Lat2 (linker for activation of T cells family, member 2) - Rat Genome Database

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Gene: Lat2 (linker for activation of T cells family, member 2) Rattus norvegicus
Analyze
Symbol: Lat2
Name: linker for activation of T cells family, member 2
RGD ID: 631397
Description: Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LAT-2 like; linker for activation of B-cells; linker for activation of T-cells family member 2; non-T cell activation linker; non-T-cell activation linker; Ntal; Wbscr5; Williams-Beuren syndrome chromosome region 5 homolog; Williams-Beuren syndrome chromosome region 5 homolog (human); Williams-Beuren syndrome chromosome region 5-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,740,647 - 27,754,760 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,740,654 - 27,755,843 (+)EnsemblGRCr8
mRatBN7.21222,104,173 - 22,118,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,104,219 - 22,118,288 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,252,803 - 23,259,102 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,863,886 - 23,870,183 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,930,369 - 22,936,714 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,114,099 - 25,128,381 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)Ensemblrn6Rnor6.0
Rnor_5.01227,114,507 - 27,128,775 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,174,554 - 23,180,908 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,873,387 - 23,879,734 (+)NCBICelera
RGSC_v3.11223,035,110 - 23,041,465 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
graphite  (EXP)
ixazomib  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
pentanal  (ISO)
perifosine  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane raft  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. Brdicka T, etal., J Exp Med 2002 Dec 16;196(12):1617-26.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, etal., Mamm Genome 2000 Oct;11(10):890-8.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12514734   PMID:14722116   PMID:15477348   PMID:17013982   PMID:17911602   PMID:20442417   PMID:20458337   PMID:21403644   PMID:23443658   PMID:26448619   PMID:29099056  


Genomics

Comparative Map Data
Lat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,740,647 - 27,754,760 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,740,654 - 27,755,843 (+)EnsemblGRCr8
mRatBN7.21222,104,173 - 22,118,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,104,219 - 22,118,288 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,252,803 - 23,259,102 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,863,886 - 23,870,183 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,930,369 - 22,936,714 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,114,099 - 25,128,381 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)Ensemblrn6Rnor6.0
Rnor_5.01227,114,507 - 27,128,775 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,174,554 - 23,180,908 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,873,387 - 23,879,734 (+)NCBICelera
RGSC_v3.11223,035,110 - 23,041,465 (+)NCBI
Cytogenetic Map12q12NCBI
LAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,210,006 - 74,229,834 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,199,652 - 74,234,454 (+)Ensemblhg38GRCh38
GRCh37773,624,336 - 73,644,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,262,023 - 73,282,100 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34773,068,925 - 73,088,808NCBI
Celera769,103,651 - 69,123,730 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,505,694 - 69,525,599 (+)NCBIHuRef
CHM1_1773,769,175 - 73,789,226 (+)NCBICHM1_1
T2T-CHM13v2.0775,412,292 - 75,432,128 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,957,159 - 72,977,236 (+)NCBI
Lat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,628,957 - 134,648,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,628,876 - 134,643,879 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385134,600,103 - 134,619,783 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,600,022 - 134,615,025 (-)Ensemblmm10GRCm38
MGSCv375135,076,135 - 135,090,893 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365134,884,892 - 134,899,650 (-)NCBIMGSCv36mm8
Celera5131,608,314 - 131,623,075 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.7NCBI
Lat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545613,674,190 - 13,688,611 (-)NCBIChiLan1.0ChiLan1.0
LAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,667,421 - 90,698,260 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17138,932,089 - 138,962,892 (-)NCBINHGRI_mPanPan1
PanPan1.1781,350,666 - 81,377,115 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,350,666 - 81,377,115 (+)EnsemblpanPan2panpan1.1
LAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,160,939 - 6,175,271 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,161,542 - 6,173,294 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha67,859,266 - 7,872,992 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.065,975,446 - 5,989,987 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl65,975,446 - 5,990,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.165,966,577 - 5,980,984 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.065,914,054 - 5,928,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,077,458 - 6,092,227 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,774,449 - 130,785,905 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365433,250,956 - 3,262,668 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,352,548 - 11,372,101 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1311,353,213 - 11,372,100 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2311,036,844 - 11,055,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,848,971 - 8,865,558 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,848,638 - 8,865,574 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660707,714,089 - 7,732,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474013,745,949 - 13,764,869 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lat2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11619,450,601 - 19,457,376 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lat2
84 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000034629
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 154 91 90 59 92 59 6 352 188 11 133 81 92 31 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_173840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB219140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC091000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC135741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY170849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ294699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000034629   ⟹   ENSRNOP00000031304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,740,654 - 27,755,843 (+)Ensembl
mRatBN7.2 Ensembl1222,104,219 - 22,118,275 (+)Ensembl
Rnor_6.0 Ensembl1225,119,355 - 25,125,749 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093800   ⟹   ENSRNOP00000083189
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,740,674 - 27,755,843 (+)Ensembl
mRatBN7.2 Ensembl1222,104,219 - 22,118,275 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098558   ⟹   ENSRNOP00000079065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,109,832 - 22,118,288 (+)Ensembl
RefSeq Acc Id: NM_173840   ⟹   NP_776212
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,715 - 27,754,760 (+)NCBI
mRatBN7.21222,104,242 - 22,118,289 (+)NCBI
Rnor_6.01225,119,379 - 25,125,733 (+)NCBI
Rnor_5.01227,114,507 - 27,128,775 (+)NCBI
RGSC_v3.41223,174,554 - 23,180,908 (+)RGD
Celera1223,873,387 - 23,879,734 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598358   ⟹   XP_017453847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,653 - 27,754,755 (+)NCBI
mRatBN7.21222,104,179 - 22,118,294 (+)NCBI
Rnor_6.01225,119,846 - 25,128,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089531   ⟹   XP_038945459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,654 - 27,754,755 (+)NCBI
mRatBN7.21222,104,180 - 22,118,289 (+)NCBI
RefSeq Acc Id: XM_039089532   ⟹   XP_038945460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,647 - 27,751,122 (+)NCBI
mRatBN7.21222,104,173 - 22,114,650 (+)NCBI
RefSeq Acc Id: XM_039089533   ⟹   XP_038945461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,647 - 27,751,122 (+)NCBI
mRatBN7.21222,104,173 - 22,114,650 (+)NCBI
RefSeq Acc Id: XM_039089534   ⟹   XP_038945462
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,691 - 27,754,755 (+)NCBI
mRatBN7.21222,104,223 - 22,118,289 (+)NCBI
RefSeq Acc Id: XR_005491642
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,648 - 27,751,776 (+)NCBI
mRatBN7.21222,104,174 - 22,115,308 (+)NCBI
RefSeq Acc Id: XR_005491643
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,740,648 - 27,751,776 (+)NCBI
mRatBN7.21222,104,174 - 22,115,308 (+)NCBI
RefSeq Acc Id: NP_776212   ⟸   NM_173840
- UniProtKB: Q8CGL2 (UniProtKB/Swiss-Prot),   A6J0I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453847   ⟸   XM_017598358
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWF7 (UniProtKB/TrEMBL),   A6J0I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031304   ⟸   ENSRNOT00000034629
RefSeq Acc Id: XP_038945460   ⟸   XM_039089532
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038945461   ⟸   XM_039089533
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038945459   ⟸   XM_039089531
- Peptide Label: isoform X1
- UniProtKB: Q8CGL2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038945462   ⟸   XM_039089534
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000083189   ⟸   ENSRNOT00000093800
Ensembl Acc Id: ENSRNOP00000079065   ⟸   ENSRNOT00000098558

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CGL2-F1-model_v2 AlphaFold Q8CGL2 1-204 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631397 AgrOrtholog
BioCyc Gene G2FUF-19580 BioCyc
Ensembl Genes ENSRNOG00000021856 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000034629 ENTREZGENE
  ENSRNOT00000093800 ENTREZGENE
InterPro LAT2 UniProtKB/Swiss-Prot
KEGG Report rno:317676 UniProtKB/Swiss-Prot
NCBI Gene 317676 ENTREZGENE
PANTHER LINKER FOR ACTIVATION OF T-CELLS FAMILY MEMBER 2 UniProtKB/Swiss-Prot
  PTHR15646 UniProtKB/Swiss-Prot
Pfam LAT2 UniProtKB/Swiss-Prot
PhenoGen Lat2 PhenoGen
RatGTEx ENSRNOG00000021856 RatGTEx
UniProt A0A8I5ZWF7 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I1 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I2 ENTREZGENE, UniProtKB/TrEMBL
  A6J0I3_RAT UniProtKB/TrEMBL
  G3V8Z1_RAT UniProtKB/TrEMBL
  NTAL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Lat2  linker for activation of T cells family, member 2      Symbol and Name updated 1299863 APPROVED
2004-12-14 Wbscr5  Williams-Beuren syndrome chromosome region 5 homolog (human)      Symbol and Name status set to approved 1299863 APPROVED