Dynll1 (dynein light chain LC8-type 1) - Rat Genome Database

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Gene: Dynll1 (dynein light chain LC8-type 1) Rattus norvegicus
Analyze
Symbol: Dynll1
Name: dynein light chain LC8-type 1
RGD ID: 619866
Description: Enables several functions, including identical protein binding activity; nitric-oxide synthase inhibitor activity; and scaffold protein binding activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus and spermatid development. Acts upstream of or within negative regulation of nitric oxide biosynthetic process. Located in axon cytoplasm and secretory granule. Part of cytoplasmic dynein complex. Used to study hypertension and impotence. Biomarker of cardiac arrest; congestive heart failure; and middle cerebral artery infarction. Orthologous to human DYNLL1 (dynein light chain LC8-type 1); PARTICIPATES IN mitochondria transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 8 kDa dynein light chain; 8kD LC; 8kDLC; Dlc8; Dnclc1; dynein LC8; dynein light chain 1, cytoplasmic; dynein, cytoplasmic, light chain 1; MGC72986; Pin; protein inhibitor of neuronal nitric oxide synthase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Dynll1-ps3   Dynll1l1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,945,291 - 46,976,867 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,973,050 - 46,976,861 (+)EnsemblGRCr8
mRatBN7.21241,312,365 - 41,316,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,312,367 - 41,314,741 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1242,479,075 - 42,481,446 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,092,738 - 43,095,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,153,290 - 42,155,661 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,074,200 - 47,076,573 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)Ensemblrn6Rnor6.0
Rnor_5.01248,867,516 - 48,869,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41242,580,542 - 42,582,915 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,933,102 - 42,935,475 (+)NCBICelera
RGSC_v3.11242,443,929 - 42,446,302 (+)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP,ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
ozone  (EXP)
p-tert-Amylphenol  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
sarin  (ISO)
sevoflurane  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
sulindac sulfide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
trichloroethene  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon cytoplasm  (IDA)
centrosome  (IEA,ISO)
chromosome  (IEA)
cilium  (IEA)
COP9 signalosome  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoplasmic dynein complex  (IBA,IDA,IEA,ISO,ISS,TAS)
cytoskeleton  (IEA,ISO)
cytosol  (ISO)
dynein complex  (IEA,ISO)
kinetochore  (IEA,ISO,ISS)
membrane  (ISO)
microtubule  (IEA)
microtubule associated complex  (IEA)
mitochondrion  (IEA)
mitotic spindle  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
secretory granule  (IDA)
site of double-strand break  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytoplasmic dynein. Allan VJ, Biochem Soc Trans. 2011 Oct;39(5):1169-78. doi: 10.1042/BST0391169.
2. Dynein light chain LC8 regulates syntaphilin-mediated mitochondrial docking in axons. Chen YM, etal., J Neurosci. 2009 Jul 29;29(30):9429-38. doi: 10.1523/JNEUROSCI.1472-09.2009.
3. Myotonia congenita with strabismus in a large family with a mutation in the SCN4A gene. Du H, etal., Eye (Lond). 2012 Aug;26(8):1039-43. doi: 10.1038/eye.2012.80. Epub 2012 Jun 1.
4. Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity. Fan JS, etal., J Biomol NMR 2002 Jun;23(2):103-14.
5. Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. Fejtova A, etal., J Cell Biol. 2009 Apr 20;185(2):341-55. doi: 10.1083/jcb.200807155.
6. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. Fuhrmann JC, etal., J Neurosci 2002 Jul 1;22(13):5393-402.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia. Gillardon F, etal., Neuroscience. 1998 May;84(1):81-8.
9. PIN: an associated protein inhibitor of neuronal nitric oxide synthase. Jaffrey SR and Snyder SH, Science 1996 Nov 1;274(5288):774-7.
10. Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. King SM, etal., J Biol Chem. 1996 Aug 9;271(32):19358-66.
11. Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion. Lajoix AD, etal., Diabetes. 2006 Dec;55(12):3279-88.
12. Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Lajoix AD, etal., Mol Divers. 2004;8(3):281-90.
13. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. Lo KW, etal., J Biol Chem. 2007 Dec 21;282(51):36871-8. Epub 2007 Oct 27.
14. Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. Magee TR, etal., J Sex Med. 2007 May;4(3):633-43. Epub 2007 Apr 13.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Proteomic identification of brain proteins that interact with dynein light chain LC8. Navarro-Lerida I, etal., Proteomics. 2004 Feb;4(2):339-46.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. Ninomiya K, etal., Cell Mol Neurobiol. 2005 Aug;25(5):899-911. doi: 10.1007/s10571-005-4955-5.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Angiotensin II-mediated post-translational modification of nNOS in the PVN of rats with CHF: Role for PIN. Sharma NM, etal., Am J Physiol Heart Circ Physiol. 2013 Jul 5.
23. Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. Thompson S, etal., J Biol Chem. 2011 Jun 3;286(22):19331-9. doi: 10.1074/jbc.M110.197707. Epub 2011 Apr 8.
24. Stage-specific expression of dynein light chain-1 and its interacting kinase, p21-activated kinase-1, in rodent testes: implications in spermiogenesis. Wang RA, etal., J Histochem Cytochem. 2005 Oct;53(10):1235-43. Epub 2005 Jun 27.
25. RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats. Wang SC, etal., J Am Soc Hypertens. 2014 Jan;8(1):5-13. doi: 10.1016/j.jash.2013.07.010. Epub 2013 Sep 12.
26. Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly. Wang W, etal., J Biol Chem 2003 Oct 17;278(42):41491-9.
Additional References at PubMed
PMID:8628263   PMID:9299562   PMID:11148209   PMID:11148215   PMID:11178896   PMID:12477932   PMID:14561217   PMID:14713293   PMID:15136728   PMID:15489334   PMID:15891768   PMID:16098226  
PMID:16176937   PMID:18579519   PMID:18850735   PMID:19946888   PMID:20133940   PMID:21145319   PMID:21399614   PMID:22871113   PMID:22926577   PMID:23376485   PMID:24958506   PMID:25002582  
PMID:25294941   PMID:25830415   PMID:26459761   PMID:30018294   PMID:31904090  


Genomics

Comparative Map Data
Dynll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81246,945,291 - 46,976,867 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1246,973,050 - 46,976,861 (+)EnsemblGRCr8
mRatBN7.21241,312,365 - 41,316,157 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,312,367 - 41,314,741 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1242,479,075 - 42,481,446 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,092,738 - 43,095,109 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,153,290 - 42,155,661 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,074,200 - 47,076,573 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)Ensemblrn6Rnor6.0
Rnor_5.01248,867,516 - 48,869,889 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41242,580,542 - 42,582,915 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1242,933,102 - 42,935,475 (+)NCBICelera
RGSC_v3.11242,443,929 - 42,446,302 (+)NCBI
Cytogenetic Map12q16NCBI
DYNLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812120,469,842 - 120,498,493 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12120,469,804 - 120,498,495 (+)Ensemblhg38GRCh38
GRCh3712120,907,645 - 120,936,296 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612119,392,043 - 119,420,681 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412119,396,652 - 119,399,010NCBI
Celera12120,542,375 - 120,570,391 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12117,917,550 - 117,946,088 (+)NCBIHuRef
CHM1_112120,876,465 - 120,905,100 (+)NCBICHM1_1
T2T-CHM13v2.012120,459,024 - 120,487,665 (+)NCBIT2T-CHM13v2.0
Dynll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395115,435,129 - 115,438,995 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5115,435,169 - 115,439,058 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385115,297,110 - 115,300,990 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5115,297,110 - 115,300,999 (-)Ensemblmm10GRCm38
MGSCv375115,747,119 - 115,750,999 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365115,559,422 - 115,561,933 (-)NCBIMGSCv36mm8
Celera5112,394,410 - 112,398,301 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map556.04NCBI
Dynll1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545511,148,047 - 11,150,859 (-)Ensembl
ChiLan1.0NW_00495545511,148,041 - 11,150,860 (-)NCBIChiLan1.0ChiLan1.0
DYNLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210128,539,098 - 128,567,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112128,535,475 - 128,563,886 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,078,401 - 118,080,822 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112121,452,118 - 121,454,550 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12121,452,118 - 121,454,550 (+)EnsemblpanPan2panpan1.1
DYNLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12616,369,878 - 16,402,302 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2616,398,886 - 16,402,021 (-)EnsemblcanFam3CanFam3.1
CanFam3.1 Ensembl2616,399,889 - 16,402,458 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2616,373,479 - 16,405,461 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02616,637,042 - 16,669,452 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2616,667,035 - 16,670,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12616,597,102 - 16,629,472 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02616,673,811 - 16,705,772 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02616,715,648 - 16,747,621 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dynll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118145,952,956 - 145,985,917 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936668448,489 - 500,800 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936668451,846 - 484,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYNLL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1440,455,985 - 40,459,104 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11440,455,954 - 40,458,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,956,562 - 42,958,960 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DYNLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111115,851,020 - 115,855,526 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11115,851,381 - 115,851,647 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037129,247,006 - 129,249,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dynll1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474713,169,865 - 13,172,525 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474713,169,865 - 13,172,592 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dynll1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11638,522,286 - 38,524,688 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:181
