Afap1 (actin filament associated protein 1) - Rat Genome Database

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Gene: Afap1 (actin filament associated protein 1) Rattus norvegicus
Analyze
Symbol: Afap1
Name: actin filament associated protein 1
RGD ID: 619959
Description: Enables SH2 domain binding activity and SH3 domain binding activity. Involved in cellular response to mechanical stimulus and regulation of signal transduction. Located in actin filament. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human AFAP1 (actin filament associated protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 110 kDa actin filament-associated protein; actin filament associated protein; actin filament-associated protein 1; Afap; AFAP-110
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,967,961 - 79,081,032 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,967,961 - 79,080,939 (-)EnsemblGRCr8
mRatBN7.21474,743,322 - 74,856,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,743,320 - 74,856,263 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,184,574 - 79,297,848 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,425,450 - 80,538,722 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,870,445 - 76,983,714 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1479,487,359 - 79,600,315 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1478,116,025 - 78,228,978 (-)NCBILyon_Normotensive
Lyon_Hypertensive1479,634,904 - 79,747,847 (-)NCBILyon_Hypertensive
F344_StmMcwi1478,561,442 - 78,674,419 (-)NCBIF344_StmMcwi
Rnor_6.01479,923,132 - 80,035,096 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,919,717 - 79,988,110 (-)Ensemblrn6Rnor6.0
Rnor_5.01479,558,456 - 79,622,351 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,355,358 - 80,448,224 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,679,280 - 73,741,995 (-)NCBICelera
RGSC_v3.11480,357,748 - 80,450,615 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
okadaic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
phenol red  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
thapsigargin  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO)
actin filament  (IBA,IDA)
cytosol  (IBA)
plasma membrane  (IEA,ISO)
stress fiber  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma. Gharahkhani P, etal., Nat Genet. 2014 Oct;46(10):1120-1125. doi: 10.1038/ng.3079. Epub 2014 Aug 31.
3. Molecular cloning of actin filament-associated protein: a putative adaptor in stretch-induced Src activation. Lodyga M, etal., Am J Physiol Lung Cell Mol Physiol 2002 Aug;283(2):L265-74.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18577577   PMID:19540230   PMID:21423176   PMID:26340021  


Genomics

Comparative Map Data
Afap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,967,961 - 79,081,032 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,967,961 - 79,080,939 (-)EnsemblGRCr8
mRatBN7.21474,743,322 - 74,856,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,743,320 - 74,856,263 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1479,184,574 - 79,297,848 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,425,450 - 80,538,722 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,870,445 - 76,983,714 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1479,487,359 - 79,600,315 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1478,116,025 - 78,228,978 (-)NCBILyon_Normotensive
Lyon_Hypertensive1479,634,904 - 79,747,847 (-)NCBILyon_Hypertensive
F344_StmMcwi1478,561,442 - 78,674,419 (-)NCBIF344_StmMcwi
Rnor_6.01479,923,132 - 80,035,096 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,919,717 - 79,988,110 (-)Ensemblrn6Rnor6.0
Rnor_5.01479,558,456 - 79,622,351 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41480,355,358 - 80,448,224 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,679,280 - 73,741,995 (-)NCBICelera
RGSC_v3.11480,357,748 - 80,450,615 (-)NCBI
Cytogenetic Map14q21NCBI
AFAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3847,758,713 - 7,939,861 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl47,758,713 - 7,939,926 (-)Ensemblhg38GRCh38
GRCh3747,760,440 - 7,941,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3647,811,340 - 7,992,553 (-)NCBIBuild 36Build 36hg18NCBI36
Celera47,662,306 - 7,842,025 (-)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef47,682,587 - 7,779,433 (-)NCBIHuRef
HuRef47,791,849 - 7,862,997 (-)NCBIHuRef
CHM1_147,758,814 - 7,939,654 (-)NCBICHM1_1
T2T-CHM13v2.047,730,695 - 7,918,406 (-)NCBIT2T-CHM13v2.0
Afap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39536,050,713 - 36,161,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl536,050,663 - 36,161,267 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38535,893,319 - 36,003,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,893,319 - 36,003,923 (+)Ensemblmm10GRCm38
MGSCv37536,235,968 - 36,346,571 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36536,210,180 - 36,320,783 (+)NCBIMGSCv36mm8
Celera533,366,584 - 33,481,553 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.02NCBI
Afap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,987,408 - 3,050,558 (+)Ensembl
ChiLan1.0NW_0049555142,934,115 - 3,050,347 (+)NCBIChiLan1.0ChiLan1.0
AFAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v238,035,095 - 8,218,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan147,965,803 - 8,146,437 (-)NCBINHGRI_mPanPan1
PanPan1.147,821,426 - 7,933,202 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl47,826,585 - 7,939,478 (-)EnsemblpanPan2panpan1.1
AFAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1359,686,887 - 59,828,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl359,689,014 - 59,829,041 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha362,335,857 - 62,477,761 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0360,158,767 - 60,301,082 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl360,158,770 - 60,301,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1359,655,394 - 59,756,032 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0359,857,852 - 59,999,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0360,215,949 - 60,358,554 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Afap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,586,383 - 65,716,842 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647719,287,856 - 19,418,568 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647719,288,075 - 19,418,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl83,069,959 - 3,202,533 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.183,070,031 - 3,198,319 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.284,036,949 - 4,078,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12743,715,242 - 43,892,127 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2743,715,243 - 43,892,220 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605119,859 - 207,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,659,490 - 23,769,325 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475523,659,997 - 23,771,148 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Afap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11169,079,673 - 69,188,374 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Afap1
410 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:44
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000010346
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
BE119858  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21474,749,450 - 74,749,643 (+)MAPPERmRatBN7.2
Rnor_6.01479,925,867 - 79,926,059NCBIRnor6.0
Rnor_5.01479,560,842 - 79,561,034UniSTSRnor5.0
RGSC_v3.41480,357,739 - 80,357,931UniSTSRGSC3.4
Celera1473,681,795 - 73,681,987UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 77 59 6 341 177 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000089006   ⟹   ENSRNOP00000069806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1478,972,689 - 79,080,939 (-)Ensembl
mRatBN7.2 Ensembl1474,747,044 - 74,856,263 (-)Ensembl
Rnor_6.0 Ensembl1479,923,137 - 79,987,915 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090597   ⟹   ENSRNOP00000069497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1478,967,961 - 79,080,939 (-)Ensembl
mRatBN7.2 Ensembl1474,743,320 - 74,856,263 (-)Ensembl
Rnor_6.0 Ensembl1479,919,717 - 79,988,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116217   ⟹   ENSRNOP00000078869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1474,743,594 - 74,811,122 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117533   ⟹   ENSRNOP00000095531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1478,967,961 - 79,080,939 (-)Ensembl
mRatBN7.2 Ensembl1474,743,320 - 74,856,263 (-)Ensembl
RefSeq Acc Id: NM_080900   ⟹   NP_543176
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,967,961 - 79,080,939 (-)NCBI
mRatBN7.21474,743,322 - 74,856,300 (-)NCBI
Dahl_SR_JrHsd1479,487,359 - 79,600,315 (-)NCBI
Lyon_Normotensive1478,116,025 - 78,228,978 (-)NCBI
Lyon_Hypertensive1479,634,904 - 79,747,847 (-)NCBI
F344_StmMcwi1478,561,442 - 78,674,419 (-)NCBI
Rnor_6.01479,923,132 - 79,987,915 (-)NCBI
Rnor_5.01479,558,456 - 79,622,351 (-)NCBI
RGSC_v3.41480,355,358 - 80,448,224 (-)RGD
Celera1473,679,280 - 73,741,995 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770245   ⟹   XP_008768467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,974,051 - 79,081,032 (-)NCBI
mRatBN7.21474,749,413 - 74,856,295 (-)NCBI
Rnor_6.01479,925,829 - 80,035,094 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770247   ⟹   XP_008768469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,967,961 - 79,081,032 (-)NCBI
mRatBN7.21474,743,322 - 74,856,295 (-)NCBI
Rnor_6.01479,923,138 - 80,035,096 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599057   ⟹   XP_017454546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,974,051 - 79,081,032 (-)NCBI
mRatBN7.21474,749,413 - 74,856,295 (-)NCBI
Rnor_6.01479,925,829 - 80,035,096 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091572   ⟹   XP_038947500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,972,102 - 79,081,032 (-)NCBI
mRatBN7.21474,748,022 - 74,856,295 (-)NCBI
RefSeq Acc Id: XM_039091573   ⟹   XP_038947501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,974,051 - 79,081,032 (-)NCBI
mRatBN7.21474,749,413 - 74,856,295 (-)NCBI
RefSeq Acc Id: XM_063272812   ⟹   XP_063128882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,967,961 - 79,081,032 (-)NCBI
RefSeq Acc Id: XM_063272813   ⟹   XP_063128883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,972,660 - 79,081,032 (-)NCBI
RefSeq Acc Id: XM_063272815   ⟹   XP_063128885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,972,669 - 79,081,032 (-)NCBI
RefSeq Acc Id: NP_543176   ⟸   NM_080900
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot),   A0A0G2JVI5 (UniProtKB/TrEMBL),   A6IJY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768469   ⟸   XM_008770247
- Peptide Label: isoform X2
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot),   A0A8I6ALM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768467   ⟸   XM_008770245
- Peptide Label: isoform X7
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017454546   ⟸   XM_017599057
- Peptide Label: isoform X1
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069806   ⟸   ENSRNOT00000089006
Ensembl Acc Id: ENSRNOP00000069497   ⟸   ENSRNOT00000090597
RefSeq Acc Id: XP_038947500   ⟸   XM_039091572
- Peptide Label: isoform X3
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038947501   ⟸   XM_039091573
- Peptide Label: isoform X4
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000078869   ⟸   ENSRNOT00000116217
Ensembl Acc Id: ENSRNOP00000095531   ⟸   ENSRNOT00000117533
RefSeq Acc Id: XP_063128882   ⟸   XM_063272812
- Peptide Label: isoform X5
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128883   ⟸   XM_063272813
- Peptide Label: isoform X6
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063128885   ⟸   XM_063272815
- Peptide Label: isoform X8
- UniProtKB: Q8VH46 (UniProtKB/Swiss-Prot),   G3V6Z3 (UniProtKB/TrEMBL)
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VH46-F1-model_v2 AlphaFold Q8VH46 1-731 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619959 AgrOrtholog
BioCyc Gene G2FUF-15330 BioCyc
Ensembl Genes ENSRNOG00000060665 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000089006 ENTREZGENE
  ENSRNOT00000090597 ENTREZGENE
  ENSRNOT00000117533 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
InterPro AFAP UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report rno:140935 UniProtKB/Swiss-Prot
NCBI Gene 140935 ENTREZGENE
PANTHER PTHR14338 UniProtKB/Swiss-Prot
  PTHR14338:SF8 UniProtKB/Swiss-Prot
Pfam PF00169 UniProtKB/Swiss-Prot
PhenoGen Afap1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060665 RatGTEx
SMART SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
UniProt A0A0G2JVI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALM6 ENTREZGENE, UniProtKB/TrEMBL
  A6IJY7 ENTREZGENE, UniProtKB/TrEMBL
  AFAP1_RAT UniProtKB/Swiss-Prot
  G3V6Z3 ENTREZGENE, UniProtKB/TrEMBL
  Q8VH46 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-22 Afap1  actin filament associated protein 1  Afap  actin filament associated protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Afap  actin filament associated protein      Symbol and Name status set to approved 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization colocalizes with actin filaments in epithelial cells and fibroblasts 625602
gene_domains Src SH2 and Src SH3 domains are conserved 625602
gene_expression expressed in fetal rat lung 625602
gene_expression mRNA present in the brain intestine and kidney 625602