Grk5 (G protein-coupled receptor kinase 5) - Rat Genome Database

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Gene: Grk5 (G protein-coupled receptor kinase 5) Rattus norvegicus
Analyze
Symbol: Grk5
Name: G protein-coupled receptor kinase 5
RGD ID: 61985
Description: Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in negative regulation of G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; and response to cocaine. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease and hypertension. Orthologous to human GRK5 (G protein-coupled receptor kinase 5); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: g protein-coupled receptor kinase GRK5; Gprk5; MGC93405
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81270,014,314 - 270,208,294 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1270,014,282 - 270,204,928 (+)EnsemblGRCr8
mRatBN7.21260,028,269 - 260,223,699 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,028,242 - 260,218,701 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1268,234,940 - 268,425,947 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,940,966 - 275,131,956 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,595,271 - 267,786,197 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,265,371 - 282,467,842 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,265,370 - 282,462,605 (+)Ensemblrn6Rnor6.0
Rnor_5.01289,603,922 - 289,802,914 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41267,495,534 - 267,693,144 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1255,668,943 - 255,859,242 (+)NCBICelera
RGSC_v3.11267,706,618 - 267,904,229 (+)NCBI
Cytogenetic Map1q55NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-adrenaline  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carvedilol  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-linolenic acid  (ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (ISO)
melphalan  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
metoprolol  (ISO)
morphine  (EXP)
nitrates  (ISO)
nitrobenzenes  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
membrane  (IEA)
nuclear membrane  (ISO)
nuclear speck  (ISO)
nucleus  (IEA)
plasma membrane  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Ahmed MR, etal., J Neurochem. 2008 Mar;104(6):1622-36. Epub 2007 Nov 7.
2. Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Arraes SM, etal., Blood. 2006 Nov 1;108(9):2906-13. Epub 2006 Jul 18.
3. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia. Bychkov ER, etal., Neurobiol Aging. 2008 Mar;29(3):379-96. Epub 2006 Nov 27.
5. Does GRK-ß arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways? Daniele S, etal., Cell Signal. 2014 Jun;26(6):1310-25. doi: 10.1016/j.cellsig.2014.02.016. Epub 2014 Mar 5.
6. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
7. Beta-adrenergic stimulation and myocardial function in the failing heart. El-Armouche A and Eschenhagen T, Heart Fail Rev. 2009 Dec;14(4):225-41.
8. Acute and chronic morphine treatments and morphine withdrawal differentially regulate GRK2 and GRK5 gene expression in rat brain. Fan X, etal., Neuropharmacology 2002 Oct;43(5):809-16.
9. Cocaine potentiates multiple 5-HT2A receptor signaling pathways and is associated with decreased phosphorylation of 5-HT2A receptors in vivo. Franklin JM and Carrasco GA, J Mol Neurosci. 2015 Mar;55(3):770-7. doi: 10.1007/s12031-014-0419-z. Epub 2014 Sep 12.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice. Li L, etal., J Neuroinflammation. 2008 Jun 3;5:24.
14. GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. Liu J, etal., J Biol Chem. 2009 Jul 17;284(29):19564-71. doi: 10.1074/jbc.M109.005959. Epub 2009 May 28.
15. Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. Lombardi MS, etal., FASEB J. 1999 Apr;13(6):715-25.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. beta2- and beta1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases. Monto F, etal., J Cardiovasc Pharmacol. 2015 Nov;66(5):478-86. doi: 10.1097/FJC.0000000000000299.
18. Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables. Montó F, etal., Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H368-76. doi: 10.1152/ajpheart.01061.2011. Epub 2012 Jun 8.
19. Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor. Nagayama Y, etal., J Biol Chem 1996 Apr 26;271(17):10143-8.
20. Differential regulation of ß2-adrenoceptor and adenosine A2B receptor signalling by GRK and arrestin proteins in arterial smooth muscle. Nash CA, etal., Cell Signal. 2018 Nov;51:86-98. doi: 10.1016/j.cellsig.2018.07.013. Epub 2018 Jul 31.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFkappaB activation in primary macrophages and modulates inflammation in vivo in mice. Patial S, etal., J Cell Physiol. 2011 May;226(5):1323-33. doi: 10.1002/jcp.22460.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
29. Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells. Simon V, etal., Endocrinology 2003 Jul;144(7):3058-66.
