Gcsh (glycine cleavage system protein H) - Rat Genome Database

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Gene: Gcsh (glycine cleavage system protein H) Rattus norvegicus
Analyze
Symbol: Gcsh
Name: glycine cleavage system protein H
RGD ID: 619946
Description: Enables aminomethyltransferase activity and enzyme binding activity. Involved in glycine decarboxylation via glycine cleavage system. Predicted to be part of glycine cleavage complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome. Orthologous to human GCSH (glycine cleavage system protein H); PARTICIPATES IN folate cycle metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier); MGC108603
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,944,850 - 61,955,607 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1961,944,850 - 61,955,607 (-)EnsemblGRCr8
mRatBN7.21945,036,013 - 45,046,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,036,011 - 45,046,792 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1951,845,779 - 51,856,555 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,498,793 - 52,509,569 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,743,032 - 54,753,808 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,522,054 - 49,532,811 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)Ensemblrn6Rnor6.0
Rnor_5.01960,313,300 - 60,324,057 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41947,091,226 - 47,101,983 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1944,309,198 - 44,319,954 (-)NCBICelera
RGSC_v3.11947,096,114 - 47,106,831 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
glycine cleavage complex  (IBA,IC,IEA)
mitochondrion  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Regulation of the glycine cleavage system in isolated rat liver mitochondria. Hampson RK, etal., J Biol Chem. 1983 Mar 10;258(5):2993-9.
3. Purification and properties of glycine decarboxylase, a component of the glycine cleavage system, from rat liver mitochondria and immunochemical comparison of this enzyme from various sources. Hayasaka K, etal., J Biochem (Tokyo). 1980 Oct;88(4):1193-9.
4. Glycine cleavage system in ketotic hyperglycinemia: a reduction of H-protein activity. Hayasaka K, etal., Pediatr Res. 1982 Jan;16(1):5-7.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Structure and expression of the glycine cleavage system in rat central nervous system. Sakata Y, etal., Brain Res Mol Brain Res 2001 Oct 19;94(1-2):119-30.
12. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
13. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
Additional References at PubMed
PMID:1671321   PMID:12477932   PMID:15489334   PMID:18614015   PMID:34800366  


Genomics

Comparative Map Data
Gcsh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81961,944,850 - 61,955,607 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1961,944,850 - 61,955,607 (-)EnsemblGRCr8
mRatBN7.21945,036,013 - 45,046,770 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1945,036,011 - 45,046,792 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1951,845,779 - 51,856,555 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01952,498,793 - 52,509,569 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01954,743,032 - 54,753,808 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01949,522,054 - 49,532,811 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)Ensemblrn6Rnor6.0
Rnor_5.01960,313,300 - 60,324,057 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41947,091,226 - 47,101,983 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1944,309,198 - 44,319,954 (-)NCBICelera
RGSC_v3.11947,096,114 - 47,106,831 (-)NCBI
Cytogenetic Map19q12NCBI
GCSH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381681,081,945 - 81,096,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1681,081,945 - 81,096,406 (-)Ensemblhg38GRCh38
GRCh371681,115,550 - 81,130,000 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361679,673,430 - 79,687,481 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341679,673,429 - 79,687,481NCBI
Celera1665,413,951 - 65,428,027 (-)NCBICelera
Cytogenetic Map16q23.2NCBI
HuRef1666,872,363 - 66,886,447 (-)NCBIHuRef
CHM1_11682,526,910 - 82,541,365 (-)NCBICHM1_1
T2T-CHM13v2.01687,143,482 - 87,157,585 (-)NCBIT2T-CHM13v2.0
Gcsh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398117,708,706 - 117,720,237 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8117,708,549 - 117,720,276 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388116,981,967 - 116,993,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8116,981,810 - 116,993,537 (-)Ensemblmm10GRCm38
MGSCv378119,505,728 - 119,517,349 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368119,867,805 - 119,879,426 (-)NCBIMGSCv36mm8
Celera8121,201,218 - 121,212,838 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map863.43NCBI
Gcsh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555223,857,628 - 3,870,228 (-)Ensembl
ChiLan1.0NW_0049555223,858,156 - 3,869,730 (-)NCBIChiLan1.0ChiLan1.0
GCSH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21890,834,688 - 90,848,126 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11696,725,228 - 96,767,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01661,688,959 - 61,702,364 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11681,116,064 - 81,124,145 (-)NCBIPanPan1.1PanPan1.1panPan2
GCSH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1570,745,591 - 70,757,292 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl570,745,258 - 70,756,830 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha570,694,364 - 70,706,021 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0571,050,605 - 71,062,318 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl571,050,245 - 71,062,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1570,992,920 - 71,004,627 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0570,828,128 - 70,839,843 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0571,305,698 - 71,317,366 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gcsh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934930,828,885 - 30,839,553 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647528,749,580 - 28,760,230 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647528,749,545 - 28,760,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCSH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl67,171,192 - 7,184,729 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.167,171,186 - 7,184,732 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GCSH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1566,538,377 - 66,551,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl566,538,871 - 66,550,817 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660479,286,311 - 9,298,577 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gcsh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247466,264,458 - 6,278,085 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247466,264,447 - 6,278,085 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gcsh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11736,619,382 - 36,640,745 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:72
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000015967
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH129471  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01960,313,440 - 60,313,632NCBIRnor5.0
Rnor_5.01626,411,703 - 26,411,894NCBIRnor5.0
Rnor_5.01626,207,568 - 26,207,759NCBIRnor5.0
RGSC_v3.41626,388,485 - 26,388,675UniSTSRGSC3.4
RGSC_v3.41947,091,367 - 47,091,558UniSTSRGSC3.4
Celera1624,733,039 - 24,733,229UniSTS
Celera1944,309,339 - 44,309,530UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map19q12UniSTS
RH129771  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21945,036,029 - 45,036,179 (+)MAPPERmRatBN7.2
Rnor_6.01949,522,071 - 49,522,220NCBIRnor6.0
Rnor_5.01960,313,317 - 60,313,466UniSTSRnor5.0
RGSC_v3.41947,091,243 - 47,091,392UniSTSRGSC3.4
Celera1944,309,215 - 44,309,364UniSTS
RH 3.4 Map19613.8UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 89 59 6 353 189 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015967   ⟹   ENSRNOP00000015967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1961,944,850 - 61,955,607 (-)Ensembl
mRatBN7.2 Ensembl1945,036,011 - 45,046,792 (-)Ensembl
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)Ensembl
RefSeq Acc Id: NM_133598   ⟹   NP_598282
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81961,944,850 - 61,955,607 (-)NCBI
mRatBN7.21945,036,013 - 45,046,770 (-)NCBI
Rnor_6.01949,522,054 - 49,532,811 (-)NCBI
Rnor_5.01960,313,300 - 60,324,057 (-)NCBI
RGSC_v3.41947,091,226 - 47,101,983 (-)RGD
Celera1944,309,198 - 44,319,954 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_598282 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88114 (Get FASTA)   NCBI Sequence Viewer  
  CAB56621 (Get FASTA)   NCBI Sequence Viewer  
  EDL92643 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015967
  ENSRNOP00000015967.5
GenBank Protein Q5I0P2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_598282   ⟸   NM_133598
- Peptide Label: precursor
- UniProtKB: Q5I0P2 (UniProtKB/Swiss-Prot),   A6IZG4 (UniProtKB/TrEMBL),   A0A0G2JZ02 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015967   ⟸   ENSRNOT00000015967
Protein Domains
Lipoyl-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5I0P2-F1-model_v2 AlphaFold Q5I0P2 1-170 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701169
Promoter ID:EPDNEW_R11692
Type:initiation region
Name:Gcsh_1
Description:glycine cleavage system protein H
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01949,532,792 - 49,532,852EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619946 AgrOrtholog
BioCyc Gene G2FUF-5558 BioCyc
BioCyc Pathway 1CMET2-PWY [folate transformations III (E. coli)] BioCyc
  GLYCINE-SYN2-PWY [glycine biosynthesis II] BioCyc
  GLYCLEAV-PWY [glycine cleavage] BioCyc
BioCyc Pathway Image 1CMET2-PWY BioCyc
  GLYCINE-SYN2-PWY BioCyc
  GLYCLEAV-PWY BioCyc
Ensembl Genes ENSRNOG00000011535 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015967 ENTREZGENE
  ENSRNOT00000015967.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7321648 IMAGE-MGC_LOAD
InterPro 2-oxoA_DH_lipoyl-BS UniProtKB/Swiss-Prot
  Biotin_lipoyl UniProtKB/Swiss-Prot
  GCV_H UniProtKB/Swiss-Prot
  GCV_H/Fam206 UniProtKB/Swiss-Prot
  GCV_H_sub UniProtKB/Swiss-Prot
  Single_hybrid_motif UniProtKB/Swiss-Prot
KEGG Report rno:171133 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108603 IMAGE-MGC_LOAD
NCBI Gene 171133 ENTREZGENE
PANTHER GLYCINE CLEAVAGE SYSTEM H PROTEIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR11715 UniProtKB/Swiss-Prot
Pfam GCV_H UniProtKB/Swiss-Prot
PhenoGen Gcsh PhenoGen
PROSITE BIOTINYL_LIPOYL UniProtKB/Swiss-Prot
  LIPOYL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011535 RatGTEx
Superfamily-SCOP SSF51230 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ02 ENTREZGENE, UniProtKB/TrEMBL
  A6IZG4 ENTREZGENE, UniProtKB/TrEMBL
  GCSH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Gcsh  glycine cleavage system protein H  Gcsh  glycine cleavage system protein H (aminomethyl carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gcsh  glycine cleavage system protein H (aminomethyl carrier)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gcsh  glycine cleavage system protein H (aminomethyl carrier)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease may play a role in the forebrain and cerebellum neuropathogenesis of nonketotic hyperglycinemia (NKH) 708332
gene_expression may be induced after certain types of damages to liver 70249
gene_function aminomethyl carrier 70249
gene_protein 170 amino acids 708332