;34(5):625-33. Epub 2006 Jan 19.
13. Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer. Montanaro L, etal., J Pathol. 2006 Sep;210(1):10-8.
14. Expression of telomerase mRNA component (hTR) in transitional cell carcinoma of the upper urinary tract. Nakanishi K, etal., Cancer. 1999 Nov 15;86(10):2109-16.
15. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
16. Detection of telomerase RNA in the plasma of patients with breast cancer, malignant melanoma or thyroid cancer. Novakovic S, etal., Oncol Rep. 2004 Jan;11(1):245-52.
17. Up-regulation of telomerase in primary cultured rat hepatocytes. Nozawa K, etal., J Biochem (Tokyo) 1999 Aug;126(2):361-7.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. In situ nucleic acid detection of human telomerase in intrahepatic cholangiocarcinoma and its preneoplastic lesion. Ozaki S, etal., Hepatology. 1999 Oct;30(4):914-9. doi: 10.1002/hep.510300419.
20. Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. Poremba C, etal., J Pathol. 2002 Oct;198(2):181-9.
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue. Rohde V, etal., Clin Cancer Res. 2000 Dec;6(12):4803-9.
25. Telomerase in relation to expression of p53, c-Myc and estrogen receptor in ovarian tumours. Wisman GB, etal., Int J Oncol. 2003 Nov;23(5):1451-9.
Additional References at PubMed
PMID:9334263   PMID:9335332   PMID:11381263   PMID:15235603   PMID:15367665   PMID:17145779   PMID:17554309   PMID:17982445  


Genomics

Comparative Map Data
Terc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82114,744,148 - 114,744,535 (+)NCBIGRCr8GRCr8GRCr8
mRatBN7.22112,815,654 - 112,816,041 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2119,466,989 - 119,467,376 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02117,579,552 - 117,579,939 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02112,290,386 - 112,290,773 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02116,432,723 - 116,433,110 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,432,691 - 116,433,110 (+)Ensemblrn6Rnor6.0
Rnor_5.02136,126,300 - 136,126,687 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42117,234,446 - 117,234,833 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2107,993,694 - 107,994,082 (+)NCBICelera
RGSC_v3.12117,179,407 - 117,179,795 (+)NCBI
Cytogenetic Map2q24NCBI
TERC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383169,764,610 - 169,765,060 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3169,764,610 - 169,765,060 (-)Ensemblhg38GRCh38
GRCh373169,482,398 - 169,482,848 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363170,965,092 - 170,965,542 (-)NCBIBuild 36Build 36hg18NCBI36
Celera3167,881,540 - 167,881,990 (-)NCBICelera
Cytogenetic Map3q26.2NCBI
HuRef3166,852,038 - 166,852,488 (-)NCBIHuRef
CHM1_13169,445,476 - 169,445,926 (-)NCBICHM1_1
T2T-CHM13v2.03172,548,562 - 172,549,012 (-)NCBIT2T-CHM13v2.0
Terc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,321,753 - 96,322,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,321,753 - 96,322,149 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38396,414,437 - 96,414,833 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,414,437 - 96,414,859 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl396,414,437 - 96,414,833 (-)Ensemblmm10GRCm38
MGSCv37396,218,360 - 96,218,756 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36396,499,842 - 96,500,238 (-)NCBIMGSCv36mm8
Celera397,832,081 - 97,832,477 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.82NCBI

Variants

.
Variants in Terc
3 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)2105628029150628029Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
2317886Alcrsp23Alcohol response QTL 232.40.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)295142371140142371Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359035Bp276Blood pressure QTL 276arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2100807373145807373Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2106869825151869825Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)293602631145807373Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
7488933Bp368Blood pressure QTL 3680.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2104957381149957381Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1581552Pur12Proteinuria QTL 125.190.0009urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)2114032149150226270Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)2114440891159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH142549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,816,146 - 112,816,258 (+)MAPPERmRatBN7.2
Rnor_6.02116,433,216 - 116,433,327NCBIRnor6.0
Rnor_5.02136,126,793 - 136,126,904UniSTSRnor5.0
RGSC_v3.42117,234,939 - 117,235,050UniSTSRGSC3.4
Celera2107,994,188 - 107,994,299UniSTS
RH 3.4 Map2686.6UniSTS
Cytogenetic Map2q24UniSTS
RH143059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22112,815,731 - 112,815,985 (+)MAPPERmRatBN7.2
Rnor_6.02116,432,801 - 116,433,054NCBIRnor6.0
Rnor_5.02136,126,378 - 136,126,631UniSTSRnor5.0
RGSC_v3.42117,234,524 - 117,234,777UniSTSRGSC3.4
Celera2107,993,772 - 107,994,026UniSTS
RH 3.4 Map2713.7UniSTS
Cytogenetic Map2q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 9 42 84 79 78 48 65 48 6 267 131 10 55 68 47 30 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000084300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2116,432,691 - 116,433,110 (+)Ensembl
RefSeq Acc Id: NR_001567
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82114,744,148 - 114,744,535 (+)NCBI
mRatBN7.22112,815,654 - 112,816,041 (+)NCBI
Rnor_6.02116,432,723 - 116,433,110 (+)NCBI
Rnor_5.02136,126,300 - 136,126,687 (+)NCBI
RGSC_v3.42117,234,446 - 117,234,833 (+)RGD
Celera2107,993,694 - 107,994,082 (+)RGD
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727802 AgrOrtholog
BioCyc Gene G2FUF-53449 BioCyc
Ensembl Genes ENSRNOG00000051777 Ensembl
NCBI Gene 378461 ENTREZGENE
PhenoGen Terc PhenoGen
RatGTEx ENSRNOG00000051777 RatGTEx
RNAcentral URS00001ED027 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Terc  telomerase RNA component  Terc  telomerase RNA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Terc  telomerase RNA  Tr    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_evolution based on the similarities of the secondary structure of the telomerase RNA of vertebrates and ciliate organisms, it appears that its global architecture, but not its actual sequence, is strongly conserved evolutionarily 1299554
gene_regulation transcription is upregulated in rat hepatocytes in response to growth in serum-free medium 1299555