Trak2 (trafficking kinesin protein 2) - Rat Genome Database

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Gene: Trak2 (trafficking kinesin protein 2) Rattus norvegicus
Analyze
Symbol: Trak2
Name: trafficking kinesin protein 2
RGD ID: 620915
Description: Enables several functions, including GABA receptor binding activity; TPR domain binding activity; and kinesin binding activity. Involved in several processes, including dendrite morphogenesis; dendritic transport of mitochondrion; and negative regulation of axonogenesis. Located in several cellular components, including axonal growth cone; early endosome; and neuronal cell body. Orthologous to human TRAK2 (trafficking kinesin protein 2); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Als2cr3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog (human); amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein homolog; GABA-A receptor interacting factor-1; GABA-A receptor-interacting factor 1; GRIF-1; MGC93214; O-GlcNAc transferase-interacting protein of 98 kDa; trafficking kinesin-binding protein 2; trafficking protein, kinesin binding 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,842,680 - 67,909,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,842,683 - 67,908,158 (-)EnsemblGRCr8
mRatBN7.2960,348,531 - 60,414,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,350,012 - 60,413,996 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,844,354 - 68,909,801 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,960,314 - 74,025,761 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,278,580 - 72,344,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd971,572,560 - 71,637,940 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive967,347,863 - 67,413,243 (-)NCBILyon_Normotensive
Lyon_Hypertensive967,483,912 - 67,549,294 (-)NCBILyon_Hypertensive
F344_StmMcwi969,399,108 - 69,464,486 (-)NCBIF344_StmMcwi
Rnor_6.0965,698,706 - 65,763,351 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,698,712 - 65,763,273 (-)Ensemblrn6Rnor6.0
Rnor_5.0965,505,448 - 65,570,090 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4957,474,682 - 57,540,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,788,961 - 57,853,095 (-)NCBICelera
RGSC_v3.1957,624,566 - 57,661,312 (-)NCBI
Cytogenetic Map9q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
iron dichloride  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification, Molecular Cloning, and Characterization of a Novel GABAA Receptor-associated Protein, GRIF-1. Beck M, etal., J Biol Chem 2002 Aug 16;277(33):30079-90.
2. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. Brickley K, etal., J Biol Chem. 2005 Apr 15;280(15):14723-32. Epub 2005 Jan 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. Iyer SP, etal., J Biol Chem 2003 Feb 14;278(7):5399-409.
5. GRIF1 binds Hrs and is a new regulator of endosomal trafficking. Kirk E, etal., J Cell Sci. 2006 Nov 15;119(Pt 22):4689-701. Epub 2006 Oct 24.
6. HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. Li Y, etal., J Cell Biol. 2009 Jun 15;185(6):1065-81. doi: 10.1083/jcb.200811033.
7. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
8. Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons. Loss O and Stephenson FA, J Neurosci Res. 2015 Jul;93(7):1056-66. doi: 10.1002/jnr.23549. Epub 2015 Feb 4.
9. GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons. MacAskill AF, etal., Mol Cell Neurosci. 2009 Mar;40(3):301-12. Epub 2008 Dec 3.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Delineation of the TRAK binding regions of the kinesin-1 motor proteins. Randall TS, etal., FEBS Lett. 2013 Nov 29;587(23):3763-9. doi: 10.1016/j.febslet.2013.09.049. Epub 2013 Oct 22.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. van Spronsen M, etal., Neuron. 2013 Feb 6;77(3):485-502. doi: 10.1016/j.neuron.2012.11.027.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16630562  


Genomics

Comparative Map Data
Trak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,842,680 - 67,909,786 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl967,842,683 - 67,908,158 (-)EnsemblGRCr8
mRatBN7.2960,348,531 - 60,414,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,350,012 - 60,413,996 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx968,844,354 - 68,909,801 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,960,314 - 74,025,761 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,278,580 - 72,344,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd971,572,560 - 71,637,940 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive967,347,863 - 67,413,243 (-)NCBILyon_Normotensive
Lyon_Hypertensive967,483,912 - 67,549,294 (-)NCBILyon_Hypertensive
F344_StmMcwi969,399,108 - 69,464,486 (-)NCBIF344_StmMcwi
Rnor_6.0965,698,706 - 65,763,351 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,698,712 - 65,763,273 (-)Ensemblrn6Rnor6.0
Rnor_5.0965,505,448 - 65,570,090 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4957,474,682 - 57,540,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera957,788,961 - 57,853,095 (-)NCBICelera
RGSC_v3.1957,624,566 - 57,661,312 (-)NCBI
Cytogenetic Map9q31NCBI
TRAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,377,207 - 201,451,458 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,377,207 - 201,453,449 (-)Ensemblhg38GRCh38
GRCh372202,241,930 - 202,316,181 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,950,175 - 202,024,499 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342202,067,436 - 202,141,760NCBI
Celera2195,993,770 - 196,068,264 (-)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2194,090,332 - 194,144,077 (-)NCBIHuRef
CHM1_12202,247,949 - 202,322,415 (-)NCBICHM1_1
T2T-CHM13v2.02201,857,884 - 201,933,333 (-)NCBIT2T-CHM13v2.0
Trak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,939,608 - 59,013,509 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,939,608 - 59,012,589 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38158,900,449 - 58,974,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,900,449 - 58,973,430 (-)Ensemblmm10GRCm38
MGSCv37158,957,294 - 59,030,326 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36158,844,996 - 58,891,044 (-)NCBIMGSCv36mm8
Celera159,419,476 - 59,489,206 (-)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.2NCBI
Trak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403206,146 - 261,326 (+)Ensembl
ChiLan1.0NW_004955403205,372 - 261,210 (+)NCBIChiLan1.0ChiLan1.0
TRAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213104,000,055 - 104,075,173 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B104,015,054 - 104,090,173 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,630,665 - 88,705,709 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,785,541 - 206,861,102 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,785,541 - 206,861,102 (-)EnsemblpanPan2panpan1.1
TRAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,457,985 - 10,521,432 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,461,104 - 10,497,820 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3711,341,722 - 11,405,148 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03710,362,764 - 10,426,223 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,362,766 - 10,426,177 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,343,403 - 10,406,849 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,322,444 - 10,385,866 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,315,865 - 10,379,295 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,679,121 - 158,738,519 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726649,418 - 708,820 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936726649,413 - 708,816 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,991,726 - 105,055,025 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115104,991,261 - 105,056,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,383,936 - 116,416,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11087,022,038 - 87,096,685 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1087,022,043 - 87,096,666 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040112,322,842 - 112,398,263 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899300,096 - 332,392 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624899275,291 - 335,555 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Trak2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14133,531,663 - 133,591,464 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Trak2
468 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:945
Count of miRNA genes:264
Interacting mature miRNAs:358
Transcripts:ENSRNOT00000014939, ENSRNOT00000015034
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1598849Memor17Memory QTL 172.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)95746049778547958Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
D9Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8967,863,981 - 67,864,210 (+)Marker Load Pipeline
mRatBN7.2960,369,837 - 60,370,066 (+)MAPPERmRatBN7.2
Rnor_6.0965,720,011 - 65,720,239NCBIRnor6.0
Rnor_5.0965,526,753 - 65,526,981UniSTSRnor5.0
RGSC_v3.4957,496,531 - 57,496,760RGDRGSC3.4
RGSC_v3.4957,496,532 - 57,496,760UniSTSRGSC3.4
Celera957,810,265 - 57,810,493UniSTS
RGSC_v3.1957,643,514 - 57,643,742RGD
RH 3.4 Map9495.2UniSTS
RH 3.4 Map9495.2RGD
RH 2.0 Map9568.4RGD
SHRSP x BN Map942.1498RGD
Cytogenetic Map9q31UniSTS
RH127778  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,348,597 - 60,348,783 (+)MAPPERmRatBN7.2
Rnor_6.0965,698,772 - 65,698,957NCBIRnor6.0
Rnor_5.0965,505,515 - 65,505,700UniSTSRnor5.0
RGSC_v3.4957,474,745 - 57,474,930UniSTSRGSC3.4
Celera957,789,024 - 57,789,209UniSTS
RH 3.4 Map9494.69UniSTS
Cytogenetic Map9q31UniSTS
RH140019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2960,350,918 - 60,351,105 (+)MAPPERmRatBN7.2
Rnor_6.0965,701,093 - 65,701,279NCBIRnor6.0
Rnor_5.0965,507,836 - 65,508,022UniSTSRnor5.0
RGSC_v3.4957,477,066 - 57,477,252UniSTSRGSC3.4
Celera957,791,345 - 57,791,531UniSTS
RH 3.4 Map9495.2UniSTS
Cytogenetic Map9q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_133560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039082996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF474163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ288898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014939   ⟹   ENSRNOP00000014939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,351,438 - 60,413,964 (-)Ensembl
Rnor_6.0 Ensembl965,701,413 - 65,737,538 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000015034   ⟹   ENSRNOP00000015035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl967,842,683 - 67,908,158 (-)Ensembl
mRatBN7.2 Ensembl960,350,012 - 60,413,964 (-)Ensembl
Rnor_6.0 Ensembl965,698,712 - 65,763,273 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087458   ⟹   ENSRNOP00000072887
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl960,350,403 - 60,413,996 (-)Ensembl
Rnor_6.0 Ensembl965,701,612 - 65,736,852 (-)Ensembl
RefSeq Acc Id: NM_133560   ⟹   NP_598244
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,908,158 (-)NCBI
mRatBN7.2960,348,535 - 60,414,018 (-)NCBI
Dahl_SR_JrHsd971,572,560 - 71,637,940 (-)NCBI
Lyon_Normotensive967,347,863 - 67,413,243 (-)NCBI
Lyon_Hypertensive967,483,912 - 67,549,294 (-)NCBI
F344_StmMcwi969,399,108 - 69,464,486 (-)NCBI
Rnor_6.0965,698,709 - 65,763,273 (-)NCBI
Rnor_5.0965,505,448 - 65,570,090 (-)NCBI
RGSC_v3.4957,474,682 - 57,540,751 (-)RGD
Celera957,788,961 - 57,853,095 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767072   ⟹   XP_008765294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,908,227 (-)NCBI
mRatBN7.2960,348,531 - 60,413,996 (-)NCBI
Rnor_6.0965,698,706 - 65,763,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596256   ⟹   XP_017451745
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,908,233 (-)NCBI
mRatBN7.2960,351,137 - 60,414,032 (-)NCBI
Rnor_6.0965,698,706 - 65,763,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082996   ⟹   XP_038938924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,908,225 (-)NCBI
mRatBN7.2960,351,952 - 60,414,036 (-)NCBI
RefSeq Acc Id: XM_063266620   ⟹   XP_063122690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,908,233 (-)NCBI
RefSeq Acc Id: XM_063266621   ⟹   XP_063122691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,909,786 (-)NCBI