30. Potential genetic risk factors for chronic TMD: genetic associations from the OPPERA case control study. Smith SB, etal., J Pain. 2011 Nov;12(11 Suppl):T92-101.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease. Tarantino P, etal., Am J Med Genet B Neuropsychiatr Genet. 2011 Jan;156B(1):104-7. doi: 10.1002/ajmg.b.31129. Epub 2010 Nov 2.
33. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Tarrant TK, etal., Clin Immunol. 2008 Oct;129(1):115-22. Epub 2008 Jul 26.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. Walker JK, etal., Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L312-9. Epub 2003 Oct 17.
36. Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. Yi XP, etal., Hypertension 2002 Jun;39(6):1058-63.
37. Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents. Álvaro-Bartolomé M and García-Sevilla JA, Neuroscience. 2013 Sep 5;247:294-308. doi: 10.1016/j.neuroscience.2013.05.035. Epub 2013 May 29.
Additional References at PubMed
PMID:14976207   PMID:17986524   PMID:20038610   PMID:20124405   PMID:22099983   PMID:22389501   PMID:22507984   PMID:22753221   PMID:22888001   PMID:23139825   PMID:23472081   PMID:23592773  
PMID:27613164   PMID:29080472   PMID:29543709   PMID:37380112  


Genomics

Comparative Map Data
Grk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81270,014,314 - 270,208,294 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1270,014,282 - 270,204,928 (+)EnsemblGRCr8
mRatBN7.21260,028,269 - 260,223,699 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1260,028,242 - 260,218,701 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1268,234,940 - 268,425,947 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01274,940,966 - 275,131,956 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01267,595,271 - 267,786,197 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01282,265,371 - 282,467,842 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1282,265,370 - 282,462,605 (+)Ensemblrn6Rnor6.0
Rnor_5.01289,603,922 - 289,802,914 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41267,495,534 - 267,693,144 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1255,668,943 - 255,859,242 (+)NCBICelera
RGSC_v3.11267,706,618 - 267,904,229 (+)NCBI
Cytogenetic Map1q55NCBI
GRK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810119,207,571 - 119,459,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10119,207,543 - 119,459,745 (+)Ensemblhg38GRCh38
GRCh3710120,967,083 - 121,219,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610120,957,187 - 121,205,121 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410120,957,186 - 121,205,120NCBI
Celera10114,696,799 - 114,943,133 (+)NCBICelera
Cytogenetic Map10q26.11NCBI
HuRef10114,596,405 - 114,842,644 (+)NCBIHuRef
CHM1_110121,251,583 - 121,499,541 (+)NCBICHM1_1
T2T-CHM13v2.010120,102,994 - 120,355,311 (+)NCBIT2T-CHM13v2.0
Grk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391960,877,995 - 61,084,406 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1960,878,187 - 61,084,406 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381960,889,560 - 61,095,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1960,889,749 - 61,095,968 (+)Ensemblmm10GRCm38
MGSCv371960,965,652 - 61,168,459 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361960,945,139 - 61,147,005 (+)NCBIMGSCv36mm8
Celera1963,189,741 - 63,294,504 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1956.52NCBI
Grk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495555144,156 - 254,534 (+)Ensembl
ChiLan1.0NW_00495555143,918 - 255,118 (+)NCBIChiLan1.0ChiLan1.0
GRK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28131,064,338 - 131,314,329 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110131,069,692 - 131,319,683 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010115,776,236 - 116,026,221 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110119,200,901 - 119,448,006 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10119,200,688 - 119,450,809 (+)EnsemblpanPan2panpan1.1
