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Gene: Klhl41 (kelch-like family member 41) Rattus norvegicus

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Symbol:

Klhl41

Name:

kelch-like family member 41

RGD ID:

620852

Description:

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in pseudopodium assembly. Located in pseudopodium. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Kbtbd10; kel-like protein 23; kelch related protein 1; kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10; kelch-like 41; kelch-like 41 (Drosophila); kelch-like protein 41; kelch-related protein 1; Krp1; sarcomeric muscle protein; Sarcosin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KLHL41 (kelch like family member 41)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Klhl41 (kelch-like 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Klhl41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KLHL41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KLHL41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Klhl41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KLHL41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KLHL41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Klhl41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Klhl41 (kelch like family member 41)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Klhl41 (kelch-like 41)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	KLHL41 (kelch like family member 41)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	klhl41a (kelch-like family member 41a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	klhl41b (kelch-like family member 41b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	klhl41	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	klhl41	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	74,842,118 - 74,855,244 (+)	NCBI	GRCr8	GRCr8		GRCr8
mRatBN7.2	3	54,434,291 - 54,447,415 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	54,434,234 - 54,449,222 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	57,834,266 - 57,847,390 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	66,417,864 - 66,430,988 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	64,180,224 - 64,193,348 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	55,910,177 - 55,923,303 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	55,910,177 - 55,923,303 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	62,521,998 - 62,535,124 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	51,816,016 - 51,829,140 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	53,994,900 - 54,008,018 (+)	NCBI		Celera
RGSC_v3.1	3	51,712,387 - 51,725,512 (+)	NCBI
Cytogenetic Map	3	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hypertrophic cardiomyopathy (ISO)

nemaline myopathy (ISO,ISS)

nemaline myopathy 9 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2-palmitoylglycerol (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

carbofuran (EXP)

Cuprizon (ISO)

cytarabine (ISO)

diisononyl phthalate (ISO)

dimethyl sulfoxide (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

endosulfan (EXP)

fenvalerate (EXP)

genistein (EXP)

isoprenaline (EXP)

leflunomide (ISO)

methylmercury chloride (ISO)

nickel subsulfide (EXP)

nitrofen (EXP)

Nonylphenol (EXP)

okadaic acid (ISO)

paraquat (EXP)

perfluorooctanoic acid (EXP)

pioglitazone (ISO)

potassium dichromate (ISO)

razoxane (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

Soman (EXP)

sunitinib (ISO)

thimerosal (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vanadyl sulfate (ISO)

vorinostat (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

myofibril assembly (ISO,ISS)

proteasome-mediated ubiquitin-dependent protein catabolic process (IBA)

protein ubiquitination (ISO)

pseudopodium assembly (IMP)

regulation of myoblast differentiation (IBA,ISO,ISS)

regulation of myoblast proliferation (IBA,ISO,ISS)

regulation of skeletal muscle cell differentiation (IBA,ISO)

skeletal muscle cell differentiation (ISO,ISS)

Cellular Component

Cul3-RING ubiquitin ligase complex (IBA,ISO)

cytoplasm (IBA,IEA,ISO)

cytoskeleton (IBA,IEA,ISO,ISS)

cytosol (ISO)

endoplasmic reticulum membrane (IEA,ISO,ISS)

M band (IBA,IEA,ISO,ISS)

pseudopodium (IDA,IEA)

ruffle (IEA)

sarcoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

Molecular Function

protein binding (IPI,ISO)

ubiquitin-like ligase-substrate adaptor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes.	Lim DS, etal., J Am Coll Cardiol. 2001 Oct;38(4):1175-80.
4.	New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly.	Lu S, etal., J Cell Sci. 2003 Jun 1;116(Pt 11):2169-78. Epub 2003 Apr 8.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells.	Spence HJ, etal., Oncogene 2000 Mar 2;19(10):1266-76.

