Cetn1 (centrin 1) - Rat Genome Database

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Gene: Cetn1 (centrin 1) Rattus norvegicus
Analyze
Symbol: Cetn1
Name: centrin 1
RGD ID: 620246
Description: Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; calcium ion binding activity; and heterotrimeric G-protein binding activity. Predicted to be involved in centriole replication. Predicted to act upstream of or within cellular response to heat. Predicted to be located in microtubule organizing center; photoreceptor connecting cilium; and spindle pole. Predicted to be active in centriole; centrosome; and nucleus. Orthologous to human CETN1 (centrin 1); INTERACTS WITH acrylamide; bisphenol A; atrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: centrin, EF-hand protein, 1; centrin-1; EF-hand protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818924,428 - 925,130 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl18922,112 - 925,332 (-)EnsemblGRCr8
mRatBN7.218651,591 - 652,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18651,591 - 652,293 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx18871,206 - 871,908 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0181,659,031 - 1,659,733 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018873,114 - 873,816 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.018785,972 - 786,674 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18785,972 - 786,674 (-)Ensemblrn6Rnor6.0
Rnor_5.018829,964 - 830,666 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.418913,895 - 914,597 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera18548,510 - 549,212 (-)NCBICelera
RGSC_v3.118914,058 - 914,424 (-)NCBI
Cytogenetic Map18p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein. Hart PE, etal., Genomics 1999 Sep 1;60(2):111-20.
4. The mammalian interphase centrosome: two independent units maintained together by the dynamics of the microtubule cytoskeleton. Jean C, etal., Eur J Cell Biol 1999 Aug;78(8):549-60.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8175926   PMID:12840069   PMID:15347651   PMID:18269917   PMID:18331714   PMID:18755693   PMID:18762898   PMID:22851319   PMID:24421332   PMID:30120214  


Genomics

Comparative Map Data
Cetn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818924,428 - 925,130 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl18922,112 - 925,332 (-)EnsemblGRCr8
mRatBN7.218651,591 - 652,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18651,591 - 652,293 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx18871,206 - 871,908 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0181,659,031 - 1,659,733 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018873,114 - 873,816 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.018785,972 - 786,674 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18785,972 - 786,674 (-)Ensemblrn6Rnor6.0
Rnor_5.018829,964 - 830,666 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.418913,895 - 914,597 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera18548,510 - 549,212 (-)NCBICelera
RGSC_v3.118914,058 - 914,424 (-)NCBI
Cytogenetic Map18p13NCBI
CETN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818580,380 - 582,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18580,380 - 582,114 (+)Ensemblhg38GRCh38
GRCh3718580,380 - 582,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618570,367 - 571,524 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3418570,368 - 571,524NCBI
Celera18455,077 - 456,233 (+)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef18540,396 - 541,552 (+)NCBIHuRef
CHM1_118579,798 - 580,953 (+)NCBICHM1_1
T2T-CHM13v2.018734,775 - 736,509 (+)NCBIT2T-CHM13v2.0
Cetn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39189,618,419 - 9,619,469 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl189,615,524 - 9,619,478 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38189,618,419 - 9,619,469 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl189,615,524 - 9,619,478 (-)Ensemblmm10GRCm38
MGSCv37189,618,417 - 9,619,467 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36189,615,522 - 9,619,493 (-)NCBIMGSCv36mm8
Celera189,647,953 - 9,649,003 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.91NCBI
Cetn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554029,381,570 - 9,382,088 (-)Ensembl
ChiLan1.0NW_0049554029,381,400 - 9,382,158 (-)NCBIChiLan1.0ChiLan1.0
CETN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21737,918,069 - 37,922,823 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11823,610,661 - 23,615,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01813,743,197 - 13,744,490 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11817,385,106 - 17,386,772 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1817,386,201 - 17,386,719 (-)EnsemblpanPan2panpan1.1
CETN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1767,431,020 - 67,431,774 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl767,431,081 - 67,431,599 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha766,884,510 - 66,885,259 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0767,497,055 - 67,497,804 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl767,497,111 - 67,497,629 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1767,173,664 - 67,174,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0767,185,219 - 67,185,968 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0767,487,155 - 67,487,904 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cetn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494463,713,028 - 63,713,902 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936550102,360 - 103,032 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CETN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6105,740,550 - 105,741,465 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16105,740,188 - 105,742,226 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CETN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11859,952,305 - 59,954,453 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1859,952,717 - 59,953,235 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605034,743,456 - 34,744,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cetn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477011,073,242 - 11,073,757 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477011,072,793 - 11,074,972 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cetn1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11534,459,008 - 34,459,698 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cetn1
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:44
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000021955
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat

Markers in Region
BE103209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218651,629 - 651,820 (+)MAPPERmRatBN7.2
Rnor_6.018786,011 - 786,201NCBIRnor6.0
Rnor_5.018830,003 - 830,193UniSTSRnor5.0
RGSC_v3.418913,934 - 914,124UniSTSRGSC3.4
Celera18548,549 - 548,739UniSTS
RH 3.4 Map1832.1UniSTS
Cytogenetic Map18p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 8 10 50 38 38 11 21 11 5 85 49 35 12 52 27 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000021955   ⟹   ENSRNOP00000021955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18651,591 - 652,293 (-)Ensembl
Rnor_6.0 Ensembl18785,972 - 786,674 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164206   ⟹   ENSRNOP00000108891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl18922,112 - 925,332 (-)Ensembl
RefSeq Acc Id: NM_053461   ⟹   NP_445913
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818924,428 - 925,130 (-)NCBI
mRatBN7.218651,591 - 652,293 (-)NCBI
Rnor_6.018785,972 - 786,674 (-)NCBI
Rnor_5.018829,964 - 830,666 (-)NCBI
RGSC_v3.418913,895 - 914,597 (-)RGD
Celera18548,510 - 549,212 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445913 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK20385 (Get FASTA)   NCBI Sequence Viewer  
  EDL86659 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000108891
  ENSRNOP00000108891.1
RefSeq Acc Id: NP_445913   ⟸   NM_053461
- UniProtKB: G3V832 (UniProtKB/TrEMBL),   A6KND4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021955   ⟸   ENSRNOT00000021955
Ensembl Acc Id: ENSRNOP00000108891   ⟸   ENSRNOT00000164206
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V832-F1-model_v2 AlphaFold G3V832 1-172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700625
Promoter ID:EPDNEW_R11149
Type:initiation region
Name:Cetn1_1
Description:centrin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.018786,673 - 786,733EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620246 AgrOrtholog
BioCyc Gene G2FUF-8430 BioCyc
Ensembl Genes ENSRNOG00000016409 Ensembl
  ENSRNOG00000084288 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000164206 ENTREZGENE
  ENSRNOT00000164206.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro CALM/Myosin/TropC-like UniProtKB/TrEMBL
  EF-hand-like_dom UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
  RNA-helicase_DEAD-box_CS UniProtKB/TrEMBL
KEGG Report rno:84592 UniProtKB/TrEMBL
NCBI Gene 84592 ENTREZGENE
PANTHER EF-HAND SUPERFAMILY PROTEIN UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN 1, 3 UniProtKB/TrEMBL
Pfam EF_hand_5 UniProtKB/TrEMBL
PhenoGen Cetn1 PhenoGen
PROSITE DEAD_ATP_HELICASE UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016409 RatGTEx
  ENSRNOG00000084288 RatGTEx
SMART EFh UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0ABK0LU82_RAT UniProtKB/TrEMBL
  A6KND4 ENTREZGENE, UniProtKB/TrEMBL
  G3V832 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Cetn1  centrin 1  Cetn1  centrin, EF-hand protein, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cetn1  centrin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Cetn1  centrin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript mouse homolog has a coding region flanked by direct repeats and has no introns, characteristics of expressed retrotransposons 635265