Count of miRNA genes:136
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000014910
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
RH128914  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q16UniSTS
BF418128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,306,773 - 41,307,220 (+)MAPPERmRatBN7.2
mRatBN7.21241,307,011 - 41,307,220 (+)MAPPERmRatBN7.2
Rnor_6.01247,068,845 - 47,069,053NCBIRnor6.0
Rnor_6.01247,068,457 - 47,069,053NCBIRnor6.0
Rnor_5.01248,861,773 - 48,862,369UniSTSRnor5.0
Rnor_5.01248,862,161 - 48,862,369UniSTSRnor5.0
RGSC_v3.41242,575,187 - 42,575,395UniSTSRGSC3.4
Celera1242,927,740 - 42,927,948UniSTS
RH 3.4 Map12774.62UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014910   ⟹   ENSRNOP00000061342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,312,367 - 41,314,741 (+)Ensembl
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000165275   ⟹   ENSRNOP00000106438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1246,973,050 - 46,976,861 (+)Ensembl
RefSeq Acc Id: NM_053319   ⟹   NP_445771
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,973,077 - 46,976,867 (+)NCBI
mRatBN7.21241,312,365 - 41,316,157 (+)NCBI
Rnor_6.01247,074,200 - 47,076,573 (+)NCBI
Rnor_5.01248,867,516 - 48,869,889 (+)NCBI
RGSC_v3.41242,580,542 - 42,582,915 (+)RGD
Celera1242,933,102 - 42,935,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271606   ⟹   XP_063127676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81246,945,291 - 46,975,452 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445771 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127676 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB38257 (Get FASTA)   NCBI Sequence Viewer  
  AAH63183 (Get FASTA)   NCBI Sequence Viewer  
  EDM13893 (Get FASTA)   NCBI Sequence Viewer  
  EDM13894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061342.1
  ENSRNOP00000106438
GenBank Protein P63170 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445771   ⟸   NM_053319
- UniProtKB: P63170 (UniProtKB/Swiss-Prot),   A6J1V5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061342   ⟸   ENSRNOT00000014910
RefSeq Acc Id: XP_063127676   ⟸   XM_063271606
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000106438   ⟸   ENSRNOT00000165275

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63170-F1-model_v2 AlphaFold P63170 1-89 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698695
Promoter ID:EPDNEW_R9220
Type:multiple initiation site
Name:Dynll1_1
Description:dynein light chain LC8-type 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,074,200 - 47,074,260EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619866 AgrOrtholog
BIND 134400
BioCyc Gene G2FUF-18983 BioCyc
Ensembl Genes ENSRNOG00000011222 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000083010 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014910.6 UniProtKB/Swiss-Prot
  ENSRNOT00000165275 ENTREZGENE
Gene3D-CATH 3.30.740.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6887897 IMAGE-MGC_LOAD
InterPro DLC_sf UniProtKB/Swiss-Prot
  Dynein_light_1/2_CS UniProtKB/Swiss-Prot
  Dynein_light_chain_typ-1/2 UniProtKB/Swiss-Prot
KEGG Report rno:58945 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72986 IMAGE-MGC_LOAD
NCBI Gene 58945 ENTREZGENE
PANTHER DYNEIN LIGHT CHAIN 1, CYTOPLASMIC UniProtKB/Swiss-Prot
  PTHR11886 UniProtKB/Swiss-Prot
Pfam Dynein_light UniProtKB/Swiss-Prot
PhenoGen Dynll1 PhenoGen
PROSITE DYNEIN_LIGHT_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011222 RatGTEx
  ENSRNOG00000083010 RatGTEx
SMART Dynein_light UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54648 UniProtKB/Swiss-Prot
UniProt A6J1V5 ENTREZGENE, UniProtKB/TrEMBL
  DYL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q15701 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Dynll1  dynein light chain LC8-type 1  Dnclc1  dynein, cytoplasmic, light chain 1  Symbol and Name updated 1299863 APPROVED
2004-12-14 Dnclc1  dynein, cytoplasmic, light chain 1  Pin    Symbol updated 1299863 APPROVED
2002-08-07 Pin  dynein, cytoplasmic, light chain 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization cytoplasmic and synaptic localization in hippocampal cells 628355
gene_function destabilizes the nNOS dimer 633683
gene_function light chain of cytoplasmic dynein 628355
gene_function binds to gephyrin, a tubulin-binding protein 628355
gene_physical_interaction directily interacts with synaptic scaffolding protein gephyrin 628355
gene_process plays a role in postsynaptic targeting of neurotransmitter receptors or scaffolding proteins 628355
gene_protein 89 amino acids 633683