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Gene: Tgm4 (transglutaminase 4) Rattus norvegicus

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Symbol:

Tgm4

Name:

transglutaminase 4

RGD ID:

620785

Description:

Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to act upstream of or within mating plug formation. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular matrix. Orthologous to human TGM4 (transglutaminase 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dorsal prostate transglutaminase; dorsal protein 1; Dp1; glutamine gamma-glutamyltransferase 4; protein-glutamine gamma-glutamyltransferase 4; TGase-4; transglutaminase 4 (prostate); transglutaminase-4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TGM4 (transglutaminase 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tgm4 (transglutaminase 4 (prostate))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tgm4 (transglutaminase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TGM4 (transglutaminase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TGM4 (transglutaminase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tgm4 (transglutaminase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tgm4 (transglutaminase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TGM1 (transglutaminase 1)	HGNC	Treefam
Homo sapiens (human):	F13A1 (coagulation factor XIII A chain)	HGNC	Treefam
Homo sapiens (human):	TGM2 (transglutaminase 2)	HGNC	Treefam
Alliance orthologs ³
Homo sapiens (human):	TGM4 (transglutaminase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tgm4 (transglutaminase 4 (prostate))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tg	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	tgm4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tgm4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100488471	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	131,566,887 - 131,603,920 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	131,566,887 - 131,603,920 (+)	Ensembl				GRCr8
mRatBN7.2	8	122,689,429 - 122,726,463 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	122,689,429 - 122,726,463 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	128,278,855 - 128,316,606 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	126,477,795 - 126,515,546 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	124,305,997 - 124,343,725 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	132,117,279 - 132,157,485 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	132,120,452 - 132,157,485 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	131,272,260 - 131,311,091 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	127,782,460 - 127,819,491 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	121,803,208 - 121,839,825 (+)	NCBI		Celera
RGSC_v3.1	8	127,802,187 - 127,838,603 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

essential tremor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

8'-apo-beta,psi-caroten-8'-al (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-carotene (ISO)

bisphenol A (EXP,ISO)

calcitriol (ISO)

chlordecone (ISO)

D-glucose (ISO)

folic acid (ISO)

fructose (ISO)

fulvestrant (ISO)

glucose (ISO)

herbicide (ISO)

indole-3-methanol (EXP)

methapyrilene (ISO)

N-nitrosodiethylamine (EXP)

okadaic acid (ISO)

ozone (ISO)

paracetamol (EXP)

phenethyl caffeate (EXP)

resveratrol (ISO)

sodium arsenite (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mating plug formation (IEA,ISO)

peptide cross-linking (IBA)

Cellular Component

cytoplasm (IEA,ISO)

extracellular matrix (IBA,IEA,ISO)

extracellular region (IEA)

Golgi apparatus (IEA,ISO)

plasma membrane (IEA)

side of membrane (IEA)

Molecular Function

acyltransferase activity (IEA)

metal ion binding (IEA)

protein-glutamine gamma-glutamyltransferase activity (IBA,IEA)

transferase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Molecular cloning of rat prostate transglutaminase complementary DNA. The major androgen-regulated protein DP1 of rat dorsal prostate and coagulating gland.	Ho KC, etal., J Biol Chem 1992 Jun 25;267(18):12660-7.
4.	Androgen regulated prostate genes: structural analysis and regulation.	Ho KC, etal., Prog Clin Biol Res 1987;239:125-53.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:19056867	PMID:20569004	PMID:20596668	PMID:23341775	PMID:23533145

Genomics

Comparative Map Data

Tgm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	131,566,887 - 131,603,920 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	131,566,887 - 131,603,920 (+)	Ensembl				GRCr8
mRatBN7.2	8	122,689,429 - 122,726,463 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	122,689,429 - 122,726,463 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	128,278,855 - 128,316,606 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	126,477,795 - 126,515,546 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	124,305,997 - 124,343,725 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	132,117,279 - 132,157,485 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	132,120,452 - 132,157,485 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	131,272,260 - 131,311,091 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	127,782,460 - 127,819,491 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	121,803,208 - 121,839,825 (+)	NCBI		Celera
RGSC_v3.1	8	127,802,187 - 127,838,603 (+)	NCBI
Cytogenetic Map	8	q32	NCBI