Additional References at PubMed

PMID:15983046	PMID:16449658	PMID:18178185	PMID:19424503	PMID:19726686	PMID:21368295	PMID:22562206	PMID:24268659

Genomics

Comparative Map Data

Klhl41
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	74,842,118 - 74,855,244 (+)	NCBI	GRCr8	GRCr8		GRCr8
mRatBN7.2	3	54,434,291 - 54,447,415 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	54,434,234 - 54,449,222 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	57,834,266 - 57,847,390 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	66,417,864 - 66,430,988 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	64,180,224 - 64,193,348 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	55,910,177 - 55,923,303 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	55,910,177 - 55,923,303 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	62,521,998 - 62,535,124 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	51,816,016 - 51,829,140 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	53,994,900 - 54,008,018 (+)	NCBI		Celera
RGSC_v3.1	3	51,712,387 - 51,725,512 (+)	NCBI
Cytogenetic Map	3	q21	NCBI

KLHL41
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	169,509,702 - 169,526,258 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	169,509,687 - 169,526,262 (+)	Ensembl			hg38	GRCh38
GRCh37	2	170,366,212 - 170,382,768 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	170,074,458 - 170,091,018 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	2	170,191,718 - 170,208,279	NCBI
Celera	2	163,985,145 - 164,001,693 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	162,256,791 - 162,273,335 (+)	NCBI		HuRef
CHM1_1	2	170,372,126 - 170,388,680 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	169,986,941 - 170,003,489 (+)	NCBI		T2T-CHM13v2.0

Klhl41
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	69,500,464 - 69,514,583 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	69,500,464 - 69,514,574 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	69,670,120 - 69,684,239 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	69,670,120 - 69,684,230 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	69,508,177 - 69,522,296 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	69,470,959 - 69,485,078 (+)	NCBI		MGSCv36	mm8
Celera	2	71,339,447 - 71,353,726 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	40.92	NCBI

Klhl41
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	5,023,362 - 5,061,705 (-)	Ensembl
ChiLan1.0	NW_004955449	5,023,362 - 5,041,006 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLHL41
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	72,168,114 - 72,184,579 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	72,183,087 - 72,202,911 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	56,778,475 - 56,798,317 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	174,248,884 - 174,265,508 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	174,248,884 - 174,265,508 (+)	Ensembl			panPan2	panpan1.1

KLHL41
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	14,235,845 - 14,251,621 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	14,235,941 - 14,251,083 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	14,246,436 - 14,262,204 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	14,352,500 - 14,368,230 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	14,352,589 - 14,368,045 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	14,436,418 - 14,452,160 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	14,426,418 - 14,442,160 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	14,538,249 - 14,553,986 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Klhl41
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	131,493,634 - 131,508,703 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	47,463 - 66,556 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	47,298 - 62,608 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLHL41
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	75,875,859 - 75,893,799 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	75,875,694 - 75,893,789 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	84,996,215 - 85,014,712 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLHL41
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	55,023,978 - 55,044,196 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666040	144,487,050 - 144,505,140 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klhl41
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	7,065,137 - 7,077,841 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624787	7,065,121 - 7,077,857 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Klhl41
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	46,972,821 - 46,986,015 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Klhl41
289 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	152
Count of miRNA genes:	118
Interacting mature miRNAs:	134
Transcripts:	ENSRNOT00000009969
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	51490129	111359995	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	73592611	110333156	Rat
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	74364268	119364268	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1331795	Rf30	Renal function QTL 30	3.708		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	3	59863663	87321459	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	53651826	98651826	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	48876619	93876619	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	48876619	93876619	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	35403199	97383526	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
631832	Sach1	Saccharin preference QTL 1	2.7	0.02	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	3	47904172	92904172	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1331777	Bw24	Body weight QTL 24	3.503		body mass (VT:0001259)	body weight (CMO:0000012)	3	59863663	87321459	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	51092561	96092561	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	36425116	81425116	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	48657744	93657744	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	37796919	82796919	Rat
2302276	Bw82	Body weight QTL 82	4.32		body mass (VT:0001259)	body weight (CMO:0000012)	3	59863663	83358329	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	58925062	103925062	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	70311536	115311536	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	48657744	93657744	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	50766145	95766145	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	51092561	96092561	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	36721849	110333156	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	50766145	95766145	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	48657744	93657744	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
1582249	Bw77	Body weight QTL 77	3.2	0.0025	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	85062403	Rat
2325840	Bp345	Blood pressure QTL 345		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	38708931	83708931	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	48657744	93657744	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	37363734	82363734	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	36101403	81101403	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	48657744	93657744	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat

Markers in Region

RH132483

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	54,446,898 - 54,447,101 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	55,922,787 - 55,922,989	NCBI	Rnor6.0
Rnor_5.0	3	62,534,608 - 62,534,810	UniSTS	Rnor5.0
RGSC_v3.4	3	51,828,626 - 51,828,828	UniSTS	RGSC3.4
Celera	3	54,007,502 - 54,007,704	UniSTS
RH 3.4 Map	13	149.0	UniSTS
Cytogenetic Map	3	q21	UniSTS

fd52b08.x1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	54,436,608 - 54,437,968 (+)	MAPPER	mRatBN7.2
mRatBN7.2	3	54,436,618 - 54,437,968 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	55,912,507 - 55,913,856	NCBI	Rnor6.0
Rnor_6.0	3	55,912,497 - 55,913,856	NCBI	Rnor6.0
Rnor_5.0	3	62,524,328 - 62,525,677	UniSTS	Rnor5.0
Rnor_5.0	3	62,524,318 - 62,525,677	UniSTS	Rnor5.0
RGSC_v3.4	3	51,818,346 - 51,819,695	UniSTS	RGSC3.4
RGSC_v3.4	3	51,818,336 - 51,819,695	UniSTS	RGSC3.4
Celera	3	53,997,216 - 53,998,575	UniSTS
Celera	3	53,997,226 - 53,998,575	UniSTS
Cytogenetic Map	3	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	65	162	90	89	58	80	58	6	335	178	11	141	75	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057191	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ293948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009969 ⟹ ENSRNOP00000009969

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	54,434,234 - 54,449,222 (+)	Ensembl
Rnor_6.0 Ensembl	3	55,910,177 - 55,923,303 (+)	Ensembl

RefSeq Acc Id:

NM_057191 ⟹ NP_476539

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	74,842,118 - 74,855,244 (+)	NCBI
mRatBN7.2	3	54,434,291 - 54,447,415 (+)	NCBI
Rnor_6.0	3	55,910,177 - 55,923,303 (+)	NCBI
Rnor_5.0	3	62,521,998 - 62,535,124 (+)	NCBI
RGSC_v3.4	3	51,816,016 - 51,829,140 (+)	RGD
Celera	3	53,994,900 - 54,008,018 (+)	NCBI

Sequence:

show sequence

ATGGATTCCCAGCGGGAGCTTGCAGAGGAACTCCGGCTTTACCAATCCACCCTTCTTCAGGATG
GTCTAAAAGATCTCCTGGAAGAGAAAAAATTCATCGATTGTACCCTAAAAGCAGGTGACAAAAG
TTTTCCTTGCCACAGACTGATATTGTCGGCTTGTAGCCCTTACTTCCGTGAGTATTTCTTATCT
GAAATTGAGGAGGAGAAGAAAAAGGAGATGGCGCTAGACAATGTAGATCCTGCTATACTTGATT
TGATCATCAAATACCTGTACTCTGCCAGTATTGATCTCAATGACGGGAACGTGCAAGACATCTT
CGCCCTGTCCAGCCGCTTCCAGATTCCGTCGGTGTTCACCGTCTGTGTGTCTTACCTTCAGAAA
AGACTGGCTCCTGGTAACTGTCTGGCCATCCTAAGATTGGGGCTTCTTCTCGACTGTCCAAGAC
TTGCCATTTCTGCCCGGGAGTTTGTGTCAGATCGCTTTGTGCAGATTTGTAAGGAAGAAGACTT
CATGCAACTGTCCCCACAGGAGCTGATCTCTGTCATTTCAAATGACAGCCTCAATGTAGAAAAG
GAGGAAGTGGTATTTGAGGCCGTGATGAAATGGGTACGGACAGACAAAGAAAACAGGGCGAAAA
ATCTTAGTGAAGTATTTGACTGTATTCGTTTTCGCCTTATGGCTGAGAAATATTTCAAAGATCA
TGTCGAGAAGGATGACATAATTAAAAGCAACCCAGAAGTCCAGAAAAAAATCAAAGTTCTAAAG
GACGCTTTTGCAGGCAAACTTCCGGAACCCAGCAAAAGCGCAGAGAAAGGGGGGACGGGCGAGG
TGAACGGTGATGTTGGTGATGAAGACTTACTTCCTGGTTACCTGAATGATATCCCCAGGCATGG
AATGTTCGTCAAAGATCTCATCCTCTTGGTCAATGACACAGCTGCAGTGGCGTATGACCCCATG
GAAAATGAGTGTTATCTTACTGCCCTAGCTGAGCAGATCCCCAGAAATCATTCCAGTATTGTTA
CCCAACAGAACCAGGTCTACGTGGTCGGAGGACTGTACGTGGACGAAGAGAATAAAGATCAACC
CCTGCAATCCTACTTTTTCCAGCTTGATAACGTATCATCTGAGTGGGTTGGACTACCGCCTCTC
CCGTCAGCCAGGTGCCTCTTTGGTCTGGGAGAGGTAGATGACAAAATCTATGTGGTCGCCGGCA
AAGACCTTCAGACAGAGGCCTCCCTGGATTCCGTGTTATGCTATGATCCTGTGGCTGCAAAGTG
GAGCGAAGTGAAAAATCTTCCTATTAAAGTTTATGGGCATAATGTGATCTCACATAATGGGATG
ATATACTGTCTGGGCGGAAAGACAGATGACAAAAAGTGTACGAATAGGGTGTTTATCTACAACC
CCAAGAAAGGAGACTGGAAGGATCTGGCTCCAATGAAAACCCCACGTTCCATGTTTGGAGTGGC
AATCCACAAAGGCAAAATCGTGATCGCAGGAGGCGTCACTGAAGATGGCCTTTCAGCTTCAGTT
GAAGCCTTCGACCTCAAAACCAATAAGTGGGAAGTGATGACGGAATTTCCCCAAGAAAGAAGCT
CCATCAGCCTGGTGAGCCTGGCCGGATCCCTGTACGCCATCGGCGGCTTTGCGATGATTCAGTT
GGAATCTAAAGAGTTCGCGCCCACTGAAGTCAATGACATATGGAAGTATGAAGATGATAAAAAA
GAATGGGCTGGGATGCTGAAGGAGATTCGATATGCTTCGGGAGCTAGTTGCCTAGCAACACGCT
TAAATCTGTTTAAACTGTCTAAACTATAAAGGAGGTGACAAAGACACGGTTTGAGAGGTGGCTT
GTTGGGACAAGAGGGCCTTAATGTATTGTCCTTCTTTAAGCCTATACAATGATTCATGTAGGGT
AACATTGATCTGTGCAGTTCCCCGGGAGATAAAACAGTGTAACCGAATCCCCAAGGTGTTTTAG
CGTGTGGAGTATAAAACCGTTTGCTAGGGAGTTAGTATACAGTTGAACAATGTATTTTGTCAAA
CCTTTCTCATAGAAGCGAGCTTTCTACATCCTGATGTTTACTAATCCTTTGTATTCTTAAGGTA
CATTTACACTTGTTTTCTATTATAAATGAAATGCATATGTCTACACTCTCAAGAGATGTTTGAG
TAACAGAAACCTCTCCCCGGTTTTGAGCTACGACAGGAATCTTGTGCATTTTAATGAAGATGAC
TGGAAGTGCTGTATAAGAAGTGTAATAAAGGAGTGTCCAGTCCCTTCCCCATTAAAAAAAAAAA
AAAAAAAAACTC

