Slc28a2 (solute carrier family 28 member 2) - Rat Genome Database

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Gene: Slc28a2 (solute carrier family 28 member 2) Rattus norvegicus
Analyze
Symbol: Slc28a2
Name: solute carrier family 28 member 2
RGD ID: 61840
Description: Enables nucleoside:sodium symporter activity. Involved in protein localization to cell surface and retina homeostasis. Located in coated vesicle; plasma membrane; and vesicle membrane. Orthologous to human SLC28A2 (solute carrier family 28 member 2); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CNT 2; concentrative nucleoside transporter 2; LOC102556085; Na(+)/nucleoside cotransporter 2; rCNT2; sodium-coupled nucleoside transporter 2; sodium/nucleoside cotransporter 2; sodium/nucleoside cotransporter 2-like; sodium/purine nucleoside cotransporter; solute carrier family 28 (concentrative nucleoside transporter), member 2; solute carrier family 28 (sodium-coupled nucleoside transporter) member 2; solute carrier family 28 (sodium-coupled nucleoside transporter), member 2; solute carrier family 28, member 2; SPNT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,778,425 - 129,841,292 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3129,807,537 - 129,841,291 (+)EnsemblGRCr8
mRatBN7.23109,324,815 - 109,387,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,366,996 - 109,387,702 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3113,039,238 - 113,060,743 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,634,754 - 121,656,259 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,295,132 - 119,316,637 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3127,683,910 - 127,705,419 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3134,600,438 - 134,621,951 (+)NCBILyon_Normotensive
Lyon_Hypertensive3126,480,237 - 126,501,746 (+)NCBILyon_Hypertensive
F344_StmMcwi3107,784,797 - 107,806,302 (+)NCBIF344_StmMcwi
Rnor_6.03114,355,003 - 114,647,382 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,355,798 - 114,647,382 (+)Ensemblrn6Rnor6.0
Rnor_5.03120,897,082 - 120,921,371 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43109,350,531 - 109,372,027 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3108,262,866 - 108,284,103 (+)NCBICelera
RGSC_v3.13109,256,103 - 109,277,600 (-)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bromuconazole  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
coumarin  (EXP)
D-penicillamine  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
dimethylarsinic acid  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
flutamide  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
indole-3-methanol  (EXP)
leflunomide  (EXP)
methimazole  (EXP)
methylarsonic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium dichromate  (EXP,ISO)
succimer  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
toluene  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
uridine  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Demonstration of the existence of mRNAs encoding N1/cif and N2/cit sodium/nucleoside cotransporters in rat brain. Anderson CM, etal., Brain Res Mol Brain Res 1996 Dec;42(2):358-61.
2. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter. Che M, etal., J Biol Chem 1995 Jun 9;270(23):13596-9.
3. Bile acids alter the subcellular localization of CNT2 (concentrative nucleoside cotransporter) and increase CNT2-related transport activity in liver parenchymal cells. Fernandez-Veledo S, etal., Biochem J. 2006 Apr 15;395(2):337-44.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Characterization of the rat Na+/nucleoside cotransporter 2 and transport of nucleoside-derived drugs using electrophysiological methods. Larrayoz IM, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1395-404. Epub 2006 Jul 12.
7. Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2. Li JY, etal., J Cereb Blood Flow Metab 2001 Aug;21(8):929-36.
8. Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum. Melani A, etal., Exp Neurol. 2012 Jan;233(1):193-204. doi: 10.1016/j.expneurol.2011.09.036. Epub 2011 Oct 6.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Study on intestinal absorption sites of mizoribine and ribavirin, substrates for concentrative nucleoside transporter(s), in rats. Mori N, etal., Eur J Pharmacol. 2010 Feb 25;628(1-3):214-9. Epub 2009 Dec 2.
11. Functional and molecular characterization of adenosine transport at the rat inner blood-retinal barrier. Nagase K, etal., Biochim Biophys Acta. 2006 Jan;1758(1):13-9. Epub 2006 Feb 2.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes. Rodriguez-Mulero S, etal., Kidney Int. 2005 Aug;68(2):665-72.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes. Yao SY, etal., Mol Pharmacol 1996 Dec;50(6):1529-35.
