Hmga1 (high mobility group AT-hook 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Hmga1 (high mobility group AT-hook 1) Rattus norvegicus
Analyze
Symbol: Hmga1
Name: high mobility group AT-hook 1
RGD ID: 628699
Description: Predicted to enable several functions, including DNA binding activity; catalytic activity, acting on DNA; and nuclear retinoid X receptor binding activity. Predicted to be involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including hemopoiesis; insulin receptor signaling pathway; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in male germ cell nucleus and senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex and SUMO ligase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: high mobility group AT-hook protein 1; high mobility group protein A1; high mobility group protein HMG-I/HMG-Y; HMG-I(Y); Hmgi; Hmgiy; hypothetical protein LOC689053; LOC689053
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Hmga1-ps2  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,612,902 - 5,620,596 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl205,613,471 - 5,620,593 (+)EnsemblGRCr8
mRatBN7.2205,611,088 - 5,618,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,611,694 - 5,618,752 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx206,327,117 - 6,330,067 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,688,869 - 5,691,819 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,169,005 - 6,171,956 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,132,501 - 7,140,155 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,136,007 - 7,138,980 (+)Ensemblrn6Rnor6.0
Rnor_5.0209,334,866 - 9,342,510 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4205,769,052 - 5,772,269 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera207,177,471 - 7,180,533 (+)NCBICelera
RGSC_v3.1205,769,278 - 5,772,496 (+)NCBI
Cytogenetic Map20p12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimony(0)  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
chromium atom  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
Ethylenethiourea  (EXP,ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
furfural  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (ISO)
nicotine  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
pepstatin A  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
autophagy  (ISO)
B cell differentiation  (ISO)
base-excision repair  (ISO)
cell population proliferation  (ISO)
chromatin organization  (ISO)
DNA-templated transcription  (IEA)
erythrocyte differentiation  (ISO)
gene expression  (ISO)
glucose homeostasis  (ISO)
heart development  (ISO)
inflammatory cell apoptotic process  (ISO)
inflammatory response  (ISO)
insulin receptor signaling pathway  (ISO)
insulin secretion  (ISO)
intracellular signal transduction  (IBA)
lung morphogenesis  (ISO)
lymphoid progenitor cell differentiation  (ISO)
multicellular organism growth  (ISO)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
neurogenesis  (ISO)
oncogene-induced cell senescence  (ISO,ISS)
peroxisome proliferator activated receptor signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of macromolecule biosynthetic process  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (IBA,IEA)
regulation of gene expression  (IEA)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
respiratory system process  (ISO)
response to cAMP  (ISO)
response to glucagon  (ISO)
response to glucose  (ISO)
response to insulin  (ISO)
response to wounding  (ISO)
spermatogenesis  (ISO)
T cell differentiation  (ISO)
thyroid gland development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Thyroid cell transformation requires the expression of the HMGA1 proteins. Berlingieri MT, etal., Oncogene 2002 May 2;21(19):2971-80.
2. Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis. Bussemakers MJ, etal., Cancer Res 1991 Jan 15;51(2):606-11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9253416   PMID:10428834   PMID:12032866   PMID:12653562   PMID:12874803   PMID:15192124   PMID:16157300   PMID:16641100   PMID:16791210   PMID:16901784   PMID:17005673   PMID:19389484  
PMID:19465398   PMID:21423176   PMID:24680881   PMID:25002582   PMID:25557289   PMID:29634420   PMID:30414623   PMID:30652345   PMID:30720182   PMID:35216347  


Genomics

Comparative Map Data
Hmga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,612,902 - 5,620,596 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl205,613,471 - 5,620,593 (+)EnsemblGRCr8
mRatBN7.2205,611,088 - 5,618,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,611,694 - 5,618,752 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx206,327,117 - 6,330,067 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,688,869 - 5,691,819 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,169,005 - 6,171,956 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,132,501 - 7,140,155 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,136,007 - 7,138,980 (+)Ensemblrn6Rnor6.0
Rnor_5.0209,334,866 - 9,342,510 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4205,769,052 - 5,772,269 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera207,177,471 - 7,180,533 (+)NCBICelera
RGSC_v3.1205,769,278 - 5,772,496 (+)NCBI
Cytogenetic Map20p12NCBI
HMGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,236,873 - 34,246,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,235,618 - 34,246,236 (+)Ensemblhg38GRCh38
GRCh37634,204,650 - 34,214,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,312,628 - 34,321,986 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34634,314,545 - 34,321,986NCBI
