Afap1 (actin filament associated protein 1) - Rat Genome Database

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Gene: Afap1 (actin filament associated protein 1) Chinchilla lanigera
Analyze
Symbol: Afap1
Name: actin filament associated protein 1
RGD ID: 9010466
Description: ENCODES a protein that exhibits SH2 domain binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); regulation of signal transduction (ortholog); ASSOCIATED WITH genetic disease (ortholog); open-angle glaucoma (ortholog); FOUND IN actin cytoskeleton (ortholog); actin filament (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: actin filament-associated protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,987,408 - 3,050,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,934,115 - 3,050,347 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Afap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,987,408 - 3,050,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,934,115 - 3,050,347 (+)NCBIChiLan1.0ChiLan1.0
AFAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3847,758,713 - 7,939,861 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl47,758,714 - 7,939,926 (-)EnsemblGRCh38hg38GRCh38
GRCh3747,760,440 - 7,941,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3647,811,340 - 7,992,553 (-)NCBINCBI36Build 36hg18NCBI36
Celera47,662,306 - 7,842,025 (-)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef47,682,587 - 7,779,433 (-)NCBIHuRef
HuRef47,791,849 - 7,862,997 (-)NCBIHuRef
CHM1_147,758,814 - 7,939,654 (-)NCBICHM1_1
T2T-CHM13v2.047,730,695 - 7,918,406 (-)NCBIT2T-CHM13v2.0
Afap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39536,050,713 - 36,161,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl536,050,663 - 36,161,267 (+)EnsemblGRCm39 Ensembl
GRCm38535,893,319 - 36,003,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl535,893,319 - 36,003,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv37536,235,968 - 36,346,571 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36536,210,180 - 36,320,783 (+)NCBIMGSCv36mm8
Celera533,366,584 - 33,481,553 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.02NCBI
Afap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,967,961 - 79,081,032 (-)NCBIGRCr8
mRatBN7.21474,743,322 - 74,856,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,743,320 - 74,856,263 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1479,184,574 - 79,297,848 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01480,425,450 - 80,538,722 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,870,445 - 76,983,714 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,923,132 - 80,035,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,919,717 - 79,988,110 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01479,558,456 - 79,622,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41480,355,358 - 80,448,224 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11480,357,748 - 80,450,615 (-)NCBI
Celera1473,679,280 - 73,741,995 (-)NCBICelera
Cytogenetic Map14q21NCBI
AFAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v238,035,095 - 8,218,160 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan147,965,803 - 8,146,437 (-)NCBINHGRI_mPanPan1
PanPan1.147,821,426 - 7,933,202 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl47,826,585 - 7,939,478 (-)Ensemblpanpan1.1panPan2
AFAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1359,686,887 - 59,828,924 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl359,689,014 - 59,829,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha362,335,857 - 62,477,761 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0360,158,767 - 60,301,082 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl360,158,770 - 60,301,107 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1359,655,394 - 59,756,032 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0359,857,852 - 59,999,931 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0360,215,949 - 60,358,554 (-)NCBIUU_Cfam_GSD_1.0
Afap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,586,383 - 65,716,842 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647719,287,856 - 19,418,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647719,288,075 - 19,418,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl83,069,959 - 3,202,533 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.183,070,031 - 3,198,319 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.284,036,949 - 4,078,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12743,715,242 - 43,892,127 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2743,715,243 - 43,892,220 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605119,859 - 207,620 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Afap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,659,490 - 23,769,325 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475523,659,997 - 23,771,148 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017119   ⟹   ENSCLAP00000016953
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555142,987,408 - 3,050,558 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000017120   ⟹   ENSCLAP00000016954
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555142,987,409 - 3,050,558 (+)Ensembl
RefSeq Acc Id: XM_013506784   ⟹   XP_013362238
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555142,934,115 - 3,050,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013506786   ⟹   XP_013362240
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555142,985,638 - 3,050,347 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013506787   ⟹   XP_013362241
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555142,987,409 - 3,050,347 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013362238 (Get FASTA)   NCBI Sequence Viewer  
  XP_013362240 (Get FASTA)   NCBI Sequence Viewer  
  XP_013362241 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016953
  ENSCLAP00000016953.1
  ENSCLAP00000016954
  ENSCLAP00000016954.1
Reference Protein Sequences
RefSeq Acc Id: XP_013362238   ⟸   XM_013506784
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VPJ3 (UniProtKB/TrEMBL),   A0A8C2VSA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362240   ⟸   XM_013506786
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VPJ3 (UniProtKB/TrEMBL),   A0A8C2VSA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362241   ⟸   XM_013506787
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VSA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000016953   ⟸   ENSCLAT00000017119
RefSeq Acc Id: ENSCLAP00000016954   ⟸   ENSCLAT00000017120
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011637 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017119 ENTREZGENE
  ENSCLAT00000017119.1 UniProtKB/TrEMBL
  ENSCLAT00000017120 ENTREZGENE
  ENSCLAT00000017120.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro AFAP UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene Afap1 ENTREZGENE
PANTHER PTHR14338 UniProtKB/TrEMBL
  PTHR14338:SF8 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A8C2VPJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VSA6 ENTREZGENE, UniProtKB/TrEMBL