TGM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	44,874,608 - 44,914,990 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	44,874,608 - 44,914,990 (+)	Ensembl			hg38	GRCh38
GRCh37	3	44,916,100 - 44,956,482 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	44,891,102 - 44,931,092 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	44,891,130 - 44,931,097	NCBI
Celera	3	44,854,064 - 44,894,051 (+)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	44,959,958 - 44,999,946 (+)	NCBI		HuRef
CHM1_1	3	44,866,110 - 44,906,068 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	44,890,333 - 44,930,718 (+)	NCBI		T2T-CHM13v2.0

Tgm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	122,863,806 - 122,896,623 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	122,863,791 - 122,896,626 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	123,034,741 - 123,067,558 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	123,034,726 - 123,067,561 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	122,943,859 - 122,976,676 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	122,883,439 - 122,916,256 (+)	NCBI		MGSCv36	mm8
Celera	9	123,496,347 - 123,518,874 (+)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	73.56	NCBI

Tgm4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	26,737,533 - 26,766,386 (-)	Ensembl
ChiLan1.0	NW_004955420	26,736,880 - 26,766,386 (-)	NCBI	ChiLan1.0	ChiLan1.0

TGM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	44,833,048 - 44,873,279 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	44,837,814 - 44,878,045 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	44,775,855 - 44,815,691 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	45,830,764 - 45,870,208 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	45,830,764 - 45,870,208 (+)	Ensembl			panPan2	panpan1.1

TGM4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	6,362,600 - 6,391,099 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	6,362,782 - 6,390,223 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	160,778,265 - 160,798,323 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tgm4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624730	75,597,903 - 75,619,589 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tgm4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	114,175,104 - 114,203,175 (+)	NCBI		Rrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	213
Count of miRNA genes:	157
Interacting mature miRNAs:	177
Transcripts:	ENSRNOT00000055822
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

BE112987

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	122,732,875 - 122,733,044 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	132,163,898 - 132,164,066	NCBI	Rnor6.0
Rnor_5.0	8	131,317,504 - 131,317,672	UniSTS	Rnor5.0
RGSC_v3.4	8	127,825,904 - 127,826,072	UniSTS	RGSC3.4
Celera	8	121,845,977 - 121,846,145	UniSTS
RH 3.4 Map	8	1276.3	UniSTS
Cytogenetic Map	8	q32	UniSTS

BF416391

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	122,741,028 - 122,741,231 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	132,172,050 - 132,172,252	NCBI	Rnor6.0
Rnor_5.0	8	131,325,353 - 131,325,555	UniSTS	Rnor5.0
RGSC_v3.4	8	127,835,249 - 127,835,451	UniSTS	RGSC3.4
Celera	8	121,854,133 - 121,854,335	UniSTS
RH 3.4 Map	8	1276.29	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	11	47	105	88	87	56	45	56	6	243	115	1	88	54	66	31	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC133294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC066665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA339697	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN931716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN934649	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KM669281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M32725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000055822 ⟹ ENSRNOP00000052677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	131,566,887 - 131,603,920 (+)	Ensembl
mRatBN7.2 Ensembl	8	122,689,429 - 122,726,463 (+)	Ensembl
Rnor_6.0 Ensembl	8	132,120,452 - 132,157,485 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091791 ⟹ ENSRNOP00000075565

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	131,581,281 - 131,603,920 (+)	Ensembl
mRatBN7.2 Ensembl	8	122,703,824 - 122,726,463 (+)	Ensembl
Rnor_6.0 Ensembl	8	132,135,187 - 132,156,683 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115588 ⟹ ENSRNOP00000079467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	131,566,949 - 131,603,920 (+)	Ensembl
mRatBN7.2 Ensembl	8	122,689,491 - 122,726,463 (+)	Ensembl

RefSeq Acc Id:

NM_022713 ⟹ NP_073204

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	131,566,887 - 131,603,920 (+)	NCBI
mRatBN7.2	8	122,689,429 - 122,726,463 (+)	NCBI
Rnor_6.0	8	132,120,452 - 132,157,485 (+)	NCBI
Rnor_5.0	8	131,272,260 - 131,311,091 (+)	NCBI
RGSC_v3.4	8	127,782,460 - 127,819,491 (+)	RGD
Celera	8	121,803,208 - 121,839,825 (+)	RGD

Sequence:

show sequence

TCTGGCAGCGCCGCTGGCATCAGACTGGAGACTTGACAGGGTTGGAGAGAGGCAGCAGGACCAT
GGACTCCAGGAACATGCTTGTCGTTTACTCTGTGAACTTGGAGAAAAAGCTGAACGCTGCTGCC
CACCACACGATTGAGTACCAAACTCAGAAGCTCGTGCTCAGGCGTGGACAGATATTCTCCCTGA
AGGTGATGCTAAACAGACCGCTCCAATCTCATGATGAACTGAAGCTGATATTCAATACTGGACA
CAACATGCCATTCTACACTGTGGAGCTTGATCCAATGACATCCTACCGTTCCAAGGGCTGGCAG
GTGAAGATTGCTAAACAGTCTGGTGTAGAGGTTGTATTGAATGTCATCAGTGCTGCCGACGCCG
TGGTGGGGAGGTACACGATGAACGTGAACGAATTTGACGCTGGAGTGTTCTTCCTTCTCTTCAA
TCCGTGGTGCTCAGATGACAGTGTCTTCATGGCTAGTGAGGAAGACCGAGCAGAGTACGTCCTT
AATGATACCGGTTACATGTACATGGGTTTTGCCAAACAGATTAAAGAGAAGCCCTGGACCTTTG
GTCAGTTTGAGAAGTACATCTTGAACTGCTGCTTCCGATTGTTGACCCATTTGGAGCCCAAGGA
AATGCAGAGCCCAGTGCTTGTGTCCAGGGCCATTTGTACTATGATGTGTGCTGCAAACAATTTT
GGAGTGCTGGTGGGGAACTGGACAGGAGACTATAGCAATGGCACTGCCCCGTATGTGTGGGCCA
GCAGTGTACCCATTCTCCAGCAGCACTACATCACCAGGATGCCTGTACGCTTTGGCCAGTGCTG
GGTTTTCTCTGGAGTCCTGACCACAGCACTGAGAGCAGTGGGCATCCCAGCTCGCAGCGTGACT
AACTTTGAGTCAGCCCACGATACAGAAAAGAACCTCAGAGTAGACATCTACCTGGATGAATCGG
GCAAGACAATTCCACATCTGACCAAAGACTCTGTCTGGAATTTCCATGTGTGGACAGATGCCTG
GATGAAAAGACAGGATCTACCCCAGGGCCATGATGGTTGGCAGGTCCTGGATTCTACACCACAG
GAAATCAGTGAAGGACAATTCCGCATTGGACCTTCACCGGTGTCTGCTATCCGCCAGGGATTGG
TCCAAATCATGTATGACACCACATTTGTGTTCACGGAGGTGAACGGTGACAAGTACATCTGGCT
GGTGAAGCAGAACCAGGAAAGGGAGAAGAATGTCCTCATCGCTGTGGAGACTGCTAGCATCGGC
AAGAACATCAGCACCAAGATGGTGGGCGAGAACAGGCGTCAAGATATTACCTTGCATTACAAGT
TCCCAGAAGGCAGCCCAGAGGAGAGGAAGGCCATGGAGAAGGCCTCTGGGAAACGTCCTGATGA
CAAGCTCAACTCTCGGACACTTCACATATCTGTCCTCCAGAACTCTGTGGAGCTAGGACATCCT
ATCAATTTGACCATAGTGTTGAAAAGGAAAACGGCCACACCACAGAATGTCAACATTTCATGCT
CCCTTGACCTACAGACTTACACAGGCAACAAGAAGACAAACCTGGGAGTCATCCAGAAGACTGT
GCAGATTCAAGGCCAAGAATCAGAGGTGTCTCTCAGCATGGATTCCAGTTTCTACATCTATAAA
CTGGGCATGGTTGATGATGAGATGGTCATTAAAGGGTTCATCATTGCAGAAATTGTTGATTCTG
GTGAACGGGTAGCCACTGATACGACCCTGTGTTTCCTGTACTCTGCCTTCTCTGTAGAGATGCC
GAGCACAAGCAAGGTCAACCAGCCTCTGACCATCACCTGCAACTTCAAGAACACCCTGCCCATC
CCTTTGACTAACATCAAGTTCTCAGTGGAAAGCCTGGGCCTCAATAACATGAAGTCCTGGGAGC
AAGAGACGGTGCCGCCCGGAAAGACCATCAATTTCCAGATAGAATGCACCCCAGTGAAAACTGG
ACCCAGGAAGTTCATTGTCAAGTTTATTTCCAGACAAGTGAAAGAGGTTCATGCCGAGAAGGTC
GTTCTCATCACAAAGTAGCCCATCTGATACCATTGAGATGGAGGCAGGAGCCCTGATTGGCTCT
GAGCCTTGGTAAGCATGTTAGCATTTCCTAAATTGCATTTAGCTCTCAGGTCAGAAATGATTAA
ATTTTAGGGGTTGGGGATTTAGCTCAGTGGTAGAGCGCTTGCCTAGGAAGCGCAAGGCCCTGGG
TTCGGTCCCCAGCTCCGGGAAAAAAAAAAAAAAAAGAAATGATTAAATTTTGATTACTCATATG
AAGGCAGATTCAAGAGCCAGCCCAGCAAAAGACAGAGCTCAAAGGCCAATGTAACCACCGGCAG
TAGCTCCAGGGAGCCAGGTTACCTAAGCACATGTCATACATAGGCAGACATCTCAAATACATAT
TTAGGAACTGTGGCCTCAGAAGACAGTGCCACTGTCATCTGGATTCAGAACCATATCCAGAGCC
CAGATAGAGAAGTGCCAGAGGCATCTTCCATCTACACCATGGATTCTATCAAGTCCAGGGGTGC
CTGGAGGCTGTGCTGGAAGTCCTGTAGGAAGCATCGTGGAGCTGGTCCTTGACCAGGTGCTACA
AGCTCTTACCCTAGGGCTCCGTCCTCTCGGAAGCAGGCCCCACGCTGGCGTGAGGCCCCTCTTG
CTCTAGATGGGCCAGGGGAGGGAGGCCCTTTCCTTAAGTAAGAGTCTATGGCCAGTGACAACAT
CTGAAGAAGCAAGGTATCCTTCCCTGTTCCCTGGAGTCTGTGCTTTACTATGCTGTAAAGGGAT
CTGCTCATGTATCACTGTGCTTTGAATTAAACTCTGGCAACTTTAAGATGGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_073204	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41092	(Get FASTA)	NCBI Sequence Viewer
	AAH66665	(Get FASTA)	NCBI Sequence Viewer
	AJD87524	(Get FASTA)	NCBI Sequence Viewer
	EDL76772	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052677
GenBank Protein	Q99041	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_073204 ⟸ NM_022713

