Clcnka (chloride voltage-gated channel Ka) - Rat Genome Database

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Gene: Clcnka (chloride voltage-gated channel Ka) Rattus norvegicus
Analyze
Symbol: Clcnka
Name: chloride voltage-gated channel Ka
RGD ID: 68435
Description: Enables chloride channel activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including body fluid secretion; response to calcium ion; and response to pH. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka) and CLCNKB (chloride voltage-gated channel Kb); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (4-chloro-2-methylphenoxy)acetic acid; 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chloride channel K1; chloride channel Ka; chloride channel protein ClC-Ka; chloride channel, voltage-sensitive Ka; clC-K1; Clcnk1; MGC93313
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,974,190 - 158,989,275 (-)NCBIGRCr8
mRatBN7.25153,691,208 - 153,706,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,691,209 - 153,706,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,378,149 - 156,393,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,151,434 - 158,166,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,140,613 - 158,155,555 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,931,497 - 159,946,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,651,964 - 163,667,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,274,377 - 160,290,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,284,564 - 160,300,557 (-)NCBI
Celera5152,055,371 - 152,067,986 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Two highly homologous members of the ClC chloride channel family in both rat and human kidney. Kieferle S, etal., Proc Natl Acad Sci U S A 1994 Jul 19;91(15):6943-7.
4. Developmental expression of CLC-K1 in the postnatal rat kidney. Kobayashi K, etal., Histochem Cell Biol. 2001 Jul;116(1):49-56.
5. Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel. Matsumura Y, etal., Nat Genet 1999 Jan;21(1):95-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Salt wasting and deafness resulting from mutations in two chloride channels. Schlingmann KP, etal., N Engl J Med 2004 Mar 25;350(13):1314-9.
14. Barttin modulates trafficking and function of ClC-K channels. Scholl U, etal., Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11411-6. Epub 2006 Jul 18.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. Uchida S, etal., J Biol Chem 1993 Feb 25;268(6):3821-4.
18. Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla. Uchida S, etal., J Biol Chem 1994 Jul 22;269(29):19192.
19. Localization and functional characterization of rat kidney-specific chloride channel, ClC-K1. Uchida S, etal., J Clin Invest. 1995 Jan;95(1):104-13.
20. Barttin increases surface expression and changes current properties of ClC-K channels. Waldegger S, etal., Pflugers Arch 2002 Jun;444(3):411-8.
Additional References at PubMed
PMID:11133517   PMID:11423561   PMID:12759757   PMID:17562318   PMID:18945830  


Genomics

Comparative Map Data
Clcnka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85158,974,190 - 158,989,275 (-)NCBIGRCr8
mRatBN7.25153,691,208 - 153,706,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5153,691,209 - 153,706,148 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5156,378,149 - 156,393,093 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,151,434 - 158,166,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,140,613 - 158,155,555 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05159,931,497 - 159,946,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,651,964 - 163,667,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,274,377 - 160,290,369 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15160,284,564 - 160,300,557 (-)NCBI
Celera5152,055,371 - 152,067,986 (-)NCBICelera
Cytogenetic Map5q36NCBI
CLCNKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,022,036 - 16,034,050 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,018,875 - 16,034,050 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,348,531 - 16,360,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,221,073 - 16,233,132 (+)NCBINCBI36Build 36hg18NCBI36
Build 34116,094,415 - 16,105,850NCBI
Celera114,828,391 - 14,840,450 (+)NCBICelera
Cytogenetic Map1p36.13NCBI
HuRef114,867,532 - 14,879,195 (+)NCBIHuRef
CHM1_1116,146,987 - 16,159,046 (+)NCBICHM1_1
T2T-CHM13v2.0115,463,347 - 15,475,360 (+)NCBIT2T-CHM13v2.0
Clcnka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,111,922 - 141,126,017 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,111,921 - 141,126,035 (-)EnsemblGRCm39 Ensembl
GRCm384141,384,611 - 141,398,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,384,610 - 141,398,724 (-)EnsemblGRCm38mm10GRCm38
MGSCv374140,940,526 - 140,954,621 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364139,138,024 - 139,141,158 (-)NCBIMGSCv36mm8
MGSCv364140,656,686 - 140,670,775 (-)NCBIMGSCv36mm8
Celera4143,203,482 - 143,215,208 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map473.94NCBI
LOC100986591
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21210,887,107 - 210,901,016 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,135,593 - 210,147,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0115,159,362 - 15,171,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,152,022 - 16,163,777 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,152,022 - 16,163,777 (+)Ensemblpanpan1.1panPan2
Clcnka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,766,062 - 37,777,337 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364743,591,134 - 3,601,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Clcnka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247642,202,579 - 2,212,337 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247642,202,438 - 2,212,185 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clcnka
59 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:60
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000013103
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5144358090157869054Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5143799107158428037Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat

Markers in Region
C75963  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,691,291 - 153,691,539 (+)MAPPERmRatBN7.2
Rnor_6.05159,931,592 - 159,931,839NCBIRnor6.0
Rnor_5.05163,652,047 - 163,652,294UniSTSRnor5.0
Rnor_5.05163,648,170 - 163,648,417UniSTSRnor5.0
RGSC_v3.45160,274,460 - 160,274,707UniSTSRGSC3.4
Celera5152,055,454 - 152,055,701UniSTS
Cytogenetic Map5q36UniSTS
BE115105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25153,691,207 - 153,691,360 (+)MAPPERmRatBN7.2
Rnor_6.05159,931,508 - 159,931,660NCBIRnor6.0
Rnor_5.05163,651,963 - 163,652,115UniSTSRnor5.0
Rnor_5.05163,648,086 - 163,648,238UniSTSRnor5.0
RGSC_v3.45160,274,376 - 160,274,528UniSTSRGSC3.4
Celera5152,055,370 - 152,055,522UniSTS
RH 3.4 Map51053.1UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 23 96 28 41 16 9 16 5 100 32 91 45 55 25

Sequence


Ensembl Acc Id: ENSRNOT00000089184   ⟹   ENSRNOP00000072591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,691,211 - 153,706,148 (-)Ensembl
Rnor_6.0 Ensembl5159,931,511 - 159,946,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108320   ⟹   ENSRNOP00000097659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5153,691,209 - 153,705,531 (-)Ensembl
RefSeq Acc Id: NM_053327   ⟹   NP_445779
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,974,191 - 158,989,148 (-)NCBI
mRatBN7.25153,691,209 - 153,706,168 (-)NCBI
Rnor_6.05159,931,509 - 159,946,466 (-)NCBI
Rnor_5.05163,651,964 - 163,667,008 (-)NCBI
RGSC_v3.45160,274,377 - 160,290,369 (-)RGD
Celera5152,055,371 - 152,067,986 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764292   ⟹   XP_008762514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,974,190 - 158,989,152 (-)NCBI
mRatBN7.25153,691,208 - 153,706,295 (-)NCBI
Rnor_6.05159,931,497 - 159,946,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288464   ⟹   XP_063144534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85158,974,190 - 158,989,275 (-)NCBI
RefSeq Acc Id: NP_445779   ⟸   NM_053327
- UniProtKB: Q06393 (UniProtKB/Swiss-Prot),   P97709 (UniProtKB/Swiss-Prot),   Q66HN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762514   ⟸   XM_008764292
- Peptide Label: isoform X1
- UniProtKB: Q06393 (UniProtKB/Swiss-Prot),   P97709 (UniProtKB/Swiss-Prot),   Q66HN9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072591   ⟸   ENSRNOT00000089184
Ensembl Acc Id: ENSRNOP00000097659   ⟸   ENSRNOT00000108320
RefSeq Acc Id: XP_063144534   ⟸   XM_063288464
- Peptide Label: isoform X1
- UniProtKB: Q06393 (UniProtKB/Swiss-Prot),   P97709 (UniProtKB/Swiss-Prot),   Q66HN9 (UniProtKB/TrEMBL)
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06393-F1-model_v2 AlphaFold Q06393 1-687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68435 AgrOrtholog
BioCyc Gene G2FUF-39351 BioCyc
Ensembl Genes ENSRNOG00000052368 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055023434 UniProtKB/Swiss-Prot
  ENSRNOG00060019218 UniProtKB/Swiss-Prot
  ENSRNOG00065026000 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089184.2 UniProtKB/TrEMBL
  ENSRNOT00000108320.1 UniProtKB/TrEMBL
  ENSRNOT00055040358 UniProtKB/Swiss-Prot
  ENSRNOT00060033683 UniProtKB/Swiss-Prot
  ENSRNOT00065045004 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Clc chloride channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108273 IMAGE-MGC_LOAD
InterPro CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl-channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel-K UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cl_channel_volt-gated UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93313 IMAGE-MGC_LOAD
NCBI Gene 79425 ENTREZGENE
PANTHER CHLORIDE CHANNEL PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHLORIDE CHANNEL PROTEIN CLC-KB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage_CLC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clcnka PhenoGen
PRINTS CLCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLCHANNELKDY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052368 RatGTEx
  ENSRNOG00055023434 RatGTEx
  ENSRNOG00060019218 RatGTEx
  ENSRNOG00065026000 RatGTEx
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234636
UniProt A0A8I6ATE0_RAT UniProtKB/TrEMBL
  CLCKA_RAT UniProtKB/Swiss-Prot
  P97709 ENTREZGENE
  Q06393 ENTREZGENE
  Q66HN9 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary P97709 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Clcnka  chloride voltage-gated channel Ka  Clcnka  chloride channel, voltage-sensitive Ka  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Clcnka  chloride channel, voltage-sensitive Ka  Clcnka  chloride channel Ka  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Clcnka  chloride channel Ka  Clcnk1  chloride channel K1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Clcnk1  chloride channel K1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mainly expressed in the thin ascending limb of henle's loop 68223
gene_regulation expression is upregulated by dehydration 68223