Additional References at PubMed
PMID:1315767   PMID:10721696   PMID:15024061   PMID:15287894   PMID:16840788   PMID:17013559   PMID:20421393   PMID:22136384   PMID:22354287   PMID:23819782   PMID:25315414   PMID:28322028  


Genomics

Comparative Map Data
Slc28a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,778,425 - 129,841,292 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3129,807,537 - 129,841,291 (+)EnsemblGRCr8
mRatBN7.23109,324,815 - 109,387,702 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,366,996 - 109,387,702 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3113,039,238 - 113,060,743 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03121,634,754 - 121,656,259 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03119,295,132 - 119,316,637 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3127,683,910 - 127,705,419 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive3134,600,438 - 134,621,951 (+)NCBILyon_Normotensive
Lyon_Hypertensive3126,480,237 - 126,501,746 (+)NCBILyon_Hypertensive
F344_StmMcwi3107,784,797 - 107,806,302 (+)NCBIF344_StmMcwi
Rnor_6.03114,355,003 - 114,647,382 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,355,798 - 114,647,382 (+)Ensemblrn6Rnor6.0
Rnor_5.03120,897,082 - 120,921,371 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43109,350,531 - 109,372,027 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3108,262,866 - 108,284,103 (+)NCBICelera
RGSC_v3.13109,256,103 - 109,277,600 (-)NCBI
Cytogenetic Map3q35NCBI
SLC28A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,252,234 - 45,277,846 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,252,234 - 45,277,846 (+)Ensemblhg38GRCh38
GRCh371545,544,432 - 45,570,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,331,726 - 43,355,425 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341543,331,725 - 43,355,425NCBI
Celera1522,435,715 - 22,459,420 (+)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,368,444 - 22,392,157 (+)NCBIHuRef
CHM1_11545,662,894 - 45,686,614 (+)NCBICHM1_1
T2T-CHM13v2.01543,060,158 - 43,086,086 (+)NCBIT2T-CHM13v2.0
Slc28a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,256,836 - 122,291,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,256,958 - 122,291,618 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382122,426,357 - 122,461,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,426,477 - 122,461,137 (+)Ensemblmm10GRCm38
MGSCv372122,252,213 - 122,286,866 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362122,117,918 - 122,152,571 (+)NCBIMGSCv36mm8
Celera2123,576,831 - 123,613,534 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.63NCBI
Slc28a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,144,304 - 8,175,360 (-)Ensembl
ChiLan1.0NW_0049554098,145,723 - 8,175,256 (-)NCBIChiLan1.0ChiLan1.0
SLC28A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,491,976 - 34,519,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,670,150 - 38,697,435 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,199,846 - 24,223,378 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,554,204 - 42,577,891 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,554,142 - 42,578,096 (+)EnsemblpanPan2panpan1.1
Slc28a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864090,088,338 - 90,119,863 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,937,490 - 7,967,568 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,937,490 - 7,967,568 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC28A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,472,525 - 126,511,095 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11126,472,500 - 126,511,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,072,725 - 141,110,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC28A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12637,927,200 - 37,956,729 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048103,107,096 - 103,134,707 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc28a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473113,998,505 - 14,025,732 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473113,999,029 - 14,051,964 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc28a2
497 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:96
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000036435
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH127610  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,534,736 - 109,534,918 (+)MAPPERmRatBN7.2
Rnor_6.03114,379,146 - 114,379,328NCBIRnor6.0
Rnor_5.03120,920,944 - 120,921,126UniSTSRnor5.0
RGSC_v3.43109,199,517 - 109,199,698UniSTSRGSC3.4
RH 3.4 Map3954.4UniSTS
Cytogenetic Map3q35UniSTS
RH131217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23109,387,372 - 109,387,564 (+)MAPPERmRatBN7.2
Rnor_6.03114,647,053 - 114,647,244NCBIRnor6.0
Rnor_5.03121,185,952 - 121,186,143UniSTSRnor5.0
RGSC_v3.43109,350,669 - 109,350,860UniSTSRGSC3.4
Celera3108,476,193 - 108,476,389UniSTS
Celera3108,283,774 - 108,283,965UniSTS
RH 3.4 Map3953.5UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010064689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB485922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY029302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU032627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U25055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U66723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024658   ⟹   ENSRNOP00000024658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3129,807,537 - 129,841,291 (+)Ensembl
mRatBN7.2 Ensembl3109,366,996 - 109,387,702 (+)Ensembl
