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Gene: Eif2ak1 (eukaryotic translation initiation factor 2 alpha kinase 1) Rattus norvegicus

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Symbol:

Eif2ak1

Name:

eukaryotic translation initiation factor 2 alpha kinase 1

RGD ID:

70883

Description:

Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; regulation of protein metabolic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; multicellular organismal-level iron ion homeostasis; and regulation of protein metabolic process. Predicted to be active in cytosol and nucleus. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

eukaryotic translation initiation factor 2-alpha kinase 1; HCR; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; hemin-sensitive initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2a kinase; Hri

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,824,431 - 15,858,266 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	15,825,124 - 15,858,281 (-)	Ensembl				GRCr8
mRatBN7.2	12	10,710,771 - 10,744,597 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,705,874 - 10,744,573 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	11,518,738 - 11,551,933 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	12,142,030 - 12,175,225 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	11,165,859 - 11,198,988 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	12,749,026 - 12,782,078 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,748,785 - 12,782,146 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	14,792,379 - 14,825,284 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	11,039,139 - 11,072,708 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	12,508,244 - 12,541,227 (-)	NCBI		Celera
RGSC_v3.1	12	10,969,549 - 11,102,636 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

Chemical and Drug Induced Liver Injury (ISO)

hemolytic anemia (ISO)

Leukoencephalopathy, Motor Delay, Spasticity, and Dysarthria Syndrome (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Splenomegaly (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bilirubin IXalpha (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbamazepine (ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diclofenac (ISO)

doxorubicin (ISO)

ethanol (ISO)

FR900359 (ISO)

gentamycin (EXP)

glafenine (EXP)

glyphosate (EXP)

josamycin (ISO)

lead nitrate (ISO)

lead(0) (ISO)

malonaldehyde (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methidathion (ISO)

methylmercury chloride (ISO)

nefazodone (EXP)

nimesulide (EXP)

nitric oxide (ISO)

oxaliplatin (EXP)

pirinixic acid (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute inflammatory response (ISO)

HRI-mediated signaling (IEA,ISO,ISS)

integrated stress response signaling (IEA,ISO,ISS)

macrophage differentiation (ISO)

multicellular organismal-level iron ion homeostasis (ISO)

negative regulation of cell population proliferation (IEA,ISO,ISS)

negative regulation of hemoglobin biosynthetic process (IEA,ISO,ISS)

negative regulation of translation (IEA)

phagocytosis (ISO)

positive regulation of mitophagy (IEA,ISO,ISS)

protein autophosphorylation (ISO,ISS)

protein localization to mitochondrion (IEA,ISO)

protoporphyrinogen IX metabolic process (ISO)

regulation of eIF2 alpha phosphorylation by heme (ISO)

regulation of hemoglobin biosynthetic process (ISO)

regulation of translation (IEA,ISO)

regulation of translational initiation (IBA)

response to iron ion starvation (IEA,ISO,ISS)

response to stress (IEA)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA)

Molecular Function

ATP binding (IEA)

eukaryotic translation initiation factor 2alpha kinase activity (IBA,IDA,IEA,ISO,ISS)

heme binding (IEA,ISO,ISS)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO,ISS)

protein kinase activity (IEA,ISO)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Endoplasmic Reticulum-associated degradation pathway (IEA)

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression.	Mellor H, etal., J Biol Chem 1994 Apr 8;269(14):10201-4.
4.	Gene Data Set	MGD Curation, June 12, 2002
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:10671563	PMID:11036079	PMID:11050009	PMID:11560503	PMID:11726526	PMID:15931390	PMID:17932563

Genomics

Comparative Map Data

Eif2ak1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	15,824,431 - 15,858,266 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	15,825,124 - 15,858,281 (-)	Ensembl				GRCr8
mRatBN7.2	12	10,710,771 - 10,744,597 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	10,705,874 - 10,744,573 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	11,518,738 - 11,551,933 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	12,142,030 - 12,175,225 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	11,165,859 - 11,198,988 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	12,749,026 - 12,782,078 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	12,748,785 - 12,782,146 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	14,792,379 - 14,825,284 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	11,039,139 - 11,072,708 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	12,508,244 - 12,541,227 (-)	NCBI		Celera
RGSC_v3.1	12	10,969,549 - 11,102,636 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

