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Gene: Epha8 (Eph receptor A8) Rattus norvegicus

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Symbol:

Epha8

Name:

Eph receptor A8

RGD ID:

708543

Description:

Predicted to enable GPI-linked ephrin receptor activity and growth factor binding activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within cellular response to follicle-stimulating hormone stimulus. Predicted to be located in neuron projection. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Orthologous to human EPHA8 (EPH receptor A8); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

eph and elk-related kinase; EPH- and ELK-related kinase; ephrin receptor EphA8; ephrin type-A receptor 8; LOC60589; tyrosine-protein kinase receptor EEK

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EPHA8 (EPH receptor A8)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Epha8 (Eph receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Epha8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EPHA8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EPHA8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Epha8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EPHA8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EPHA8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Epha8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Epha8 (EPH receptor A8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EPHA8 (EPH receptor A8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PANTHER\|PhylomeDB)
Homo sapiens (human):	EPHA8 (EPH receptor A8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|PhylomeDB)
Mus musculus (house mouse):	Epha8 (Eph receptor A8)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Epha8 (Eph receptor A8)	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)
Danio rerio (zebrafish):	epha4a (eph receptor A4a)	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Eph	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	Eph	Alliance	DIOPT (Ensembl Compara\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	vab-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	vab-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	epha8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	epha8	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	154,449,566 - 154,476,966 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	154,449,566 - 154,476,966 (-)	Ensembl				GRCr8
mRatBN7.2	5	149,166,107 - 149,193,515 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,166,697 - 149,193,399 (-)	Ensembl				mRatBN7.2
Rnor_6.0	5	155,293,731 - 155,321,016 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	155,295,314 - 155,316,495 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	159,055,846 - 159,085,645 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	155,696,393 - 155,717,598 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	147,563,833 - 147,590,905 (-)	NCBI		Celera
RGSC_v3.1	5	155,706,431 - 155,709,122 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

High Myopia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

Aflatoxin B2 alpha (ISO)

aldrin (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

cocaine (EXP)

Cuprizon (EXP)

DDD (ISO)

DDE (ISO)

DDT (ISO)

dieldrin (ISO)

dorsomorphin (ISO)

endrin (ISO)

entinostat (ISO)

ethylparaben (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gamma-hexachlorocyclohexane (ISO)

genistein (EXP,ISO)

hydralazine (ISO)

lead diacetate (EXP)

methapyrilene (ISO)

N-nitrosodiethylamine (EXP)

niclosamide (ISO)

Nonylphenol (EXP)

perfluorooctanoic acid (EXP)

ponatinib (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

simvastatin (ISO)

sodium arsenite (EXP)

sotorasib (ISO)

succimer (ISO)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

trametinib (ISO)

triclosan (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon guidance (IEA,ISO,ISS)

cell adhesion (IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IBA,IEA)

cellular response to follicle-stimulating hormone stimulus (ISO)

ephrin receptor signaling pathway (IEA,ISO,ISS)

nervous system development (IEA)

neuron projection development (IEA,ISO,ISS)

neuron remodeling (IEA,ISO,ISS)

positive regulation of MAPK cascade (IEA,ISO,ISS)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO,ISS)

protein autophosphorylation (ISO)

regulation of cell adhesion (IEA,ISO,ISS)

regulation of cell adhesion mediated by integrin (IEA,ISO,ISS)

substrate-dependent cell migration (IEA,ISO,ISS)

Cellular Component

cell projection (IEA)

early endosome membrane (IEA)

membrane (IEA)

neuron projection (IEA,ISO,ISS)

plasma membrane (IBA,IEA,ISO,ISS)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

ephrin receptor activity (IEA,ISO,ISS)

GPI-linked ephrin receptor activity (IEA,ISO,ISS)

growth factor binding (IEA,ISO)

kinase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

protein kinase activity (IEA)

protein tyrosine kinase activity (IEA)

transferase activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases.	Chan J and Watt VM, Oncogene 1991 Jun;6(6):1057-61.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9053851	PMID:9214628	PMID:10498895	PMID:11416136	PMID:15782114	PMID:17875921	PMID:23242526

