Wfdc1 (WAP four-disulfide core domain 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Wfdc1 (WAP four-disulfide core domain 1) Rattus norvegicus
Analyze
Symbol: Wfdc1
Name: WAP four-disulfide core domain 1
RGD ID: 68938
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of epithelial cell proliferation; regulation of cell growth; and response to estradiol. Located in extracellular space. Orthologous to human WFDC1 (WAP four-disulfide core domain 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 20-kDa prostate stromal protein; prostate stromal protein ps20; ps20; ps20 growth inhibitor; WAP four-disulfide core domain protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,628,689 - 64,647,739 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1964,607,794 - 64,648,028 (+)EnsemblGRCr8
mRatBN7.21947,720,191 - 47,739,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,720,423 - 47,739,108 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1954,514,762 - 54,533,453 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,195,467 - 55,214,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,408,721 - 57,427,398 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1958,426,561 - 58,445,282 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1956,550,172 - 56,568,893 (+)NCBILyon_Normotensive
Lyon_Hypertensive1958,424,446 - 58,443,139 (+)NCBILyon_Hypertensive
F344_StmMcwi1956,157,165 - 56,175,876 (+)NCBIF344_StmMcwi
Rnor_6.01952,313,771 - 52,332,721 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,313,795 - 52,332,697 (+)Ensemblrn6Rnor6.0
Rnor_5.01963,061,860 - 63,080,795 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41949,924,440 - 49,943,113 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1946,978,401 - 46,997,044 (+)NCBICelera
RGSC_v3.11949,929,319 - 49,947,994 (+)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)
melanoma  (ISO)
prostate cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,7-dihydropurine-6-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
isoprenaline  (ISO)
lead(0)  (ISO)
manganese(II) chloride  (EXP)
mercaptopurine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
purine-6-thiol  (EXP)
raloxifene  (EXP)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
triadimefon  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Suppression of ps20 expression in the rat uterus by tamoxifen and estrogens. Hung H Endocrinology. 2005 May;146(5):2388-96. Epub 2005 Jan 27.
4. Molecular cloning and expression of ps20 growth inhibitor. A novel WAP-type "four-disulfide core" domain protein expressed in smooth muscle. Larsen M, etal., J Biol Chem 1998 Feb 20;273(8):4574-84.
5. Decreased stromal expression and increased epithelial expression of WFDC1/ps20 in prostate cancer is associated with reduced recurrence-free survival. McAlhany SJ, etal., Prostate. 2004 Oct 1;61(2):182-91.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Purification of a novel protein (ps20) from urogenital sinus mesenchymal cells with growth inhibitory properties in vitro. Rowley DR, etal., J Biol Chem. 1995 Sep 15;270(37):22058-65.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Molecular analysis of WFDC1/ps20 gene in prostate cancer. Watson JE, etal., Prostate. 2004 Oct 1;61(2):192-9.
Additional References at PubMed
PMID:15489334   PMID:25219356  


Genomics

Comparative Map Data
Wfdc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,628,689 - 64,647,739 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1964,607,794 - 64,648,028 (+)EnsemblGRCr8
mRatBN7.21947,720,191 - 47,739,121 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,720,423 - 47,739,108 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1954,514,762 - 54,533,453 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,195,467 - 55,214,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,408,721 - 57,427,398 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1958,426,561 - 58,445,282 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1956,550,172 - 56,568,893 (+)NCBILyon_Normotensive
Lyon_Hypertensive1958,424,446 - 58,443,139 (+)NCBILyon_Hypertensive
F344_StmMcwi1956,157,165 - 56,175,876 (+)NCBIF344_StmMcwi
Rnor_6.01952,313,771 - 52,332,721 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,313,795 - 52,332,697 (+)Ensemblrn6Rnor6.0
Rnor_5.01963,061,860 - 63,080,795 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41949,924,440 - 49,943,113 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1946,978,401 - 46,997,044 (+)NCBICelera
RGSC_v3.11949,929,319 - 49,947,994 (+)NCBI
Cytogenetic Map19q12NCBI
WFDC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,294,878 - 84,329,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,294,615 - 84,329,853 (+)Ensemblhg38GRCh38
GRCh371684,328,484 - 84,363,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361682,885,902 - 82,920,951 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341682,885,901 - 82,920,950NCBI
Celera1668,630,194 - 68,665,222 (+)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1670,082,125 - 70,116,484 (+)NCBIHuRef
CHM1_11685,739,741 - 85,774,785 (+)NCBICHM1_1
T2T-CHM13v2.01690,352,943 - 90,396,238 (+)NCBIT2T-CHM13v2.0
Wfdc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,393,104 - 120,414,759 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,393,104 - 120,414,961 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388119,666,365 - 119,688,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,666,365 - 119,688,222 (+)Ensemblmm10GRCm38
MGSCv378122,190,265 - 122,211,920 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368122,552,342 - 122,573,997 (+)NCBIMGSCv36mm8
Celera8123,883,441 - 123,905,242 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.15NCBI
Wfdc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495556422,536 - 38,091 (-)NCBIChiLan1.0ChiLan1.0