- UniProtKB:

Q6NYB5 (UniProtKB/Swiss-Prot), Q99041 (UniProtKB/Swiss-Prot), Z4YP11 (UniProtKB/TrEMBL), A6I4A2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDSRNMLVVYSVNLEKKLNAAAHHTIEYQTQKLVLRRGQIFSLKVMLNRPLQSHDELKLIFNTG
HNMPFYTVELDPMTSYRSKGWQVKIAKQSGVEVVLNVISAADAVVGRYTMNVNEFDAGVFFLLF
NPWCSDDSVFMASEEDRAEYVLNDTGYMYMGFAKQIKEKPWTFGQFEKYILNCCFRLLTHLEPK
EMQSPVLVSRAICTMMCAANNFGVLVGNWTGDYSNGTAPYVWASSVPILQQHYITRMPVRFGQC
WVFSGVLTTALRAVGIPARSVTNFESAHDTEKNLRVDIYLDESGKTIPHLTKDSVWNFHVWTDA
WMKRQDLPQGHDGWQVLDSTPQEISEGQFRIGPSPVSAIRQGLVQIMYDTTFVFTEVNGDKYIW
LVKQNQEREKNVLIAVETASIGKNISTKMVGENRRQDITLHYKFPEGSPEERKAMEKASGKRPD
DKLNSRTLHISVLQNSVELGHPINLTIVLKRKTATPQNVNISCSLDLQTYTGNKKTNLGVIQKT
VQIQGQESEVSLSMDSSFYIYKLGMVDDEMVIKGFIIAEIVDSGERVATDTTLCFLYSAFSVEM
PSTSKVNQPLTITCNFKNTLPIPLTNIKFSVESLGLNNMKSWEQETVPPGKTINFQIECTPVKT
GPRKFIVKFISRQVKEVHAEKVVLITK