Genomics

Comparative Map Data

Epha8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	154,449,566 - 154,476,966 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	154,449,566 - 154,476,966 (-)	Ensembl				GRCr8
mRatBN7.2	5	149,166,107 - 149,193,515 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	149,166,697 - 149,193,399 (-)	Ensembl				mRatBN7.2
Rnor_6.0	5	155,293,731 - 155,321,016 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	155,295,314 - 155,316,495 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	159,055,846 - 159,085,645 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	155,696,393 - 155,717,598 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	147,563,833 - 147,590,905 (-)	NCBI		Celera
RGSC_v3.1	5	155,706,431 - 155,709,122 (-)	NCBI
Cytogenetic Map	5	q36	NCBI

EPHA8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	22,563,489 - 22,603,595 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	22,563,489 - 22,603,595 (+)	Ensembl			hg38	GRCh38
GRCh37	1	22,889,982 - 22,930,088 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	22,762,591 - 22,802,674 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	22,635,309 - 22,675,393	NCBI
Celera	1	21,213,404 - 21,254,789 (+)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	21,133,248 - 21,174,608 (+)	NCBI		HuRef
CHM1_1	1	23,008,057 - 23,042,609 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	22,387,196 - 22,428,607 (+)	NCBI		T2T-CHM13v2.0

Epha8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	136,656,729 - 136,684,170 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	136,656,730 - 136,684,127 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	136,929,419 - 136,956,859 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	136,929,419 - 136,956,816 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	136,485,334 - 136,512,731 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	136,201,495 - 136,228,894 (-)	NCBI		MGSCv36	mm8
Celera	4	135,136,846 - 135,164,245 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	69.05	NCBI

Epha8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	2,701,803 - 2,729,277 (+)	Ensembl
ChiLan1.0	NW_004955452	2,702,277 - 2,729,161 (+)	NCBI	ChiLan1.0	ChiLan1.0

EPHA8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	204,340,369 - 204,386,161 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	203,443,413 - 203,489,190 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	21,746,846 - 21,792,635 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	22,700,852 - 22,735,944 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	22,700,512 - 22,735,944 (+)	Ensembl			panPan2	panpan1.1

EPHA8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	76,703,538 - 76,739,327 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	76,703,524 - 76,739,259 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	73,208,442 - 73,244,029 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	77,264,217 - 77,298,257 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	77,262,555 - 77,293,354 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	74,083,641 - 74,119,220 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	75,091,930 - 75,127,511 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	76,095,721 - 76,131,311 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Epha8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	42,131,740 - 42,157,180 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	7,928,700 - 7,981,962 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	7,928,700 - 7,981,961 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EPHA8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	80,516,967 - 80,550,588 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	80,516,967 - 80,548,955 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	74,545,330 - 74,579,144 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EPHA8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	110,061,871 - 110,095,354 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	110,063,727 - 110,101,072 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	6,215,437 - 6,253,423 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Epha8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	7,307,967 - 7,339,169 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	7,307,967 - 7,339,187 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Epha8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	21,277,321 - 21,303,026 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Epha8
166 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	85
Count of miRNA genes:	81
Interacting mature miRNAs:	85
Transcripts:	ENSRNOT00000017559
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat

Markers in Region

AW047546

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	149,166,156 - 149,166,253 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	155,293,776 - 155,293,872	NCBI	Rnor6.0
Rnor_5.0	5	159,055,891 - 159,055,987	UniSTS	Rnor5.0
RGSC_v3.4	5	155,694,855 - 155,694,951	UniSTS	RGSC3.4
Celera	5	147,563,878 - 147,563,974	UniSTS
Cytogenetic Map	5	q36	UniSTS

Epha4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	149,166,209 - 149,166,328 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	155,293,829 - 155,293,947	NCBI	Rnor6.0
Rnor_5.0	5	159,055,944 - 159,056,062	UniSTS	Rnor5.0
RGSC_v3.4	5	155,694,908 - 155,695,026	UniSTS	RGSC3.4
Celera	5	147,563,931 - 147,564,049	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
8	3	40	139	38	38	12	18	12	6	144	71	1	120	50	84	26	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001419265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288336	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063288338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC113790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X59290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017559 ⟹ ENSRNOP00000017559

