Lama3 (laminin subunit alpha 3) - Rat Genome Database

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Gene: Lama3 (laminin subunit alpha 3) Rattus norvegicus
Analyze
Symbol: Lama3
Name: laminin subunit alpha 3
RGD ID: 628776
Description: Predicted to be an extracellular matrix structural constituent. Involved in cell-cell adhesion and hemidesmosome assembly. Located in adherens junction; extracellular matrix; and hemidesmosome. Part of laminin-3 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMA3 (laminin subunit alpha 3); PARTICIPATES IN syndecan signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: laminin 5 alpha 3; laminin subunit alpha-3; laminin, alpha 3; LOC307582; similar to Laminin alpha-3 chain precursor (Nicein alpha subunit)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8183,797,898 - 4,033,021 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl183,797,939 - 4,026,449 (+)EnsemblGRCr8
mRatBN7.2183,523,168 - 3,751,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,523,133 - 3,751,353 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,744,392 - 3,974,325 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0184,531,960 - 4,761,892 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,781,462 - 4,020,783 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,704,866 - 3,941,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,705,916 - 3,940,838 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,712,673 - 3,939,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4184,030,463 - 4,121,355 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera183,569,544 - 3,806,888 (+)NCBICelera
RGSC_v3.1184,030,462 - 4,121,355 (+)NCBI
Cytogenetic Map18p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brequinar  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
ferric oxide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
ibuprofen  (ISO)
ifosfamide  (ISO)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (EXP)
lysophosphatidylcholine  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylphenidate  (ISO)
mifepristone  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sphingosine 1-phosphate  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. Baker SE, etal., J Cell Sci 1996 Oct;109 ( Pt 10):2509-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones JC, etal., J Cell Sci. 2005 Jun 15;118(Pt 12):2557-66. Epub 2005 May 31.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Epigenetic inactivation of laminin-5-encoding genes in lung cancers. Sathyanarayana UG, etal., Clin Cancer Res. 2003 Jul;9(7):2665-72.
11. Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa. Vidal F, etal., Genomics. 1995 Nov 20;30(2):273-80.
12. Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes. Yan HH and Cheng CY, J Biol Chem. 2006 Jun 23;281(25):17286-303. Epub 2006 Apr 11.
Additional References at PubMed
PMID:9264260   PMID:12051813   PMID:15895400   PMID:18757743   PMID:20039268   PMID:20301201   PMID:23154389   PMID:23533145   PMID:27068509  


Genomics

Comparative Map Data
Lama3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8183,797,898 - 4,033,021 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl183,797,939 - 4,026,449 (+)EnsemblGRCr8
mRatBN7.2183,523,168 - 3,751,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,523,133 - 3,751,353 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx183,744,392 - 3,974,325 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0184,531,960 - 4,761,892 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0183,781,462 - 4,020,783 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0183,704,866 - 3,941,215 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,705,916 - 3,940,838 (+)Ensemblrn6Rnor6.0
Rnor_5.0183,712,673 - 3,939,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4184,030,463 - 4,121,355 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera183,569,544 - 3,806,888 (+)NCBICelera
RGSC_v3.1184,030,462 - 4,121,355 (+)NCBI
Cytogenetic Map18p13NCBI
LAMA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381823,689,453 - 23,955,066 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1823,689,453 - 23,956,222 (+)Ensemblhg38GRCh38
GRCh371821,269,417 - 21,535,030 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361819,523,560 - 19,789,028 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341819,707,003 - 19,789,025NCBI
Celera1818,085,885 - 18,351,313 (+)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1818,125,049 - 18,390,663 (+)NCBIHuRef
CHM1_11821,196,874 - 21,462,312 (+)NCBICHM1_1
T2T-CHM13v2.01823,883,722 - 24,149,324 (+)NCBIT2T-CHM13v2.0
Lama3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391812,466,806 - 12,716,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1812,466,876 - 12,716,070 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381812,333,417 - 12,583,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1812,333,819 - 12,583,013 (+)Ensemblmm10GRCm38
MGSCv371812,492,533 - 12,741,522 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361812,477,560 - 12,726,182 (+)NCBIMGSCv36mm8
Celera1812,567,449 - 12,814,993 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map186.2NCBI
Lama3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540212,300,654 - 12,361,742 (+)Ensembl
ChiLan1.0NW_00495540211,980,980 - 12,362,143 (+)NCBIChiLan1.0ChiLan1.0
LAMA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21741,120,722 - 41,389,529 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11826,998,373 - 27,082,969 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01816,941,316 - 17,208,363 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11820,750,271 - 20,832,028 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1820,565,649 - 20,831,957 (+)EnsemblpanPan2panpan1.1
LAMA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1764,405,719 - 64,654,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl764,406,082 - 64,655,268 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha763,854,180 - 64,103,577 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0764,463,775 - 64,714,403 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl764,463,779 - 64,714,403 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1764,132,606 - 64,382,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0764,147,994 - 64,397,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0764,453,184 - 64,703,083 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101971816
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494460,496,309 - 60,694,484 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365503,122,089 - 3,355,319 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365503,121,163 - 3,357,517 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAMA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6108,548,715 - 108,805,690 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16108,548,818 - 108,805,700 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26101,146,225 - 101,337,451 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LAMA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11856,580,245 - 56,851,381 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1856,580,700 - 56,850,451 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605031,327,064 - 31,599,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lama3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247708,237,085 - 8,482,770 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lama3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11531,106,773 - 31,335,392 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lama3
1487 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000015363
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat

Markers in Region
BF406322  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8183,918,093 - 3,918,258 (+)Marker Load Pipeline
mRatBN7.2183,643,357 - 3,643,522 (+)MAPPERmRatBN7.2
Rnor_6.0183,826,815 - 3,826,979NCBIRnor6.0
Rnor_5.0183,832,653 - 3,832,817UniSTSRnor5.0
RGSC_v3.4183,995,549 - 3,995,713UniSTSRGSC3.4
Celera183,699,431 - 3,699,595UniSTS
RH 3.4 Map1881.41UniSTS
Cytogenetic Map18p13UniSTS
PMC113197P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,677,970 - 3,678,151 (+)MAPPERmRatBN7.2
Rnor_6.0183,861,420 - 3,861,600NCBIRnor6.0
Rnor_5.0183,867,258 - 3,867,438UniSTSRnor5.0
RGSC_v3.4184,030,403 - 4,030,583UniSTSRGSC3.4
Celera183,733,932 - 3,734,112UniSTS
Cytogenetic Map18p13UniSTS
ECD14724  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0183,787,813 - 3,789,309NCBIRnor6.0
Rnor_5.0183,793,999 - 3,795,495UniSTSRnor5.0
Cytogenetic Map18p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 159 91 90 59 92 59 6 354 190 11 137 81 91 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000015363   ⟹   ENSRNOP00000015363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl183,952,751 - 4,026,449 (+)Ensembl
mRatBN7.2 Ensembl183,678,031 - 3,751,353 (+)Ensembl
Rnor_6.0 Ensembl183,861,539 - 3,940,823 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092814   ⟹   ENSRNOP00000075975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,900,714 - 3,940,838 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092846   ⟹   ENSRNOP00000075948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl183,797,939 - 4,026,343 (+)Ensembl
mRatBN7.2 Ensembl183,523,133 - 3,751,353 (+)Ensembl
Rnor_6.0 Ensembl183,705,916 - 3,887,148 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093089   ⟹   ENSRNOP00000076030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl183,887,419 - 3,893,314 (+)Ensembl
RefSeq Acc Id: NM_001393748   ⟹   NP_001380677
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,797,939 - 4,026,343 (+)NCBI
mRatBN7.2183,523,201 - 3,751,611 (+)NCBI
RefSeq Acc Id: NM_173306   ⟹   NP_775428
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,952,767 - 4,026,343 (+)NCBI
mRatBN7.2183,678,031 - 3,751,611 (+)NCBI
RefSeq Acc Id: XM_039096924   ⟹   XP_038952852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,842,647 - 4,033,021 (+)NCBI
mRatBN7.2183,567,893 - 3,751,326 (+)NCBI
RefSeq Acc Id: XM_039096925   ⟹   XP_038952853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,872,315 - 4,033,021 (+)NCBI
mRatBN7.2183,597,529 - 3,751,326 (+)NCBI
RefSeq Acc Id: XM_039096926   ⟹   XP_038952854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,909,407 - 4,033,021 (+)NCBI
mRatBN7.2183,634,707 - 3,751,722 (+)NCBI
RefSeq Acc Id: XM_039096927   ⟹   XP_038952855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,937,871 - 4,033,021 (+)NCBI
mRatBN7.2183,658,410 - 3,751,722 (+)NCBI
RefSeq Acc Id: XR_005496046
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8183,797,898 - 3,980,219 (+)NCBI
mRatBN7.2183,523,168 - 3,705,490 (+)NCBI
Ensembl Acc Id: ENSRNOP00000075948   ⟸   ENSRNOT00000092846
Ensembl Acc Id: ENSRNOP00000075975   ⟸   ENSRNOT00000092814
Ensembl Acc Id: ENSRNOP00000076030   ⟸   ENSRNOT00000093089
Ensembl Acc Id: ENSRNOP00000015363   ⟸   ENSRNOT00000015363
RefSeq Acc Id: XP_038952852   ⟸   XM_039096924
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952853   ⟸   XM_039096925
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952854   ⟸   XM_039096926
- Peptide Label: isoform X3
- UniProtKB: A6KLR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952855   ⟸   XM_039096927
- Peptide Label: isoform X4
- UniProtKB: A6KLR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_775428   ⟸   NM_173306
- Peptide Label: isoform A precursor
- UniProtKB: A6KLR5 (UniProtKB/TrEMBL),   D3ZN05 (UniProtKB/TrEMBL),   P70570 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380677   ⟸   NM_001393748
- Peptide Label: isoform B precursor
- UniProtKB: A0A1B0GWM3 (UniProtKB/TrEMBL)
Protein Domains
Laminin EGF-like   Laminin G   Laminin IV type A   Laminin N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628776 AgrOrtholog
BioCyc Gene G2FUF-8364 BioCyc
Ensembl Genes ENSRNOG00000011300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015363 ENTREZGENE
  ENSRNOT00000015363.9 UniProtKB/TrEMBL
  ENSRNOT00000092846 ENTREZGENE
  ENSRNOT00000092846.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  2.60.120.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Laminin/Netrin_ECM UniProtKB/TrEMBL
  Laminin_aI UniProtKB/TrEMBL
  Laminin_dom_II UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Laminin_IV UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
  LMN_ATRN_NET-like_EGF UniProtKB/TrEMBL
  Neurexin-related_CASP UniProtKB/TrEMBL
NCBI Gene Lama3 ENTREZGENE
PANTHER AXOTACTIN UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA 3 UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA-3 UniProtKB/TrEMBL
  LAMININ SUBUNIT ALPHA-4 UniProtKB/TrEMBL
  NETRIN/LAMININ-RELATED UniProtKB/TrEMBL
  PIKACHURIN-LIKE PROTEIN UniProtKB/TrEMBL
Pfam EGF_LMN_ATRN UniProtKB/TrEMBL
  Laminin_B UniProtKB/TrEMBL
  Laminin_EGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
  Laminin_I UniProtKB/TrEMBL
  Laminin_II UniProtKB/TrEMBL
  Laminin_N UniProtKB/TrEMBL
PhenoGen Lama3 PhenoGen
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE EGF_LAM_1 UniProtKB/TrEMBL
  EGF_LAM_2 UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
  LAMININ_IVA UniProtKB/TrEMBL
  LAMININ_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011300 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_Lam UniProtKB/TrEMBL
  LamB UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  LamNT UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A1B0GWM3 ENTREZGENE, UniProtKB/TrEMBL
  A6KLR4 ENTREZGENE, UniProtKB/TrEMBL
  A6KLR5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN05 ENTREZGENE, UniProtKB/TrEMBL
  P70570 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Lama3  laminin subunit alpha 3  Lama3  laminin, alpha 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-11 Lama3  laminin, alpha 3  LOC307582  similar to Laminin alpha-3 chain precursor (Nicein alpha subunit)  Data merged from RGD:1589756 737654 APPROVED
2006-11-19 LOC307582  similar to Laminin alpha-3 chain precursor (Nicein alpha subunit)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Lama3  laminin, alpha 3    laminin 5 alpha 3  Name updated 1299863 APPROVED
2003-02-27 Lama3  laminin 5 alpha 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 150 kDa in size 633107