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Gene: Barhl1 (BarH-like homeobox 1) Rattus norvegicus

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Symbol:

Barhl1

Name:

BarH-like homeobox 1

RGD ID:

620648

Description:

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of outer hair cell apoptotic process; nervous system development; and sensory perception of sound. Predicted to be active in nucleus. Orthologous to human BARHL1 (BarH like homeobox 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

bar-class homeodomain protein MBH2; BarH-like 1 (Drosophila); barH-like 1 homeobox protein; BarH-like 2; BarH-like 2 (Drosophila); barH-related homeobox protein 1; Barhl2; Mbh2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BARHL1 (BarH like homeobox 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Barhl1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Barhl1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BARHL1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BARHL1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Barhl1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BARHL1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BARHL1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Barhl1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Barhl1 (BarH like homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	HIGD2A (HIG1 hypoxia inducible domain family member 2A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	BARHL1 (BarH like homeobox 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Barhl1 (BarH like homeobox 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	barhl1b (BarH-like homeobox 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	barhl1b (BarH-like homeobox 1b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	barhl1a (BarH-like homeobox 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	barhl1a (BarH-like homeobox 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	B-H1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	B-H1	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	B-H2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceh-30	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceh-30	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ceh-31	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	barhl1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	barhl1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	32,639,283 - 32,646,605 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	32,638,644 - 32,646,605 (-)	Ensembl				GRCr8
mRatBN7.2	3	12,241,327 - 12,248,649 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	12,241,327 - 12,248,649 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	15,314,424 - 15,321,756 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	23,899,395 - 23,906,727 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	22,153,843 - 22,161,175 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	7,491,234 - 7,498,555 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	7,491,234 - 7,498,555 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	12,841,460 - 12,848,781 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	7,917,842 - 7,925,164 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	7,020,613 - 7,027,935 (-)	NCBI		Celera
RGSC_v3.1	3	7,918,141 - 7,925,464 (-)	NCBI
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Hearing Loss (ISO)

high grade glioma (ISO)

triple-receptor negative breast cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium dichloride (EXP)

clothianidin (ISO)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

decabromodiphenyl ether (ISO)

dorsomorphin (ISO)

folic acid (ISO)

fonofos (ISO)

fulvestrant (ISO)

lead diacetate (ISO)

Monobutylphthalate (EXP)

paracetamol (ISO)

parathion (ISO)

PCB138 (ISO)

SB 431542 (ISO)

terbufos (ISO)

Tetrachlorobisphenol A (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

midbrain development (ISO)

negative regulation of neuron apoptotic process (ISO)

neuron migration (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

sensory perception of sound (ISO)

Cellular Component

nucleus (IBA,IEA,ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

sequence-specific double-stranded DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways.	Barh D, etal., Genes (Basel). 2017 Sep 28;8(10). pii: genes8100245. doi: 10.3390/genes8100245.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene.	Li S, etal., Development. 2002 Jul;129(14):3523-32.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Information Derived from GenBank Report	RGD, Sept. 2003

Additional References at PubMed

PMID:15044550	PMID:16752387	PMID:18212062

Genomics

Comparative Map Data

Barhl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	32,639,283 - 32,646,605 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	32,638,644 - 32,646,605 (-)	Ensembl				GRCr8
mRatBN7.2	3	12,241,327 - 12,248,649 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	12,241,327 - 12,248,649 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	15,314,424 - 15,321,756 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	23,899,395 - 23,906,727 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	22,153,843 - 22,161,175 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	7,491,234 - 7,498,555 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	7,491,234 - 7,498,555 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	12,841,460 - 12,848,781 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	7,917,842 - 7,925,164 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	7,020,613 - 7,027,935 (-)	NCBI		Celera
RGSC_v3.1	3	7,918,141 - 7,925,464 (-)	NCBI
Cytogenetic Map	3	p12	NCBI

BARHL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	132,582,606 - 132,590,252 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	132,582,606 - 132,590,252 (+)	Ensembl			hg38	GRCh38
GRCh37	9	135,457,993 - 135,465,639 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	134,447,814 - 134,455,461 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	132,487,546 - 132,495,194	NCBI
Celera	9	105,999,743 - 106,007,390 (+)	NCBI		Celera
Cytogenetic Map	9	q34.13	NCBI
HuRef	9	104,951,812 - 104,959,454 (+)	NCBI		HuRef
CHM1_1	9	135,608,371 - 135,616,013 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	144,793,810 - 144,801,451 (+)	NCBI		T2T-CHM13v2.0

Barhl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	28,797,692 - 28,807,996 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	28,797,691 - 28,806,680 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	28,907,680 - 28,917,984 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	28,907,679 - 28,916,668 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	28,763,200 - 28,771,960 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	28,729,682 - 28,738,430 (-)	NCBI		MGSCv36	mm8
Celera	2	28,613,544 - 28,622,304 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	19.38	NCBI

Barhl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	1,959,634 - 1,966,247 (+)	Ensembl
ChiLan1.0	NW_004955513	1,955,906 - 1,970,110 (+)	NCBI	ChiLan1.0	ChiLan1.0

BARHL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	6,768,517 - 6,778,456 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	6,770,853 - 6,780,706 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	103,698,024 - 103,709,834 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	132,331,662 - 132,343,116 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	132,331,770 - 132,338,661 (+)	Ensembl			panPan2	panpan1.1

BARHL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	51,704,590 - 51,711,726 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	51,703,936 - 51,712,093 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	50,968,439 - 50,976,455 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	52,596,767 - 52,604,794 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	52,597,590 - 52,604,205 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	51,376,679 - 51,384,690 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	51,701,143 - 51,709,148 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	51,780,866 - 51,788,879 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Barhl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	199,343,376 - 199,351,136 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	19,111,726 - 19,119,677 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	19,112,479 - 19,119,677 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BARHL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	272,373,402 - 272,381,224 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	272,373,125 - 272,380,223 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	306,405,596 - 306,412,475 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BARHL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	5,549,484 - 5,557,348 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	5,549,234 - 5,556,945 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666079	10,081,270 - 10,089,322 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Barhl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	3,765,714 - 3,772,315 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	3,765,938 - 3,772,347 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Barhl1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	7,756,803 - 7,764,300 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Barhl1
75 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	365
Count of miRNA genes:	183
Interacting mature miRNAs:	211
Transcripts:	ENSRNOT00000017725
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29056275	47904329	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10450811	Scl73	Serum cholesterol level QTL 73	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat
10450808	Scl72	Serum cholesterol level QTL 72	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
10450806	Scl71	Serum cholesterol level QTL 71	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	28625339	67641995	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	6125437	51125437	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	30832384	44921701	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	36721849	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	6556347	51556347	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	3e-08	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	15272348	60272348	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	29056275	47904329	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat

Markers in Region

BE120051

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	12,241,351 - 12,241,501 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	7,491,259 - 7,491,408	NCBI	Rnor6.0
Rnor_5.0	3	12,841,485 - 12,841,634	UniSTS	Rnor5.0
RGSC_v3.4	3	7,917,867 - 7,918,016	UniSTS	RGSC3.4
Celera	3	7,020,638 - 7,020,787	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
5	4	15	122	39	40	11	68	11	3	155	101	1	108	36	81	29	6	6

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB043981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017725 ⟹ ENSRNOP00000017725

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	32,638,644 - 32,646,605 (-)	Ensembl
mRatBN7.2 Ensembl	3	12,241,327 - 12,248,649 (-)	Ensembl
Rnor_6.0 Ensembl	3	7,491,234 - 7,498,555 (-)	Ensembl

RefSeq Acc Id:

NM_057109 ⟹ NP_476450

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	32,639,283 - 32,646,605 (-)	NCBI
mRatBN7.2	3	12,241,327 - 12,248,649 (-)	NCBI
Rnor_6.0	3	7,491,234 - 7,498,555 (-)	NCBI
Rnor_5.0	3	12,841,460 - 12,848,781 (-)	NCBI
RGSC_v3.4	3	7,917,842 - 7,925,164 (-)	RGD
Celera	3	7,020,613 - 7,027,935 (-)	RGD

Sequence:

show sequence

GAAACAACAACAAAAAAGCCAGCCCTAAAGTAAAAGTGACACAAGTTCTATTTTTTTTTTTAAA
GGAAGGAGGGGGGTTGGCGGCGAAGGCGCGCGCCGAGGACAGGTGAGAGCTGCAGTGGGAGCGG
CAGGGAGCTGTCCACGGTGCTGACGGGCCCTGGCGGGGCCGAGCGTGCACGCAGGAGCTCTGGG
GCCAGGTGGGGCTGCTTGATCCTGGGGCCGCGGCCGCTGTCCGCGGTGCTGAGACCTCCAGGTG
CGCTCCGTTCTGCCTGCTGGTAACGCGGCCCGGGCCGGCTGCTATCCGCCGTGCTGACCCCTGC
CCTGGGCTACCGTTTGCCTGGAGGAAGCGTGCCGTTTGGATTTTGCTTTTTCAAAAGACGATCT
TTATTCAGATTCCATCAGCCTCGCGTTTCTTCAGTGCCAAAGGGGCCCTCGGGCCGTTCTTCTA
CCCTTTGGCTCTTCCCAACTTGGCGCGCCCTCCTCCCATTCCTCCCTGACACTCCCACCACCAC
CACCCCACCCCCTCGGCTCGGCGGCTCGGCGCGGTGCTGCAGAAGACGCTTTGAGCCCTTTTGG
ATGTGATGCGCAGAGGAGGTTGGCCCAGAGCTCCCAGGCTCCCCCAAGGCTGAACTCCATCCAA
GGTGCCCACAGGCTCCCTGCCCGCCTTCCCCATGCCAGCCCGCAGCTAGGGGCAGGGGCAGCGG
CGGCTGGGGTTGGGGGTGGGTGGGGAGCTTTTGGGGAGGACAGGTCGCAGCTTGGCTATGGAAG
GCTCCAATGGCTTTGGGATTGACTCCATTCTCTCCCACCGAGCGGGCAGCCCCGCCCTTCCCAA
GGGGGACCCCTTGCTTGGGGACTGCCGTTCACCCCTGGAGCTGAGTCCACGCTCAGAGAGCAGC
AGCGACTGCTCTTCACCAGCCTCGCCCGGAAGAGACTGTCTGGAGACCAGTACCTCGCGGCCTG
GTGCAGCATCTGGCCCAGGTTTGGACTCCCACCTGCAGCCGGGGCAGCTTTCAGCCCCAGCCCA
GTCGCGAACTGTCACCTCCTCCTTTCTGATCAGGGACATCCTTGCTGACTGCAAACCTCTGGCG
GCCTGTGCACCCTACTCTAGCAGTGGGCAGCCTGCAGCCCCTGAGCCTGGGGGCCGCCTTGCGG
CCAAGGCCGGGGAGGACTTTCGAGACAAGCTGGACAAAAGTGTCAGCAGCGCTTCATCGGACTC
TGAGTACAAAGTGAAGGAGGAGGGCGACCGCGAAATCTCCAGCTCTCGGGACAGTCCTCCCGTG
CGCCTGAAAAAGCCACGCAAAGCACGCACCGCCTTCACCGACCATCAGCTGGCGCAGCTGGAGC
GTAGCTTCGAGCGGCAGAAATACCTGAGTGTGCAAGACCGCATGGAGCTGGCCGCCTCTCTGAA
CCTCACCGACACGCAGGTCAAGACCTGGTACCAGAACCGCAGGACTAAATGGAAGCGACAGACC
GCTGTGGGGCTGGAGCTGCTAGCGGAGGCAGGCAATTATTCGGCGCTCCAGAGAATGTTCCCGT
CGCCTTATTTCTACCCGCAGAGTCTCGTTTCCAACCTGGACCCCGGCGCCGCACTCTATCTGTA
CCGCGGACCCAGTGCGCCACCACCTGCCCTCCAGAGACCTCTGGTGCCCCGCATCCTCATCCAC
GGACTCCAGGGCGCCAGCGAGCCGCCCCCACCGCTGCCCCCGCTGCCCGGCGTCCTTCCGCGCG
CTGCGCAGCCCCGGTGAAGCGCGCGCTTGCCCCAAGCCATGCTCTGGGACCCACAGCTCAGCCT
GGGCGCGGGTCCCTCCCTTCGTCCCGGGGCAGGGCTGCCCGGCTCCCCGCCGCAGCCCAGTGTC
CCCGTGGGAAAGAAATTCACTGAGGCTACCCCTCCCCTGCGTCCTCTCTTGGCTGCTCCATCCA
GGAACCACTCACACCCGCCGGATGTACATATGCGCCCCTGCCCACCTCTCAGCCACCCCCAGGT
CCCTGCCGGCTTCCCCAGGTGTCCCCTGTCCCCTCAGCAGCAGGTAGGGGACGCCGGTCTCCCA
GACCTGGGCCCACCCTTCTTGCGCCTCTGCGGGACAGGGTGGGAGCGCTGTACGGAGTTTCCCT
CCCATTTCTTTTATTCTCCCTGAGCCCCGGGCTAGCAGCGGAGCTGTACATACAGTGTGCAAAG
TGTATATGAAGTTATTTATTCGTGACCCATGAGCCCGTGACCGTGTCCGTGAATCAGTGAGTCT
GTGGCCTGTGCCCTCCCCATCCCGGGTGGGGCAGGAAGGGGCCGAGAGGGCTTGCCCACGCGTC
CTGGCCCCCAGCCCCGCTCGCTCCACCCAGGTCCCAGGACAGCCAGATCTCTTGGGTTCTCTTT
TTTTAAATGTGGAAATAAACTTCTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_476450	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB18600	(Get FASTA)	NCBI Sequence Viewer
	EDL93393	(Get FASTA)	NCBI Sequence Viewer
	EDL93394	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017725.1
GenBank Protein	P63156	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476450 ⟸ NM_057109

- UniProtKB:

P63156 (UniProtKB/Swiss-Prot), A6JTQ3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGSNGFGIDSILSHRAGSPALPKGDPLLGDCRSPLELSPRSESSSDCSSPASPGRDCLETSTS
RPGAASGPGLDSHLQPGQLSAPAQSRTVTSSFLIRDILADCKPLAACAPYSSSGQPAAPEPGGR
LAAKAGEDFRDKLDKSVSSASSDSEYKVKEEGDREISSSRDSPPVRLKKPRKARTAFTDHQLAQ
LERSFERQKYLSVQDRMELAASLNLTDTQVKTWYQNRRTKWKRQTAVGLELLAEAGNYSALQRM
FPSPYFYPQSLVSNLDPGAALYLYRGPSAPPPALQRPLVPRILIHGLQGASEPPPPLPPLPGVL
PRAAQPR

hide sequence

Ensembl Acc Id:

ENSRNOP00000017725 ⟸ ENSRNOT00000017725

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P63156-F1-model_v2	AlphaFold	P63156	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620648	AgrOrtholog
BioCyc Gene	G2FUF-50266	BioCyc
Ensembl Genes	ENSRNOG00000013209	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000017725.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot
	Homeobox_CS	UniProtKB/Swiss-Prot
	Homeobox_dom	UniProtKB/Swiss-Prot
	Homeobox_metazoa	UniProtKB/Swiss-Prot
	Homeobox_TF	UniProtKB/Swiss-Prot
KEGG Report	rno:117232	UniProtKB/Swiss-Prot
NCBI Gene	117232	ENTREZGENE
PANTHER	HOMEO BOX HB9 LIKE A-RELATED	UniProtKB/Swiss-Prot
	HOMEOBOX DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	Homeodomain	UniProtKB/Swiss-Prot
PhenoGen	Barhl1	PhenoGen
PRINTS	HOMEOBOX	UniProtKB/Swiss-Prot
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot
	HOMEOBOX_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013209	RatGTEx
SMART	HOX	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot
UniProt	A6JTQ3	ENTREZGENE, UniProtKB/TrEMBL
	BARH1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q9JK26	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-25	Barhl1	BarH-like homeobox 1	Barhl1	BarH-like 1 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Barhl1	BarH-like 1 (Drosophila)	Barhl2	BarH-like 2 (Drosophila)	Symbol and Name updated	1299863	APPROVED
2002-08-07	Barhl2				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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