RefSeq Acc Id: XM_063266622   ⟹   XP_063122692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,909,786 (-)NCBI
RefSeq Acc Id: XM_063266623   ⟹   XP_063122693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8967,842,680 - 67,908,233 (-)NCBI
RefSeq Acc Id: NP_598244   ⟸   NM_133560
- UniProtKB: Q8R2H6 (UniProtKB/Swiss-Prot),   Q8R4G3 (UniProtKB/Swiss-Prot),   Q8R2H7 (UniProtKB/Swiss-Prot),   A6IP87 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765294   ⟸   XM_008767072
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K434 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451745   ⟸   XM_017596256
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K434 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014939   ⟸   ENSRNOT00000014939
Ensembl Acc Id: ENSRNOP00000072887   ⟸   ENSRNOT00000087458
Ensembl Acc Id: ENSRNOP00000015035   ⟸   ENSRNOT00000015034
RefSeq Acc Id: XP_038938924   ⟸   XM_039082996
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063122692   ⟸   XM_063266622
- Peptide Label: isoform X2
- UniProtKB: Q8R4G3 (UniProtKB/Swiss-Prot),   Q8R2H7 (UniProtKB/Swiss-Prot),   Q8R2H6 (UniProtKB/Swiss-Prot),   A6IP87 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122691   ⟸   XM_063266621
- Peptide Label: isoform X2
- UniProtKB: Q8R4G3 (UniProtKB/Swiss-Prot),   Q8R2H7 (UniProtKB/Swiss-Prot),   Q8R2H6 (UniProtKB/Swiss-Prot),   A6IP87 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122693   ⟸   XM_063266623
- Peptide Label: isoform X4
- UniProtKB: A6IP86 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122690   ⟸   XM_063266620
- Peptide Label: isoform X2
- UniProtKB: Q8R4G3 (UniProtKB/Swiss-Prot),   Q8R2H7 (UniProtKB/Swiss-Prot),   Q8R2H6 (UniProtKB/Swiss-Prot),   A6IP87 (UniProtKB/TrEMBL),   A6IP85 (UniProtKB/TrEMBL)
Protein Domains
HAP1 N-terminal   Trafficking kinesin-binding protein C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R2H7-F1-model_v2 AlphaFold Q8R2H7 1-913 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696695
Promoter ID:EPDNEW_R7220
Type:initiation region
Name:Trak2_1
Description:trafficking kinesin protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0965,763,201 - 65,763,261EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620915 AgrOrtholog
BioCyc Gene G2FUF-27429 BioCyc
Ensembl Genes ENSRNOG00000010881 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014939.7 UniProtKB/Swiss-Prot
  ENSRNOT00000015034 ENTREZGENE
  ENSRNOT00000015034.8 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124967 IMAGE-MGC_LOAD
InterPro HAP1_N UniProtKB/Swiss-Prot
  Intracell_Traff-Reg UniProtKB/Swiss-Prot
  Traffickng_kinesin-bd_prot_dom UniProtKB/Swiss-Prot
KEGG Report rno:171086 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93214 IMAGE-MGC_LOAD
NCBI Gene 171086 ENTREZGENE
PANTHER TRAFFICKING KINESIN-BINDING PROTEIN UniProtKB/Swiss-Prot
  TRAFFICKING KINESIN-BINDING PROTEIN 2 UniProtKB/Swiss-Prot
Pfam HAP1_N UniProtKB/Swiss-Prot
  Milton UniProtKB/Swiss-Prot
PhenoGen Trak2 PhenoGen
RatGTEx ENSRNOG00000010881 RatGTEx
SMART HAP1_N UniProtKB/Swiss-Prot
  Milton UniProtKB/Swiss-Prot
UniProt A0A0G2K434 ENTREZGENE
  A6IP85 ENTREZGENE, UniProtKB/TrEMBL
  A6IP86 ENTREZGENE, UniProtKB/TrEMBL
  A6IP87 ENTREZGENE, UniProtKB/TrEMBL
  Q8R2H6 ENTREZGENE
  Q8R2H7 ENTREZGENE
  Q8R4G3 ENTREZGENE
  TRAK2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8R2H6 UniProtKB/Swiss-Prot
  Q8R4G3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Trak2  trafficking kinesin protein 2  Trak2  trafficking protein, kinesin binding 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Trak2  trafficking protein, kinesin binding 2  Als2cr3  amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog (human)  Symbol and Name updated 1299863 APPROVED
2004-12-14 Als2cr3  amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog (human)    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3  Name updated 1299863 APPROVED
2002-08-07 Als2cr3  amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains consensus sequences for phosphorylation by protein kinase A, protein kinase C and casein kinase and contains a proline-rich domain 625504
gene_expression mRNA expressed in a variety of tissues but protein expression is predominantly in excitable tissues 625504
gene_homology has 47% homology over 297 aa with the rat huntingtin-associated protein (HAP-1) 625504
gene_product 913 amino acid protein 625504
gene_transcript expressed as two alternative splicing forms 625504