Nptx1 (neuronal pentraxin 1) - Rat Genome Database

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Gene: Nptx1 (neuronal pentraxin 1) Rattus norvegicus
Analyze
Symbol: Nptx1
Name: neuronal pentraxin 1
RGD ID: 628894
Description: Predicted to enable metal ion binding activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; neurotransmitter receptor localization to postsynaptic specialization membrane; and postsynaptic density assembly. Is active in glutamatergic synapse and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human NPTX1 (neuronal pentraxin 1); INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 47 kDa taipoxin-binding protein; LOC360249; neuronal pentraxin I; neuronal pentraxin-1; NP-I; NP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,309,578 - 105,318,829 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10105,309,578 - 105,318,863 (-)EnsemblGRCr8
mRatBN7.210104,811,107 - 104,820,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,811,403 - 104,820,367 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10109,914,282 - 109,923,567 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,377,316 - 109,386,601 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,731,702 - 104,740,953 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,682,637 - 108,691,592 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,682,638 - 108,691,367 (-)Ensemblrn6Rnor6.0
Rnor_5.010108,286,989 - 108,295,944 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410108,918,661 - 108,927,616 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10103,356,568 - 103,365,489 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
dichloroacetic acid  (ISO)
diiodine  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triptonide  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. Clayton KB, etal., J Neurosci. 2012 Jan 25;32(4):1453-66.
2. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Farhy-Tselnicker I, etal., Neuron. 2017 Oct 11;96(2):428-445.e13. doi: 10.1016/j.neuron.2017.09.053.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Schlimgen AK, etal., Neuron 1995 Mar;14(3):519-26.
9. Modulation of Neuronal Pentraxin 1 Expression in Rat Pancreatic beta-Cells Submitted to Chronic Glucotoxic Stress. Schvartz D, etal., Mol Cell Proteomics. 2012 Aug;11(8):244-54. Epub 2012 Mar 16.
Additional References at PubMed
PMID:10748068   PMID:15115814   PMID:16763034   PMID:22956834   PMID:27986928   PMID:32357304   PMID:34142698  


Genomics

Comparative Map Data
Nptx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,309,578 - 105,318,829 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10105,309,578 - 105,318,863 (-)EnsemblGRCr8
mRatBN7.210104,811,107 - 104,820,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,811,403 - 104,820,367 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10109,914,282 - 109,923,567 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,377,316 - 109,386,601 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,731,702 - 104,740,953 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,682,637 - 108,691,592 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,682,638 - 108,691,367 (-)Ensemblrn6Rnor6.0
Rnor_5.010108,286,989 - 108,295,944 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410108,918,661 - 108,927,616 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10103,356,568 - 103,365,489 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
NPTX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,466,834 - 80,476,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,466,834 - 80,477,843 (-)Ensemblhg38GRCh38
GRCh371778,440,634 - 78,450,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,055,228 - 76,064,999 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341776,055,227 - 76,064,999NCBI
Celera1775,069,005 - 75,078,529 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,878,650 - 73,888,424 (-)NCBIHuRef
CHM1_11778,526,902 - 78,536,673 (-)NCBICHM1_1
T2T-CHM13v2.01781,368,723 - 81,378,497 (-)NCBIT2T-CHM13v2.0
Nptx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,429,545 - 119,438,646 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,429,545 - 119,438,579 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3811119,538,719 - 119,547,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,538,719 - 119,547,753 (-)Ensemblmm10GRCm38
MGSCv3711119,400,033 - 119,409,134 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611119,355,462 - 119,363,915 (-)NCBIMGSCv36mm8
Celera11131,286,494 - 131,295,595 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.95NCBI
Nptx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,447,109 - 2,456,965 (+)Ensembl
ChiLan1.0NW_0049555062,447,429 - 2,456,612 (+)NCBIChiLan1.0ChiLan1.0
NPTX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,048,221 - 97,057,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117101,948,062 - 101,957,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,896,150 - 74,905,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,629,443 - 80,638,376 (-)NCBIPanPan1.1PanPan1.1panPan2
NPTX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,388,728 - 1,398,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,388,407 - 1,399,390 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha92,006,248 - 2,015,635 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.091,998,099 - 2,007,496 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,998,127 - 2,007,488 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.192,021,740 - 2,031,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.092,147,267 - 2,156,623 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.092,228,148 - 2,237,541 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nptx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056022,027,566 - 2,038,459 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,373,473 - 4,384,461 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,373,500 - 4,384,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPTX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,036,810 - 2,046,193 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1122,036,727 - 2,046,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,938,606 - 1,948,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPTX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,438,728 - 72,449,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,439,482 - 72,449,139 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607743,751,846 - 43,761,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nptx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,628,882 - 9,637,859 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248019,628,878 - 9,637,869 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Nptx1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1964,469,033 - 64,478,286 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nptx1
60 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000005067
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
Nptx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,811,149 - 104,811,263 (+)MAPPERmRatBN7.2
Rnor_6.010108,682,384 - 108,682,497NCBIRnor6.0
Rnor_5.010108,286,736 - 108,286,849UniSTSRnor5.0
RGSC_v3.410108,918,408 - 108,918,521UniSTSRGSC3.4
Celera10103,356,315 - 103,356,428UniSTS
Cytogenetic Map10q32.3UniSTS
RH143293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,811,580 - 104,811,721 (+)MAPPERmRatBN7.2
Rnor_6.010108,682,815 - 108,682,955NCBIRnor6.0
Rnor_5.010108,287,167 - 108,287,307UniSTSRnor5.0
RGSC_v3.410108,918,839 - 108,918,979UniSTSRGSC3.4
Celera10103,356,746 - 103,356,886UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 63 161 62 61 30 41 30 6 264 137 11 140 75 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005067   ⟹   ENSRNOP00000005067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10105,309,578 - 105,318,863 (-)Ensembl
mRatBN7.2 Ensembl10104,811,403 - 104,820,367 (-)Ensembl
Rnor_6.0 Ensembl10108,682,638 - 108,691,367 (-)Ensembl
RefSeq Acc Id: NM_153735   ⟹   NP_714957
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,309,578 - 105,318,829 (-)NCBI
mRatBN7.210104,811,107 - 104,820,358 (-)NCBI
Rnor_6.010108,682,637 - 108,691,592 (-)NCBI
Rnor_5.010108,286,989 - 108,295,944 (-)NCBI
RGSC_v3.410108,918,661 - 108,927,616 (-)RGD
Celera10103,356,568 - 103,365,489 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_714957 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005067
  ENSRNOP00000005067.6
GenBank Protein P47971 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_714957   ⟸   NM_153735
- Peptide Label: precursor
- UniProtKB: P47971 (UniProtKB/Swiss-Prot),   A6HL92 (UniProtKB/TrEMBL),   A0A0H2UHC1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005067   ⟸   ENSRNOT00000005067
Protein Domains
Pentraxin (PTX)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47971-F1-model_v2 AlphaFold P47971 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628894 AgrOrtholog
BioCyc Gene G2FUF-22477 BioCyc
Ensembl Genes ENSRNOG00000003741 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005067 ENTREZGENE
  ENSRNOT00000005067.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Neuronal_Pentraxin_Related UniProtKB/Swiss-Prot
  Pentaxin_CS UniProtKB/Swiss-Prot
  Pentraxin-related UniProtKB/Swiss-Prot
KEGG Report rno:266777 UniProtKB/Swiss-Prot
NCBI Gene 266777 ENTREZGENE
PANTHER NEURONAL PENTRAXIN-1 UniProtKB/Swiss-Prot
  PENTRAXIN UniProtKB/Swiss-Prot
Pfam Pentaxin UniProtKB/Swiss-Prot
PhenoGen Nptx1 PhenoGen
PRINTS PENTAXIN UniProtKB/Swiss-Prot
PROSITE PTX_1 UniProtKB/Swiss-Prot
  PTX_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003741 RatGTEx
SMART PTX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt A0A0H2UHC1 ENTREZGENE, UniProtKB/TrEMBL
  A6HL92 ENTREZGENE, UniProtKB/TrEMBL
  NPTX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Nptx1  neuronal pentraxin 1  Nptx1  neuronal pentraxin I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-19 Nptx1  neuronal pentraxin I  Nptx1  neuronal pentraxin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Nptx1  neuronal pentraxin 1  Nptx1_predicted  neuronal pentraxin 1 (predicted)  Data merged from RGD:1310581 737654 APPROVED
2005-01-20 Nptx1  neuronal pentraxin 1      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Nptx1_predicted  neuronal pentraxin 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-02-27 Nptx1  neuronal pentraxin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons of cerebellum, hippocampus, and cerebral cortex 729007