Ugt2b7 (UDP glucuronosyltransferase family 2 member B7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ugt2b7 (UDP glucuronosyltransferase family 2 member B7) Rattus norvegicus
Analyze
Symbol: Ugt2b7
Name: UDP glucuronosyltransferase family 2 member B7
RGD ID: 708417
Description: Predicted to enable glucuronosyltransferase activity. Predicted to be involved in androgen metabolic process; estrogen metabolic process; and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human UGT2B7 (UDP glucuronosyltransferase family 2 member B7); PARTICIPATES IN artemether pharmacokinetics pathway; codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; INTERACTS WITH 3-chloropropane-1,2-diol; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC286989; UDP glucuronosyltransferase 2 family, polypeptide B7; UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 2B7; UDP-glucuronosyltransferase 2B8; UDPGT 2B7; UDPGT 2B8; UGT2B-RH4; Ugt2b8
RGD Orthologs
Human
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,251,535 - 21,274,451 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,251,535 - 21,274,451 (+)EnsemblGRCr8
mRatBN7.21420,896,682 - 20,919,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,896,682 - 20,919,604 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,234,855 - 21,257,777 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,553,786 - 22,576,709 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,084,881 - 21,107,803 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,597,103 - 22,619,968 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01422,498,982 - 22,521,751 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,499,152 - 22,522,842 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,401,346 - 20,422,368 (+)NCBICelera
RGSC_v3.11422,499,151 - 22,522,842 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-isoborneol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-indene  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-tert-butylhydroquinone  (ISO)
20-HETE  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (ISO)
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one  (ISO)
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one  (ISO)
4-hydroxyestrone  (ISO)
4-methylumbelliferone  (ISO)
4-methylumbelliferone beta-D-glucuronide  (ISO)
4-tert-Octylphenol  (ISO)
6-hydroxywarfarin  (ISO)
7-Hydroxywarfarin  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP,ISO)
alclofenac  (ISO)
aldosterone  (ISO)
Aldosterone 18-glucuronide  (ISO)
aminoguanidine  (ISO)
ammonium chloride  (EXP)
amobarbital  (ISO)
amodiaquine  (ISO)
androsterone  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (EXP,ISO)
Aroclor 1254  (ISO)
belinostat  (ISO)
benoxaprofen  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bromfenac  (ISO)
bromuconazole  (EXP)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP)
cadmium dichloride  (EXP)
calycosin  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorogenic acid  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
clofibric acid  (ISO)
clopidogrel  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
denopamine  (ISO)
deoxynivalenol  (ISO)
dibenzo[a,l]pyrene  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diflunisal  (ISO)
disodium selenite  (ISO)
drometrizole  (ISO)
emodin  (EXP,ISO)
enilconazole  (ISO)
erythrosin B  (ISO)
estriol  (ISO)
estrone  (ISO)
etodolac  (ISO)
ezetimibe  (ISO)
farnesol  (ISO)
fenoprofen  (ISO)
fluconazole  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
furan  (EXP)
furosemide  (ISO)
galangin  (ISO)
glabridin  (ISO)
hyodeoxycholic acid  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
kaempferol  (ISO)
ketoprofen  (ISO)
ketorolac  (ISO)
labetalol  (ISO)
levofloxacin  (ISO)
Licochalcone A  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lorcaserin  (ISO)
mangiferin  (ISO)
meclofenamic acid  (ISO)
mefenamic acid  (ISO)
mercury dichloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
morphine  (ISO)
myricetin  (ISO)
N-nitrosodiethylamine  (EXP)
naloxone  (ISO)
naproxen  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
osimertinib  (ISO)
oxazepam  (ISO)
Oxazepam glucuronide  (ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phloretin  (ISO)
phlorizin  (ISO)
pirprofen  (ISO)
pravastatin  (ISO)
primidone  (ISO)
probenecid  (ISO)
procyanidin B2  (ISO)
propanal  (ISO)
prostaglandin B1  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
ranirestat  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
selumetinib  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulindac  (ISO)
sulindac sulfone  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
tiaprofenic acid  (ISO)
ticlopidine  (ISO)
topiramate  (ISO)
trans-caffeic acid  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
UDP-alpha-D-glucuronic acid  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
warfarin  (ISO)
zidovudine  (ISO)
zomepirac  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:17442341   PMID:18052087   PMID:20056724   PMID:20308471   PMID:22028316   PMID:22579593   PMID:23376485   PMID:28770824   PMID:30347696  


Genomics

Comparative Map Data
Ugt2b7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,251,535 - 21,274,451 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,251,535 - 21,274,451 (+)EnsemblGRCr8
mRatBN7.21420,896,682 - 20,919,604 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1420,896,682 - 20,919,604 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,234,855 - 21,257,777 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01422,553,786 - 22,576,709 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,084,881 - 21,107,803 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01422,597,103 - 22,619,968 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01422,498,982 - 22,521,751 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41422,499,152 - 22,522,842 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1420,401,346 - 20,422,368 (+)NCBICelera
RGSC_v3.11422,499,151 - 22,522,842 (+)NCBI
Cytogenetic Map14p21NCBI
UGT2B7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38469,051,375 - 69,112,987 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl469,051,363 - 69,112,987 (+)Ensemblhg38GRCh38
GRCh37469,917,093 - 69,978,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36469,996,814 - 70,013,293 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34470,142,984 - 70,159,464NCBI
Celera467,303,842 - 67,320,327 (+)NCBICelera
Cytogenetic Map4q13.2NCBI
HuRef465,757,832 - 65,774,338 (+)NCBIHuRef
CHM1_1469,998,516 - 70,014,999 (+)NCBICHM1_1
T2T-CHM13v2.0472,492,136 - 72,553,482 (+)NCBIT2T-CHM13v2.0
LOC100623255
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1865,915,718 - 65,936,113 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2870,337,489 - 70,357,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Ugt2b7
116 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:104
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000002716
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
ectoderm
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
6 2 40 1 1 1 33 21

Sequence


Ensembl Acc Id: ENSRNOT00000048482   ⟹   ENSRNOP00000050445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,251,535 - 21,274,451 (+)Ensembl
mRatBN7.2 Ensembl1420,896,682 - 20,919,604 (+)Ensembl
RefSeq Acc Id: NM_173323   ⟹   NP_775445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,251,535 - 21,274,451 (+)NCBI
mRatBN7.21420,896,682 - 20,919,604 (+)NCBI
Rnor_6.01422,597,103 - 22,619,968 (+)NCBI
Rnor_5.01422,498,982 - 22,521,751 (+)NCBI
RGSC_v3.41422,499,152 - 22,522,842 (+)RGD
Celera1420,401,346 - 20,422,368 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_775445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA86833 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050445
GenBank Protein Q62789 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775445   ⟸   NM_173323
- Peptide Label: precursor
- UniProtKB: Q62789 (UniProtKB/Swiss-Prot),   F1LLV5 (UniProtKB/TrEMBL),   A6JCQ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050445   ⟸   ENSRNOT00000048482

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62789-F1-model_v2 AlphaFold Q62789 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708417 AgrOrtholog
BioCyc Gene G2FUF-16099 BioCyc
Ensembl Genes ENSRNOG00000070682 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000048482 ENTREZGENE
Gene3D-CATH Glycogen Phosphorylase B UniProtKB/Swiss-Prot
InterPro UDP-glycosyltransferase UniProtKB/Swiss-Prot
  UDP_glucos_trans UniProtKB/Swiss-Prot
  UDP_glycos_trans_CS UniProtKB/Swiss-Prot
KEGG Report rno:286989 UniProtKB/Swiss-Prot
NCBI Gene 286989 ENTREZGENE
PANTHER EG:EG0003.4 PROTEIN-RELATED UniProtKB/Swiss-Prot
  UDP-GLUCURONOSYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam UDPGT UniProtKB/Swiss-Prot
PharmGKB UGT2B7 RGD
PhenoGen Ugt2b7 PhenoGen
PROSITE UDPGT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000070682 RatGTEx
Superfamily-SCOP UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/Swiss-Prot
UniProt A6JCQ2 ENTREZGENE, UniProtKB/TrEMBL
  F1LLV5 ENTREZGENE, UniProtKB/TrEMBL
  Q62789 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ugt2b7  UDP glucuronosyltransferase family 2 member B7  Ugt2b7  UDP glucuronosyltransferase 2 family, polypeptide B7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-03-12 Ugt2b7  UDP glucuronosyltransferase 2 family, polypeptide B7  LOC286989  UDP-glucuronosyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-28 LOC286989        Symbol and Name status set to provisional 70820 PROVISIONAL