Idh3b (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta) - Rat Genome Database

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Gene: Idh3b (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta) Rattus norvegicus
Analyze
Symbol: Idh3b
Name: isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
RGD ID: 621881
Description: Predicted to enable enzyme activator activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in retinitis pigmentosa 46. Orthologous to human IDH3B (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: isocitrate dehydrogenase (NAD(+)) 3 beta; isocitrate dehydrogenase 3 (NAD+) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitric dehydrogenase subunit beta; MGC94111; NAD(+)-specific ICDH subunit beta; NAD+-specific isocitrate dehydrogenase b subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,934,971 - 137,940,275 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3137,934,697 - 137,940,107 (-)EnsemblGRCr8
mRatBN7.23117,481,845 - 117,486,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,481,845 - 117,486,982 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3121,379,896 - 121,384,925 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,975,515 - 129,980,544 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,636,012 - 127,641,041 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,808,564 - 122,813,638 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,808,564 - 122,813,583 (-)Ensemblrn6Rnor6.0
Rnor_5.03129,308,279 - 129,313,315 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43117,892,614 - 117,897,633 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3116,298,150 - 116,303,169 (-)NCBICelera
RGSC_v3.13117,798,468 - 117,800,065 (-)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Expression of NAD(+)-dependent isocitrate dehydrogenase in brown adipose tissue. Shinohara Y, etal., Biochem Biophys Res Commun 2001 Mar 2;281(3):634-8.
12. Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. Soundar S, etal., J Biol Chem. 2003 Dec 26;278(52):52146-53. doi: 10.1074/jbc.M306178200. Epub 2003 Oct 10.
Additional References at PubMed
PMID:12477932   PMID:14651853   PMID:15489334   PMID:18614015   PMID:21630459   PMID:21700703   PMID:25931508   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Idh3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83137,934,971 - 137,940,275 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3137,934,697 - 137,940,107 (-)EnsemblGRCr8
mRatBN7.23117,481,845 - 117,486,909 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,481,845 - 117,486,982 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3121,379,896 - 121,384,925 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03129,975,515 - 129,980,544 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,636,012 - 127,641,041 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,808,564 - 122,813,638 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,808,564 - 122,813,583 (-)Ensemblrn6Rnor6.0
Rnor_5.03129,308,279 - 129,313,315 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43117,892,614 - 117,897,633 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3116,298,150 - 116,303,169 (-)NCBICelera
RGSC_v3.13117,798,468 - 117,800,065 (-)NCBI
Cytogenetic Map3q36NCBI
IDH3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38202,658,395 - 2,664,216 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl202,658,393 - 2,664,219 (-)Ensemblhg38GRCh38
GRCh37202,639,041 - 2,644,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36202,587,041 - 2,592,843 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34202,587,042 - 2,592,843NCBI
Celera202,703,504 - 2,709,306 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef202,588,269 - 2,594,156 (-)NCBIHuRef
CHM1_1202,639,448 - 2,645,272 (-)NCBICHM1_1
T2T-CHM13v2.0202,688,862 - 2,694,697 (-)NCBIT2T-CHM13v2.0
Idh3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,121,229 - 130,126,371 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,121,229 - 130,126,467 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382130,279,309 - 130,284,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,279,309 - 130,284,547 (-)Ensemblmm10GRCm38
MGSCv372130,105,045 - 130,110,187 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362129,970,753 - 129,983,751 (-)NCBIMGSCv36mm8
Celera2131,503,716 - 131,508,858 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.2NCBI
Idh3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541513,643,168 - 13,649,463 (-)Ensembl
ChiLan1.0NW_00495541513,642,804 - 13,649,023 (-)NCBIChiLan1.0ChiLan1.0
IDH3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,647,477 - 3,677,553 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1203,644,302 - 3,674,378 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0202,766,598 - 2,772,571 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1202,529,510 - 2,559,894 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl202,529,510 - 2,535,570 (-)EnsemblpanPan2panpan1.1
IDH3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,556,437 - 18,561,399 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,556,508 - 18,561,391 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2418,385,740 - 18,390,707 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02419,014,265 - 19,019,181 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2419,014,285 - 19,019,174 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,570,449 - 18,575,416 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,680,753 - 18,685,668 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02419,009,851 - 19,014,767 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Idh3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,601,899 - 167,606,729 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648516,033,128 - 16,042,821 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648516,033,287 - 16,038,097 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDH3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,955,101 - 32,960,104 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11732,955,061 - 32,960,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,446,330 - 37,451,309 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDH3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,875,991 - 53,882,069 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl253,875,390 - 53,881,716 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666087292,746 - 299,180 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idh3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247413,808,784 - 3,814,510 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247413,808,436 - 3,814,239 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Idh3b
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:17
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000009681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
MARC_26079-26080:1032790967:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,482,203 - 117,483,037 (+)MAPPERmRatBN7.2
Rnor_6.03122,808,923 - 122,809,756NCBIRnor6.0
Rnor_5.03129,308,638 - 129,309,471UniSTSRnor5.0
RGSC_v3.43117,892,973 - 117,893,806UniSTSRGSC3.4
Celera3116,298,509 - 116,299,342UniSTS
Cytogenetic Map3q36UniSTS
MARC_26128-26129:1030370563:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,483,026 - 117,483,470 (+)MAPPERmRatBN7.2
mRatBN7.2795,301,953 - 95,302,102 (+)MAPPERmRatBN7.2
Rnor_6.07104,350,215 - 104,350,363NCBIRnor6.0
Rnor_6.03122,809,746 - 122,810,189NCBIRnor6.0
Rnor_5.07104,920,275 - 104,920,423UniSTSRnor5.0
Rnor_5.03129,309,461 - 129,309,904UniSTSRnor5.0
RGSC_v3.43117,893,796 - 117,894,239UniSTSRGSC3.4
RGSC_v3.47100,794,934 - 100,795,082UniSTSRGSC3.4
Celera791,915,100 - 91,915,248UniSTS
Celera3116,299,332 - 116,299,775UniSTS
Cytogenetic Map3q36UniSTS
Cytogenetic Map7q33UniSTS
RH78746  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83137,935,340 - 137,936,172 (+)Marker Load Pipeline
mRatBN7.23117,482,214 - 117,483,046 (+)MAPPERmRatBN7.2
Rnor_6.03122,808,934 - 122,809,765NCBIRnor6.0
Rnor_5.03129,308,649 - 129,309,480UniSTSRnor5.0
RGSC_v3.43117,892,984 - 117,893,815UniSTSRGSC3.4
Celera3116,298,520 - 116,299,351UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009681   ⟹   ENSRNOP00000009681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,934,971 - 137,940,107 (-)Ensembl
mRatBN7.2 Ensembl3117,481,845 - 117,486,982 (-)Ensembl
Rnor_6.0 Ensembl3122,808,564 - 122,813,583 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112690   ⟹   ENSRNOP00000093884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,934,697 - 137,939,994 (-)Ensembl
mRatBN7.2 Ensembl3117,482,069 - 117,486,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146469   ⟹   ENSRNOP00000103294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3137,934,972 - 137,939,994 (-)Ensembl
RefSeq Acc Id: NM_053581   ⟹   NP_446033
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,971 - 137,939,990 (-)NCBI
mRatBN7.23117,481,845 - 117,486,865 (-)NCBI
Rnor_6.03122,808,564 - 122,813,583 (-)NCBI
Rnor_5.03129,308,279 - 129,313,315 (-)NCBI
RGSC_v3.43117,892,614 - 117,897,633 (-)RGD
Celera3116,298,150 - 116,303,169 (-)RGD
Sequence:
RefSeq Acc Id: XM_006235048   ⟹   XP_006235110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,974 - 137,940,275 (-)NCBI
mRatBN7.23117,481,848 - 117,486,909 (-)NCBI
Rnor_6.03122,808,567 - 122,813,638 (-)NCBI
Rnor_5.03129,308,279 - 129,313,315 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063284749   ⟹   XP_063140819
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,974 - 137,940,275 (-)NCBI
RefSeq Acc Id: XM_063284750   ⟹   XP_063140820
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83137,934,974 - 137,937,374 (-)NCBI
RefSeq Acc Id: NP_446033   ⟸   NM_053581
- Peptide Label: precursor
- UniProtKB: Q68FX0 (UniProtKB/Swiss-Prot),   A6HQ80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235110   ⟸   XM_006235048
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000009681   ⟸   ENSRNOT00000009681
Ensembl Acc Id: ENSRNOP00000093884   ⟸   ENSRNOT00000112690
RefSeq Acc Id: XP_063140819   ⟸   XM_063284749
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AMM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140820   ⟸   XM_063284750
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000103294   ⟸   ENSRNOT00000146469
Protein Domains
Isopropylmalate dehydrogenase-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FX0-F1-model_v2 AlphaFold Q68FX0 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692429
Promoter ID:EPDNEW_R2954
Type:multiple initiation site
Name:Idh3B_1
Description:isocitrate dehydrogenase 3 (NAD+) beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03122,813,581 - 122,813,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621881 AgrOrtholog
BioCyc Gene G2FUF-47863 BioCyc
BioCyc Pathway PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
BioCyc Pathway Image PWY-5690 BioCyc
Ensembl Genes ENSRNOG00000007316 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000112690 ENTREZGENE
  ENSRNOT00000146469 ENTREZGENE
Gene3D-CATH Isopropylmalate Dehydrogenase UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126029 IMAGE-MGC_LOAD
InterPro IsoCit/isopropylmalate_DH_CS UniProtKB/Swiss-Prot
  Isocitrate_DH_NAD UniProtKB/Swiss-Prot
  IsoPropMal-DH-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:94173 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94111 IMAGE-MGC_LOAD
NCBI Gene 94173 ENTREZGENE
PANTHER DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE UniProtKB/Swiss-Prot
  ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Iso_dh UniProtKB/Swiss-Prot
PhenoGen Idh3b PhenoGen
PROSITE IDH_IMDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007316 RatGTEx
SMART Iso_dh UniProtKB/Swiss-Prot
Superfamily-SCOP Isocitrate/Isopropylmalate dehydrogenase-like UniProtKB/Swiss-Prot
UniProt A0A8I6AMM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q4B4_RAT UniProtKB/TrEMBL
  A0ABK0L2U0_RAT UniProtKB/TrEMBL
  A6HQ80 ENTREZGENE, UniProtKB/TrEMBL
  IDH3B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Idh3b  isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta  Idh3b  isocitrate dehydrogenase (NAD(+)) 3 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-29 Idh3b  isocitrate dehydrogenase (NAD(+)) 3 beta  Idh3B  isocitrate dehydrogenase 3 (NAD+) beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Idh3B  isocitrate dehydrogenase 3 (NAD+) beta  IDH3B  NAD+-specific isocitrate dehydrogenase b subunit  Name updated 1299863 APPROVED
2002-08-07 IDH3B  NAD+-specific isocitrate dehydrogenase b subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brown adipose tissue 70770