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Gene: Afdn (afadin, adherens junction formation factor) Rattus norvegicus

Analyze

Symbol:

Afdn

Name:

afadin, adherens junction formation factor

RGD ID:

708561

Description:

Enables LIM domain binding activity. Involved in several processes, including dendrite arborization; positive regulation of mini excitatory postsynaptic potential; and regulation of cell morphogenesis. Located in several cellular components, including adherens junction; axon; and excitatory synapse. Is active in glutamatergic synapse. Orthologous to human AFDN (afadin, adherens junction formation factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Af6; afadin; Mllt4; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog (Drosophila); myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; protein Af-6; translocated to, 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AFDN (afadin, adherens junction formation factor)	HGNC	Ensembl, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Afdn (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Afdn (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AFDN (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AFDN (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Afdn (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AFDN (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AFDN (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Afdn (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Afdn (afadin, adherens junction formation factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	AFDN (afadin, adherens junction formation factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Afdn (afadin, adherens junction formation factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	afd-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	afdna	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	cno	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	afdn	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	afdn	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	58,041,065 - 58,170,505 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	58,041,641 - 58,170,505 (+)	Ensembl				GRCr8
mRatBN7.2	1	53,905,344 - 54,034,216 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	53,905,373 - 54,034,216 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	55,490,165 - 55,631,752 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	61,552,688 - 61,681,463 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	55,432,745 - 55,574,335 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	53,713,873 - 53,861,918 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	53,715,693 - 53,802,658 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	54,955,635 - 55,043,460 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	48,827,687 - 48,913,175 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	50,355,039 - 50,445,230 (-)	NCBI		Celera
RGSC_v3.1	1	48,790,891 - 48,914,438 (+)	NCBI
Cytogenetic Map	1	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

breast carcinoma (ISO)

Parkinson's disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

calcitriol (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP,ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

diuron (EXP)

dorsomorphin (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

fenvalerate (EXP)

formaldehyde (ISO)

FR900359 (ISO)

furfural (ISO)

genistein (ISO)

glycidol (EXP)

hydrogen cyanide (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methidathion (ISO)

okadaic acid (ISO)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (EXP,ISO)

potassium cyanide (ISO)

rofecoxib (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adherens junction maintenance (ISO)

bicellular tight junction assembly (ISO)

brain morphogenesis (ISO)

cell adhesion (IEA)

cell differentiation (IEA)

cell junction organization (IEA)

cell-cell adhesion mediated by cadherin (ISO)

cerebral cortex development (ISO)

dendrite arborization (IMP)

establishment of endothelial intestinal barrier (ISO)

establishment of protein localization to plasma membrane (ISO)

homeostasis of number of cells (ISO)

negative regulation of cell migration (ISO)

neuroepithelial cell differentiation (ISO)

pore complex assembly (ISO)

positive regulation of cell-cell adhesion (ISO)

positive regulation of cell-cell adhesion mediated by cadherin (ISO)

positive regulation of dendrite extension (IMP)

positive regulation of dendrite morphogenesis (IMP)

positive regulation of dendritic spine morphogenesis (IMP)

positive regulation of gene expression (ISO)

positive regulation of mini excitatory postsynaptic potential (IMP)

postsynaptic specialization organization (IDA,IMP)

protein localization to cell junction (ISO)

radial glial cell differentiation (ISO)

regulation of oligodendrocyte progenitor proliferation (ISO)

regulation of postsynapse assembly (ISO)

regulation of postsynapse organization (IEA)

regulation of protein localization (IBA)

signal transduction (IEA)

telencephalon development (ISO)

Cellular Component

adherens junction (IBA,IDA,IEA,ISO)

apical junction complex (ISO)

apical part of cell (ISO)

axon (IDA)

cell junction (ISO)

cell-cell contact zone (ISO)

cell-cell junction (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (TAS)

excitatory synapse (IDA)

glutamatergic synapse (IDA,IMP)

hippocampal mossy fiber to CA3 synapse (ISO)

nucleoplasm (ISO)

plasma membrane (ISO)

pore complex (ISO)

postsynaptic density membrane (ISO)

presynaptic active zone membrane (ISO)

somatodendritic compartment (IDA)

tight junction (ISO)

Molecular Function

actin filament binding (ISO)

cell adhesion molecule binding (IBA,ISO)

LIM domain binding (IPI)

protein binding (IPI,ISO)

small GTPase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

platelet-derived growth factor signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions.	Asada M, etal., J Biol Chem 2003 Feb 7;278(6):4103-11.
2.	Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1.	Ebnet K, etal., J Biol Chem. 2000 Sep 8;275(36):27979-88.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease.	Haskin J, etal., Hum Mol Genet. 2013 May 15;22(10):2083-96. doi: 10.1093/hmg/ddt058. Epub 2013 Feb 7.
6.	nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP).	Kawabe H, etal., J Biol Chem 1999 Oct 22;274(43):30914-8.
7.	Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.	Kurita S, etal., J Biol Chem. 2013 Oct 11;288(41):29356-68. doi: 10.1074/jbc.M113.453464. Epub 2013 Aug 29.
8.	Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.	Letessier A, etal., Oncogene. 2007 Jan 11;26(2):298-307. doi: 10.1038/sj.onc.1209772. Epub 2006 Jul 3.
9.	Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.	Lim ST, etal., J Comp Neurol. 2008 Mar 10;507(2):1228-44.
10.	Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction.	Mandai K, etal., J Cell Biol 1997 Oct 20;139(2):517-28.
11.	s-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons.	Maruo T, etal., J Biol Chem. 2023 Apr;299(4):103040. doi: 10.1016/j.jbc.2023.103040. Epub 2023 Feb 18.
12.	Spermine increases arginase activity in the liver after carbon tetrachloride-induced hepatic injury in Long-Evans rats.	Mendez JD, etal., Biomed Pharmacother. 2006 Feb;60(2):82-5. Epub 2005 Dec 27.
13.	Purification and molecular cloning of succinyltransferase of the rat alpha-ketoglutarate dehydrogenase complex. Absence of a sequence motif of the putative E3 and/or E1 binding site.	Nakano K, etal., J Biol Chem 1991 Oct 5;266(28):19013-7.
14.	Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells.	Ooshio T, etal., J Biol Chem 2004 Jul 23;279(30):31365-73. Epub 2004 May 12.
15.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16.	Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions.	Rehm K, etal., J Cell Sci. 2013 Aug 15;126(Pt 16):3756-69. doi: 10.1242/jcs.129437. Epub 2013 Jun 7.
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Afadin is required for maintenance of dendritic structure and excitatory tone.	Srivastava DP, etal., J Biol Chem. 2012 Oct 19;287(43):35964-74. doi: 10.1074/jbc.M112.363358. Epub 2012 Sep 4.
19.	Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins.	Tachibana K, etal., J Cell Biol. 2000 Sep 4;150(5):1161-76.

