Frmd4b (FERM domain containing 4B) - Rat Genome Database

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Gene: Frmd4b (FERM domain containing 4B) Rattus norvegicus
Analyze
Symbol: Frmd4b
Name: FERM domain containing 4B
RGD ID: 620172
Description: Predicted to act upstream of or within establishment of epithelial cell polarity. Predicted to be located in cytoplasm and ruffle. Predicted to be active in adherens junction and bicellular tight junction. Orthologous to human FRMD4B (FERM domain containing 4B); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FERM domain-containing protein 4B; GRP1 binding protein GRSP1; Grsp1; Nitzin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,452,361 - 131,778,734 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4131,452,365 - 131,640,287 (-)EnsemblGRCr8
mRatBN7.24129,895,401 - 130,222,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)EnsemblmRatBN7.2
Rnor_6.04129,658,137 - 129,984,735 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,658,840 - 129,846,642 (-)Ensemblrn6Rnor6.0
Rnor_5.04194,157,499 - 194,480,974 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44132,012,943 - 132,207,644 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4118,771,260 - 119,095,704 (-)NCBICelera
RGSC_v3.14132,278,240 - 132,323,694 (-)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
FR900359  (ISO)
glyphosate  (EXP)
imidacloprid  (EXP)
inulin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
melphalan  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
quercetin  (ISO)
rimonabant  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
Tesaglitazar  (EXP)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
adherens junction  (IBA,IEA,ISO)
bicellular tight junction  (IBA,IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
ruffle  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis. Grifman M, etal., Proc Natl Acad Sci U S A 1998 Nov 10;95(23):13935-40.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11445584   PMID:20080746   PMID:23580065  


Genomics

Comparative Map Data
Frmd4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,452,361 - 131,778,734 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4131,452,365 - 131,640,287 (-)EnsemblGRCr8
mRatBN7.24129,895,401 - 130,222,070 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)EnsemblmRatBN7.2
Rnor_6.04129,658,137 - 129,984,735 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4129,658,840 - 129,846,642 (-)Ensemblrn6Rnor6.0
Rnor_5.04194,157,499 - 194,480,974 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44132,012,943 - 132,207,644 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4118,771,260 - 119,095,704 (-)NCBICelera
RGSC_v3.14132,278,240 - 132,323,694 (-)NCBI
Cytogenetic Map4q34NCBI
FRMD4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,168,782 - 69,542,586 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,168,782 - 69,542,583 (-)Ensemblhg38GRCh38
GRCh37369,217,933 - 69,435,239 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,301,836 - 69,518,120 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34369,302,666 - 69,332,399NCBI
Celera369,147,274 - 69,362,951 (-)NCBICelera
Cytogenetic Map3p14.1NCBI
HuRef369,220,047 - 69,435,240 (-)NCBIHuRef
CHM1_1369,170,368 - 69,386,663 (-)NCBICHM1_1
T2T-CHM13v2.0369,205,753 - 69,579,785 (-)NCBIT2T-CHM13v2.0
Frmd4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,263,828 - 97,594,618 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,263,828 - 97,594,502 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38697,286,867 - 97,617,657 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,286,867 - 97,617,541 (-)Ensemblmm10GRCm38
MGSCv37697,236,861 - 97,567,651 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36697,252,330 - 97,583,044 (-)NCBIMGSCv36mm8
Celera699,148,219 - 99,479,337 (-)NCBICelera
Cytogenetic Map6D3NCBI
cM Map644.93NCBI
Frmd4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542118,483,857 - 18,673,519 (+)Ensembl
ChiLan1.0NW_00495542118,423,238 - 18,669,514 (+)NCBIChiLan1.0ChiLan1.0
FRMD4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2269,124,610 - 69,497,596 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1369,130,439 - 69,502,383 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0369,105,231 - 69,478,192 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1370,471,897 - 70,842,474 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl370,471,897 - 70,686,895 (-)EnsemblpanPan2panpan1.1
