St13 (ST13, Hsp70 interacting protein) - Rat Genome Database

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Gene: St13 (ST13, Hsp70 interacting protein) Rattus norvegicus
Analyze
Symbol: St13 (Ensembl: Slc25a17)
Name: ST13, Hsp70 interacting protein (Ensembl:solute carrier family 25 member 17)
RGD ID: 621312
Description: Enables several functions, including Hsp70 protein binding activity; dATP binding activity; and unfolded protein binding activity. Involved in negative regulation of protein refolding and positive regulation of protein folding. Located in cytosol. Part of protein-containing complex. Orthologous to several human genes including ST13 (ST13 Hsp70 interacting protein); PARTICIPATES IN androgen signaling pathway; chaperone mediated autophagy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hip; hsc70-interacting protein; protein ST13 homolog; suppression of tumorigenicity 13; suppression of tumorigenicity 13 (colon carcinoma) Hsp70-interacting protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau6
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,769,758 - 114,805,877 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,769,759 - 114,805,941 (-)EnsemblGRCr8
mRatBN7.27112,891,007 - 112,925,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,844,375 - 112,925,945 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,653,298 - 114,688,067 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,876,850 - 116,911,568 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,846,210 - 116,880,977 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7116,805,053 - 116,839,784 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive7117,751,692 - 117,786,401 (-)NCBILyon_Normotensive
Lyon_Hypertensive7117,877,355 - 117,912,069 (-)NCBILyon_Hypertensive
F344_StmMcwi7116,363,610 - 116,398,267 (-)NCBIF344_StmMcwi
Rnor_6.07122,585,770 - 122,635,731 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,585,771 - 122,635,731 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,561,392 - 122,612,277 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,694,123 - 119,728,936 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,210,016 - 109,245,175 (-)NCBICelera
RGSC_v3.17119,728,353 - 119,763,166 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-methoxyethanol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
albendazole  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (ISO)
clomipramine  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
cyclophosphamide  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
felbamate  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (EXP)
gabapentin  (EXP)
gamma-linolenic acid  (ISO)
gentamycin  (EXP)
imipramine  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-methionine  (EXP)
lead diacetate  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenytoin  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SCH 23390  (EXP)
selenium atom  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
temozolomide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of the molecular-chaperone function of the heat-shock-cognate-70-interacting protein. Bruce BD and Churchich J, Eur J Biochem. 1997 May 1;245(3):738-44.
2. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors. Demand J, etal., Mol Cell Biol 1998 Apr;18(4):2023-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Hohfeld J, etal., Cell 1995 Nov 17;83(4):589-98.
6. Characterization of functional domains of the eukaryotic co-chaperone Hip. Irmer H and Hohfeld J, J Biol Chem. 1997 Jan 24;272(4):2230-5.
7. Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. Li Z, etal., Nat Struct Mol Biol. 2013 Aug;20(8):929-35. doi: 10.1038/nsmb.2608. Epub 2013 Jun 30.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Molecular chaperones throughout the life cycle of the androgen receptor. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases. Xilouri M and Stefanis L, Mol Cell Neurosci. 2015 May;66(Pt A):29-36. doi: 10.1016/j.mcn.2015.01.003. Epub 2015 Feb 25.
14. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E617-24. doi: 10.1073/pnas.1104391108. Epub 2011 Aug 1.