hide sequence

Protein Sequences


Protein RefSeqs	NP_476539	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAC08185	(Get FASTA)	NCBI Sequence Viewer
	EDL79060	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009969.2
GenBank Protein	Q9ER30	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476539 ⟸ NM_057191

- UniProtKB:

Q9ER30 (UniProtKB/Swiss-Prot), A6HM09 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLS
EIEEEKKKEMALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQK
RLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEK
EEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLK
DAFAGKLPEPSKSAEKGGTGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPM
ENECYLTALAEQIPRNHSSIVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVSSEWVGLPPL
PSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGM
IYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASV
EAFDLKTNKWEVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKK
EWAGMLKEIRYASGASCLATRLNLFKLSKL

hide sequence

Ensembl Acc Id:

ENSRNOP00000009969 ⟸ ENSRNOT00000009969

Protein Domains

BACK BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ER30-F1-model_v2	AlphaFold	Q9ER30	1-606	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692116

Promoter ID:

EPDNEW_R2641

Type:

initiation region

Name:

Klhl41_1

Description:

kelch-like family member 41

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	55,910,082 - 55,910,142	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620852	AgrOrtholog
BioCyc Gene	G2FUF-49505	BioCyc
Ensembl Genes	ENSRNOG00000007461	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000009969.4	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.40.420	UniProtKB/Swiss-Prot
	2.120.10.80	UniProtKB/Swiss-Prot
	Potassium Channel Kv1.1, Chain A	UniProtKB/Swiss-Prot
InterPro	BACK	UniProtKB/Swiss-Prot
	BTB-kelch_protein	UniProtKB/Swiss-Prot
	BTB/POZ_dom	UniProtKB/Swiss-Prot
	Kelch-typ_b-propeller	UniProtKB/Swiss-Prot
	Kelch_1	UniProtKB/Swiss-Prot
	KLHL41	UniProtKB/Swiss-Prot
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:117537	UniProtKB/Swiss-Prot
NCBI Gene	117537	ENTREZGENE
PANTHER	KELCH PROTEIN	UniProtKB/Swiss-Prot
	KELCH-LIKE PROTEIN 41	UniProtKB/Swiss-Prot
Pfam	BACK	UniProtKB/Swiss-Prot
	BTB	UniProtKB/Swiss-Prot
	Kelch_KLHDC2_KLHL20_DRC7	UniProtKB/Swiss-Prot
PhenoGen	Klhl41	PhenoGen
PIRSF	Kelch-like_protein_gigaxonin	UniProtKB/Swiss-Prot
PROSITE	BTB	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000007461	RatGTEx
SMART	BACK	UniProtKB/Swiss-Prot
	BTB	UniProtKB/Swiss-Prot
	Kelch	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF117281	UniProtKB/Swiss-Prot
	SSF54695	UniProtKB/Swiss-Prot
UniProt	A6HM09	ENTREZGENE, UniProtKB/TrEMBL
	KLH41_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-27	Klhl41	kelch-like family member 41	Klhl41	kelch-like 41 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-01-17	Klhl41	kelch-like 41 (Drosophila)	Kbtbd10	kelch repeat and BTB (POZ) domain containing 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Kbtbd10	kelch repeat and BTB (POZ) domain containing 10	Sarcosin	sarcomeric muscle protein	Symbol and Name updated	1299863	APPROVED
2002-08-07	Sarcosin	sarcomeric muscle protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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