Celera635,758,945 - 35,768,381 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,927,318 - 33,936,673 (+)NCBIHuRef
CHM1_1634,207,231 - 34,216,597 (+)NCBICHM1_1
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBIT2T-CHM13v2.0
Hmga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,774,798 - 27,782,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,775,471 - 27,782,648 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381727,556,574 - 27,563,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,556,497 - 27,563,674 (+)Ensemblmm10GRCm38
GRCm38.p6 Ensembl11120,762,794 - 120,764,419 (+)Ensemblmm10GRCm38
MGSCv371727,693,519 - 27,700,617 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361727,284,171 - 27,291,260 (+)NCBIMGSCv36mm8
Celera1728,108,639 - 28,115,776 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.5NCBI
Hmga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,478,414 - 2,486,809 (+)Ensembl
ChiLan1.0NW_0049554372,478,414 - 2,486,809 (+)NCBIChiLan1.0ChiLan1.0
HMGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,712,783 - 48,722,294 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,580,061 - 44,589,567 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,807,171 - 33,816,603 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,914,923 - 34,920,482 (+)NCBIPanPan1.1PanPan1.1panPan2
HMGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,528,818 - 3,538,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,533,102 - 3,538,533 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha123,544,725 - 3,554,094 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0123,865,251 - 3,874,712 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,865,303 - 3,888,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,527,697 - 3,537,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,609,068 - 3,618,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,707,513 - 3,716,880 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hmga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,156,880 - 39,164,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,795,877 - 24,801,567 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,795,854 - 24,803,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,320,410 - 30,329,408 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1730,320,090 - 30,329,413 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,981,570 - 34,990,089 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q11NCBI
HMGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11737,848,110 - 37,857,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1737,849,412 - 37,853,880 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604434,150,889 - 34,160,977 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,892,226 - 22,898,807 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475422,888,052 - 22,900,685 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hmga1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1186,286,781 - 6,294,377 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hmga1
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:80
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000000580
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2016693431Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126128279Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362632310078622Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2016693431Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036263239244918Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat

Markers in Region
RH128050  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X31,610,924 - 31,611,116 (+)MAPPERmRatBN7.2
mRatBN7.2205,618,454 - 5,618,649 (+)MAPPERmRatBN7.2
Rnor_6.0207,139,855 - 7,140,049NCBIRnor6.0
Rnor_6.0X33,348,165 - 33,348,356NCBIRnor6.0
Rnor_5.0209,342,210 - 9,342,404UniSTSRnor5.0
Rnor_5.0X33,695,628 - 33,695,819UniSTSRnor5.0
RGSC_v3.4X52,351,648 - 52,351,839UniSTSRGSC3.4
RGSC_v3.4205,773,144 - 5,773,338UniSTSRGSC3.4
Celera207,181,408 - 7,181,602UniSTS
CeleraX31,924,692 - 31,924,883UniSTS
RH 3.4 Map2076.95UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_139327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF507966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF511040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000580   ⟹   ENSRNOP00000000580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl205,613,494 - 5,619,687 (+)Ensembl
mRatBN7.2 Ensembl205,611,694 - 5,618,622 (+)Ensembl
Rnor_6.0 Ensembl207,136,007 - 7,138,980 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099939   ⟹   ENSRNOP00000082413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl205,613,471 - 5,620,593 (+)Ensembl
mRatBN7.2 Ensembl205,611,697 - 5,618,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113836   ⟹   ENSRNOP00000086846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,614,569 - 5,618,737 (+)Ensembl
RefSeq Acc Id: NM_001412159   ⟹   NP_001399088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,613,508 - 5,620,596 (+)NCBI
mRatBN7.2205,611,665 - 5,618,755 (+)NCBI
RefSeq Acc Id: NM_139327   ⟹   NP_647543
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,613,508 - 5,620,596 (+)NCBI
mRatBN7.2205,611,665 - 5,618,755 (+)NCBI
Rnor_6.0207,136,007 - 7,138,980 (+)NCBI
Rnor_5.0209,334,866 - 9,342,510 (+)NCBI
RGSC_v3.4205,769,052 - 5,772,269 (+)RGD
Celera207,177,471 - 7,180,533 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256157   ⟹   XP_006256219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,613,446 - 5,620,596 (+)NCBI
mRatBN7.2205,611,604 - 5,618,755 (+)NCBI
Rnor_6.0207,133,038 - 7,140,155 (+)NCBI
Rnor_5.0209,334,866 - 9,342,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256158   ⟹   XP_006256220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,612,902 - 5,620,596 (+)NCBI
mRatBN7.2205,611,088 - 5,618,755 (+)NCBI
Rnor_6.0207,132,501 - 7,140,155 (+)NCBI
Rnor_5.0209,334,866 - 9,342,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256162   ⟹   XP_006256224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,612,902 - 5,620,596 (+)NCBI
mRatBN7.2205,611,089 - 5,618,755 (+)NCBI
Rnor_6.0207,132,503 - 7,140,155 (+)NCBI
Rnor_5.0209,334,866 - 9,342,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256163   ⟹   XP_006256225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,614,759 - 5,620,596 (+)NCBI
mRatBN7.2205,612,372 - 5,618,755 (+)NCBI
Rnor_6.0207,133,946 - 7,140,155 (+)NCBI
Rnor_5.0209,334,866 - 9,342,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256164   ⟹   XP_006256226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,613,441 - 5,620,596 (+)NCBI
mRatBN7.2205,611,598 - 5,617,614 (+)NCBI
Rnor_6.0207,133,023 - 7,140,153 (+)NCBI
Rnor_5.0209,334,866 - 9,342,510 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098388   ⟹   XP_038954316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,614,759 - 5,620,596 (+)NCBI
mRatBN7.2205,612,372 - 5,618,755 (+)NCBI
RefSeq Acc Id: XM_039098389   ⟹   XP_038954317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,614,784 - 5,620,596 (+)NCBI
mRatBN7.2205,613,077 - 5,618,755 (+)NCBI
RefSeq Acc Id: XM_063278936   ⟹   XP_063135006
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,613,448 - 5,620,596 (+)NCBI
RefSeq Acc Id: XM_063278937   ⟹   XP_063135007
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,613,442 - 5,620,596 (+)NCBI
RefSeq Acc Id: XM_063278938   ⟹   XP_063135008
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8205,614,889 - 5,620,596 (+)NCBI
RefSeq Acc Id: NP_647543   ⟸   NM_139327
- UniProtKB: Q8K585 (UniProtKB/Swiss-Prot),   Q8K1F5 (UniProtKB/Swiss-Prot),   A6JJM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256220   ⟸   XM_006256158
- Peptide Label: isoform X1
- UniProtKB: Q8K1F5 (UniProtKB/Swiss-Prot),   Q8K585 (UniProtKB/Swiss-Prot),   A6JJM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256224   ⟸   XM_006256162
- Peptide Label: isoform X2
- UniProtKB: A0A8L2PYB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256226   ⟸   XM_006256164
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006256219   ⟸   XM_006256157
- Peptide Label: isoform X1
- UniProtKB: Q8K1F5 (UniProtKB/Swiss-Prot),   Q8K585 (UniProtKB/Swiss-Prot),   A6JJM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256225   ⟸   XM_006256163
- Peptide Label: isoform X2
- UniProtKB: A0A8L2PYB4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000580   ⟸   ENSRNOT00000000580
RefSeq Acc Id: XP_038954316   ⟸   XM_039098388
- Peptide Label: isoform X1
- UniProtKB: Q8K585 (UniProtKB/Swiss-Prot),   Q8K1F5 (UniProtKB/Swiss-Prot),   A6JJM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954317   ⟸   XM_039098389
- Peptide Label: isoform X1
- UniProtKB: Q8K585 (UniProtKB/Swiss-Prot),   Q8K1F5 (UniProtKB/Swiss-Prot),   A6JJM1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000082413   ⟸   ENSRNOT00000099939
Ensembl Acc Id: ENSRNOP00000086846   ⟸   ENSRNOT00000113836
RefSeq Acc Id: NP_001399088   ⟸   NM_001412159
- UniProtKB: Q8K585 (UniProtKB/Swiss-Prot),   Q8K1F5 (UniProtKB/Swiss-Prot),   A6JJM1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135007   ⟸   XM_063278937
- Peptide Label: isoform X2
- UniProtKB: A0A8L2PYB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135006   ⟸   XM_063278936
- Peptide Label: isoform X2
- UniProtKB: A0A8L2PYB4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135008   ⟸   XM_063278938
- Peptide Label: isoform X2
- UniProtKB: A0A8L2PYB4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K585-F1-model_v2 AlphaFold Q8K585 1-107 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628699 AgrOrtholog
BioCyc Gene G2FUF-4466 BioCyc
Ensembl Genes ENSRNOG00000000488 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000099939 ENTREZGENE
  ENSRNOT00000113836.1 UniProtKB/Swiss-Prot
InterPro AT_hook_DNA-bd_motif UniProtKB/Swiss-Prot
  HMGA UniProtKB/Swiss-Prot
  HMGI/Y_DNA-bd_CS UniProtKB/Swiss-Prot
KEGG Report rno:117062 UniProtKB/Swiss-Prot
NCBI Gene 117062 ENTREZGENE
PANTHER HIGH MOBILITY GROUP PROTEIN HMG-I/HMG-Y UniProtKB/Swiss-Prot
  HIGH MOBILITY GROUP PROTEINS HMG-A AND C UniProtKB/Swiss-Prot
Pfam AT_hook UniProtKB/Swiss-Prot
PhenoGen Hmga1 PhenoGen
PRINTS ATHOOK UniProtKB/Swiss-Prot
  HIGHMOBLTYIY UniProtKB/Swiss-Prot
PROSITE HMGI_Y UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000488 RatGTEx
SMART AT_hook UniProtKB/Swiss-Prot
UniProt A0A8I5ZXW2_RAT UniProtKB/TrEMBL
  A0A8L2PYB4 ENTREZGENE
  A6JJM1 ENTREZGENE, UniProtKB/TrEMBL
  HMGA1_RAT UniProtKB/Swiss-Prot
  Q8K1F5 ENTREZGENE
  Q8K585 ENTREZGENE
UniProt Secondary Q8K1F5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Hmga1  high mobility group AT-hook 1  LOC689053  hypothetical protein LOC689053  Data merged from RGD:1597433 737654 PROVISIONAL
2006-11-20 LOC689053  hypothetical protein LOC689053      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Hmga1  high mobility group AT-hook 1      Symbol and Name status set to approved 1299863 APPROVED
2003-02-27 Hmga1  high mobility group AT-hook 1      Symbol and Name status set to provisional 70820 PROVISIONAL