GRK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12829,424,350 - 29,636,552 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2829,424,593 - 29,632,741 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2829,566,413 - 29,778,694 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02829,955,098 - 30,167,121 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2829,955,134 - 30,165,427 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12829,509,598 - 29,721,404 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02829,529,525 - 29,741,448 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02829,723,728 - 29,936,023 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721316,730,225 - 16,924,264 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364868,720,036 - 8,831,075 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364868,720,036 - 8,830,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14129,113,603 - 129,347,152 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114129,113,933 - 129,351,135 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214140,638,292 - 140,875,396 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19111,996,780 - 112,249,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9111,996,599 - 112,244,570 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604873,269,146 - 73,517,028 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473727,375,149 - 27,600,210 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473727,379,114 - 27,600,132 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grk5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1255,067,222 - 55,266,753 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000015687
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
71112Bw115Body weight QTL 11560.0001body mass (VT:0001259)body weight (CMO:0000012)1269633753270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
737975Bw122Body weight QTL 1229.110.005body mass (VT:0001259)body weight (CMO:0000012)1269158828270108840Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat

Markers in Region
D1Rat459  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81270,108,630 - 270,108,840 (+)Marker Load Pipeline
mRatBN7.21260,122,597 - 260,122,809 (+)MAPPERmRatBN7.2
Rnor_6.01282,365,175 - 282,365,384NCBIRnor6.0
Rnor_5.01289,700,208 - 289,700,417UniSTSRnor5.0
RGSC_v3.41267,593,348 - 267,593,558RGDRGSC3.4
RGSC_v3.41267,593,349 - 267,593,558UniSTSRGSC3.4
Celera1255,762,929 - 255,763,138UniSTS
RGSC_v3.11267,804,434 - 267,804,643RGD
RH 3.4 Map11704.5UniSTS
RH 3.4 Map11704.5RGD
RH 2.0 Map11311.7999RGD
SHRSP x BN Map1148.19RGD
Cytogenetic Map1q55UniSTS
AU047024  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21260,122,572 - 260,122,795 (+)MAPPERmRatBN7.2
Rnor_6.01282,365,150 - 282,365,370NCBIRnor6.0
Rnor_5.01289,700,183 - 289,700,403UniSTSRnor5.0
RGSC_v3.41267,593,324 - 267,593,544UniSTSRGSC3.4
Celera1255,762,904 - 255,763,124UniSTS
Cytogenetic Map1q55UniSTS
RH139164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21260,219,003 - 260,219,129 (+)MAPPERmRatBN7.2
Rnor_6.01282,462,915 - 282,463,040NCBIRnor6.0
Rnor_5.01289,797,987 - 289,798,112UniSTSRnor5.0
RGSC_v3.41267,693,447 - 267,693,572UniSTSRGSC3.4
Celera1255,859,545 - 255,859,670UniSTS
RH 3.4 Map11713.3UniSTS
Cytogenetic Map1q55UniSTS
UniSTS:496009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21260,212,603 - 260,212,706 (+)MAPPERmRatBN7.2
Rnor_6.01282,456,515 - 282,456,617NCBIRnor6.0
Rnor_5.01289,791,587 - 289,791,689UniSTSRnor5.0
RGSC_v3.41267,687,047 - 267,687,149UniSTSRGSC3.4
Celera1255,853,145 - 255,853,247UniSTS
Cytogenetic Map1q55UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC081792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U34841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015687   ⟹   ENSRNOP00000015687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1270,014,313 - 270,204,928 (+)Ensembl
mRatBN7.2 Ensembl1260,028,242 - 260,218,694 (+)Ensembl
Rnor_6.0 Ensembl1282,265,370 - 282,462,605 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096363   ⟹   ENSRNOP00000082434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1270,014,282 - 270,204,928 (+)Ensembl
mRatBN7.2 Ensembl1260,028,269 - 260,218,701 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114259   ⟹   ENSRNOP00000089346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1270,014,285 - 270,160,931 (+)Ensembl
mRatBN7.2 Ensembl1260,028,242 - 260,174,905 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139040   ⟹   ENSRNOP00000104808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1270,014,313 - 270,204,928 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000154886   ⟹   ENSRNOP00000101851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1270,014,285 - 270,203,201 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167762   ⟹   ENSRNOP00000110672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1270,014,300 - 270,204,926 (+)Ensembl
RefSeq Acc Id: NM_030829   ⟹   NP_110456
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,014,336 - 270,204,726 (+)NCBI
mRatBN7.21260,028,293 - 260,218,701 (+)NCBI
Rnor_6.01282,265,422 - 282,462,612 (+)NCBI
Rnor_5.01289,603,922 - 289,802,914 (+)NCBI
RGSC_v3.41267,495,534 - 267,693,144 (+)RGD
Celera1255,668,943 - 255,859,242 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088800   ⟹   XP_038944728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,014,316 - 270,208,294 (+)NCBI