FRMD4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12022,253,619 - 22,574,917 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2022,402,128 - 22,598,594 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2022,222,606 - 22,544,043 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02022,282,339 - 22,600,372 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2022,430,099 - 22,600,861 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12021,968,263 - 22,290,330 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02022,317,068 - 22,639,260 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02022,387,643 - 22,710,010 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Frmd4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,349,427 - 1,485,645 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,369,851 - 1,485,661 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,369,943 - 1,485,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FRMD4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1350,597,414 - 50,980,016 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11350,602,910 - 50,980,236 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21355,735,642 - 56,114,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FRMD4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,196,103 - 30,554,140 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,195,908 - 30,452,885 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041136,232,993 - 136,595,817 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Frmd4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247733,763,222 - 3,961,536 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247733,763,706 - 3,961,465 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Frmd4b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1649,564,057 - 49,747,967 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Frmd4b
1710 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000010717
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
D4Rat80  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84131,698,712 - 131,698,847 (+)Marker Load Pipeline
mRatBN7.24130,142,051 - 130,142,186 (+)MAPPERmRatBN7.2
Rnor_6.04129,904,890 - 129,905,024NCBIRnor6.0
Rnor_5.04194,401,210 - 194,401,344UniSTSRnor5.0
RGSC_v3.44132,262,558 - 132,262,922RGDRGSC3.4
RGSC_v3.44132,262,560 - 132,262,694UniSTSRGSC3.4
Celera4119,016,792 - 119,016,926UniSTS
RGSC_v3.14132,507,401 - 132,507,535RGD
RH 3.4 Map4795.7UniSTS
RH 3.4 Map4795.7RGD
RH 2.0 Map4873.5RGD
SHRSP x BN Map456.66RGD
FHH x ACI Map478.46RGD
Cytogenetic Map4q34UniSTS
D4Rat88  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,018,906 - 130,019,145 (+)MAPPERmRatBN7.2
Rnor_6.04129,783,241 - 129,783,479NCBIRnor6.0
Rnor_5.04194,279,802 - 194,280,040UniSTSRnor5.0
RGSC_v3.44132,142,791 - 132,143,030RGDRGSC3.4
RGSC_v3.44132,142,792 - 132,143,030UniSTSRGSC3.4
Celera4118,893,705 - 118,893,943UniSTS
RGSC_v3.14132,387,617 - 132,387,963RGD
SHRSP x BN Map456.66UniSTS
SHRSP x BN Map456.66RGD
FHH x ACI Map477.9799RGD
Cytogenetic Map4q34UniSTS
D4Rat92  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,998,172 - 129,998,394 (+)MAPPERmRatBN7.2
Rnor_6.04129,762,437 - 129,762,658NCBIRnor6.0
Rnor_5.04194,258,998 - 194,259,219UniSTSRnor5.0
RGSC_v3.44132,121,127 - 132,121,349RGDRGSC3.4
RGSC_v3.44132,121,128 - 132,121,349UniSTSRGSC3.4
Celera4118,873,054 - 118,873,275UniSTS
RGSC_v3.14132,365,968 - 132,366,190RGD
FHH x ACI Map477.9799RGD
FHH x ACI Map477.9799UniSTS
Cytogenetic Map4q34UniSTS
D4Got96  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,960,443 - 129,960,637 (+)MAPPERmRatBN7.2
Rnor_6.04129,723,226 - 129,723,419NCBIRnor6.0
Rnor_5.04194,222,303 - 194,222,496UniSTSRnor5.0
RGSC_v3.44132,076,920 - 132,077,114RGDRGSC3.4
RGSC_v3.44132,076,921 - 132,077,114UniSTSRGSC3.4
Celera4118,835,840 - 118,836,033UniSTS
RGSC_v3.14132,321,762 - 132,321,955RGD
RH 3.4 Map4794.91RGD
RH 3.4 Map4794.91UniSTS
Cytogenetic Map4q34UniSTS
RH142646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,911,850 - 129,912,008 (+)MAPPERmRatBN7.2
Rnor_6.04129,674,642 - 129,674,799NCBIRnor6.0
Rnor_5.04194,174,004 - 194,174,161UniSTSRnor5.0
RGSC_v3.44132,027,842 - 132,027,999UniSTSRGSC3.4
Celera4118,787,691 - 118,787,848UniSTS
RH 3.4 Map4807.91UniSTS
Cytogenetic Map4q34UniSTS
RH143872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,896,509 - 129,896,750 (+)MAPPERmRatBN7.2
Rnor_6.04129,659,248 - 129,659,488NCBIRnor6.0
Rnor_5.04194,158,610 - 194,158,850UniSTSRnor5.0
RGSC_v3.44132,012,236 - 132,012,476UniSTSRGSC3.4
Celera4118,772,368 - 118,772,608UniSTS
RH 3.4 Map4794.9UniSTS
Cytogenetic Map4q34UniSTS
BF399462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,113,532 - 130,113,693 (+)MAPPERmRatBN7.2
Rnor_6.04129,876,550 - 129,876,710NCBIRnor6.0
Rnor_5.04194,372,980 - 194,373,140UniSTSRnor5.0
RGSC_v3.44132,234,513 - 132,234,673UniSTSRGSC3.4
Celera4118,987,961 - 118,988,121UniSTS
RH 3.4 Map4794.3UniSTS
Cytogenetic Map4q34UniSTS
RH138356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24129,985,162 - 129,985,383 (+)MAPPERmRatBN7.2
Rnor_6.04129,748,713 - 129,748,933NCBIRnor6.0
Rnor_5.04194,246,070 - 194,246,290UniSTSRnor5.0
RGSC_v3.44132,106,180 - 132,106,400UniSTSRGSC3.4
Celera4118,860,054 - 118,860,274UniSTS
RH 3.4 Map4794.0UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001077268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003749805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF087945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010717   ⟹   ENSRNOP00000010717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,452,365 - 131,588,139 (-)Ensembl
mRatBN7.2 Ensembl4129,895,708 - 130,031,669 (-)Ensembl
Rnor_6.0 Ensembl4129,658,840 - 129,846,642 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103395   ⟹   ENSRNOP00000091085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110229   ⟹   ENSRNOP00000079661
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,452,894 - 131,611,599 (-)Ensembl
mRatBN7.2 Ensembl4129,895,708 - 130,084,197 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115420   ⟹   ENSRNOP00000082847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,452,365 - 131,640,287 (-)Ensembl
mRatBN7.2 Ensembl4129,895,708 - 130,056,033 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120645   ⟹   ENSRNOP00000098279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,452,365 - 131,611,599 (-)Ensembl
RefSeq Acc Id: NM_001427301   ⟹   NP_001414230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,365 - 131,640,181 (-)NCBI
RefSeq Acc Id: XM_063285579   ⟹   XP_063141649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,640,612 (-)NCBI
RefSeq Acc Id: XM_063285580   ⟹   XP_063141650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,589,957 (-)NCBI
RefSeq Acc Id: XM_063285582   ⟹   XP_063141652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,620,171 (-)NCBI
RefSeq Acc Id: XM_063285583   ⟹   XP_063141653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,778,734 (-)NCBI
RefSeq Acc Id: XM_063285584   ⟹   XP_063141654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,482,190 (-)NCBI
RefSeq Acc Id: XM_063285585   ⟹   XP_063141655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,452,361 - 131,477,921 (-)NCBI
Ensembl Acc Id: ENSRNOP00000010717   ⟸   ENSRNOT00000010717
Ensembl Acc Id: ENSRNOP00000091085   ⟸   ENSRNOT00000103395
Ensembl Acc Id: ENSRNOP00000079661   ⟸   ENSRNOT00000110229
Ensembl Acc Id: ENSRNOP00000082847   ⟸   ENSRNOT00000115420
RefSeq Acc Id: XP_063141653   ⟸   XM_063285583
- Peptide Label: isoform X4
- UniProtKB: A6IBG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141649   ⟸   XM_063285579
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141652   ⟸   XM_063285582
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZUV5 (UniProtKB/TrEMBL),   A6IBG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141650   ⟸   XM_063285580
- Peptide Label: isoform X2
- UniProtKB: F1LZB7 (UniProtKB/TrEMBL),   A6IBG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141654   ⟸   XM_063285584
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063141655   ⟸   XM_063285585
- Peptide Label: isoform X5
RefSeq Acc Id: NP_001414230   ⟸   NM_001427301
- UniProtKB: A0A8I5ZRG3 (UniProtKB/TrEMBL),   A0A8I6AFH5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098279   ⟸   ENSRNOT00000120645
Protein Domains
FERM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZB7-F1-model_v2 AlphaFold F1LZB7 1-1035 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693281
Promoter ID:EPDNEW_R3795
Type:single initiation site
Name:Frmd4b_1
Description:FERM domain containing 4B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04129,846,724 - 129,846,784EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620172 AgrOrtholog
BioCyc Gene G2FUF-43599 BioCyc
Ensembl Genes ENSRNOG00000007764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010717 ENTREZGENE
  ENSRNOT00000010717.8 UniProtKB/TrEMBL
  ENSRNOT00000110229 ENTREZGENE
  ENSRNOT00000110229.2 UniProtKB/TrEMBL
  ENSRNOT00000115420 ENTREZGENE
  ENSRNOT00000115420.2 UniProtKB/TrEMBL
  ENSRNOT00000120645 ENTREZGENE
  ENSRNOT00000120645.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.80.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  DUF3338 UniProtKB/TrEMBL
  FERM/acyl-CoA-bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_CS UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
  FERM_PH-like_C UniProtKB/TrEMBL
  FRMD4A/B UniProtKB/TrEMBL
  FRMD4A/B_FERM_C UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
NCBI Gene 252858 ENTREZGENE
PANTHER FERM DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  FERM DOMAIN-CONTAINING PROTEIN 4B UniProtKB/TrEMBL
Pfam DUF3338 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
  FERM_M UniProtKB/TrEMBL
  FERM_N UniProtKB/TrEMBL
PhenoGen Frmd4b PhenoGen
PRINTS BAND41 UniProtKB/TrEMBL
PROSITE FERM_2 UniProtKB/TrEMBL
  FERM_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007764 RatGTEx
SMART B41 UniProtKB/TrEMBL
  FERM_C UniProtKB/TrEMBL
Superfamily-SCOP FERM_3-hlx UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I5ZRG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFH5 ENTREZGENE
  A0ABK0L3U2_RAT UniProtKB/TrEMBL
  A6IBG0_RAT UniProtKB/TrEMBL
  A6IBG1 ENTREZGENE, UniProtKB/TrEMBL
  F1LZB7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Frmd4b  FERM domain containing 4B  Grsp1  GRP1 binding protein GRSP1  Symbol and Name updated 1299863 APPROVED
2002-08-07 Grsp1  GRP1 binding protein GRSP1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression high mRNA expression is observed in the developing nervous system 632835
gene_homology 42% homology to the band 4.1 protein superfamily 632835