Additional References at PubMed

PMID:8889548	PMID:9707552	PMID:10225955	PMID:10704870	PMID:11731229	PMID:12203721	PMID:12515806	PMID:15489334	PMID:15509704	PMID:15728677	PMID:16301177	PMID:16396499
PMID:16641100	PMID:16882694	PMID:17013812	PMID:18604197	PMID:19461049	PMID:21478912	PMID:22027834	PMID:22512338	PMID:23885123	PMID:24567331	PMID:25100583	PMID:25468996
PMID:25808489	PMID:25893857	PMID:27815408	PMID:30268521	PMID:30463011	PMID:30572094	PMID:32357304

Genomics

Comparative Map Data

Afdn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	58,041,065 - 58,170,505 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	58,041,641 - 58,170,505 (+)	Ensembl				GRCr8
mRatBN7.2	1	53,905,344 - 54,034,216 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	53,905,373 - 54,034,216 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	55,490,165 - 55,631,752 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	61,552,688 - 61,681,463 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	55,432,745 - 55,574,335 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	53,713,873 - 53,861,918 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	53,715,693 - 53,802,658 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	54,955,635 - 55,043,460 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	48,827,687 - 48,913,175 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	50,355,039 - 50,445,230 (-)	NCBI		Celera
RGSC_v3.1	1	48,790,891 - 48,914,438 (+)	NCBI
Cytogenetic Map	1	q12	NCBI

AFDN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	167,826,564 - 167,972,023 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	167,826,859 - 167,972,023 (+)	Ensembl			hg38	GRCh38
GRCh37	6	168,227,244 - 168,372,703 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	167,970,520 - 168,115,552 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	168,046,368 - 168,171,498	NCBI
Celera	6	168,944,733 - 169,081,690 (+)	NCBI		Celera
Cytogenetic Map	6	q27	NCBI
HuRef	6	165,693,043 - 165,800,385 (+)	NCBI		HuRef
CHM1_1	6	168,490,726 - 168,635,428 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	169,164,770 - 169,309,528 (+)	NCBI		T2T-CHM13v2.0

Afdn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	13,980,735 - 14,126,059 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	13,980,801 - 14,126,412 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	13,760,391 - 13,905,798 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	13,760,539 - 13,906,150 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	13,897,548 - 14,042,801 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	13,497,079 - 13,642,343 (+)	NCBI		MGSCv36	mm8
Celera	17	14,603,626 - 14,705,325 (+)	NCBI		Celera
Cytogenetic Map	17	A1- A2	NCBI
cM Map	17	8.95	NCBI

Afdn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955439	14,326,793 - 14,428,850 (-)	Ensembl
ChiLan1.0	NW_004955439	14,324,910 - 14,428,846 (-)	NCBI	ChiLan1.0	ChiLan1.0

AFDN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	188,019,190 - 188,164,989 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	185,907,465 - 186,052,560 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	165,778,026 - 165,923,685 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	170,776,707 - 170,882,784 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	170,775,904 - 170,882,784 (+)	Ensembl			panPan2	panpan1.1

AFDN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	55,435,451 - 55,535,534 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	55,435,472 - 55,535,543 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	56,188,344 - 56,325,812 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	55,579,883 - 55,717,395 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	55,579,898 - 55,717,391 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	55,476,722 - 55,614,176 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	55,323,987 - 55,461,386 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	55,950,758 - 56,088,230 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Afdn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	149,626,431 - 149,719,240 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936489	16,878,321 - 16,971,311 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936489	16,878,423 - 16,971,229 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AFDN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	1,570,272 - 1,698,694 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	1,569,652 - 1,698,475 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	2,720,204 - 2,814,551 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AFDN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	95,646,820 - 95,788,662 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	95,646,887 - 95,789,437 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	67,478,670 - 67,620,627 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Afdn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624785	11,551,687 - 11,697,921 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624785	11,549,805 - 11,698,029 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Afdn
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	183,478,953 - 183,499,338 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Afdn
1007 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	255
Count of miRNA genes:	172
Interacting mature miRNAs:	199
Transcripts:	ENSRNOT00000032667, ENSRNOT00000042807
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
1357397	Bw41	Body weight QTL 41	4.19	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	29409279	74409279	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1578756	Iddm22	Insulin dependent diabetes mellitus QTL 22	2.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	20508326	65508326	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
1300172	Bp172	Blood pressure QTL 172	3.56		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	34565726	79565726	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	51909206	91302615	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
634353	Rends2	Renal damage susceptibility QTL 2		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	1	20656420	65656420	Rat

Markers in Region

RH129150

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	54,033,983 - 54,034,189 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	53,713,900 - 53,714,105	NCBI	Rnor6.0
Rnor_5.0	1	54,955,662 - 54,955,867	UniSTS	Rnor5.0
RGSC_v3.4	1	48,912,943 - 48,913,148	UniSTS	RGSC3.4
Celera	1	50,355,066 - 50,355,271	UniSTS
RH 3.4 Map	1	636.2	UniSTS
Cytogenetic Map	1	q12	UniSTS

RH129198

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	54,033,983 - 54,034,194 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	53,713,895 - 53,714,105	NCBI	Rnor6.0
Rnor_5.0	1	54,955,657 - 54,955,867	UniSTS	Rnor5.0
RGSC_v3.4	1	48,912,943 - 48,913,153	UniSTS	RGSC3.4
Celera	1	50,355,061 - 50,355,271	UniSTS
RH 3.4 Map	1	636.6	UniSTS
Cytogenetic Map	1	q12	UniSTS

RH143433

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	53,970,484 - 53,970,679 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	53,776,437 - 53,776,631	NCBI	Rnor6.0
Rnor_5.0	1	55,018,199 - 55,018,393	UniSTS	Rnor5.0
Celera	1	50,418,540 - 50,418,734	UniSTS
RH 3.4 Map	1	646.3	UniSTS
Cytogenetic Map	1	q12	UniSTS

RH143971

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	54,026,890 - 54,027,065 (-)	MAPPER	mRatBN7.2
Rnor_6.0	1	53,720,964 - 53,721,138	NCBI	Rnor6.0
Rnor_5.0	1	54,962,726 - 54,962,900	UniSTS	Rnor5.0
RGSC_v3.4	1	48,905,852 - 48,906,026	UniSTS	RGSC3.4
Celera	1	50,362,188 - 50,362,362	UniSTS
RH 3.4 Map	1	651.5	UniSTS
Cytogenetic Map	1	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_013217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282472	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282492	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282497	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282503	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282563	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA963026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA511204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK476731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CN542111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EV767501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U83230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U83231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000032667 ⟹ ENSRNOP00000029044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	58,041,641 - 58,170,505 (+)	Ensembl
mRatBN7.2 Ensembl	1	53,905,373 - 54,025,006 (+)	Ensembl
Rnor_6.0 Ensembl	1	53,715,693 - 53,802,658 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096238 ⟹ ENSRNOP00000079686

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	58,080,269 - 58,170,505 (+)	Ensembl
mRatBN7.2 Ensembl	1	53,943,977 - 54,034,216 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096510 ⟹ ENSRNOP00000094008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	58,080,269 - 58,170,505 (+)	Ensembl
mRatBN7.2 Ensembl	1	53,943,977 - 54,034,216 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106034 ⟹ ENSRNOP00000088861

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	58,041,641 - 58,170,505 (+)	Ensembl
mRatBN7.2 Ensembl	1	53,905,373 - 54,034,216 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107704 ⟹ ENSRNOP00000078878

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	58,041,641 - 58,170,505 (+)	Ensembl
mRatBN7.2 Ensembl	1	53,905,373 - 54,034,216 (+)	Ensembl

RefSeq Acc Id:

NM_013217 ⟹ NP_037349

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,641 - 58,170,505 (+)	NCBI
mRatBN7.2	1	53,905,344 - 54,034,216 (+)	NCBI
Rnor_6.0	1	53,713,873 - 53,861,918 (-)	NCBI
Rnor_5.0	1	54,955,635 - 55,043,460 (-)	NCBI
RGSC_v3.4	1	48,827,687 - 48,913,175 (+)	RGD
Celera	1	50,355,039 - 50,445,230 (-)	RGD

Sequence:

show sequence

CTTGCACACTGCCGTGGTTTGGAAGAAGCGAACACTGAAGACGCTACTGTTGTTAATGACCATC
TTCCTGCTGTCAGGGTAACCTGGTCCCTGACATAAGGAGACCCCAGGCAGGGAACGTCTCCCTA
GAGGGCAGTTCCCCTTCTGGAAGGCAGAAAGCGAGCGGCTGAACGCCCGGGACACGCAGCGGGA
CCGGGACAGCATCGCGGAGCCAGCGGGATGGAGGGCGGGAGGACGCGCGGCGGCTGCGGCGGCG
GCGGTGGTGGTGGTGAGGCGGCCTGAGGTGTTCCGGCCCAGCGGGTCGCGGAGAGGAGCCGCCG
CGATCATGTCGGCGGGCGGCCGCGACGAAGAGCGGCGGAAGCTGGCCGACATCATTCACCACTG
GAACGCCAACCGGCTGGACCTGTTCGAGATCAGCCAGCCGACCGAGGATTTGGAGTTTCATGGA
GTCATGAGATTTTATTTTCAAGATAAAGCTGCTGGAAACTTTGCAACAAAATGTATTCGGGTCT
CTAGCACAGCAACCACTCAAGATGTCATTGAAACACTGGCAGAGAAGTTCCGCCCTGATATGCG
CATGCTCTCCTCTCCCAAGTACTCCCTCTATGAAGTGCATGTCAGTGGAGAAAGAAGATTGGAC
ATTGATGAGAAACCTCTAGTTGTACAGTTGAATTGGAACAAAGATGATCGGGAGGGTAGATTCG
TCCTTAAGAACGAGAATGACGCCATTCCTGCCAAGAAGGCTCAGAGTAATGGACCTGAGAAGCA
GGAGAAAGAAGGTGTTATTCAGAACTTCAAAAGAACTCTGTCAAAGAAAGAAAAGAAGGAAAAA
AAGAAGAGAGAGAAGGAGGCTTTGAGACAAGCCTCTGATAAGGAAGAAAGGCCTTCTCAAGGGG
ATGACAGTGAGAATTCTCGTCTGGCTGCTGAAGTTTACAAAGACATGCCTGAAACCAGCTTTAC
TCGAACGATTTCTAATCCTGAAGTTGTTATGAAACGGCGGCGGCAGCAAAAACTGGAGAAGAGA
ATGCAAGAGTTTCGGAGCTCAGATGGGCGGCCCGACTCGGGTGGAACACTGAGAATCTATGCAG
ACAGTTTAAAACCAAATATTCCATACAAGACAATCCTGCTGTCTACTACAGATCCTGCAGACTT
TGCTGTAGCAGAGTCCTTAGAGAAGTATGGTCTGGAAAAAGAGAACCCCAAGGACTACTGCATT
GCTCGGGTTATGCTTCCTCCTGGAGCCCAGCATTCTGATGAGAGAGGTGCTAAGGAAATAATTC
TTGATGACGATGAATGCCCTTTACAAATCTTCAGGGAATGGCCAAGTGACAAAGGGATTTTAGT
CTTTCAGTTGAAGAGGAGACCACCGGACTACATTCCAAAGAAAATGAAGAAACATGTTGAAGGC
AAGCCATTGAAGGGGAAAGATAGAGCTGACGGGTCTGGCTACGGCTCTGCTCTTCCTCCTGAGA
AGCTGCCCTACTTAGTAGAGCTCAGCCCAGGGAGAAGGAATCACTTTGCCTACTACAGCTATCA
CACTTACGAAGATGGCTCTGACTCCAGAGACAAGCCAAAGTTATACCGCCTTCAGTTAAGTGTG
ACTGAAGTTGGGACAGAGAAGTTCGATGACAATTCTATTCAGCTGTTTGGTCCTGGAATTCAGC
CCCATCACTGTGATCTCACCAACATGGATGGAGTGGTCACTGTGACACCCAGAAGTATGGATGC
AGAGACCTATGTGGATGGTCAGCGCATCTCAGAGACCACAATGCTACAGAGTGGCATGAGACTG
CAGTTTGGCACCTCGCATGTGTTTAAGTTTGTGGACCCCATCCAGGACCACGTTCTTTCCAAGA
GATCTGTGGATGGAGGCCTGATGGTCAAGGGCCCAAGACATAAACCTGGAGCCGTTCAAGAGAC
AACCTTTGAATTGGGAGGAGATATCCACAGTGGGACAGCATTGCCGGCAAGCAGGAGCACTACT
AGATTGGACAGTGACAGGGTGTCCTCTGCCTCTAGCACAGCTGAGCGAGGGATGGTGAAGCCAA
TGATCCGACTGGACCAGGAGCAGGACTACCGGCGAAGAGAAAGCAGGACTCAGGATGCTGCTGG
GCCTGAACTGATGCTGCCTGCCAGCATTGAATTCCGGGAAAGCTCTGAAGACTCTTTTTTATCT
GCCATTATAAACTATACCAATAGCTCTACAGTTCATTTTAAGTTGTCACCTACATATGTGTTAT
ACATGGCATGCCGGTATGTATTGTCCAGCCAGCACAGGCCCGACATCAGTCCTACAGAGCGGAC
ACATAAGGCCATTGCTGTTGTGAACAAGATGGTGAGCATGATGGAAGGGGTCATCCAGGAAGTA
GACCAGGTTGATCAGAAACAGAAGAACATTGCAGGAGCACTTGCTTTCTGGATGGCAAATGCAT
CTGAGCTTCTCAACTTCATCAAGCAGGACCGAGACCTTAGTCGGATTACTCTGGATGCCCAGGA
TGTTCTAGCACACTTGGTTCAGATGGCATTTAAGTACTTGGTTCACTGCCTTCAGTCAGAACTT
AATAACTACATGCCAGCCTTTCTGGATGATCCCGAGGAGAACAGTCTGCAGAGACCAAAAATAG
ATGATGTGCTGCATACGCTCACAGGAGCCATGTCCTTGTTGCGGCGCTGCAGAGTCAATGCCGC
CTTGACCATCCAGCTGTTCTCTCAGCTTTTCCACTTCATCAATATGTGGCTATTCAACAGACTG
GTGACTGACCCAGATTCAGGCCTGTGTTCCCACTACTGGGGCGCAATTATCCGCCAGCAGCTGG
GGCATATTGAAGCTTGGGCAGAGAAGCAGGGACTAGAGTTGGCAGCTGACTGTCACTTGAGCAG
GATCGTGCAGGCTACTACGTTGCTTACAATGGATAAGTATGTACCTGATGACATTCCAAATATA
AACAGCACATGCTTTAAGTTAAATTCTCTGCAGCTTCAAGCCCTCTTACAGAATTACCACTGTG
CACCTGATGAGCCTTTTATTCCTACGGATCTCATAGAAAATGTCGTGGCTGTTGCTGAGAACAC
AGCTGATGAGCTTGCCCGCAGTGATGGCAGAGATGTGCAGTTAGAGGAGGACCCTGATCTACAA
CTGCCCTTTCTTCTGCCAGAAGATGGCTATTCCTGTGATGTTGTCAGAAACATTCCAAATGGTT
TACAAGAATTTTTAGACCCTCTGTGCCAGAGAGGATTTTGCAGGTTGGTTCCTCACACACGTTC
TCCAGGTACCTGGACAATATATTTTGAAGGAGCAGATTATGAAAGTCACCTCATGCGTGAGAAC
ACAGAACTGACCCAGCCTCTGAGGAAGGAGCCTGAGGTAATCACTGTGACCCTGAAGAAGCAGA
ATGGAATGGGCCTCAGCATTGTTGCAGCAAAGGGTGCTGGCCAGGATAAACTGGGAATCTACGT
TAAGTCCGTTGTCAAAGGAGGTGCTGCAGATGTGGATGGACGCCTAGCTGCTGGTGACCAACTC
CTTAGTGTGGATGGACGAAGTCTGGTTGGACTTTCTCAGGAAAGGGCAGCAGAACTCATGACAA
GAACCAGTTCCGTGGTAACACTGGAAGTTGCAAAGCAAGGCGCTATCTATCACGGACTGGCCAC
TCTCCTTAACCAGCCATCACCCATGATGCAGAGAATTTCAGATCGTCGTGGCTCAGGTAAACCC
AGACCAAAGAGCGAAGGTTTTGAGCTCTATAATAATTCAGCTCAAAACGGCTCCCCAGAGAGTC
CTCAGATGCCTTGGACAGAGTACAGTGAGCCAAAGAAGCTGCCTGGTGACGACAGGCTGATGAA
AAACAGAGCTGACCACCGTTCCAGCCCCAATGTGGCAAATCAGCCCCCTAGTCCTGGAGGGAAG
AGTCCATATACCTCTGGAACAGCAGCTAAAATAACATCTGTCTCTACTGGAAACCTCTGCACTG
AGGAGCAGACCCCTCCACCTAGACCTGAAGCCTATCCTATCCCTACTCAGACATATACCAGAGA
GTATTTTACCTTTCCAGCTTCAAAGTCGCAGGATCGGATGGCTCCTGTTCAAAACCAGTGGCCA
AATTATGAGGAAAAACCACACATGCACACAGAAAGTGATCATGCCAGTATTGCAATCCAGCGTG
TTACCCGTTCCCAGGAAGAGCTTCGGGAAGAGAAGGTTTACCAACTTGAGCGTCATCGAGTAGA
GTCAGGCATGGATCGCAAGTGTGACAGTGATATGTGGATCAATCAGAGCTCCTCAGTGGAATCT
AGCACGTCTAGCCAGGAGCACCTGAACCATTCCTCCAAGTCAGTTACCCCTGCTTCCACTCTGA
CCAAGAGTGGTCCTGGTCGTTGGAAAACCCCAGCAGCTGTGCTCCCCACCCCTGTGGCTGTCTC
CCAACCCATTCGAACAGACCTCCCTCCACCACCACCTCCACCACCTGCCCACTACACCAGTGAT
TTTGATGGTATTTCAATGGATTTGCCCCTCCCACCTCCTCCTGCCAACCAAGCAGCTCCCCAGT
CTGCTCAGGTGGCTGCTGCAGAGAGGAAAAAGAGAGAGGAGCATCAGAGGTGGTATGAAAAAGA
GAAGGCCCGCCTGGAGGAGGAACGAGAGAGAAAGCGCAGGGAGCAAGAGAGGAAGTTGGGGCAG
ATGCGCACTCAGTCCCTGAACCCTGCTTCCTTCTCTCCTTTGGCCACACAGGCCAAGCCAGAAA
AGCCTTCCACACTGCAGAGGCCCCAAGAAACGGTCATTCGGGAGCTGCAGCCCCAGCAGCAGCC
CCGTACTATTGAGCGCAGGGATCTGCAGTACATAACCATCAGTAAAGAGGAGCTGTCCTCTGGG
GATAGTCTGTCTCCAGACCCATGGAAACGAGATGCCAGGGAGAAGCTGGAGAAGCAACAGCAAA
TGCACATTGTAGACATGCTAAGCAAGGAGATCCATGAGCTGCAAAACAAGGGGGACCGTACTGC
AGAGGAGAGTGACCGCCTGCGGAAGCTTATGCTGGAGTGGCAGTTCCAGAAGAGACTACAGGAG
TCCAAGCAGAAGGATGAGGATGATGATGAAGAGGAAGATGATGATGTTGACACCATGCTGATCA
TGCAGCGACTGGAGGCGGAGCGGAGAGCCAGGTTGCAGGATGAAGAGCGCAGGCGCCAGCAACA
GTTGGAAGAGATGCGGAAACGAGAAGTTGAAGACAGAGTAAGACAAGAGGAAGATGGACGCCAT
CAGGAGGAGGAGCGAGTAAAGAGAGATGCTGAAGAAAAGAGGCGACAGGAAGAAGGGTATTACA
GCCGCCTAGAAGCTGAGAGGCGCAGACAGCATGAAGAGGCAGCACGCAGGTTGCTGGAGCCCGA
AGAACCCGGGCTGAGCCGACCTCCACTTCCACAGGACTACGAGCCCCCATCCCAGTCCTCAGCA
CCCAGTGCCCCTCCTCCCCCACCTCAGCGAAATGCCTCCTACCTCAAAACACAGGTCCTCTCCC
CAGACTCGCTGTTCACTGCCAAGTTTGTTGCGTATGATGATGATGATGAGGAGGAGAACTACGT
CCCAGCAGGACCAAACTCTTATTCGGGATCTGCTGGCACAACTGCTGGAACTTATGATGCTCCT
CGGGACACAAGAGAAAAACTCAGTAGAAGCCAAGATGCAGACTTACCTGGCAGTTCTGGAGCCC
CTGAAAACCTGACATTTAGAGAGCGTCAGCGCCTCTTTTCACAAGGTCAAGATGTGTCAGACAA
AGTGAAAGCTTCTCGTAAATTAACAGAGCTTGAGAATGAACTCAACACCAAGTGAGAAGAGAGA
GGTCACCTGTACTCAAGCAGGTCTGACCTTGGCAGTGGATTTGTGGGGTGGGCCTGAAGAGGAA
GGAACAATTGTACTTCTAAGTGATGTTTAATTTCTTTCTGAAATGGTTGCAATTGAGAGATGTT
CCAAATCCAAGAAACTTTGTTTTACTTTACCAAGAAAAATCCTGCCTTGTTCTTAGTGATCGGA
CTTCGTGAAGTTACCTGTTCTTGTTAGTTTTAGGGAGTCTTGGACTCAAAGGGCAGAATGAAGG
GCTGTAAAGATGACAGGGTGTTTCCTTTACCCTATCTTCTCCATTGTCATTCCAAGGGCAGTAG
GCCTAGAAATTATCTTTCCATTCTTTCTCCAAACTCCATTCAGCTACGCAATAGTGACAGCTGA
GCATTTCAGAGCACTACTGTGTCATAGTGGACCCTGTCTGCAGGAGACAGACCTCTCAGCACAG
GTGAAATGTTGCCTTTATCTTCTGTAATTTGCATGAGGTGGTCTGAAGGAGTCTTTTTATGTAA
GGTGCACAACACAACATTCTTGACAAGTAAGAGCCTCCTGATCAATTCTAAATGTTTGAGATTG
AATATCTTATTAATAATTCAATTTTGAAAATTCTAAAGAAACATTTGTGAATTTAATCCTAGGG
ATTTTATAAATACAAATCATCATTAGACTAATCACTGGTGGAAATTAAAGATGACAGTTCTGTT
AGAAAGTTACCTAGGTTCCAAAGTCTCTAGGGCGCTCTAATTACAGCGCTTTCTTGCAGGTAGG
AGCAAAGACGTCCGAGAAGAATGGGAGCTCATGGGTGGCAGTCAAACACAGCTATCTCAGAAGT
TATAAATTTAGTAAAGAGATTTAGAAACACTGTCAGGAAAGGAAGAAGCGTGTTGCTGTGCCTC
CTGTGACTTAAGTGCTATAAGAACACTTGTGTCAGTTGAGTCTGCATCTCTTTCTCAGCGTAAT
AGAGTTATTTAATTTTAATTACTCAATTTTGCACTGTCATTCCTCAGCTGAGTTATGGGAGAAA
GAACTCAGTTTGCTTATTTTGTGGTAATGTTGACTTTATTATTTCAAGCACATTTTCTCTTTGA
GAATCCTCTAATGTGGGTCCAGATAATCTTTCTGTATCATACTATTCTCTTACAAATCTGTGCA
TCAGGAAAATATGCACACTTTCAAGTAGAACAGAGGTATTTGCAACCCAAAAAACCACTTTTAA
TAAGAGCTGTATGATAAAATGTTGAAATACAAGTGTAAATATTTTTTATGTTTATCCAGTTTCC
TATTTGAAAGTGTGTCTTTGCTTTTTCCTCTGTAAGAGAATAGAATGTCCCAGAGAGCTGATGA
AGGATTTGCACACTTGTCTTGCCCAGGAAGTGCATTCTCCTTGTGTCTGCAGCACATGGGCAGC
CTTTGATATCATAAAAATACCTCCCGAAGAAGAGCAGGTACCTGCTGTCCCTAGTCCATGGGAA
GACAGATGCACTCAAGAACCTGCAAGCATCTGCAAACTCTGCATGTGTGTTTGTGAGACCTGTA
GTGAAGTAGACATGGCCATCCCTGCACAGTGAGGTCAGATGTGAATAAGTGTTGCAAGAACACA
TTGAATAGTGTGTATTACTGTGGGGAAATACCCAAACTGCTGTTTCCATTTCTACTGTATTTCA
GTTGCAGCCTATTTTTAATAAACTTTGTATCTATTTAAGTGTATTTGCTATTGTTTTCAAAGTG
CTGACAAAGTTTATATTTGTAATGCCAGCATTCCTTTTTCCCATTTCCATCTTTCACTCCTTCA
TTAAACTGCTGAGTCATTCCTTCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063282455 ⟹ XP_063138525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,066 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282461 ⟹ XP_063138531

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,066 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282468 ⟹ XP_063138538

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,066 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282472 ⟹ XP_063138542

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,066 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282476 ⟹ XP_063138546

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,065 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282479 ⟹ XP_063138549

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,070 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282481 ⟹ XP_063138551

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,065 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282491 ⟹ XP_063138561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,070 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282492 ⟹ XP_063138562

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,071 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282494 ⟹ XP_063138564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,066 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282497 ⟹ XP_063138567

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282501 ⟹ XP_063138571

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282503 ⟹ XP_063138573

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282505 ⟹ XP_063138575

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282507 ⟹ XP_063138577

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,070 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282509 ⟹ XP_063138579

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282513 ⟹ XP_063138583

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282518 ⟹ XP_063138588

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282519 ⟹ XP_063138589

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,072 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282523 ⟹ XP_063138593

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282526 ⟹ XP_063138596

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,071 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282529 ⟹ XP_063138599

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,071 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282534 ⟹ XP_063138604

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282537 ⟹ XP_063138607

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282539 ⟹ XP_063138609

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282542 ⟹ XP_063138612

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282545 ⟹ XP_063138615

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282551 ⟹ XP_063138621

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282554 ⟹ XP_063138624

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282558 ⟹ XP_063138628

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282559 ⟹ XP_063138629

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282560 ⟹ XP_063138630

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,570 - 58,163,383 (+)	NCBI

RefSeq Acc Id:

XM_063282561 ⟹ XP_063138631

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,161,165 (+)	NCBI

RefSeq Acc Id:

XM_063282563 ⟹ XP_063138633

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,068 - 58,163,383 (+)	NCBI

RefSeq Acc Id:

XM_063282565 ⟹ XP_063138635

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,073 - 58,163,383 (+)	NCBI

RefSeq Acc Id:

XM_063282572 ⟹ XP_063138642

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,119,370 - 58,170,501 (+)	NCBI

RefSeq Acc Id:

XM_063282574 ⟹ XP_063138644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	58,041,077 - 58,170,501 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_037349	(Get FASTA)	NCBI Sequence Viewer
	XP_063138525	(Get FASTA)	NCBI Sequence Viewer
	XP_063138531	(Get FASTA)	NCBI Sequence Viewer
	XP_063138538	(Get FASTA)	NCBI Sequence Viewer
	XP_063138542	(Get FASTA)	NCBI Sequence Viewer
	XP_063138546	(Get FASTA)	NCBI Sequence Viewer
	XP_063138549	(Get FASTA)	NCBI Sequence Viewer
	XP_063138551	(Get FASTA)	NCBI Sequence Viewer
	XP_063138561	(Get FASTA)	NCBI Sequence Viewer
	XP_063138562	(Get FASTA)	NCBI Sequence Viewer
	XP_063138564	(Get FASTA)	NCBI Sequence Viewer
	XP_063138567	(Get FASTA)	NCBI Sequence Viewer
	XP_063138571	(Get FASTA)	NCBI Sequence Viewer
	XP_063138573	(Get FASTA)	NCBI Sequence Viewer
	XP_063138575	(Get FASTA)	NCBI Sequence Viewer
	XP_063138577	(Get FASTA)	NCBI Sequence Viewer
	XP_063138579	(Get FASTA)	NCBI Sequence Viewer
	XP_063138583	(Get FASTA)	NCBI Sequence Viewer
	XP_063138588	(Get FASTA)	NCBI Sequence Viewer
	XP_063138589	(Get FASTA)	NCBI Sequence Viewer
	XP_063138593	(Get FASTA)	NCBI Sequence Viewer
	XP_063138596	(Get FASTA)	NCBI Sequence Viewer
	XP_063138599	(Get FASTA)	NCBI Sequence Viewer
	XP_063138604	(Get FASTA)	NCBI Sequence Viewer
	XP_063138607	(Get FASTA)	NCBI Sequence Viewer
	XP_063138609	(Get FASTA)	NCBI Sequence Viewer
	XP_063138612	(Get FASTA)	NCBI Sequence Viewer
	XP_063138615	(Get FASTA)	NCBI Sequence Viewer
	XP_063138621	(Get FASTA)	NCBI Sequence Viewer
	XP_063138624	(Get FASTA)	NCBI Sequence Viewer
	XP_063138628	(Get FASTA)	NCBI Sequence Viewer
	XP_063138629	(Get FASTA)	NCBI Sequence Viewer
	XP_063138630	(Get FASTA)	NCBI Sequence Viewer
	XP_063138631	(Get FASTA)	NCBI Sequence Viewer
	XP_063138633	(Get FASTA)	NCBI Sequence Viewer
	XP_063138635	(Get FASTA)	NCBI Sequence Viewer
	XP_063138642	(Get FASTA)	NCBI Sequence Viewer
	XP_063138644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC53390	(Get FASTA)	NCBI Sequence Viewer
	AAC53391	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000078878
	ENSRNOP00000079686
	ENSRNOP00000088861
	ENSRNOP00000088861.1
	ENSRNOP00000094008
GenBank Protein	O35889	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037349 ⟸ NM_013217

- UniProtKB:

O35890 (UniProtKB/Swiss-Prot), O35889 (UniProtKB/Swiss-Prot), A6KS86 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMRFYFQDKAAGNFATKCIRVSS
TATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVL
KNENDAIPAKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKEERPSQGDD
SENSRLAAEVYKDMPETSFTRTISNPEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADS
LKPNIPYKTILLSTTDPADFAVAESLEKYGLEKENPKDYCIARVMLPPGAQHSDERGAKEIILD
DDECPLQIFREWPSDKGILVFQLKRRPPDYIPKKMKKHVEGKPLKGKDRADGSGYGSALPPEKL
PYLVELSPGRRNHFAYYSYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKFDDNSIQLFGPGIQPH
HCDLTNMDGVVTVTPRSMDAETYVDGQRISETTMLQSGMRLQFGTSHVFKFVDPIQDHVLSKRS
VDGGLMVKGPRHKPGAVQETTFELGGDIHSGTALPASRSTTRLDSDRVSSASSTAERGMVKPMI
RLDQEQDYRRRESRTQDAAGPELMLPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYM
ACRYVLSSQHRPDISPTERTHKAIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASE
LLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDD
VLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGH
IEAWAEKQGLELAADCHLSRIVQATTLLTMDKYVPDDIPNINSTCFKLNSLQLQALLQNYHCAP
DEPFIPTDLIENVVAVAENTADELARSDGRDVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQ
EFLDPLCQRGFCRLVPHTRSPGTWTIYFEGADYESHLMRENTELTQPLRKEPEVITVTLKKQNG
MGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRT
SSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSAQNGSPESPQ
MPWTEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSPYTSGTAAKITSVSTGNLCTEE
QTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPVQNQWPNYEEKPHMHTESDHASIAIQRVT
RSQEELREEKVYQLERHRVESGMDRKCDSDMWINQSSSVESSTSSQEHLNHSSKSVTPASTLTK
SGPGRWKTPAAVLPTPVAVSQPIRTDLPPPPPPPPAHYTSDFDGISMDLPLPPPPANQAAPQSA
QVAAAERKKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPASFSPLATQAKPEKP
STLQRPQETVIRELQPQQQPRTIERRDLQYITISKEELSSGDSLSPDPWKRDAREKLEKQQQMH
IVDMLSKEIHELQNKGDRTAEESDRLRKLMLEWQFQKRLQESKQKDEDDDEEEDDDVDTMLIMQ
RLEAERRARLQDEERRRQQQLEEMRKREVEDRVRQEEDGRHQEEERVKRDAEEKRRQEEGYYSR
LEAERRRQHEEAARRLLEPEEPGLSRPPLPQDYEPPSQSSAPSAPPPPPQRNASYLKTQVLSPD
SLFTAKFVAYDDDDEEENYVPAGPNSYSGSAGTTAGTYDAPRDTREKLSRSQDADLPGSSGAPE
NLTFRERQRLFSQGQDVSDKVKASRKLTELENELNTK

hide sequence

Ensembl Acc Id:

ENSRNOP00000029044 ⟸ ENSRNOT00000032667

Ensembl Acc Id:

ENSRNOP00000079686 ⟸ ENSRNOT00000096238

Ensembl Acc Id:

ENSRNOP00000078878 ⟸ ENSRNOT00000107704

Ensembl Acc Id:

ENSRNOP00000088861 ⟸ ENSRNOT00000106034

Ensembl Acc Id:

ENSRNOP00000094008 ⟸ ENSRNOT00000096510

RefSeq Acc Id:	XP_063138546 ⟸ XM_063282476
- Peptide Label:	isoform X5
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138551 ⟸ XM_063282481
- Peptide Label:	isoform X7
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138525 ⟸ XM_063282455
- Peptide Label:	isoform X1
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138564 ⟸ XM_063282494
- Peptide Label:	isoform X10
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138531 ⟸ XM_063282461
- Peptide Label:	isoform X2
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138538 ⟸ XM_063282468
- Peptide Label:	isoform X3
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138542 ⟸ XM_063282472
- Peptide Label:	isoform X4
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138567 ⟸ XM_063282497
- Peptide Label:	isoform X11
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138579 ⟸ XM_063282509
- Peptide Label:	isoform X16
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138573 ⟸ XM_063282503
- Peptide Label:	isoform X13
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138583 ⟸ XM_063282513
- Peptide Label:	isoform X17
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138575 ⟸ XM_063282505
- Peptide Label:	isoform X14
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138588 ⟸ XM_063282518
- Peptide Label:	isoform X18
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138633 ⟸ XM_063282563
- Peptide Label:	isoform X34
- UniProtKB:	F1LT10 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138631 ⟸ XM_063282561
- Peptide Label:	isoform X33
- UniProtKB:	F1LT10 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138549 ⟸ XM_063282479
- Peptide Label:	isoform X6
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138577 ⟸ XM_063282507
- Peptide Label:	isoform X15
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138561 ⟸ XM_063282491
- Peptide Label:	isoform X8
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138596 ⟸ XM_063282526
- Peptide Label:	isoform X21
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138599 ⟸ XM_063282529
- Peptide Label:	isoform X22
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138562 ⟸ XM_063282492
- Peptide Label:	isoform X9
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138589 ⟸ XM_063282519
- Peptide Label:	isoform X19
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138635 ⟸ XM_063282565
- Peptide Label:	isoform X35
- UniProtKB:	F1LT10 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138644 ⟸ XM_063282574
- Peptide Label:	isoform X37
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138607 ⟸ XM_063282537
- Peptide Label:	isoform X24
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138604 ⟸ XM_063282534
- Peptide Label:	isoform X23
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138571 ⟸ XM_063282501
- Peptide Label:	isoform X12
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138609 ⟸ XM_063282539
- Peptide Label:	isoform X25
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138612 ⟸ XM_063282542
- Peptide Label:	isoform X26
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138621 ⟸ XM_063282551
- Peptide Label:	isoform X28
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138628 ⟸ XM_063282558
- Peptide Label:	isoform X30
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138593 ⟸ XM_063282523
- Peptide Label:	isoform X20
- UniProtKB:	A0A8I5ZLU6 (UniProtKB/TrEMBL), A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138615 ⟸ XM_063282545
- Peptide Label:	isoform X27
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138624 ⟸ XM_063282554
- Peptide Label:	isoform X29
- UniProtKB:	A6KS86 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138629 ⟸ XM_063282559
- Peptide Label:	isoform X31
- UniProtKB:	A0A8I5ZNL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138630 ⟸ XM_063282560
- Peptide Label:	isoform X32
- UniProtKB:	F1LT10 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138642 ⟸ XM_063282572
- Peptide Label:	isoform X36

Protein Domains

Dilute FHA PDZ Ras-associating

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O35889-F1-model_v2	AlphaFold	O35889	1-1829	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708561	AgrOrtholog
BioCyc Gene	G2FUF-61408	BioCyc
Ensembl Genes	ENSRNOG00000023753	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000096238	ENTREZGENE
	ENSRNOT00000096510	ENTREZGENE
	ENSRNOT00000106034	ENTREZGENE
	ENSRNOT00000106034.1	UniProtKB/Swiss-Prot
	ENSRNOT00000107704	ENTREZGENE
Gene3D-CATH	2.30.42.10	UniProtKB/Swiss-Prot
	2.60.200.20	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
InterPro	Afadin	UniProtKB/Swiss-Prot
	CBD_Afadin	UniProtKB/Swiss-Prot
	Dilute_dom	UniProtKB/Swiss-Prot
	FHA_dom	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PDZ_sf	UniProtKB/Swiss-Prot
	RA_dom	UniProtKB/Swiss-Prot
	SMAD_FHA_dom_sf	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
KEGG Report	rno:26955	UniProtKB/Swiss-Prot
NCBI Gene	26955	ENTREZGENE
PANTHER	AFADIN	UniProtKB/Swiss-Prot
	AFADIN	UniProtKB/Swiss-Prot
Pfam	DIL	UniProtKB/Swiss-Prot
	FHA	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PF00788	UniProtKB/Swiss-Prot
PhenoGen	Afdn	PhenoGen
PROSITE	DILUTE	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	PS50200	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000023753	RatGTEx
SMART	DIL	UniProtKB/Swiss-Prot
	FHA	UniProtKB/Swiss-Prot
	PDZ	UniProtKB/Swiss-Prot
	SM00314	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49879	UniProtKB/Swiss-Prot
	SSF50156	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZLU6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZNL2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AL62_RAT	UniProtKB/TrEMBL
	A6KS86	ENTREZGENE, UniProtKB/TrEMBL
	AFAD_RAT	UniProtKB/Swiss-Prot
	F1LT10	ENTREZGENE, UniProtKB/TrEMBL
	O35889	ENTREZGENE
	O35890	ENTREZGENE
UniProt Secondary	O35890	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-05	Afdn	afadin, adherens junction formation factor	Mllt4	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-07-01	Mllt4	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4	Mllt4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-19	Mllt4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Mllt4	myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-26	Mllt4	myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog (Drosophila)	Af6	afadin	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-10-07	Af6				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)