mRatBN7.21260,028,270 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088801   ⟹   XP_038944729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,066,695 - 270,208,294 (+)NCBI
mRatBN7.21260,080,658 - 260,223,699 (+)NCBI
RefSeq Acc Id: XM_039088806   ⟹   XP_038944734
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,014,318 - 270,208,294 (+)NCBI
mRatBN7.21260,028,271 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088810   ⟹   XP_038944738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,014,318 - 270,208,294 (+)NCBI
mRatBN7.21260,028,272 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088820   ⟹   XP_038944748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,014,314 - 270,208,294 (+)NCBI
mRatBN7.21260,028,269 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088827   ⟹   XP_038944755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,014,317 - 270,208,294 (+)NCBI
mRatBN7.21260,028,271 - 260,222,269 (+)NCBI
RefSeq Acc Id: XM_039088828   ⟹   XP_038944756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,181,693 - 270,208,294 (+)NCBI
mRatBN7.21260,195,667 - 260,223,699 (+)NCBI
RefSeq Acc Id: XM_063272208   ⟹   XP_063128278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81270,167,363 - 270,208,294 (+)NCBI
RefSeq Acc Id: NP_110456   ⟸   NM_030829
- UniProtKB: Q62833 (UniProtKB/Swiss-Prot),   Q66HL7 (UniProtKB/TrEMBL),   A6JIB2 (UniProtKB/TrEMBL),   F7EZU6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015687   ⟸   ENSRNOT00000015687
RefSeq Acc Id: XP_038944748   ⟸   XM_039088820
- Peptide Label: isoform X5
- UniProtKB: Q62833 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944728   ⟸   XM_039088800
- Peptide Label: isoform X1
- UniProtKB: Q62833 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944734   ⟸   XM_039088806
- Peptide Label: isoform X3
- UniProtKB: Q62833 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944755   ⟸   XM_039088827
- Peptide Label: isoform X6
- UniProtKB: A0A8I5ZX64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944738   ⟸   XM_039088810
- Peptide Label: isoform X4
- UniProtKB: Q62833 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944729   ⟸   XM_039088801
- Peptide Label: isoform X2
- UniProtKB: Q62833 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038944756   ⟸   XM_039088828
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000082434   ⟸   ENSRNOT00000096363
Ensembl Acc Id: ENSRNOP00000089346   ⟸   ENSRNOT00000114259
RefSeq Acc Id: XP_063128278   ⟸   XM_063272208
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000110672   ⟸   ENSRNOT00000167762
Ensembl Acc Id: ENSRNOP00000104808   ⟸   ENSRNOT00000139040
Ensembl Acc Id: ENSRNOP00000101851   ⟸   ENSRNOT00000154886
Protein Domains
AGC-kinase C-terminal   Protein kinase   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62833-F1-model_v2 AlphaFold Q62833 1-590 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691025
Promoter ID:EPDNEW_R1549
Type:single initiation site
Name:Grk5_1
Description:G protein-coupled receptor kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01282,265,327 - 282,265,387EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61985 AgrOrtholog
BioCyc Gene G2FUF-55219 BioCyc
Ensembl Genes ENSRNOG00000011439 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015687 ENTREZGENE
  ENSRNOT00000139040 ENTREZGENE
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7123515 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  GPCR_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
KEGG Report rno:59075 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93405 IMAGE-MGC_LOAD
NCBI Gene 59075 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE 5 UniProtKB/Swiss-Prot
  G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
PhenoGen Grk5 PhenoGen
PRINTS GPCRKINASE UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011439 RatGTEx
SMART RGS UniProtKB/Swiss-Prot
  S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC204836
UniProt A0A8I5ZX64 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GI07_RAT UniProtKB/TrEMBL
  A0ABK0LER5_RAT UniProtKB/TrEMBL
  A0ABK0LSM1_RAT UniProtKB/TrEMBL
  A0ABK0M6I6_RAT UniProtKB/TrEMBL
  A6JIB2 ENTREZGENE, UniProtKB/TrEMBL
  F7EZU6 ENTREZGENE, UniProtKB/TrEMBL
  GRK5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HL7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Grk5  G protein-coupled receptor kinase 5  Gprk5  G protein-coupled receptor kinase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gprk5  G protein-coupled receptor kinase 5      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference