Nfkbib (NFKB inhibitor beta) - Rat Genome Database

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Gene: Nfkbib (NFKB inhibitor beta) Rattus norvegicus
Analyze
Symbol: Nfkbib
Name: NFKB inhibitor beta
RGD ID: 621887
Description: Predicted to be involved in cellular response to lipopolysaccharide. Predicted to act upstream of or within inflammatory response and regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm and nucleus. Orthologous to human NFKBIB (NFKB inhibitor beta); PARTICIPATES IN nuclear factor kappa B signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: I-kappa-B-beta; ikappaBbeta; ikB-B; ikB-beta; MGC93398; NF-kappa-B inhibitor beta; NF-kappa-BIB; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,173,817 - 93,181,387 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,173,820 - 93,326,366 (-)EnsemblGRCr8
mRatBN7.2184,046,292 - 84,053,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,046,295 - 84,053,862 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,456,147 - 89,463,702 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,915,267 - 97,922,812 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,212,004 - 91,219,559 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,941,073 - 86,948,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,941,074 - 86,948,845 (-)Ensemblrn6Rnor6.0
Rnor_5.0188,122,205 - 88,129,977 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,865,440 - 83,873,010 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,438,451 - 78,446,021 (-)NCBICelera
RGSC_v3.1183,943,551 - 83,951,121 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acetaldehyde  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aniline  (EXP)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astragaloside IV  (EXP)
auranofin  (ISO)
azoxystrobin  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (EXP)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CCCP  (ISO)
cerium trichloride  (ISO)
chloroform  (EXP)
chlorogenic acid  (ISO)
cholesterol  (ISO)
chromium(6+)  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproterone acetate  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Diosbulbin B  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
erythromycin estolate  (EXP)
fenofibrate  (EXP)
fenpyroximate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
gallic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycine  (ISO)
hexadecanoic acid  (EXP)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP,ISO)
irbesartan  (ISO)
L-arginine  (EXP)
L-cysteine  (ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
monosodium L-glutamate  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
o-anisidine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
scutellarin  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sincalide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
syringic acid  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
taurocholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thapsigargin  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
valproic acid  (EXP)
vanadyl sulfate  (ISO)
vitamin E  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
5. Specific pancreatic enzymes activate macrophages to produce tumor necrosis factor-alpha: role of nuclear factor kappa B and inhibitory kappa B proteins. Jaffray C, etal., J Gastrointest Surg. 2000 Jul-Aug;4(4):370-7; discussion 377-8.
6. Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkappaB) inhibitor in rat microglia. Nakajima K, etal., Neurosci Lett. 2006 Jul 3;401(3):199-202. Epub 2006 Mar 31.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Inhibitory and stimulatory effects of lactacystin on expression of nitric oxide synthase type 2 in brain glial cells. The role of Ikappa B-beta. Stasiolek M, etal., J Biol Chem 2000 Aug 11;275(32):24847-56.
Additional References at PubMed
PMID:12477932   PMID:16822942   PMID:20060382   PMID:31451219  


Genomics

Comparative Map Data
Nfkbib
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,173,817 - 93,181,387 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl193,173,820 - 93,326,366 (-)EnsemblGRCr8
mRatBN7.2184,046,292 - 84,053,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,046,295 - 84,053,862 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx189,456,147 - 89,463,702 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,915,267 - 97,922,812 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0191,212,004 - 91,219,559 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,941,073 - 86,948,845 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,941,074 - 86,948,845 (-)Ensemblrn6Rnor6.0
Rnor_5.0188,122,205 - 88,129,977 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,865,440 - 83,873,010 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera178,438,451 - 78,446,021 (-)NCBICelera
RGSC_v3.1183,943,551 - 83,951,121 (-)NCBI
Cytogenetic Map1q21NCBI
NFKBIB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,899,666 - 38,908,889 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,899,700 - 38,908,893 (+)Ensemblhg38GRCh38
GRCh371939,390,306 - 39,399,529 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,082,455 - 44,091,374 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341944,082,454 - 44,091,373NCBI
Celera1936,193,052 - 36,201,968 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,837,132 - 35,846,241 (+)NCBIHuRef
CHM1_11939,390,808 - 39,399,934 (+)NCBICHM1_1
T2T-CHM13v2.01941,703,721 - 41,712,860 (+)NCBIT2T-CHM13v2.0
Nfkbib
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,457,676 - 28,466,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,457,676 - 28,466,937 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,758,251 - 28,766,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,758,251 - 28,767,512 (-)Ensemblmm10GRCm38
MGSCv37729,543,270 - 29,551,543 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,467,011 - 28,475,284 (-)NCBIMGSCv36mm8
Celera723,319,046 - 23,327,301 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.91NCBI
Nfkbib
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468617,078 - 626,151 (-)Ensembl
ChiLan1.0NW_004955468617,078 - 626,151 (-)NCBIChiLan1.0ChiLan1.0
NFKBIB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,202,707 - 45,212,748 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,073,324 - 47,083,339 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,005,797 - 36,015,897 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,554,486 - 44,565,128 (+)NCBIPanPan1.1PanPan1.1panPan2
NFKBIB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,206,537 - 114,217,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,206,534 - 114,217,644 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1113,608,175 - 113,618,992 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,806,385 - 114,817,213 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,806,387 - 114,817,162 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,364,149 - 114,374,967 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,997,319 - 114,008,132 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,993,059 - 115,003,891 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nfkbib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,422,102 - 13,429,688 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,850,058 - 1,862,035 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,850,185 - 1,857,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,703,647 - 47,712,654 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1647,703,644 - 47,712,661 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,241,118 - 43,250,615 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,518,909 - 33,529,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,518,963 - 33,529,891 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607311,540,577 - 11,552,485 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbib
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,259,577 - 12,266,642 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,259,567 - 12,266,642 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nfkbib
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,239,860 - 167,247,438 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nfkbib
9 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000027212
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat

Markers in Region
RH128905  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8193,173,891 - 93,174,602 (+)Marker Load Pipeline
mRatBN7.2184,046,366 - 84,047,077 (+)MAPPERmRatBN7.2
Rnor_6.0186,941,148 - 86,941,858NCBIRnor6.0
Rnor_5.0188,122,280 - 88,122,990UniSTSRnor5.0
RGSC_v3.4183,865,515 - 83,866,225UniSTSRGSC3.4
Celera178,438,526 - 78,439,236UniSTS
RH 3.4 Map746.1UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027212   ⟹   ENSRNOP00000027212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,046,727 - 84,053,862 (-)Ensembl
Rnor_6.0 Ensembl186,941,074 - 86,948,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098249   ⟹   ENSRNOP00000086277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl193,173,820 - 93,326,366 (-)Ensembl
mRatBN7.2 Ensembl184,046,295 - 84,049,727 (-)Ensembl
RefSeq Acc Id: NM_030867   ⟹   NP_110494
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,173,817 - 93,181,387 (-)NCBI
mRatBN7.2184,046,292 - 84,053,862 (-)NCBI
Rnor_6.0186,941,073 - 86,948,845 (-)NCBI
Rnor_5.0188,122,205 - 88,129,977 (-)NCBI
RGSC_v3.4183,865,440 - 83,873,010 (-)RGD
Celera178,438,451 - 78,446,021 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110494 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF64191 (Get FASTA)   NCBI Sequence Viewer  
  AAH85729 (Get FASTA)   NCBI Sequence Viewer  
  EDM07877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000086277
GenBank Protein Q9JIA3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110494   ⟸   NM_030867
- UniProtKB: Q9JIA3 (UniProtKB/Swiss-Prot),   Q5U342 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027212   ⟸   ENSRNOT00000027212
Ensembl Acc Id: ENSRNOP00000086277   ⟸   ENSRNOT00000098249

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIA3-F1-model_v2 AlphaFold Q9JIA3 1-359 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689881
Promoter ID:EPDNEW_R406
Type:multiple initiation site
Name:Nfkbib_1
Description:NFKB inhibitor beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,948,639 - 86,948,699EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621887 AgrOrtholog
BioCyc Gene G2FUF-60221 BioCyc
Ensembl Genes ENSRNOG00000020063 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000098249 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7114624 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
MGC_CLONE MGC:93398 IMAGE-MGC_LOAD
NCBI Gene 81525 ENTREZGENE
PANTHER NF-KAPPA-B INHIBITOR BETA UniProtKB/Swiss-Prot
  PTHR47303 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
PhenoGen Nfkbib PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020063 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48403 UniProtKB/Swiss-Prot
UniProt A0A8I6A5K2_RAT UniProtKB/TrEMBL
  IKBB_RAT UniProtKB/Swiss-Prot
  Q5U342 ENTREZGENE, UniProtKB/TrEMBL
  Q9JIA3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Nfkbib  NFKB inhibitor beta  Nfkbib  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-25 Nfkbib  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta  Nfkbib  nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Nfkbib  nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta    I-kappa-B-beta  Name updated 1299863 APPROVED
2002-08-07 Nfkbib  I-kappa-B-beta      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process inhibits NOS2 induction 633403