EIF2AK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	6,022,247 - 6,059,175 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	6,022,247 - 6,059,231 (-)	Ensembl			hg38	GRCh38
GRCh37	7	6,061,878 - 6,098,806 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	6,029,988 - 6,065,302 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	5,836,705 - 5,872,017	NCBI
Celera	7	6,637,836 - 6,674,825 (+)	NCBI		Celera
Cytogenetic Map	7	p22.1	NCBI
HuRef	7	5,933,661 - 5,969,897 (-)	NCBI		HuRef
CHM1_1	7	6,061,585 - 6,098,572 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	6,140,020 - 6,176,976 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	6,108,223 - 6,145,211 (-)	NCBI

Eif2ak1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	143,803,586 - 143,839,535 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	143,803,543 - 143,841,069 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	143,817,792 - 143,902,717 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	143,817,788 - 143,904,251 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	144,632,731 - 144,663,586 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	144,125,388 - 144,156,112 (+)	NCBI		MGSCv36	mm8
Celera	5	140,849,644 - 140,884,939 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	82.67	NCBI

Eif2ak1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	13,723,777 - 13,754,150 (+)	Ensembl
ChiLan1.0	NW_004955460	13,723,674 - 13,754,545 (+)	NCBI	ChiLan1.0	ChiLan1.0

EIF2AK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	11,611,603 - 11,647,378 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	59,936,328 - 59,972,089 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	7,382,669 - 7,418,469 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	6,221,342 - 6,256,399 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	6,222,187 - 6,256,252 (-)	Ensembl			panPan2	panpan1.1

EIF2AK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	11,447,225 - 11,478,611 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	11,447,081 - 11,478,658 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	13,072,983 - 13,104,439 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	11,447,489 - 11,478,966 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	11,446,574 - 11,479,049 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	11,324,176 - 11,355,599 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	11,303,440 - 11,334,903 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	11,530,063 - 11,561,526 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Eif2ak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	139,515,266 - 139,555,356 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936750	389,845 - 432,460 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936750	389,913 - 430,783 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EIF2AK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	5,075,054 - 5,113,622 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	5,075,026 - 5,113,390 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	5,136,781 - 5,170,736 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EIF2AK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	15,225,768 - 15,269,692 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	15,233,909 - 15,269,594 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666102	820,984 - 859,948 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eif2ak1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	31,274,483 - 31,306,430 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	31,223,583 - 31,306,749 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Eif2ak1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	9,278,993 - 9,316,435 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Eif2ak1
260 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	153
Count of miRNA genes:	101
Interacting mature miRNAs:	119
Transcripts:	ENSRNOT00000001392
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1357337	Gluco3	Glucose level QTL 3		0.0004	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	12	1	16966671	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	11869600	16966542	Rat
61334	Gluco17	Glucose level QTL 17	6.3		adipocyte glucose uptake trait (VT:0004185)	adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)	12	1	16966671	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

BI293383

Rat Assembly	Chr	Position (strand)	Source
Celera	20	642,758 - 642,956	UniSTS
RH 3.4 Map	20	53.73	UniSTS
Cytogenetic Map	20	p12	UniSTS

RH128540

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,222,572 - 3,222,781 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	3,746,676 - 3,746,884	NCBI	Rnor6.0
Rnor_5.0	20	5,833,418 - 5,833,626	UniSTS	Rnor5.0
Celera	20	649,770 - 649,978	UniSTS
RH 3.4 Map	20	53.23	UniSTS
Cytogenetic Map	20	p12	UniSTS

RH142857

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,738,458 - 10,738,577 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,776,029 - 12,776,147	NCBI	Rnor6.0
Rnor_5.0	12	14,819,233 - 14,819,351	UniSTS	Rnor5.0
RGSC_v3.4	12	11,066,659 - 11,066,777	UniSTS	RGSC3.4
Celera	12	12,535,172 - 12,535,290	UniSTS
Cytogenetic Map	12	p11	UniSTS

BI293046

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,205,800 - 3,205,961 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	3,731,094 - 3,731,254	NCBI	Rnor6.0
Rnor_5.0	20	5,817,836 - 5,817,996	UniSTS	Rnor5.0
Celera	20	632,879 - 633,039	UniSTS
RH 3.4 Map	20	15.8	UniSTS
Cytogenetic Map	20	p12	UniSTS

BE120231

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	10,723,081 - 10,723,244 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	12,760,653 - 12,760,815	NCBI	Rnor6.0
Rnor_5.0	12	14,803,857 - 14,804,019	UniSTS	Rnor5.0
RGSC_v3.4	12	11,051,282 - 11,051,444	UniSTS	RGSC3.4
Celera	12	12,519,800 - 12,519,962	UniSTS
RH 3.4 Map	12	121.6	UniSTS
Cytogenetic Map	12	p11	UniSTS

Pou5f1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,223,376 - 3,223,553 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	3,747,480 - 3,747,656	NCBI	Rnor6.0
Rnor_5.0	20	5,834,222 - 5,834,398	UniSTS	Rnor5.0
Celera	20	650,574 - 650,750	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111575	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC126486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081838	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L27707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001392 ⟹ ENSRNOP00000001392

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	15,825,124 - 15,858,281 (-)	Ensembl
mRatBN7.2 Ensembl	12	10,705,874 - 10,744,573 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,748,785 - 12,782,139 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079836 ⟹ ENSRNOP00000075036

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	15,825,124 - 15,858,197 (-)	Ensembl
mRatBN7.2 Ensembl	12	10,705,874 - 10,744,573 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,749,081 - 12,782,146 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092346 ⟹ ENSRNOP00000075792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	12	12,752,073 - 12,752,583 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092482

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	15,827,466 - 15,858,197 (-)	Ensembl
mRatBN7.2 Ensembl	12	10,710,849 - 10,733,937 (-)	Ensembl
Rnor_6.0 Ensembl	12	12,752,472 - 12,757,217 (-)	Ensembl

RefSeq Acc Id:

NM_013223 ⟹ NP_037355

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,825,113 - 15,858,164 (-)	NCBI
mRatBN7.2	12	10,711,453 - 10,744,508 (-)	NCBI
Rnor_6.0	12	12,749,026 - 12,782,078 (-)	NCBI
Rnor_5.0	12	14,792,379 - 14,825,284 (-)	NCBI
RGSC_v3.4	12	11,039,139 - 11,072,708 (-)	RGD
Celera	12	12,508,244 - 12,541,227 (-)	RGD

Sequence:

show sequence

CTCGCGGCAACGATGCTGGGGGGCGGCTCCGTGGATGGCGAGCGCGACACGGACGACGACGCGG
CGGGGGCGGTGGCCGCGCCTCCTGCCATCGACTTCCCCGCAGAGGTGTCGGACCCCAAGTATGA
TGAGTCCGATGTCCCAGCAGAGCTCCAAGTGTTCAAAGAGCCCTTGCAGCAGCCCACGTTCCCT
TTCTTAGTGGCAAACCAGCTGCTGCTGGTCTCCTTGCTGGAACACTTGAGCCATGTGCACGAGC
CGAACCCACTTCACTCAAAACAGGTCTTTAAATTACTGTGCCAGACTTTTATCAAGATGGGGCT
GCTCTCTTCCTTTACCTGCAGCGATGAGTTCAGCTCCCTGAGACTCCACCACAACAGAGCCATC
ACTCATTTAATGAGGTCTGCCAAGGAGAGAGTCCGTCAGGATCCTTGTCAAGATAATTCTTACA
TGCAGAAAATCAGATCCAGGGAGATAGCTCTCGAAGCACAGACTTCACGCTACTTAAATGAATT
TGAAGAGCTCGCCATCTTAGGAAAAGGCGGATATGGAAGAGTTTACAAGGTCCGGAACAAATTA
GATGGTCAGCATTATGCAATTAAGAAAATCCTGATTAAGAGTGCAACTAAAACGGATTGTATGA
AGGTGCTACGGGAAGTGAAGGTTCTGGCAGGCCTCCAGCACCCCAATATCGTTGGCTACCACAC
TGCATGGATAGAGCACGTTCACGTGCTTCAGCCACAAGACAGAGTTCCCATTCAACTGCCCTCT
CTTGAAGTGTTGTCAGAGCATGAAGGGGACAGAAATCAAGGTGGTGTTAAAGATAATGAAAGCA
GTTCGTCCATTATCTTTGCTGAACTCACCCCAGAAAAAGAAAACCCTTTAGCGGAATCTGATGT
TAAGAATGAGAATAACAACTTGGTGAGCTACAGGGCCAACTTAGTGATCAGGAGCAGCAGTGAA
AGCGAATCGTCCATTGAGCTCCAAGAAGATGGCTTGAACGAGTCGCCTCTCAGACCAGTTGTCA
AGCACCAGCTGCCGCTGGGGCATAGCTCAGACGTGGAAGGGAATTTTACCTCCACGGATGAGTC
TTCTGAAGACAATTTGAACCTGCTGGGGCAGACAGAGGCGCGGTACCACCTGATGCTGCACATC
CAGATGCAGCTGTGTGAGCTCTCCCTGTGGGACTGGATAGCTGAGAGGAACAAGCGGAGCCGGA
AGTGCGTGGATGAAGCAGCTTGTCCCTATGTTATGGCCAGTGTTGCAACAAAGATTTTTCAAGA
ACTGGTGGAAGGTGTCTTTTACATACATAACATGGGCATCGTCCACAGAGATCTGAAGCCTAGA
AATATTTTTCTTCATGGTCCTGATCAACAAGTGAAAATAGGAGACTTTGGTCTGGCCTGTGCAG
ACATCATTCAGAAGAGCGCAGATTGGACCAACAGAAACGGGAAAGGAACGCCGACACACACGTC
CCGAGTGGGGACTTGTCTCTACGCGTCACCTGAGCAGTTGGAAGGATCCGAGTATGATGCCAAG
TCTGATATGTACAGCTTGGGTGTGATCCTGCTCGAGCTCTTCCAGCCATTCGGGACAGAAATGG
AGCGAGCAACAGTCCTAACAGGTGTGAGGACTGGTCGGATACCAGAGTCCCTCAGTAAAAGGTG
TCCAGTGCAAGCCAAGTATATCCAGCTCCTGACTGGGAGGAACGCGGCCCAGAGACCATCTGCT
CTTCAGCTACTGCAGAGCGAACTGTTCCAAACAACGGGAAATGTTAATCTCACATTGCAGATGA
AGATAATGGAGCAAGAAAAGGAAATTGAAGAATTAAAGAAGCAACTAAGCCTCCTTTCGCAGGA
CAAAGGGCTGAAGAGATGAGAGGGAAATGGGGGCCTACCTGTGTAGCCTGAATTATGCTCTCAA
CCATGTGAAAGTGGACTTGCATTCTTAAAAGTCACCAGGGATGTAAATTTTCAACCCTTAGCTG
AGGACGGGTGTGACTCCCAATTGTACTGAGCAAAGCTGTGTAAAGAGGTGAAAGGACGGTGGCT
GGGGATTTAGCTCAGTGGTAGAGTCGCTTACCTAGGAAGTCGCAAGGTCCCTGGGTTCGGTCCC
CAGCTCCGGAAAAAAAGAACTAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039089135 ⟹ XP_038945063

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	15,824,431 - 15,858,266 (-)	NCBI
mRatBN7.2	12	10,710,771 - 10,744,596 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_037355	(Get FASTA)	NCBI Sequence Viewer
	XP_038945063	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA18255	(Get FASTA)	NCBI Sequence Viewer
	AAH81838	(Get FASTA)	NCBI Sequence Viewer
	EDL89653	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001392
	ENSRNOP00000001392.4
	ENSRNOP00000075036
GenBank Protein	Q63185	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037355 ⟸ NM_013223