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	154,449,566 - 154,476,966 (-)	Ensembl
mRatBN7.2 Ensembl	5	149,166,697 - 149,193,399 (-)	Ensembl
Rnor_6.0 Ensembl	5	155,295,314 - 155,316,495 (-)	Ensembl

RefSeq Acc Id:

NM_001419265 ⟹ NP_001406194

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	154,449,566 - 154,476,966 (-)	NCBI
mRatBN7.2	5	149,166,112 - 149,193,515 (-)	NCBI

RefSeq Acc Id:

XM_008764322 ⟹ XP_008762544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	154,449,566 - 154,476,677 (-)	NCBI
mRatBN7.2	5	149,166,107 - 149,193,262 (-)	NCBI
Rnor_6.0	5	155,293,731 - 155,321,016 (-)	NCBI

Sequence:

show sequence

ATGCGTGCGGTGCGGTCCACGAGTGGCACGGGGCCAACGCCCCCAGGCACGAGCGGGCCCGGGC
GGGCGGAGAATGCCCTGGGGACTGAGAATCGGAGGCTGGGGACAAGGGGACAGGACTGGACAGA
AAACAGAAGAGTGAACCTGTTGGACACATCGACCATCCACGGAGACTGGGGCTGGCTCACATAT
CCTGCTCATGGGTGGGACTCCATCAACGAGGTGGACGAGTCCTTTCGGCCCATCCACACGTATC
AGGTGTGCAACGTCATGAGTCCCAACCAGAACAACTGGCTGCGTACAAGCTGGGTGCCCCGTGA
CGGCGCCAGGCGTGTCTACGCCGAGATCAAATTCACCCTGCGTGACTGCAATAGCATTCCTGGG
GTGTTGGGCACCTGCAAGGAGACCTTCAACCTTCACTACCTAGAGTCTGACCGGGATCTGGGGG
CCAGCACACAAGAGAGCCAGTTCCTCAAGATTGACACCATCGCAGCGGATGAGAGCTTCACCGG
CGCAGATCTGGGCGTGCGGAGGCTCAAGCTGAACACGGAGGTGCGTGGCGTGGGCCCGCTCAGC
AAGCGCGGCTTCTACCTGGCCTTCCAGGACATAGGTGCCTGCCTCGCCATCCTCTCACTCAGAA
TCTACTACAAGAAGTGTCCCGCCATGGTACGCAACCTGGCGGCCTTCTCGGAGGCGGTAACCGG
GGCTGACTCGTCCTCGCTGGTAGAGGTTCGAGGCCAGTGTGTGCGACACTCAGAGGAGCGCGAC
ACACCCAAGATGTACTGCAGTGCCGAGGGCGAATGGCTGGTGCCCATCGGCAAGTGCGTGTGCA
GTGCCGGCTATGAGGAGCGGCGCGATGCCTGTATGGCCTGTGAGCTGGGCTTCTACAAGTCAGC
CCCCGGGGACCAGCTGTGTGCCCGATGCCCACCCCACAGCCATTCTGCCACCCCTGCGGCCCAG
ACCTGCCGTTGTGACCTCAGCTACTACCGTGCGGCCTTGGACCCACCATCGGCAGCCTGCACCC
GGCCACCCTCAGCACCGGTGAACCTGATCTCCAGCGTGAACGGAACTTCTGTGACCCTGGAGTG
GGCCCCTCCTCTGGACCCAGGCGGCCGCAGTGACATCACCTACAACGCGGTGTGCCGCCGCTGC