Additional References at PubMed
PMID:15489334   PMID:17013759   PMID:19056867   PMID:19875982   PMID:20458337   PMID:23012479   PMID:23376485   PMID:28131823  


Genomics

Comparative Map Data
St13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,769,758 - 114,805,877 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,769,759 - 114,805,941 (-)EnsemblGRCr8
mRatBN7.27112,891,007 - 112,925,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,844,375 - 112,925,945 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,653,298 - 114,688,067 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,876,850 - 116,911,568 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,846,210 - 116,880,977 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7116,805,053 - 116,839,784 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive7117,751,692 - 117,786,401 (-)NCBILyon_Normotensive
Lyon_Hypertensive7117,877,355 - 117,912,069 (-)NCBILyon_Hypertensive
F344_StmMcwi7116,363,610 - 116,398,267 (-)NCBIF344_StmMcwi
Rnor_6.07122,585,770 - 122,635,731 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,585,771 - 122,635,731 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,561,392 - 122,612,277 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,694,123 - 119,728,936 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7109,210,016 - 109,245,175 (-)NCBICelera
RGSC_v3.17119,728,353 - 119,763,166 (-)NCBI
Cytogenetic Map7q34NCBI
ST13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,824,535 - 40,856,639 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,824,535 - 40,856,690 (-)Ensemblhg38GRCh38
GRCh372241,220,539 - 41,252,643 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,550,545 - 39,582,633 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342239,545,102 - 39,577,187NCBI
Celera2225,024,269 - 25,056,358 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2224,182,572 - 24,215,046 (-)NCBIHuRef
CHM1_12241,179,290 - 41,211,764 (-)NCBICHM1_1
T2T-CHM13v2.02241,296,730 - 41,328,831 (-)NCBIT2T-CHM13v2.0
St13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391581,247,869 - 81,284,278 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1581,247,870 - 81,284,278 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,365,044 - 81,399,694 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,363,669 - 81,400,077 (-)Ensemblmm10GRCm38
MGSCv371581,195,474 - 81,230,124 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361581,192,299 - 81,226,949 (-)NCBIMGSCv36mm8
Celera1583,483,114 - 83,517,731 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.07NCBI
St13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,476,469 - 26,507,671 (-)Ensembl
ChiLan1.0NW_00495541326,478,579 - 26,507,671 (-)NCBIChiLan1.0ChiLan1.0
ST13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,656,928 - 50,687,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12253,355,816 - 53,387,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,719,713 - 21,751,912 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12239,815,337 - 39,848,049 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,815,337 - 39,848,049 (-)EnsemblpanPan2panpan1.1
ST13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,379,997 - 24,411,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,379,997 - 24,411,766 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1024,314,161 - 24,345,833 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01025,127,715 - 25,159,445 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,127,684 - 25,161,322 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11024,842,961 - 24,874,594 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,163,854 - 25,195,541 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,338,235 - 25,369,960 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
St13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049457,966,770 - 7,998,826 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936492977,093 - 1,009,221 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936492976,928 - 1,010,748 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,583,048 - 7,617,762 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.157,583,074 - 7,617,766 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,763,686 - 4,796,346 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ST13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,373,970 - 23,413,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,375,723 - 23,412,742 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045102,161,727 - 102,195,149 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,634,970 - 7,661,974 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247527,634,910 - 7,663,135 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
St13
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11251,115,651 - 251,152,261 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in St13