- UniProtKB:

Q642C7 (UniProtKB/Swiss-Prot), Q63185 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLGGGSVDGERDTDDDAAGAVAAPPAIDFPAEVSDPKYDESDVPAELQVFKEPLQQPTFPFLVA
NQLLLVSLLEHLSHVHEPNPLHSKQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHHNRAITHLM
RSAKERVRQDPCQDNSYMQKIRSREIALEAQTSRYLNEFEELAILGKGGYGRVYKVRNKLDGQH
YAIKKILIKSATKTDCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVLQPQDRVPIQLPSLEVL
SEHEGDRNQGGVKDNESSSSIIFAELTPEKENPLAESDVKNENNNLVSYRANLVIRSSSESESS
IELQEDGLNESPLRPVVKHQLPLGHSSDVEGNFTSTDESSEDNLNLLGQTEARYHLMLHIQMQL
CELSLWDWIAERNKRSRKCVDEAACPYVMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFL
HGPDQQVKIGDFGLACADIIQKSADWTNRNGKGTPTHTSRVGTCLYASPEQLEGSEYDAKSDMY
SLGVILLELFQPFGTEMERATVLTGVRTGRIPESLSKRCPVQAKYIQLLTGRNAAQRPSALQLL
QSELFQTTGNVNLTLQMKIMEQEKEIEELKKQLSLLSQDKGLKR

hide sequence

Ensembl Acc Id:

ENSRNOP00000075792 ⟸ ENSRNOT00000092346

Ensembl Acc Id:

ENSRNOP00000075036 ⟸ ENSRNOT00000079836

Ensembl Acc Id:

ENSRNOP00000001392 ⟸ ENSRNOT00000001392

RefSeq Acc Id:	XP_038945063 ⟸ XM_039089135
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K9K9 (UniProtKB/TrEMBL)

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63185-F1-model_v2	AlphaFold	Q63185	1-620	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698435

Promoter ID:

EPDNEW_R8960

Type:

initiation region

Name:

Eif2ak1_1

Description:

eukaryotic translation initiation factor 2 alpha kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	12,782,102 - 12,782,162	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70883	AgrOrtholog
BioCyc Gene	G2FUF-20019	BioCyc
Ensembl Genes	ENSRNOG00000001050	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001392	ENTREZGENE
	ENSRNOT00000001392.9	UniProtKB/Swiss-Prot
	ENSRNOT00000079836	ENTREZGENE
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	CC_SR_Kinase	UniProtKB/Swiss-Prot
	HRI2_3H	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:27137	UniProtKB/Swiss-Prot
NCBI Gene	Eif2ak1	ENTREZGENE
PANTHER	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1	UniProtKB/Swiss-Prot
	EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED	UniProtKB/Swiss-Prot
Pfam	HRI2_3H	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Eif2ak1	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001050	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
UniProt	A0A0G2K9K9	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6G5F3_RAT	UniProtKB/TrEMBL
	E2AK1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q642C7	ENTREZGENE
UniProt Secondary	Q642C7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2003-04-09	Eif2ak1	eukaryotic translation initiation factor 2 alpha kinase 1			Symbol and Name updated	629477	APPROVED
2003-03-11	Eif2ak1	eukaryotic translation initiation factor 2 alpha kinase 1	Hri	hemin-sensitive initiation factor 2a kinase	Data merged from RGD:619810	628472	PROVISIONAL
2002-08-07	Hri	hemin-sensitive initiation factor 2a kinase			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-07-09	Eif2ak1	eukaryotic translation initiation factor 2 alpha kinase 1			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed in all tissues studied	70728
gene_homology	protein aa sequence shares 82% homology with rabbit reticulocyte HCR	70728
gene_regulation	downregulated by hemin, a hemoglobin precursor	70728

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)