CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain)

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Keyword

Gene: CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain) Homo sapiens

Symbol:

CD74

Name:

CD74 molecule, major histocompatibility complex, class II invariant chain

Description:

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cd74 antigen (invariant polypeptide of major histocompatibility complex, class ii antigen-associated); CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); DHLAG; FLJ98970; gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLADG; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; ii; II; MHC HLA-DR gamma chain; OTTHUMP00000224283; OTTHUMP00000224284; OTTHUMP00000224285; OTTHUMP00000224286; OTTHUMP00000224288; OTTHUMP00000224338; p33

Orthologs:

Mus musculus : Cd74 (CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)) MGI
Rattus norvegicus : Cd74 (Cd74 molecule, major histocompatibility complex, class II invariant chain)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	150,057,247 - 150,068,542	-	NCBI
Human Genome Assembly HuRef	5	144,928,781 - 144,940,080	-	NCBI
Human Genome Assembly GRCh37	5	149,781,200 - 149,792,499	-	NCBI
Human Genome Assembly Build 36	5	149,761,393 - 149,772,525	-	NCBI
Human Cytogenetic Map	5	q32		NCBI
Human Genome Assembly	5	149,761,396 - 149,772,511		NCBI