hide sequence

Ensembl Acc Id:

ENSRNOP00000052677 ⟸ ENSRNOT00000055822

Ensembl Acc Id:

ENSRNOP00000075565 ⟸ ENSRNOT00000091791

Ensembl Acc Id:

ENSRNOP00000079467 ⟸ ENSRNOT00000115588

Protein Domains

Transglutaminase-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99041-F1-model_v2	AlphaFold	Q99041	1-667	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696404

Promoter ID:

EPDNEW_R6928

Type:

single initiation site

Name:

Tgm4_1

Description:

transglutaminase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	132,120,445 - 132,120,505	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620785	AgrOrtholog
BioCyc Gene	G2FUF-28623	BioCyc
Ensembl Genes	ENSRNOG00000004320	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000055822	ENTREZGENE
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
	3.90.260.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5623927	IMAGE-MGC_LOAD
InterPro	Ig-like_fold	UniProtKB/Swiss-Prot
	Ig_E-set	UniProtKB/Swiss-Prot
	Papain-like_cys_pep_sf	UniProtKB/Swiss-Prot
	Transglutaminase	UniProtKB/Swiss-Prot
	Transglutaminase-like	UniProtKB/Swiss-Prot
	Transglutaminase-like_sf	UniProtKB/Swiss-Prot
	Transglutaminase_animal	UniProtKB/Swiss-Prot
	Transglutaminase_AS	UniProtKB/Swiss-Prot
	Transglutaminase_C	UniProtKB/Swiss-Prot
	Transglutaminase_C_sf	UniProtKB/Swiss-Prot
	Transglutaminase_N	UniProtKB/Swiss-Prot
KEGG Report	rno:64679	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72437	IMAGE-MGC_LOAD
NCBI Gene	64679	ENTREZGENE
PANTHER	PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE	UniProtKB/Swiss-Prot
	PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 4	UniProtKB/Swiss-Prot
Pfam	Transglut_C	UniProtKB/Swiss-Prot
	Transglut_core	UniProtKB/Swiss-Prot
	Transglut_N	UniProtKB/Swiss-Prot
PhenoGen	Tgm4	PhenoGen
PIRSF	TGM_EBP42	UniProtKB/Swiss-Prot
PROSITE	TRANSGLUTAMINASES	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004320	RatGTEx
SMART	TGc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF49309	UniProtKB/Swiss-Prot
	SSF54001	UniProtKB/Swiss-Prot
	SSF81296	UniProtKB/Swiss-Prot
UniProt	A0A0B5ABY8_RAT	UniProtKB/TrEMBL
	A0A0G2KAX6_RAT	UniProtKB/TrEMBL
	A0A8I5ZN59_RAT	UniProtKB/TrEMBL
	A6I4A2	ENTREZGENE, UniProtKB/TrEMBL
	Q6NYB5	ENTREZGENE
	Q99041	ENTREZGENE, UniProtKB/Swiss-Prot
	Z4YP11	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	Q6NYB5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-17	Tgm4	transglutaminase 4	Tgm4	transglutaminase 4 (prostate)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Tgm4	transglutaminase 4 (prostate)	Dp1	dorsal protein 1	Symbol and Name updated	1299863	APPROVED
2002-08-07	Dp1	dorsal protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed only in dorsal prostate and coagulating gland, absent in ventral prostate and other tissues	632615
gene_product	member of the transglutaminase gene family	632615
gene_regulation	mRNA greatly decreased after castration and increased rapidly following androgen replacement	632615

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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