WFDC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21894,032,071 - 94,075,948 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11699,949,260 - 99,993,217 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01664,958,920 - 64,994,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,300,848 - 84,336,328 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,301,168 - 84,333,432 (+)EnsemblpanPan2panpan1.1
WFDC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1568,067,894 - 68,095,749 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl568,067,885 - 68,096,067 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha568,082,387 - 68,110,327 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0568,301,053 - 68,328,998 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,301,057 - 68,329,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,313,918 - 68,341,842 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,150,395 - 68,178,327 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,565,748 - 68,593,720 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC120887979
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,811,077 - 27,813,916 (-)NCBIHiC_Itri_2
WFDC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,333,731 - 4,399,237 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.164,333,729 - 4,365,122 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.264,757,938 - 4,789,333 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WFDC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,700,984 - 69,734,682 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl569,701,470 - 69,731,823 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660476,025,869 - 6,054,483 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:153
Interacting mature miRNAs:173
Transcripts:ENSRNOT00000021630
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 31 59 6 295 131 11 138 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000021630   ⟹   ENSRNOP00000021630
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1964,607,794 - 64,648,028 (+)Ensembl
mRatBN7.2 Ensembl1947,720,423 - 47,739,099 (+)Ensembl
Rnor_6.0 Ensembl1952,313,795 - 52,332,697 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117897   ⟹   ENSRNOP00000095202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,720,429 - 47,739,108 (+)Ensembl
RefSeq Acc Id: NM_133581   ⟹   NP_598265
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,629,048 - 64,647,739 (+)NCBI
mRatBN7.21947,720,428 - 47,739,121 (+)NCBI
Dahl_SR_JrHsd1958,426,561 - 58,445,282 (+)NCBI
Lyon_Normotensive1956,550,172 - 56,568,893 (+)NCBI
Lyon_Hypertensive1958,424,446 - 58,443,139 (+)NCBI
F344_StmMcwi1956,157,165 - 56,175,876 (+)NCBI
Rnor_6.01952,314,030 - 52,332,721 (+)NCBI
Rnor_5.01963,061,860 - 63,080,795 (+)NCBI
RGSC_v3.41949,924,440 - 49,943,113 (+)RGD
Celera1946,978,401 - 46,997,044 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006255705   ⟹   XP_006255767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,628,689 - 64,647,717 (+)NCBI
mRatBN7.21947,720,191 - 47,739,099 (+)NCBI
Rnor_6.01952,313,771 - 52,332,718 (+)NCBI
Rnor_5.01963,061,860 - 63,080,795 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_598265 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40055 (Get FASTA)   NCBI Sequence Viewer  
  AAH63152 (Get FASTA)   NCBI Sequence Viewer  
  EDL92680 (Get FASTA)   NCBI Sequence Viewer  
  EDL92681 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021630
GenBank Protein O70280 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598265   ⟸   NM_133581
- Peptide Label: precursor
- UniProtKB: O70280 (UniProtKB/Swiss-Prot),   A6IZK1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255767   ⟸   XM_006255705
- Peptide Label: isoform X1
- UniProtKB: O70280 (UniProtKB/Swiss-Prot),   A6IZK1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021630   ⟸   ENSRNOT00000021630
Ensembl Acc Id: ENSRNOP00000095202   ⟸   ENSRNOT00000117897
Protein Domains
WAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70280-F1-model_v2 AlphaFold O70280 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701184
Promoter ID:EPDNEW_R11706
Type:initiation region
Name:Wfdc1_2
Description:WAP four-disulfide core domain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11707  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,313,792 - 52,313,852EPDNEW
RGD ID:13701185
Promoter ID:EPDNEW_R11707
Type:initiation region
Name:Wfdc1_1
Description:WAP four-disulfide core domain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11706  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01952,314,039 - 52,314,099EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68938 AgrOrtholog
BioCyc Gene G2FUF-5508 BioCyc
Ensembl Genes ENSRNOG00000015904 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021630 ENTREZGENE
Gene3D-CATH 4.10.75.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6887007 IMAGE-MGC_LOAD
InterPro Elafin-like_sf UniProtKB/Swiss-Prot
  WAP_dom UniProtKB/Swiss-Prot
  WFDC1 UniProtKB/Swiss-Prot
KEGG Report rno:171112 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72704 IMAGE-MGC_LOAD
NCBI Gene 171112 ENTREZGENE
PANTHER PTHR14308 UniProtKB/Swiss-Prot
  WAP FOUR-DISULFIDE CORE DOMAIN PROTEIN 1 UniProtKB/Swiss-Prot
Pfam WAP UniProtKB/Swiss-Prot
PhenoGen Wfdc1 PhenoGen
PROSITE WAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015904 RatGTEx
SMART WAP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57256 UniProtKB/Swiss-Prot
TIGR TC205946
UniProt A0A8L2QBA2_RAT UniProtKB/TrEMBL
  A6IZK1 ENTREZGENE, UniProtKB/TrEMBL
  A6IZK3_RAT UniProtKB/TrEMBL
  O70280 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Wfdc1  WAP four-disulfide core domain 1    wap four-disulfide core domain 1  Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Wfdc1  wap four-disulfide core domain 1      Symbol and Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in smooth muscle and prostate gland stroma 61500
gene_function may be a protease inhibitor 61500
gene_process functions as a growth inhibitor 61500
gene_protein predicted 186 amino acids 61500