200 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:153
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000025925
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000025758   ⟹   ENSRNOP00000025758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,844,375 - 112,870,868 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000025925   ⟹   ENSRNOP00000025925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,844,814 - 112,925,774 (-)Ensembl
Rnor_6.0 Ensembl7122,585,771 - 122,635,731 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107864   ⟹   ENSRNOP00000084383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,769,759 - 114,805,941 (-)Ensembl
mRatBN7.2 Ensembl7112,889,610 - 112,925,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109011   ⟹   ENSRNOP00000088770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7112,844,382 - 112,886,941 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117864   ⟹   ENSRNOP00000088669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,769,759 - 114,799,634 (-)Ensembl
mRatBN7.2 Ensembl7112,889,680 - 112,925,945 (-)Ensembl
RefSeq Acc Id: NM_031122   ⟹   NP_112384
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,771,156 - 114,805,877 (-)NCBI
mRatBN7.27112,891,007 - 112,925,727 (-)NCBI
Dahl_SR_JrHsd7116,805,053 - 116,839,784 (-)NCBI
Lyon_Normotensive7117,751,692 - 117,786,401 (-)NCBI
Lyon_Hypertensive7117,877,355 - 117,912,069 (-)NCBI
F344_StmMcwi7116,363,610 - 116,398,267 (-)NCBI
Rnor_6.07122,585,770 - 122,635,731 (-)NCBI
Rnor_5.07122,561,392 - 122,612,277 (-)NCBI
RGSC_v3.47119,694,123 - 119,728,936 (-)RGD
Celera7109,210,016 - 109,245,175 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264299   ⟹   XP_063120369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,769,758 - 114,799,749 (-)NCBI
Protein Sequences
Protein RefSeqs NP_112384 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120369 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78804 (Get FASTA)   NCBI Sequence Viewer  
  CAA57546 (Get FASTA)   NCBI Sequence Viewer  
  EDM15726 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084383
  ENSRNOP00000088669
GenBank Protein P50503 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112384   ⟸   NM_031122
- UniProtKB: P50503 (UniProtKB/Swiss-Prot),   A6HSZ6 (UniProtKB/TrEMBL),   A0A8I5ZYX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025925   ⟸   ENSRNOT00000025925
Ensembl Acc Id: ENSRNOP00000088770   ⟸   ENSRNOT00000109011
Ensembl Acc Id: ENSRNOP00000088669   ⟸   ENSRNOT00000117864
Ensembl Acc Id: ENSRNOP00000025758   ⟸   ENSRNOT00000025758
Ensembl Acc Id: ENSRNOP00000084383   ⟸   ENSRNOT00000107864
RefSeq Acc Id: XP_063120369   ⟸   XM_063264299
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6M6 (UniProtKB/TrEMBL),   A0A8I5ZYX0 (UniProtKB/TrEMBL)
Protein Domains
STI1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50503-F1-model_v2 AlphaFold P50503 1-368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695508
Promoter ID:EPDNEW_R6033
Type:initiation region
Name:St13_1
Description:ST13, Hsp70 interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,635,694 - 122,635,754EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621312 AgrOrtholog
BioCyc Gene G2FUF-32680 BioCyc
Ensembl Genes ENSRNOG00000018920 Ensembl, ENTREZGENE
  ENSRNOG00000019070 Ensembl
Ensembl Transcript ENSRNOT00000107864 ENTREZGENE
  ENSRNOT00000117864 ENTREZGENE
Gene3D-CATH 1.10.260.100 UniProtKB/Swiss-Prot
  1.25.40.10 UniProtKB/Swiss-Prot
  6.10.250.3420 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109473 IMAGE-MGC_LOAD
InterPro Hip_N UniProtKB/Swiss-Prot
  STI1 UniProtKB/Swiss-Prot
  STI1_HS-bd UniProtKB/Swiss-Prot
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report rno:81800 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93379 IMAGE-MGC_LOAD
NCBI Gene 81800 ENTREZGENE
PANTHER HSC70-INTERACTING PROTEIN UniProtKB/Swiss-Prot
  HSC70-INTERACTING PROTEIN UniProtKB/Swiss-Prot
Pfam HipN UniProtKB/Swiss-Prot
  STI1 UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PhenoGen St13 PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018920 RatGTEx
  ENSRNOG00000019070 RatGTEx
SMART STI1 UniProtKB/Swiss-Prot
  TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A0A8I5ZYX0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6M6 ENTREZGENE, UniProtKB/TrEMBL
  A6HSZ6 ENTREZGENE, UniProtKB/TrEMBL
  F10A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 St13  ST13, Hsp70 interacting protein  St13  suppression of tumorigenicity 13  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 St13  suppression of tumorigenicity 13    suppression of tumorigenicity 13 (colon carcinoma) Hsp70-interacting protein  Name updated 1299863 APPROVED
2002-08-07 St13  suppression of tumorigenicity 13 (colon carcinoma) Hsp70-interacting protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains tetratricopeptide repeats 729993
gene_function binds the ATPase domains of at least two Hsc70 molecules 729993