CCCTGGGCCCTGAGCCACTGTGAGGCTTGTGGGAGTGGAACTCGCTTTGTCCCGCAACAGACAA
GCCTGGCGCAGGCCAGCCTGCTGGTGGCCAACCTCCTGGCCCACATGAACTACTCCTTCTGGAT
CGAGGCAGTCAACGGTGTCTCCAACCTGAGCCCCGAGCCCCGCAACGCTGCTGTGGTCAACATC
ACCACAAACCAGGCAGCCCCGTCCCAGGTGGTGGTGATCCGGCAGGAGCGGGCTGGGCAGACCA
GCGTGTCACTCCTGTGGCAGGAGCCAGAGCAACCCAACGGCATCATACTGGAGTACGAGATCAA
GTACTACGAGAAGGATAAGGAGATGCAAAGCTACTCTACCCTCAAGGCTGTCACCACCCGCGCC
ACCGTGTCGGGCCTCAAACCAGGCACTCGCTACATGTTCCAGGTCCGGGCCCGCACCTCAGCAG
GCTGTGGACGCTTCAGCCAGGCCATGGAGGTGGAGACCGGGAAACCCAGGCCCCGCTATGACAC
TCGGACCATCGTCTGGATCTGCCTGACACTCATCACAGGCCTGGTGGTACTCCTCCTGCTTCTC
ATCTGCAAGAAGAGGCACTGCGGCTATAGCAAGGCATTCCAGGACTCTGATGAAGAGAAAATGC
ATTACCAGAATGGCCAAGCACCCCCGCCTGTCTTCTTGCCCTTGAACCACCCCCCGGGGAAGCT
CCCAGAAACCCAGTTCTCGGCAGAGCCCCACAACTATGAGGAACCGGGCCGTGCAGGCCGAAGC
TTTACCAGAGAGATCGAGGCCTCCAGGATCCACATTGAGAAGATCATAGGCTCGGGGGAGTCAG
GAGAAGTATGCTATGGGAGGCTGCAGGTGCCAGGACAGCGGGATGTGCCCGTGGCCATCAAGGC
TCTCAAAGCTGGCTACACGGAGAGGCAGCGCCAAGACTTCTTGAGAGAGGCAGCCATCATGGGA
CAATTCGATCATCCTAACATCATCCGCCTGGAGGGTGTGGTCACCCGTGGCCGCCTGGCAATGA
TTGTGACTGAGTACATGGAAAATGGCTCTCTGGATGCCTTCCTCAGGACCCACGATGGTCAGTT
CACCATCCTGCAGCTAGTGGGCATGCTCAAAGGGGTGGGCGCTGGCATGCGCTACCTCTCGGAC
CTGGGCTACATTCACCGTGACCTGGCCGCCCGCAACATCCTGGTAGATGGCCGTCTTGTGTGCA
AGGTGTCAGACTTTGGGCTCTCAAGGGCTCTGGAGGACGACCCTGAGGCCGCCTACACCACTGC
GGGAGGGAAGATCCCTATCCGATGGACAGCACCAGAGGCCATTGCCTTCCGCACTTTCTCCTCA
GCCAGTGATGTGTGGAGCTTTGGTGTGGTCATGTGGGAGGTGCTGGCCTATGGTGAACGGCCCT
ACTGGAACATGACCAATCAGGATGTCATCAGCTCTGTGGAAGAGGGTTATAGGCTTCCAGCGCC
CATGGGCTGCCCACGTGCCCTGCACCAACTCATGCTAGACTGCTGGCACAAGGACCGTGCCCAG
CGGCCTCGCTTCTCTCACGTCGTGAGCGTTCTGGAGGCCCTGGTCCACAGCCCCGAGAGCCTTA
GGGCCACAGCTACAGTCAGCAGGTGCCCAGCCCCTGCCTTTGCCAGGAGCTGCTTTGACCTCCG
AGCAGGCGGAAATGGGAACGGGGACCTCACTGTGGGAGATTGGCTGGATTCCATCCGAATGGGC
CGGTACCGGGACCACTTTGCAGCGGGCGGGTACTCCTCCCTTGGCATGGTGCTTCACATGAACG
CCCAGGATGTTCGTGCCCTCGGCATCACCCTCATGGGCCACCAGAAGAAAATCCTTGGAAGCAT
CCAGACAATGAGGTCCCAGCTGAGCTGCACTCAGGGGCCACGCCGGCACCTCTGACCCATGGCC
ACTTGGCACTGGTCATACCAACTGTCAGGGGCTCTGCGGGGGGGGGCCCCCAGCAGTCAGGGTA
GCCCCTGAGCTCTGCCACAGGAGAGTGACAGAGGTCAGGCACCTGGGACAAGGACCTTGGTGCT
TTAAGTAGAGAGGACACCTGCCCTCTGGAGGAAGGCACAGGACCTTGTGTCTTCTAGAGCCTGG
GGCTCCAACACCAGACGCCAATGGTGACATCACTCGCCTAGCTGTGGGTGCATGCGTGCATGCA
TACGGGTGACGGTGTGGGCGTGCCCCTCGAGGCCCTGGCGGTTGATGAAAACAATGCGTAACCA
TGTCTCTGTTCCCCCATTAGGCCCCAGCACAGATGTGTGCAGGTTACCACGCGTGTGCTTGTCT
ACTAGGGCAGGAGCCACGTGTGTATGGCCACAGATAACACGTCATGAATGAGGAGGCGTGACAG
AGTGTGAGCGACACTGCCCAGTTCCCAGGACCTGTGGGGGAACGCACAGTGCCTGGCGGCTGGA
GCCCAGGCTGCTTCCGAATCATACCAGCACCAGGCCCACCGTCCAGCCTGGGTGAACCCACCAT
GGCTGTATCTCAGGTCCGGGACGCCTTCCTACTTTGGGGGCTCTGCCTGGCTCCTCCTGCTACT
CAATAGGAAAACAGGGTTCCTGGCCAGTCCCTCTGGCCGCCTTCCGTAGAGGATCACAGCAGAG
TGTGAGATGCCCTCGGTGGGCCGTGACTGCCTGACCGTCGCTCTCATGGCTGTGATGCCTCTTT
CCAATGTCTCACTGCCCATTCCTGCTGCCCCCCTGCCCATGCTGGGAACAGGAGCCCCAAACCC
ACCCCTTCCTGTACCAGATAGGTATGCCCAGAGAAAAGGATGCCTTGTCTGATGTCACATGACA
ACCAAATTTCAGAGTTGGGACCCTCTTCCCCCCCCCCAACCATGGTCTATTCTCCCCAACCCCA
CCCAAGACAGCTAGGACGGGAGGGGCCTGGGAGACTCATCACCACAGGCTGATACCCCTCCCCC
CCTTACGGCCCACCAGGGTATGTAAATGTCTTTTTTTCTACCATGTCAGAATATTTTTTTCCCT
CACTCCTGACAATGCAAAAATGGTCTTCAAAGCACATACAAAGCACCCCGGGTGAGAACGCCCC
ATCCTAGGGGAGGCAGGGCCCAAAGAGCCCCGGCCCAGAGGACAGGGCGGCCCCCTCCCCTGCC
CATCCCTGCCCACAGCCAGCACAGCACCCCGCGTGACACCAGCACTGAGCCCCCTCCCTTCTGC
AATAATCGGGGGCTTCAGCCCCACCCAGGTGCCGCGGCCAGCTCCTGCGCTTCTATATATTATA
GTACTATGTAGCCGAGCTGCCCTTCCTTCCTATGGAAGTGGGAAACATGGTCAGGACACGAGGG
GTGGGGACACCTTGTCTTCCACCACCCCCACTCACCCAGTGTCTGGGCTTAGGATCCTCAGGCG
AGGCCCCTGGGGTGGGTCCCCCTTGGGGCTCCTGGGGCCTCTCTGTGGTTCCCATCCTGAGTCT
GGAATTACTTGCGATGAGAATAAATTGTCTCATCTTTG

hide sequence

RefSeq Acc Id:

XM_063288336 ⟹ XP_063144406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	154,449,566 - 154,458,574 (-)	NCBI

RefSeq Acc Id:

XM_063288337 ⟹ XP_063144407

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	154,456,157 - 154,476,929 (-)	NCBI

RefSeq Acc Id:

XM_063288338 ⟹ XP_063144408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	154,456,397 - 154,476,928 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001406194	(Get FASTA)	NCBI Sequence Viewer
	XP_008762544	(Get FASTA)	NCBI Sequence Viewer
	XP_063144406	(Get FASTA)	NCBI Sequence Viewer
	XP_063144407	(Get FASTA)	NCBI Sequence Viewer
	XP_063144408	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAA41979	(Get FASTA)	NCBI Sequence Viewer
	EDL80828	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017559
GenBank Protein	P29321	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_008762544 ⟸ XM_008764322
- Peptide Label:	isoform X1
- UniProtKB:	A6ITC7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRAVRSTSGTGPTPPGTSGPGRAENALGTENRRLGTRGQDWTENRRVNLLDTSTIHGDWGWLTY PAHGWDSINEVDESFRPIHTYQVCNVMSPNQNNWLRTSWVPRDGARRVYAEIKFTLRDCNSIPG VLGTCKETFNLHYLESDRDLGASTQESQFLKIDTIAADESFTGADLGVRRLKLNTEVRGVGPLS KRGFYLAFQDIGACLAILSLRIYYKKCPAMVRNLAAFSEAVTGADSSSLVEVRGQCVRHSEERD TPKMYCSAEGEWLVPIGKCVCSAGYEERRDACMACELGFYKSAPGDQLCARCPPHSHSATPAAQ TCRCDLSYYRAALDPPSAACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRC PWALSHCEACGSGTRFVPQQTSLAQASLLVANLLAHMNYSFWIEAVNGVSNLSPEPRNAAVVNI TTNQAAPSQVVVIRQERAGQTSVSLLWQEPEQPNGIILEYEIKYYEKDKEMQSYSTLKAVTTRA TVSGLKPGTRYMFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLL ICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLNHPPGKLPETQFSAEPHNYEEPGRAGRS FTREIEASRIHIEKIIGSGESGEVCYGRLQVPGQRDVPVAIKALKAGYTERQRQDFLREAAIMG QFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGMRYLSD LGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPEAIAFRTFSS ASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSVEEGYRLPAPMGCPRALHQLMLDCWHKDRAQ RPRFSHVVSVLEALVHSPESLRATATVSRCPAPAFARSCFDLRAGGNGNGDLTVGDWLDSIRMG RYRDHFAAGGYSSLGMVLHMNAQDVRALGITLMGHQKKILGSIQTMRSQLSCTQGPRRHL hide sequence

Ensembl Acc Id:

ENSRNOP00000017559 ⟸ ENSRNOT00000017559

RefSeq Acc Id:	NP_001406194 ⟸ NM_001419265
- Peptide Label:	precursor
- UniProtKB:	F1LMX3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063144406 ⟸ XM_063288336
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063144407 ⟸ XM_063288337
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063144408 ⟸ XM_063288338
- Peptide Label:	isoform X4

Protein Domains

Eph LBD Fibronectin type-III Protein kinase SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P29321-F1-model_v2	AlphaFold	P29321	1-372	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708543	AgrOrtholog
BioCyc Gene	G2FUF-39486	BioCyc
Ensembl Genes	ENSRNOG00000013036	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000017559	ENTREZGENE
Gene3D-CATH	1.10.150.50	UniProtKB/Swiss-Prot
	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot
InterPro	Ephrin_rcpt_TKs	UniProtKB/Swiss-Prot
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	SAM	UniProtKB/Swiss-Prot
	SAM/pointed_sf	UniProtKB/Swiss-Prot
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
	Tyr_kinase_AS	UniProtKB/Swiss-Prot
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot
NCBI Gene	60589	ENTREZGENE
PANTHER	EPH RECEPTOR A5	UniProtKB/Swiss-Prot
	EPHRIN TYPE-A RECEPTOR 8	UniProtKB/Swiss-Prot
Pfam	Pkinase_Tyr	UniProtKB/Swiss-Prot
	SAM_1	UniProtKB/Swiss-Prot
PhenoGen	Epha8	PhenoGen
PRINTS	TYRKINASE	UniProtKB/Swiss-Prot
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot
	SAM_DOMAIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013036	RatGTEx
SMART	SAM	UniProtKB/Swiss-Prot
	TyrKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47769	UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A6ITC7	ENTREZGENE, UniProtKB/TrEMBL
	EPHA8_RAT	UniProtKB/Swiss-Prot
	F1LMX3	ENTREZGENE, UniProtKB/TrEMBL
	P29321	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-08	Epha8	Eph receptor A8	LOC60589	eph and elk-related kinase	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)