Rnor_6.0 Ensembl3114,355,798 - 114,647,382 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000036435   ⟹   ENSRNOP00000034564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3114,355,814 - 114,378,941 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3114,650,518 - 114,652,214 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122082   ⟹   ENSRNOP00000110608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3129,807,537 - 129,841,291 (+)Ensembl
RefSeq Acc Id: NM_031664   ⟹   NP_113852
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,819,788 - 129,841,292 (+)NCBI
mRatBN7.23109,366,196 - 109,387,702 (+)NCBI
Dahl_SR_JrHsd3127,683,910 - 127,705,419 (+)NCBI
Lyon_Normotensive3134,600,438 - 134,621,951 (+)NCBI
Lyon_Hypertensive3126,480,237 - 126,501,746 (+)NCBI
F344_StmMcwi3107,784,797 - 107,806,302 (+)NCBI
Rnor_6.03114,355,003 - 114,647,382 (+)NCBI
Rnor_5.03120,897,082 - 120,921,371 (+)NCBI
RGSC_v3.43109,350,531 - 109,372,027 (-)RGD
Celera3108,262,866 - 108,284,103 (+)RGD
Sequence:
RefSeq Acc Id: XM_039105768   ⟹   XP_038961696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,816,819 - 129,841,292 (+)NCBI
mRatBN7.23109,363,227 - 109,387,185 (+)NCBI
RefSeq Acc Id: XM_039105769   ⟹   XP_038961697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,778,449 - 129,841,292 (+)NCBI
mRatBN7.23109,324,815 - 109,387,699 (+)NCBI
RefSeq Acc Id: XM_039105770   ⟹   XP_038961698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,820,049 - 129,841,292 (+)NCBI
mRatBN7.23109,366,528 - 109,387,185 (+)NCBI
RefSeq Acc Id: XM_063284459   ⟹   XP_063140529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,778,442 - 129,841,292 (+)NCBI
RefSeq Acc Id: XM_063284460   ⟹   XP_063140530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,807,442 - 129,841,292 (+)NCBI
RefSeq Acc Id: XM_063284461   ⟹   XP_063140531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,778,425 - 129,841,292 (+)NCBI
RefSeq Acc Id: XM_063284462   ⟹   XP_063140532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,778,449 - 129,841,292 (+)NCBI
RefSeq Acc Id: XR_005501974
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,816,819 - 129,839,298 (+)NCBI
mRatBN7.23109,363,227 - 109,385,722 (+)NCBI
RefSeq Acc Id: XR_010064689
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83129,816,819 - 129,840,775 (+)NCBI
RefSeq Acc Id: NP_113852   ⟸   NM_031664
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024658   ⟸   ENSRNOT00000024658
Ensembl Acc Id: ENSRNOP00000034564   ⟸   ENSRNOT00000036435
RefSeq Acc Id: XP_038961697   ⟸   XM_039105769
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961696   ⟸   XM_039105768
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961698   ⟸   XM_039105770
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140531   ⟸   XM_063284461
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140529   ⟸   XM_063284459
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140532   ⟸   XM_063284462
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140530   ⟸   XM_063284460
- Peptide Label: isoform X1
- UniProtKB: F1LN73 (UniProtKB/TrEMBL),   Q91WW8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000110608   ⟸   ENSRNOT00000122082
Protein Domains
Concentrative nucleoside transporter C-terminal   Concentrative nucleoside transporter N-terminal   Nucleoside transporter/FeoB GTPase Gate

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62773-F1-model_v2 AlphaFold Q62773 1-659 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692368
Promoter ID:EPDNEW_R2893
Type:single initiation site
Name:Slc28a2_1
Description:solute carrier family 28 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03114,355,796 - 114,355,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61840 AgrOrtholog
BioCyc Gene G2FUF-48096 BioCyc
Ensembl Genes ENSRNOG00000028668 Ensembl, ENTREZGENE
  ENSRNOG00000052651 Ensembl
Ensembl Transcript ENSRNOT00000024658 ENTREZGENE
InterPro C_nuclsd_transpt UniProtKB/Swiss-Prot
  C_nuclsd_transpt_met_bac UniProtKB/Swiss-Prot
  CNT_C_dom UniProtKB/Swiss-Prot
  CNT_N_dom UniProtKB/Swiss-Prot
  Gate_dom UniProtKB/Swiss-Prot
KEGG Report rno:60423 UniProtKB/Swiss-Prot
NCBI Gene 60423 ENTREZGENE
PANTHER PTHR10590 UniProtKB/Swiss-Prot
  PTHR10590:SF11 UniProtKB/Swiss-Prot
Pfam Gate UniProtKB/Swiss-Prot
  Nucleos_tra2_C UniProtKB/Swiss-Prot
  Nucleos_tra2_N UniProtKB/Swiss-Prot
PharmGKB SLC28A2 RGD
PhenoGen Slc28a2 PhenoGen
RatGTEx ENSRNOG00000028668 RatGTEx
  ENSRNOG00000052651 RatGTEx
TIGR TC230283
UniProt A0ABK0M573_RAT UniProtKB/TrEMBL
  C1PHX8_RAT UniProtKB/TrEMBL
  F1LN73 ENTREZGENE, UniProtKB/TrEMBL
  Q62773 ENTREZGENE
  Q91WW8 ENTREZGENE, UniProtKB/TrEMBL
  S28A2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9QWI3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc28a2  solute carrier family 28 member 2  LOC102556085  sodium/nucleoside cotransporter 2-like  Data merged from RGD:7516973 737654 PROVISIONAL
2016-02-24 Slc28a2  solute carrier family 28 member 2  Slc28a2  solute carrier family 28 (concentrative nucleoside transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-07-25 Slc28a2  solute carrier family 28 (concentrative nucleoside transporter), member 2  Slc28a2  solute carrier family 28 (sodium-coupled nucleoside transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-17 LOC102556085  sodium/nucleoside cotransporter 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Slc28a2  solute carrier family 28 (sodium-coupled nucleoside transporter), member 2    solute carrier family 28, member 2   Name updated 1299863 APPROVED
2002-06-10 Slc28a2  solute carrier family 28, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference