Limk1 (LIM domain kinase 1) - Rat Genome Database

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Gene: Limk1 (LIM domain kinase 1) Rattus norvegicus
Analyze
Symbol: Limk1
Name: LIM domain kinase 1
RGD ID: 62055
Description: Predicted to enable several functions, including heat shock protein binding activity; ubiquitin ligase inhibitor activity; and ubiquitin protein ligase binding activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Located in axonal growth cone and perinuclear region of cytoplasm. Is active in glutamatergic synapse. Orthologous to human LIMK1 (LIM domain kinase 1); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LIM motif-containing protein kinase 1; LIM-domain containing protein kinase; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase 1; LIMK-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,663,177 - 27,697,085 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,663,018 - 27,697,209 (+)EnsemblGRCr8
mRatBN7.21222,026,697 - 22,060,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,026,672 - 22,060,606 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,167,689 - 23,203,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,780,037 - 23,814,843 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,847,911 - 22,881,485 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,036,630 - 25,070,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,036,605 - 25,070,539 (+)Ensemblrn6Rnor6.0
Rnor_5.01227,037,250 - 27,070,939 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,091,809 - 23,125,717 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,790,979 - 23,824,570 (+)NCBICelera
RGSC_v3.11222,951,901 - 22,985,835 (+)NCBI
Cytogenetic Map12q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
Azoxymethane  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
dicrotophos  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
excitatory amino acid agonist  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury(1+)  (ISO)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
ouabain  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (ISO)
resveratrol  (ISO)
rhosin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Sanggenon C  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axonal growth cone  (IDA)
cell junction  (IEA)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
focal adhesion  (IEA,ISO)
glutamatergic synapse  (IDA,IEA,IMP,ISO)
lamellipodium  (IEA,ISO,ISS)
membrane  (IEA,ISO)
neuron projection  (IBA,IEA,ISO,ISS)
nuclear speck  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (IDA)
postsynapse  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells. Chiu TT, etal., Mol Biol Cell. 2010 Oct 15;21(20):3529-39. doi: 10.1091/mbc.E10-04-0316. Epub 2010 Aug 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. Geneste O, etal., J Cell Biol 2002 May 27;157(5):831-8.
4. Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity. George J, etal., Elife. 2015 Apr 17;4:e06327. doi: 10.7554/eLife.06327.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase family. Nunoue K, etal., Oncogene 1995 Aug 17;11(4):701-10.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons. Rosso S, etal., Mol Biol Cell. 2004 Jul;15(7):3433-49. Epub 2004 Apr 16.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8889548   PMID:15023529   PMID:15176434   PMID:15199148   PMID:16204183   PMID:16399995   PMID:16651380   PMID:16963613   PMID:17512523   PMID:18171679   PMID:20696146   PMID:22328514  
PMID:23086941   PMID:23600483   PMID:23633677   PMID:24792215   PMID:24962708   PMID:25107909   PMID:27973945   PMID:28116173   PMID:32697981   PMID:33559936  


Genomics

Comparative Map Data
Limk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81227,663,177 - 27,697,085 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1227,663,018 - 27,697,209 (+)EnsemblGRCr8
mRatBN7.21222,026,697 - 22,060,605 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,026,672 - 22,060,606 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1223,167,689 - 23,203,752 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,780,037 - 23,814,843 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01222,847,911 - 22,881,485 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,036,630 - 25,070,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,036,605 - 25,070,539 (+)Ensemblrn6Rnor6.0
Rnor_5.01227,037,250 - 27,070,939 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41223,091,809 - 23,125,717 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,790,979 - 23,824,570 (+)NCBICelera
RGSC_v3.11222,951,901 - 22,985,835 (+)NCBI
Cytogenetic Map12q12NCBI
LIMK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,083,804 - 74,122,525 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl774,082,933 - 74,122,527 (+)Ensemblhg38GRCh38
GRCh37773,498,134 - 73,536,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,136,092 - 73,174,790 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34772,942,806 - 72,981,505NCBI
Celera768,977,591 - 69,016,280 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef769,382,814 - 69,418,976 (+)NCBIHuRef
CHM1_1773,643,562 - 73,682,183 (+)NCBICHM1_1
T2T-CHM13v2.0775,286,937 - 75,325,667 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2772,831,179 - 72,869,927 (+)NCBI
Limk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395134,684,893 - 134,718,713 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5134,684,893 - 134,717,452 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385134,656,039 - 134,689,859 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5134,656,039 - 134,688,598 (-)Ensemblmm10GRCm38
MGSCv375135,131,909 - 135,164,460 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365134,940,679 - 134,991,269 (-)NCBIMGSCv36mm8
Celera5131,664,058 - 131,696,609 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map574.73NCBI
Limk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545613,750,889 - 13,774,021 (-)Ensembl
ChiLan1.0NW_00495545613,751,135 - 13,773,722 (-)NCBIChiLan1.0ChiLan1.0
LIMK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2690,777,071 - 90,815,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17139,041,703 - 139,080,418 (-)NCBINHGRI_mPanPan1
PanPan1.1781,233,453 - 81,271,282 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl781,231,876 - 81,271,282 (+)EnsemblpanPan2panpan1.1
LIMK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.166,263,374 - 6,285,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl66,264,548 - 6,286,026 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha67,959,877 - 7,983,548 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.066,076,858 - 6,100,527 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,078,155 - 6,100,709 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,067,274 - 6,090,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,015,097 - 6,038,762 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.066,178,780 - 6,202,457 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101971716
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344130,788,070 - 130,851,137 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365433,224,392 - 3,248,526 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049365433,185,201 - 3,208,388 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365433,190,741 - 3,208,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl311,252,648 - 11,279,284 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1311,252,820 - 11,279,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2310,936,786 - 10,961,582 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LIMK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1288,953,095 - 8,988,848 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl288,952,957 - 8,988,672 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660707,555,472 - 7,591,095 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Limk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474013,823,437 - 13,847,808 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474013,824,930 - 13,847,605 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Limk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11619,369,419 - 19,403,164 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Limk1
236 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir134rno-miR-134-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCRFunctional MTI16421561

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:113
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000001996
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)121223300030490641Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121874946936488809Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121874946934312613Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12790162533938215Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743833700556Rat

Markers in Region
RH142289  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,060,422 - 22,060,573 (+)MAPPERmRatBN7.2
Rnor_6.01225,070,356 - 25,070,506NCBIRnor6.0
Rnor_5.01227,070,757 - 27,070,907UniSTSRnor5.0
RGSC_v3.41223,125,535 - 23,125,685UniSTSRGSC3.4
Celera1223,824,388 - 23,824,538UniSTS
Cytogenetic Map12q12UniSTS
UniSTS:230793  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,059,048 - 22,059,399 (+)MAPPERmRatBN7.2
Rnor_6.01225,068,982 - 25,069,332NCBIRnor6.0
Rnor_5.01227,069,383 - 27,069,733UniSTSRnor5.0
RGSC_v3.41223,124,161 - 23,124,511UniSTSRGSC3.4
Celera1223,823,014 - 23,823,364UniSTS
Cytogenetic Map12q12UniSTS
G48114  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,060,379 - 22,060,533 (+)MAPPERmRatBN7.2
Rnor_6.01225,070,313 - 25,070,466NCBIRnor6.0
Rnor_5.01227,070,714 - 27,070,867UniSTSRnor5.0
RGSC_v3.41223,125,492 - 23,125,645UniSTSRGSC3.4
Celera1223,824,345 - 23,824,498UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001996   ⟹   ENSRNOP00000001996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,663,152 - 27,697,086 (+)Ensembl
mRatBN7.2 Ensembl1222,026,672 - 22,060,606 (+)Ensembl
Rnor_6.0 Ensembl1225,036,605 - 25,070,539 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084427   ⟹   ENSRNOP00000073078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,663,018 - 27,697,209 (+)Ensembl
mRatBN7.2 Ensembl1222,037,044 - 22,060,606 (+)Ensembl
Rnor_6.0 Ensembl1225,036,630 - 25,070,538 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118532   ⟹   ENSRNOP00000094337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1227,673,414 - 27,697,084 (+)Ensembl
mRatBN7.2 Ensembl1222,036,075 - 22,060,606 (+)Ensembl
RefSeq Acc Id: NM_031727   ⟹   NP_113915
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,663,177 - 27,697,085 (+)NCBI
mRatBN7.21222,026,697 - 22,060,605 (+)NCBI
Rnor_6.01225,036,630 - 25,070,538 (+)NCBI
Rnor_5.01227,037,250 - 27,070,939 (+)NCBI
RGSC_v3.41223,091,809 - 23,125,717 (+)RGD
Celera1223,790,979 - 23,824,570 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249185   ⟹   XP_006249247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81227,665,767 - 27,697,085 (+)NCBI
mRatBN7.21222,036,310 - 22,060,605 (+)NCBI
Rnor_6.01225,046,859 - 25,070,538 (+)NCBI
Rnor_5.01227,037,250 - 27,070,939 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_113915 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249247 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA06672 (Get FASTA)   NCBI Sequence Viewer  
  EDM13416 (Get FASTA)   NCBI Sequence Viewer  
  EDM13417 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001996
  ENSRNOP00000094337
GenBank Protein P53669 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_113915   ⟸   NM_031727
- UniProtKB: P53669 (UniProtKB/Swiss-Prot),   G3V663 (UniProtKB/TrEMBL),   A6J0H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249247   ⟸   XM_006249185
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GL45 (UniProtKB/TrEMBL),   A0A0G2K4K5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073078   ⟸   ENSRNOT00000084427
Ensembl Acc Id: ENSRNOP00000001996   ⟸   ENSRNOT00000001996
Ensembl Acc Id: ENSRNOP00000094337   ⟸   ENSRNOT00000118532
Protein Domains
LIM zinc-binding   PDZ   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53669-F1-model_v2 AlphaFold P53669 1-647 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698574
Promoter ID:EPDNEW_R9092
Type:multiple initiation site
Name:Limk1_1
Description:LIM domain kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01225,036,596 - 25,036,656EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62055 AgrOrtholog
BioCyc Gene G2FUF-19583 BioCyc
Ensembl Genes ENSRNOG00000001470 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001996 ENTREZGENE
  ENSRNOT00000118532 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  Cysteine Rich Protein UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Actin_reg-Ser/Thr_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
NCBI Gene 65172 ENTREZGENE
PANTHER LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
  LIM DOMAIN KINASE 1 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Limk1 PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001470 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF50156 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC222352
UniProt A0A0G2K4K5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL45 ENTREZGENE, UniProtKB/TrEMBL
  A6J0H7 ENTREZGENE, UniProtKB/TrEMBL
  G3V663 ENTREZGENE, UniProtKB/TrEMBL
  LIMK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-12 Limk1  LIM domain kinase 1  Limk1  LIM motif-containing protein kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Limk1  LIM motif-containing protein kinase 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed predominantly in the brain 61653
gene_process activates serum response factor (SRF) 729105